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MRLLPFGGAPGRTHRADAVVTGAGSGIGRAFAVELARRGGRVVCADRDPVTAKESAELVRQAGGEGFDIA CDVTDLEQIRNLADVSEDWFGKAASLVINNAGIGAGGNRIGATSIEDWKAAISVNLWGVIYGCETFVPRL RSSGHGGVINVASAASFGSAPRMAAYNVSKAGVLALSETLAAELSGTDVKVTVLCPTFVKTNIVKNPQID EAAARLAANLMKWTGISPQHVARTTLNAHDRGQIYVVPQLDAKVLWQLKRALPGPFTRTLGLVERMASWN DSAE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2071 | - | - | 100% (284) | short-chain dehydrogenase/reductase |
| M. abscessus ATCC 19977 | MAB_4478c | - | 3e-97 | 64.00% (275) | putative short-chain dehydrogenase/reductase |
| M. abscessus ATCC 19977 | MAB_4053c | - | 1e-89 | 60.30% (267) | putative short chain dehydrogenase/reductase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0874c | - | 4e-34 | 37.20% (250) | short chain dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4610 | - | 1e-116 | 74.73% (277) | short-chain dehydrogenase/reductase SDR |
| M. tuberculosis H37Rv | Rv0851c | - | 2e-34 | 37.20% (250) | short chain dehydrogenase |
| M. leprae Br4923 | MLBr_01094 | - | 8e-34 | 37.60% (242) | short chain alcohol dehydrogenase |
| M. marinum M | MMAR_3141 | - | 1e-148 | 89.44% (284) | short-chain membrane-associated dehydrogenase |
| M. avium 104 | MAV_1797 | - | 3e-82 | 56.27% (263) | oxidoreductase, short chain dehydrogenase/reductase family |
| M. smegmatis MC2 155 | MSMEG_4280 | - | 7e-32 | 34.75% (259) | short chain dehydrogenase |
| M. thermoresistible (build 8) | TH_4323 | - | 1e-31 | 40.32% (186) | PUTATIVE short-chain dehydrogenase/reductase SDR |
| M. ulcerans Agy99 | MUL_3643 | - | 2e-83 | 56.18% (267) | short-chain membrane-associated dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_1521 | - | 8e-83 | 55.97% (268) | short-chain dehydrogenase/reductase SDR |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_2071|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3141|M.marinum_M --------------------------------------------------
Mflv_4610|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1797|M.avium_104 --------------------------------------------------
MUL_3643|M.ulcerans_Agy99 --------------------------------------------------
Mvan_1521|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4280|M.smegmatis_MC2_155 --MYTFVTSQDGTRIAVYQQGDPERPTLVMAHGWPDSHVLWDGVVGELGD
TH_4323|M.thermoresistible__bu MATEHFIDSSGGVRIAAYEEGNPDGPTVVLVHGWPDSHVVWDSVAPLLAD
MLBr_01094|M.leprae_Br4923 --------------------------------------------------
Mb0874c|M.bovis_AF2122/97 --------------------------------------------------
Rv0851c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2071|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3141|M.marinum_M --------------------------------------------------
Mflv_4610|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1797|M.avium_104 --------------------------------------------------
MUL_3643|M.ulcerans_Agy99 --------------------------------------------------
Mvan_1521|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4280|M.smegmatis_MC2_155 RYRIVRYDNRGAGASDVPKATSAYTMERFADDFSAVIDAVSPDAPVHVLA
TH_4323|M.thermoresistible__bu RFRIIRYDNRGVGRTTAPRRVADHTMARYADDFGAVIDALAPGQRVHVLA
MLBr_01094|M.leprae_Br4923 --------------------------------------------------
Mb0874c|M.bovis_AF2122/97 --------------------------------------------------
Rv0851c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2071|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3141|M.marinum_M --------------------------------------------------
Mflv_4610|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1797|M.avium_104 --------------------------------------------------
MUL_3643|M.ulcerans_Agy99 --------------------------------------------------
Mvan_1521|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4280|M.smegmatis_MC2_155 HDWGSVGIWEYLSRQGSAARMVSFTSVSGPSTDHYGAYVRRGLARPYRPV
TH_4323|M.thermoresistible__bu HDWGSAGVWEYLARPEAEDRIASFTSVSGPSGDHLARYVLDGLAAPYRPR
MLBr_01094|M.leprae_Br4923 --------------------------------------------------
Mb0874c|M.bovis_AF2122/97 --------------------------------------------------
Rv0851c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2071|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3141|M.marinum_M --------------------------------------------------
Mflv_4610|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1797|M.avium_104 --------------------------------------------------
MUL_3643|M.ulcerans_Agy99 --------------------------------------------------
Mvan_1521|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4280|M.smegmatis_MC2_155 QFARAVNLASRFSYWIPFSIPVLAPALMR----RGAARRLQAID-TPGPK
TH_4323|M.thermoresistible__bu RFLRSLTQLLRLSYMGFFSIPVLAPLLVRGVLSKALRRSLRLRDGVPADR
MLBr_01094|M.leprae_Br4923 --------------------------------------------------
Mb0874c|M.bovis_AF2122/97 --------------------------------------------------
Rv0851c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2071|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3141|M.marinum_M --------------------------------------------------
Mflv_4610|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1797|M.avium_104 --------------------------------------------------
MUL_3643|M.ulcerans_Agy99 --------------------------------------------------
Mvan_1521|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4280|M.smegmatis_MC2_155 FQ-SENLDIDAANSLKIYRANAIRSFTHVRRDHYVQVPVQLICNRKDPVV
TH_4323|M.thermoresistible__bu LHHSDTFAADAARSIKVYGANFLRTLRHARTDHFVRVPVQLIVNTRDPYV
MLBr_01094|M.leprae_Br4923 --------------------------------------------------
Mb0874c|M.bovis_AF2122/97 --------------------------------------------------
Rv0851c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2071|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_3141|M.marinum_M --------------------------------------------------
Mflv_4610|M.gilvum_PYR-GCK --------------------------------------------------
MAV_1797|M.avium_104 --------------------------------------------------
MUL_3643|M.ulcerans_Agy99 --------------------------------------------------
Mvan_1521|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4280|M.smegmatis_MC2_155 RGEGYRDESKWVPLLWRRDLDAGHWAPFSHPRAIAQAVGEFVDHMEGAPP
TH_4323|M.thermoresistible__bu RPHVYDETDRWVSRLWRRDIKAGHWSPMSHPQVLATAVTELADHLAGAPA
MLBr_01094|M.leprae_Br4923 --------------------------------------------------
Mb0874c|M.bovis_AF2122/97 --------------------------------------------------
Rv0851c|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2071|M.abscessus_ATCC_1997 ---MRLLPFGGAPGRTHRADAVVTGAGSGIGRAFAVELARRGGRVVCADR
MMAR_3141|M.marinum_M ---MRFLPFGSSPGRTHRAHAVVTGAGSGIGRAFAVELARRGGRVVCADK
Mflv_4610|M.gilvum_PYR-GCK ---MDILRWDRPPRLSRRANAVVTGAGSGIGRAFAVELARRGGRVVCADI
MAV_1797|M.avium_104 ---MLDRLLHRS-KTSRGALAVVTGAGSGIGAAFALELGKRGGTVVCSDI
MUL_3643|M.ulcerans_Agy99 MLGPLDKLLGKSRKTSHDALAVVTGAGSGIGAAFALELGRRGSAVVCSDI
Mvan_1521|M.vanbaalenii_PYR-1 -------MGLFGAKRTHRADAVITGAGSGIGAAFAVELARRGGRVVCSDV
MSMEG_4280|M.smegmatis_MC2_155 ARALRRAEVARPRKAFSDMLVSVTGAASGIGRATALEFARLGAEIVVSDI
TH_4323|M.thermoresistible__bu GRALLRAQVGRPREYFGDMLVAITGAGGGIGRETALAFAREGAEVIVSDI
MLBr_01094|M.leprae_Br4923 ------------MEGFAGKVAVVTGAGSGIGQALAIELARSGAKLAISDV
Mb0874c|M.bovis_AF2122/97 ------------MDGFPGRGAVITGGASGIGLATGTEFARRGARVVLGDV
Rv0851c|M.tuberculosis_H37Rv ------------MDGFPGRGAVITGGASGIGLATGTEFARRGARVVLGDV
. :**...*** . :.: *. : .*
MAB_2071|M.abscessus_ATCC_1997 DPVTAKESAELVRQAGGEGFDIACDVTDLEQIRNLADVSEDWFGKAASLV
MMAR_3141|M.marinum_M DPITAKESAELVRQAGGEGFDVVCDVTDLEQVRNLADASEDWFGKAASLV
Mflv_4610|M.gilvum_PYR-GCK DPVRAKETVGLVVQAGGEGLDIACDVTDEEQVRELADSAEKWFGAAASLV
MAV_1797|M.avium_104 DQAAAQRTADAITEHGAKALATRCDVSQFGVVQALAEQSQSWFGAPPTLV
MUL_3643|M.ulcerans_Agy99 DEVAAQNTVAALTEAGARAISIGCDVSRIEDVTALAERSQAWFDGPPTLV
Mvan_1521|M.vanbaalenii_PYR-1 SVEAARGTADAIIADGGRALPAQCDVTDIDAMYRLAGEAQTWFDGPPTLV
MSMEG_4280|M.smegmatis_MC2_155 DEAGAKATATAIDEAGGVAHAYGLDVADPDAVQRFVDDVCATHG-VPDIV
TH_4323|M.thermoresistible__bu DEATAKDTAAEIAARGGVAHAYQLDVSDAAAVDRFADEVCARHG-VPDIV
MLBr_01094|M.leprae_Br4923 DGEGLAQTEGQLKAIGASARTDRLDVTEREAFLTYADVVHENFG-KVNQI
Mb0874c|M.bovis_AF2122/97 DKPGLRQAVNHLRAEGFDVHGVMCDVRHREEVTHLADEAFRLLG-HFDVV
Rv0851c|M.tuberculosis_H37Rv DKPGLRQAVNHLRAEGFDVHSVMCDVRHREEVTHLADEAFRLLG-HVDVV
. : : * ** . . . :
MAB_2071|M.abscessus_ATCC_1997 INNAGIGAGGNRIGATSIEDWKAAISVNLWGVIYGCETFVPRLRSSGH--
MMAR_3141|M.marinum_M INNAGIGAGGNRIGATSVEDWNAAISVNLWGVIYGCETFVPRLRSNGR--
Mflv_4610|M.gilvum_PYR-GCK INNAGIGIGGNVIGATPKRDWEATLSVNLWGVIYGCEIFVPRLRAKGS--
MAV_1797|M.avium_104 INNAGVGAGGAAIGDAPLDDWQWTLGINLWGPIHGCHVFTPILRDAAPSA
MUL_3643|M.ulcerans_Agy99 INNAGVGAGGAGIGEIPLDDWLWTLGINLWGPIHGCHVFTPILREAGRAV
Mvan_1521|M.vanbaalenii_PYR-1 INNAGVGAGGAFIGETELADWKWVLDINLWGPIHGCHVFAPILREAGR--
MSMEG_4280|M.smegmatis_MC2_155 VNNAGIGHAG-NFLDTPADQYERVLEVNFGGVVNCCRAFGRRLVEQGTGG
TH_4323|M.thermoresistible__bu VNNAGIGHAG-RFLDTPRDQWDRVLEVNLGGVVNGCRAFAPRLVERGTGG
MLBr_01094|M.leprae_Br4923 YNNAGIAFTG-DVEVSHFKDIERVMDVDYWGVVNGTKAFLPYLISSGDG-
Mb0874c|M.bovis_AF2122/97 FSNAGIVVGG-PIVEMTHDDWRWVIDVDLWGSIHTVEAFLPRLLEQGTGG
Rv0851c|M.tuberculosis_H37Rv FSNAGIVVGG-PIVEMTHDDWRWVIDVDLWGSIHTVEAFLPRLLEQGTGG
.***: * . : .: :: * : . * * .
MAB_2071|M.abscessus_ATCC_1997 --GGVINVASAASFGSAPRMAAYNVSKAGVLALSETLAAELSGTD--VKV
MMAR_3141|M.marinum_M --GGVINVASAASFGSAPRMGAYNVSKAGVLALSETLAAELSGTN--VNV
Mflv_4610|M.gilvum_PYR-GCK --GGIINVASAASFGAAPRMGAYNVSKAGVLSLSETLAAELSGTG--VAV
MAV_1797|M.avium_104 APRGIINVASAAAFGAAPGMAAYNVSKAGVLSLSETLAAELSGTP--VRV
MUL_3643|M.ulcerans_Agy99 GPRGIINVASAAAFGAAPGMAAYNVSKAGVLSLSETLAAELSGTG--INV
Mvan_1521|M.vanbaalenii_PYR-1 -PAGIINVASAAAFGAAPGMAAYNVSKAGTLSLSETLAAELAGTG--INV
MSMEG_4280|M.smegmatis_MC2_155 ---HIVNVASMAAYSPAGSMNAYATSKAAVFMFSDCLRAELAHAG--IGV
TH_4323|M.thermoresistible__bu ---HIVNIASMASYAPLQSLNAYCTSKAAVYMFSDCLRAELDSAG--IML
MLBr_01094|M.leprae_Br4923 ---HVINISSVFGLFSVPGQAAYNSAKFAVRGFTEALREEMALAGRPVNV
Mb0874c|M.bovis_AF2122/97 ---HVVFTASFAGLVPNAGLGAYGVAKYGVVGLAETLAREVTADG--IGV
Rv0851c|M.tuberculosis_H37Rv ---HVVFTASFAGLVPNAGLGAYGVAKYGVVGLAETLAREVTADG--IGV
:: :* . . ** :* .. ::: * *: : :
MAB_2071|M.abscessus_ATCC_1997 TVLCPTFVKTNIVKN---------PQIDEAAARLAANLMKWTGISPQHVA
MMAR_3141|M.marinum_M TVLCPTFVKTNIAKN---------PQIEESAAKLATNLMRWTGISPDQVA
Mflv_4610|M.gilvum_PYR-GCK TVLCPTFVKTNIVDN---------PGIEESAAKLATNLMKWTGVSAESVA
MAV_1797|M.avium_104 TVLCPTFVKTTILES---------GRISEESGELAAKLMRWTGFSADKVA
MUL_3643|M.ulcerans_Agy99 TVLCPTFVKTNIVES---------GRISEQSSEVVTKLIRWTGFSPDKVA
Mvan_1521|M.vanbaalenii_PYR-1 TVLCPTFVKTNIVES---------GRISTGTSQLAERLMRWTGFPAARVA
MSMEG_4280|M.smegmatis_MC2_155 TTLCPGMIDTGIVDTTRFDVPAHKAGQVEARRAQVKKTFQARRYGPEKVA
TH_4323|M.thermoresistible__bu TTICPSTVNTNIIGSTRFNAPDGLDDVVDTRREQLQKLFALRRFGPDKAA
MLBr_01094|M.leprae_Br4923 TTVYPGGIKTAIARN------ATAAEGLDVSKIASRFDTWVAHTSPQHAA
Mb0874c|M.bovis_AF2122/97 SVLCPMVVETNLVANSE-RIRGAACAQSSTTGSPGPLPLQDDNLGVDDIA
Rv0851c|M.tuberculosis_H37Rv SVLCPMVVETNLVANSE-RIRGAACAQSSTTGSPGPLPLQDDNLGVDDIA
:.: * :.* : . *
MAB_2071|M.abscessus_ATCC_1997 RTTLNAHDRGQIYVVPQLD--AKVLWQLKRALPGPFTRTLGLVERMASWN
MMAR_3141|M.marinum_M RTTLNAHDRGQIYVVPQLD--AKILWQLKRALPGQFTRALGLVERVASWN
Mflv_4610|M.gilvum_PYR-GCK RKTLDANDRGQLHVLPQVD--AKILWLFKRAVPATYTRALGLVERIAR--
MAV_1797|M.avium_104 RICLDAHDRGDLYCMPQLD--AQIGWHIKRLAPQAYTRAAGLVSRINLP-
MUL_3643|M.ulcerans_Agy99 RICLDANDRGDLYCMPQLD--AKIGWNIKRMAPGTYTRAAGLILRATMR-
Mvan_1521|M.vanbaalenii_PYR-1 RSALDTLDRGGLYCMPQPE--ARIGWGVKRFTPTVFTRAAGIATRITT--
MSMEG_4280|M.smegmatis_MC2_155 KAVTSAVSRNQALRPVTPE--AYVAYGVSRLFPAALRRAARSQVL-----
TH_4323|M.thermoresistible__bu KAIVSAVKQNKPIRPVMPE--AYFVYGVSRVLPQALRSTARGRVL-----
MLBr_01094|M.leprae_Br4923 RIILKAVRKKKARVLVGPD--AKVANVVVRFSGGAGYQRLFAQVASRLIL
Mb0874c|M.bovis_AF2122/97 QLTADAILANRLYVLPHAASRASIRRRFERIDRTFDEQAAEGWRH-----
Rv0851c|M.tuberculosis_H37Rv QLTADAILANRLYVLPHAASRASIRRRFERIDRTFDEQAAEGWRH-----
: .: * . . *
MAB_2071|M.abscessus_ATCC_1997 DSAE----
MMAR_3141|M.marinum_M DPAEQREQ
Mflv_4610|M.gilvum_PYR-GCK --------
MAV_1797|M.avium_104 --------
MUL_3643|M.ulcerans_Agy99 --------
Mvan_1521|M.vanbaalenii_PYR-1 --------
MSMEG_4280|M.smegmatis_MC2_155 --------
TH_4323|M.thermoresistible__bu --------
MLBr_01094|M.leprae_Br4923 NQR-----
Mb0874c|M.bovis_AF2122/97 --------
Rv0851c|M.tuberculosis_H37Rv --------