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MTFSSEHDDFRRTIRRYIEEKINPRVDEWEREQMMPLHEVIADMAKLGFVGLEYDPEYGGQGADHLFTLV LAEELGRVDHGSFPMAFGVHVAMATPSLHKHGSDELKREFLAPALRGEQIAAIAVTEPDAGSDVAGIKTH ARRDGDDWVINGSKMFITNSVQADWLCVLARTSDEGGYAGMSQIIVPTKAPGYEVRKLDKLGMHASDTGL ITFDDVRVPVSNTIGEIGRGFQQQMSQFVMERMFGAYGIPASVNRALQRTKEYALARHVFGKPLTKNQHL AYQYAGLAARADMLEVYNRDIAERYMAGENVTRKVTIAKLTAGPLVREAGDWCLQVHGGMGYMTETWTSR FFRDQRLLSIGGGADEVMMRVLSQIDGFS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1851 | - | - | 100% (379) | acyl-CoA dehydrogenase FadE |
| M. abscessus ATCC 19977 | MAB_2085 | - | 3e-66 | 37.40% (361) | acyl CoA dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1073c | - | 8e-66 | 38.90% (383) | acyl-CoA dehydrogenase FadE |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2743c | fadE20 | 2e-57 | 34.49% (374) | acyl-CoA dehydrogenase FADE20 |
| M. gilvum PYR-GCK | Mflv_1884 | - | 2e-66 | 38.52% (379) | acyl-CoA dehydrogenase domain-containing protein |
| M. tuberculosis H37Rv | Rv0975c | fadE13 | 5e-63 | 37.01% (381) | acyl-CoA dehydrogenase FADE13 |
| M. leprae Br4923 | MLBr_00737 | fadE25 | 4e-44 | 32.17% (373) | putative acyl-CoA dehydrogenase |
| M. marinum M | MMAR_4532 | fadE13 | 2e-63 | 35.62% (379) | acyl-CoA dehydrogenase FadE13 |
| M. avium 104 | MAV_1091 | - | 8e-69 | 38.52% (379) | putative acyl-CoA dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_5491 | - | 3e-68 | 39.11% (381) | putative acyl-CoA dehydrogenase |
| M. thermoresistible (build 8) | TH_3604 | - | 8e-64 | 36.10% (374) | PUTATIVE putative acyl-CoA dehydrogenase domain protein |
| M. ulcerans Agy99 | MUL_4704 | fadE13 | 9e-63 | 35.09% (379) | acyl-CoA dehydrogenase FadE13 |
| M. vanbaalenii PYR-1 | Mvan_4847 | - | 4e-65 | 37.60% (383) | acyl-CoA dehydrogenase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb2743c|M.bovis_AF2122/97 ---MGSATKYQRTLFEPEHELFRESYRAFLDRHVAAYHDEWEKTKIVDR-
TH_3604|M.thermoresistible__bu --------VMQRTLYDSDHEDFRAVVRNFVQTHIEPNDEKFAAEGRLSR-
Mflv_1884|M.gilvum_PYR-GCK ----------MSIWTTPERDDLRRTVRAFAEREVLPFADEWERAREIPR-
Mvan_4847|M.vanbaalenii_PYR-1 ----------MSIWTTPERDDLRKTVRAFVEREVLPHAGEWERIGELPR-
MSMEG_5491|M.smegmatis_MC2_155 ----------MSIWTTAEREALRKTVRAFAEREVLPHAHEWERAGEIPR-
MMAR_4532|M.marinum_M ----------MSIWNTPEREELRKTVRSFAEREVLPHIDEWERTGELPR-
MUL_4704|M.ulcerans_Agy99 ----------MSIWNTPEREELRKSVRSFAEREVLPHIDEWERTGELPL-
MAV_1091|M.avium_104 ----------MNLWTTPEREQLRKTVRSFAEREILPHVDEWERSGELPR-
Rv0975c|M.tuberculosis_H37Rv ----------MNIWTTPERQQLRKTVRAFAEREILPHVDEWERIGELPR-
MAB_1851|M.abscessus_ATCC_1997 ------------MTFSSEHDDFRRTIRRYIEEKINPRVDEWEREQMMPLH
MLBr_00737|M.leprae_Br4923 MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFPE-
::: :* * : .: . . .
Mb2743c|M.bovis_AF2122/97 GVWLEAGKQGFLGMAVPEEYGGGGNADFRYNTVITEETC-AGRYSGIGFG
TH_3604|M.thermoresistible__bu ELWRAAGDTGMLGLCVPEQYGGAGVNDYRFNAVMDEELTRAGMAYACGLG
Mflv_1884|M.gilvum_PYR-GCK DLHRAAAAAGLLGAGFPEEVGGDGGDGADAVVICEEMHESGCPGGVFASL
Mvan_4847|M.vanbaalenii_PYR-1 ELHRKAAEVGLLGAGFPESVGGGGGDGADAVVICEEMHRAGAPGGVFASL
MSMEG_5491|M.smegmatis_MC2_155 ELHRKAAELGLLGAGFPEDAGGSGGDGADPVVICEEMHYAGSPGGVYASL
MMAR_4532|M.marinum_M DLHRRAGAAGLLGAGLPESAGGGGGDGADSVIICEQMHQSGAPGGVFASL
MUL_4704|M.ulcerans_Agy99 DLHRRAGAAGLLGAGLPESAGGGGGDGADSVIICEQMHQSGAPGGVFASL
MAV_1091|M.avium_104 ELHRSAGAAGLLGAGFPESVGGGGGDGADAVIICEEMHQAGAPGGVFASL
Rv0975c|M.tuberculosis_H37Rv GLHRLAGAAGLLGAGFPEAVGGGGGDGADPVIICEEMHQAGAPGGVYASL
MAB_1851|M.abscessus_ATCC_1997 EVIADMAKLGFVGLEYDPEYGGQGADHLFTLVLAEELGRVDHGSFPMAFG
MLBr_00737|M.leprae_Br4923 EALAALNASGFNAIHVPEEYGGQGADSVAACIVIEEVARVDASASLIPAV
*: . ** * : :
Mb2743c|M.bovis_AF2122/97 LHNDIVAPYLLALATEEQKRRWFPNFCTGELTTAIAMTEPGTGSDLQGIT
TH_3604|M.thermoresistible__bu VHTHVVSQYLVHMTTEEQRARWLPDFVSGELITAVAMSEPSGGSDLAALR
Mflv_1884|M.gilvum_PYR-GCK FTSGIAVPHMIASQDERLIDTYVRPTLRGENIGSLAITEPGGGSDVGHLT
Mvan_4847|M.vanbaalenii_PYR-1 FTSGIAVPHMIASGDEHLIDTYVRPTLRGEKIGALAITEPGGGSDVGHLT
MSMEG_5491|M.smegmatis_MC2_155 FTCGIAVPHMIASGDQRLIDTYVRPTLRGEKIGALAITEPGGGSDVGHLR
MMAR_4532|M.marinum_M FTCGIAVPHMIASGDERLIEEFVRPTLAGDKIGALAITEPGGGSDVGHLR
MUL_4704|M.ulcerans_Agy99 FTCGIAVPHMIASGDERLIEEFVRPTLAGNKIGALAITEPGGGSDVGHLR
MAV_1091|M.avium_104 FTCGIAVPHMIASGDQRLIEEFVRPTLAGEKIGSLAITEPGGGSDVGHLR
Rv0975c|M.tuberculosis_H37Rv FTCGIAVPHMVASGDERLIATYVRPTLAGEKIGALAITEPGGGSDVGHLR
MAB_1851|M.abscessus_ATCC_1997 VHVAMATPSLHKHGSDELKREFLAPALRGEQIAAIAVTEPDAGSDVAGIK
MLBr_00737|M.leprae_Br4923 NKLGTMG--LILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMR
: :. . : *::* *** :
Mb2743c|M.bovis_AF2122/97 TRAVKHGDHYVLNGSKTFITNGINSDLVIVVAQTDPEKGAQGFSLLVVER
TH_3604|M.thermoresistible__bu TRARRDGDQWVINGSKIFITNGATADLIVVAVRTGEETGSRGISLIAVEG
Mflv_1884|M.gilvum_PYR-GCK TRAVRDGDCFIVNGAKTYITSGVRADYVVTAARTGGPG-AAGISLIVVDK
Mvan_4847|M.vanbaalenii_PYR-1 TRAVKDGDCYILNGAKTFITSGVRADYVVTAVRTGGPG-AGGISLIVVDK
MSMEG_5491|M.smegmatis_MC2_155 TRADLDGDHYVINGAKTYITSGVRADYVVTAARTGGPG-AGGVSLIVVDK
MMAR_4532|M.marinum_M TSAVRDGDHFIVNGAKTYITSGVRADFVVTAVRTGGPG-AGGVSLLVVEK
MUL_4704|M.ulcerans_Agy99 TSAVREGDHFIVNGAKTYITSGVRADFVVTAVRTGGPG-AGGVSLLVVEK
MAV_1091|M.avium_104 TSAVRDGDHYIVNGAKTYITSGVRADYVVTAVRTGGPG-AAGVSLLVVEK
Rv0975c|M.tuberculosis_H37Rv TSAVRDGDHYVINGAKTYITSGVRADYVVTAVRTGGPG-AAGVSLLVVEK
MAB_1851|M.abscessus_ATCC_1997 THARRDGDDWVINGSKMFITNSVQADWLCVLARTSDEGGYAGMSQIIVPT
MLBr_00737|M.leprae_Br4923 TRAKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGANGISAFIVHK
* * .** :::** * :**.. : . . *. *.* : *
Mb2743c|M.bovis_AF2122/97 G----MAGFERGRQLDKIGLDAQDTAELSFTDVAVPAENLLGQEGMGFIY
TH_3604|M.thermoresistible__bu D----APGLDRGRTLRKIGQHQGDTAELFFDDCRVPVANLIGEEGAGFRA
Mflv_1884|M.gilvum_PYR-GCK G----TPGFAVSRKLDKMGWRSSDTAELSYTDVRVPAANVVGAENTGFLQ
Mvan_4847|M.vanbaalenii_PYR-1 DGPGCSPGLQVTRKLDKMGWRSSDTAELSYTDARVPAGNLVGAENTGFLQ
MSMEG_5491|M.smegmatis_MC2_155 G----TPGFEVTRKLDKMGWRSSDTAELSYTDVRVPVANLVGSENTGFAQ
MMAR_4532|M.marinum_M G----TPGFVVSRKLDKMGWRSSDTAELSYTDARVPAANLVGAENSGFAQ
MUL_4704|M.ulcerans_Agy99 G----TPGFVVSRKLDKMGWRSSDTAELSYTDARIPAANLVGAENSGFAQ
MAV_1091|M.avium_104 G----TPGFEVTRKLDKMGWRSSDTAELSYTDVRVPVSNLVGAENTGFAQ
Rv0975c|M.tuberculosis_H37Rv D----TPGFEVTRKLDKMGWRSSDTAELCYTDVAVPATNLVGAENSGFTQ
MAB_1851|M.abscessus_ATCC_1997 K----APGYEV-RKLDKLGMHASDTGLITFDDVRVPVSNTIGEIGRGFQQ
MLBr_00737|M.leprae_Br4923 D----DEGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKT
* *:* * : : . :* . :* . **
Mb2743c|M.bovis_AF2122/97 LMQNLPQERISIAIMAAAGMESVLEQTLQYAKERKAFGRSIGSFQNSRFL
TH_3604|M.thermoresistible__bu MMEHLAQERLASAVCNVAHARHVLELTCRYVTERYAFGASLGALQHIRFQ
Mflv_1884|M.gilvum_PYR-GCK IAAAFVSERVGLAAQAYSSAQRCLDLTVEWCRNRQTFGKPLIARQTVQST
Mvan_4847|M.vanbaalenii_PYR-1 IAAAFVSERVGLAAQAYSSAQRCLDLTVEWCRSRETFGKPLITRQSVQNT
MSMEG_5491|M.smegmatis_MC2_155 IAAAFVAERVGLATQAYAGAQRCLDLTVEWCRNRDTFGRPLISRQAVQNT
MMAR_4532|M.marinum_M IAQAFVSERIALAAQAYSSAQRCLDITVQWCRDRETFGRPLISRQSVQNT
MUL_4704|M.ulcerans_Agy99 IAQAFVSERIALAAQAYSSAQRCLDITVQWCRDRETFGRPLISRQSVQNT
MAV_1091|M.avium_104 IAQAFVSERIGLAAQAYSSAQRCLDLTVQWCRDRETFGRPLISRQSVQNT
Rv0975c|M.tuberculosis_H37Rv IARAFVSERIGLAAQAYSSAQRCLDLTAQWCRDRETFGRPLISRQSVQNT
MAB_1851|M.abscessus_ATCC_1997 QMSQFVMERMFGAYGIPASVNRALQRTKEYALARHVFGKPLTKNQHLAYQ
MLBr_00737|M.leprae_Br4923 ALATLDHTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFM
: * . . . *: : : * ** .: *
Mb2743c|M.bovis_AF2122/97 LAELATEATVVRIMVDEFIKLHLAGKL-TAEQAAMAKWYATEKQVYLNDR
TH_3604|M.thermoresistible__bu MADMVTELDIIQTYVDACVAAHVRGDL-TAIDAAKAKLKSSDIQSQIVDT
Mflv_1884|M.gilvum_PYR-GCK LAEMARRIDVARVYTRHVVERQLAGDADLITEVCFAKNTAVEAGEWVANQ
Mvan_4847|M.vanbaalenii_PYR-1 LAEMARRIDVARVYTHHVVERELAGETNLIAEVCFAKNTAVDAGEWVAHQ
MSMEG_5491|M.smegmatis_MC2_155 LAGMARRIDVARVYTRHVVERQLAGETNLIAEVCFAKNTAVEAGEWVANQ
MMAR_4532|M.marinum_M LAEMARRIDVARVYSRSVVERQLAGEHDLIPQVCFAKNTAVEAGEWVANQ
MUL_4704|M.ulcerans_Agy99 LAEMARRIDVARVYSRSVVERQLAGEHDLIPQVCFAKNTAVEAGEWVANQ
MAV_1091|M.avium_104 LAEMARRIDVARVYSRNVVERQLAGETNLIPQVCFAKNTAVEAGEWVANQ
Rv0975c|M.tuberculosis_H37Rv LAEMARRIDVARVYAHHVVERQLAGETDLIAQVCFAKNTAVQAGEWVANQ
MAB_1851|M.abscessus_ATCC_1997 YAGLAARADMLEVYNRDIAERYMAGEN-VTRKVTIAKLTAGPLVREAGDW
MLBr_00737|M.leprae_Br4923 LADMAMKVEAARLIVYAAAARAERGEPDLGFISAASKCFASDIAMEVTTD
* :. . . *. :* :
Mb2743c|M.bovis_AF2122/97 CLQLHGGYGYMREYPVARAYLDSRVQTIYGGTTEIMKEIIGRGLGV----
TH_3604|M.thermoresistible__bu CVQLHGGYGYMEEYEVARAWRDARVTRIWAGTNEIMREVIGRSLNLREPS
Mflv_1884|M.gilvum_PYR-GCK AVQLFGGMGYMTESEVERQYRDMRILGIGGGTTEILTSLAAKTLGYQT--
Mvan_4847|M.vanbaalenii_PYR-1 AVQLFGGMGYMAESEVERQYRDMRILGIGGGTSEILTALAAKTLGYQS--
MSMEG_5491|M.smegmatis_MC2_155 AVQLFGGMGYMAESEVERQYRDMRILGIGGGTTEILTSLAAKTLGFQS--
MMAR_4532|M.marinum_M AVQLFGGMGYMAESEIERQYRDMRILGIGGGTTEILTALAAKLLGYQS--
MUL_4704|M.ulcerans_Agy99 AVQLFGGMGYMAESEIERQYRDMRILGIGGGTTEILTALAAKLLGYQS--
MAV_1091|M.avium_104 AVQLFGGMGYMAESEVERQYRDMRILGIGGGTTEILTALSAKLLGFQS--
Rv0975c|M.tuberculosis_H37Rv AVQLFGGMGYMAESEVERQYRDMRILGIGGGTTEILTALAAKTLGYQS--
MAB_1851|M.abscessus_ATCC_1997 CLQVHGGMGYMTETWTSRFFRDQRLLSIGGGADEVMMRVLSQIDGFS---
MLBr_00737|M.leprae_Br4923 AVQLFGGAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR----
.:*:.** ** : * * :: * *: :: : .:
Mb2743c|M.bovis_AF2122/97 --
TH_3604|M.thermoresistible__bu KH
Mflv_1884|M.gilvum_PYR-GCK --
Mvan_4847|M.vanbaalenii_PYR-1 --
MSMEG_5491|M.smegmatis_MC2_155 --
MMAR_4532|M.marinum_M --
MUL_4704|M.ulcerans_Agy99 --
MAV_1091|M.avium_104 --
Rv0975c|M.tuberculosis_H37Rv --
MAB_1851|M.abscessus_ATCC_1997 --
MLBr_00737|M.leprae_Br4923 --