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DAEGFITLVDRKKDMIISGGENVYPIEVEQVLFRHPAVFDAAVIGGKDAKWGERVVAVVVADPATQAPSA EEIVAWCRERLAHFKCPRDVHFVAELPRNATGKLLKTELRAQFTGIEGGVVLR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2062c | - | - | 100% (124) | long-chain-fatty-acid--CoA ligase |
| M. abscessus ATCC 19977 | MAB_3592c | - | 1e-30 | 56.36% (110) | putative medium-chain acyl-CoA ligase |
| M. abscessus ATCC 19977 | MAB_4559 | - | 1e-25 | 48.25% (114) | putative long-chain-fatty-acid CoA ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3116 | fadD13 | 3e-28 | 52.17% (115) | chain-fatty-acid-CoA ligase |
| M. gilvum PYR-GCK | Mflv_4616 | - | 2e-57 | 82.40% (125) | AMP-dependent synthetase and ligase |
| M. tuberculosis H37Rv | Rv3089 | fadD13 | 3e-28 | 52.17% (115) | chain-fatty-acid-CoA ligase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 7e-22 | 45.45% (110) | acyl-CoA synthetase |
| M. marinum M | MMAR_0452 | fadD4 | 6e-28 | 50.00% (118) | fatty-acid-CoA ligase FadD4 |
| M. avium 104 | MAV_3523 | - | 1e-33 | 60.53% (114) | acyl-CoA synthase |
| M. smegmatis MC2 155 | MSMEG_0131 | - | 7e-29 | 52.85% (123) | acyl-CoA synthetase |
| M. thermoresistible (build 8) | TH_2878 | - | 5e-28 | 54.87% (113) | PUTATIVE AMP-binding enzyme, putative |
| M. ulcerans Agy99 | MUL_1191 | fadD2 | 5e-23 | 46.36% (110) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_0943 | - | 2e-30 | 57.02% (114) | AMP-dependent synthetase and ligase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3116|M.bovis_AF2122/97 --------------------------------------------------
Rv3089|M.tuberculosis_H37Rv --------------------------------------------------
MAB_2062c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_4616|M.gilvum_PYR-GCK -------------------------------------------------M
MSMEG_0131|M.smegmatis_MC2_155 -------------------------------------MTAEPSQIEQPYL
TH_2878|M.thermoresistible__bu --------------------------------------------LQQPYL
MAV_3523|M.avium_104 -----------------------------------------------MPA
Mvan_0943|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_0452|M.marinum_M --------------------------------------------------
MLBr_02546|M.leprae_Br4923 ---------MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVA
MUL_1191|M.ulcerans_Agy99 MPNLSDLPGVAKIQQYVDRGAAELHYVRKIIESGAFRLESPLNYAAMATE
Mb3116|M.bovis_AF2122/97 ---MKNIGWMLRQRATVSPRLQAYVEPSTDVRMTYAQMNALANRCADVLT
Rv3089|M.tuberculosis_H37Rv ---MKNIGWMLRQRATVSPRLQAYVEPSTDVRMTYAQMNALANRCADVLT
MAB_2062c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_4616|M.gilvum_PYR-GCK DRGIGQWV---TKRAFLNGQRTALVQG--DTSFTYSDFDRRTNQVASSLL
MSMEG_0131|M.smegmatis_MC2_155 ARRQ-NWVNQLTRHAMMQPDKTALRFL--GRTTTWRELDDRVTRLAGALN
TH_2878|M.thermoresistible__bu ARRQ-NWVNHLARHALMQPDATALRFM--GQTTTWADLHHRVNRLAGALR
MAV_3523|M.avium_104 AETRETLAGIVERHAQRRPDAIAIRYG--ERQWSWAEWSSRIRRAAGALR
Mvan_0943|M.vanbaalenii_PYR-1 --MIHNLADIIRVHGRERPGAPALVVG--DRTVTYGELDDRSSRAAQAFA
MMAR_0452|M.marinum_M ----------MQIRQHVGADKPAVILHPSGTVVSFDELEARANRLAHRFR
MLBr_02546|M.leprae_Br4923 MRKWGDLAMLPAMPARRSPHRAALIDE--EGTLTYKELDRAAHALANGLI
MUL_1191|M.ulcerans_Agy99 IAKWGEFGMLPSFNARRHPHRAACIDE--EGEFTYQQLDEAGHAVANALL
Mb3116|M.bovis_AF2122/97 ALGIAKGDRVALLMPNSVEFCCLFYGAAKLGAVAVPINTRLAAPEVSFIL
Rv3089|M.tuberculosis_H37Rv ALGIAKGDRVALLMPNSVEFCCLFYGAAKLGAVAVPINTRLAAPEVSFIL
MAB_2062c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_4616|M.gilvum_PYR-GCK RLGVRKGDRVAILLVNSVEFLEVLLGCAKIGAITIPINVRLAGPEIGYIL
MSMEG_0131|M.smegmatis_MC2_155 RRGVGFGDRVLILMLNRTEFVEAMLAANRLGAIAVPVNFRMTPPEIAYLV
TH_2878|M.thermoresistible__bu RRGVEFGDRVLILMLNRTEFIETMLAANRLGAIAVPVNFRMTPPEIAFLA
MAV_3523|M.avium_104 GDGIERGQCVAFLDKNHPACLEVLIGGASVGAVTTVVNWRVIGDELVHVL
Mvan_0943|M.vanbaalenii_PYR-1 QAGVGVGDRVAFVDKNGAEFFEVTFGLAKVGAVGVPVNWRLAAPEMRHII
MMAR_0452|M.marinum_M RAGLREGDAVAILMENNEHIHAVMWAARRSGLYYVPINTHLTAAEAAYII
MLBr_02546|M.leprae_Br4923 AKGVRGGDGIAILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKEVS
MUL_1191|M.ulcerans_Agy99 AKGVSAGDGVAILARNHRWFLIANYGAARAGARIILLNSEFSGPQIKEVS
Mb3116|M.bovis_AF2122/97 SDSGSKVVIYGAPSAPVIDAIRAQADPPGTVTDWIG---------ADSLA
Rv3089|M.tuberculosis_H37Rv SDSGSKVVIYGAPSAPVIDAIRAQADPPGTVTDWIG---------ADSLA
MAB_2062c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_4616|M.gilvum_PYR-GCK ADSGADVFVFHAPLAAAAVSALTEPGVRVRHTLRAGGAPADG---EIPYT
MSMEG_0131|M.smegmatis_MC2_155 SDCEAHVVVTEPVLAGVAT-AVRDLDATLQTVIVAGGATEDG---VLGYD
TH_2878|M.thermoresistible__bu KDCEAKVIATEPVLAGVAT-AVRDLAPSLSSVIVAGAADGSDTPDVLDYE
MAV_3523|M.avium_104 ADSGARVLVVGAELRPAAEAAARRVPSLERIIEVG-----------DEYE
Mvan_0943|M.vanbaalenii_PYR-1 ADSGAKIVVVGQDFAGHLEAIEDGLDADIVVIGDHPRW--------PAFD
MMAR_0452|M.marinum_M ENSGAKAIVGSAALRDTCAGLGEHLRAGPPELLILAGPEG----CLTGWE
MLBr_02546|M.leprae_Br4923 EREGAKVIIYDDEYTKVVSKAEPALG-KLRALGVNPDEEEPPGSTDETLA
MUL_1191|M.ulcerans_Agy99 EREGAKLIIYDDEYTGAVSKAEPPLG-KLRALGVNPDSEEDSGSTDETLA
Mb3116|M.bovis_AF2122/97 ERLRSAAADEPAVECGGDDNLFIMYTSGTTGHPKGVVHTHESVHSAASS-
Rv3089|M.tuberculosis_H37Rv ERLRSAAADEPAVECGGDDNLFIMYTSGTTGHPKGVVHTHESVHSAASS-
MAB_2062c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_4616|M.gilvum_PYR-GCK DLLSDGAPAPLDSDVEGRDPAFIMYTSGTTGRPKGAILTHDNLRWNAIN-
MSMEG_0131|M.smegmatis_MC2_155 DLIAEEGEPPAPVDIPNDSPALIMYTSGTTGRPKGAVLTHTNLSAQAMM-
TH_2878|M.thermoresistible__bu ALIAEPGEDPPPVDIPDDSPALIMYTSGTTGNPKGAVLTHSNLTGQAMT-
MAV_3523|M.avium_104 SLLAAAEPAPSDAGVDTDETALVIYSSGTTGRPKGVLLSQRALVNHAAN-
Mvan_0943|M.vanbaalenii_PYR-1 DWVASHPPVDPGVVTGPDDVVLLMYTSGTTGAPKGVMLSNTNYVYKTGG-
MMAR_0452|M.marinum_M PYPQCVADQPDTAIDDELEGDLLQYSSGTTGRPKGIKRELLHVAPDAAPG
MLBr_02546|M.leprae_Br4923 ELIARSSSAPAPKVR--KRASIIILTSGTTGTPKGANRNTPASLAPLGG-
MUL_1191|M.ulcerans_Agy99 ELIARSSTAPAPKAG--KHASIIILTSGTTGTPKGANRSTPPTLAPVGG-
Mb3116|M.bovis_AF2122/97 -WASTIDVRYR-DRLLLPLPMFHVAALTTVIFSAMR-GVTLISMPQ--FD
Rv3089|M.tuberculosis_H37Rv -WASTIDVRYR-DRLLLPLPMFHVAALTTVIFSAMR-GVTLISMPQ--FD
MAB_2062c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_4616|M.gilvum_PYR-GCK -VLGAEQGLTGSDVTVAVAPMFHIGGLGVHTLPLLYVGGTSVILPS--FD
MSMEG_0131|M.smegmatis_MC2_155 -HLFTTGADLNSDVGFVGVPLFHIAGVAGSVLSGVTLGVPTVLYPLGAFD
TH_2878|M.thermoresistible__bu -NLFTIGVDLANDVGFIGVPLFHIAGIAGNVLSGLTLGLPTVLYPLGAFD
MAV_3523|M.avium_104 -LAPAFPFGDG-DANLVAMPLFHVGGIG-YALFGIRAGAPTIMTRE--PD
Mvan_0943|M.vanbaalenii_PYR-1 -VAGPWQFDAD-AVSLAVMPLFHMAGSG-WALAGLWQGATTVVLRD--VE
MMAR_0452|M.marinum_M MMSALVGYWMDADSIYLSPAPLYHTAPSVWSMSAQAGGITTVVLEK--FD
MLBr_02546|M.leprae_Br4923 -ILSKVPFRAH-EVTLLPAPMFHALGYL-HATLAMFLGSTLVLRRR--FK
MUL_1191|M.ulcerans_Agy99 -ILSHVPFKAN-EVTSLPAPMFHALGYL-HATIAMFLGSTLVLRRK--FK
Mb3116|M.bovis_AF2122/97 ATKVWSLIVEERVCIGGAVPAILNFMRQVPEFAE--LDAPDFRYFITGGA
Rv3089|M.tuberculosis_H37Rv ATKVWSLIVEERVCIGGAVPAILNFMRQVPEFAE--LDAPDFRYFITGGA
MAB_2062c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_4616|M.gilvum_PYR-GCK PVGTLKAMAESRATVQFMVPAMWSALTQVPDFDS--YDLSALRLAMGGGA
MSMEG_0131|M.smegmatis_MC2_155 PDGLLDVLESEQVTGIFLVPAQWQAVCAAQRARP--RNLKLRALSWG-AA
TH_2878|M.thermoresistible__bu PGGLLDVLEAEKVTGIFLVPAQWQAVCAEQRARP--RDLRLRALSWG-AA
MAV_3523|M.avium_104 AAALIGAVRAG-ATHAFFVPPVIARFLDAGEAAR--ASIAGLRYIVYGAA
Mvan_0943|M.vanbaalenii_PYR-1 PAAILDAIARHRITNMLLVPAVIQFLLDTDGVAE--VDLSTLRVIVYGAS
MMAR_0452|M.marinum_M PEGALEAIQRHRVTHAQFVPAMFTRMLKLPESIRNSYDVSSLKRVMHAAA
MLBr_02546|M.leprae_Br4923 PATVLEDIEKHQATAMVVVPVMLSRILDTLENLETKSDLSSLRVVFVSGS
MUL_1191|M.ulcerans_Agy99 PQLVLEDIEKHKVTAMVVVPVMLSRLLDAVEKIDKKPDLSSLKIVFVSGS
Mb3116|M.bovis_AF2122/97 PMPEALIKIYAAKN--IEVVQGYALTESCGGGTLLLSEDA-----LRKAG
Rv3089|M.tuberculosis_H37Rv PMPEALIKIYAAKN--IEVVQGYALTESCGGGTLLLSEDA-----LRKAG
MAB_2062c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_4616|M.gilvum_PYR-GCK PMPLTVIDFMHQR--GVPFTEGFGMTETAPMVSVLDAANI-----TTRAG
MSMEG_0131|M.smegmatis_MC2_155 PASDTLLREMNEVFPDAQIFAAFGQTEMSPVTCMLLGDDA-----IRKLG
TH_2878|M.thermoresistible__bu PASDTLLQEMTEVFPGTKIFAAFGQTEMSPVTCMLLAEDA-----VRKLG
MAV_3523|M.avium_104 PMPLPLLHRALSTWPGTKFVQVYGQTELCGAVTALSDDDHRDAARPQLQL
Mvan_0943|M.vanbaalenii_PYR-1 PISDDVLVRGIERF-GPIFAQVYGMTETTGSITQLDGPDH----VPALLR
MMAR_0452|M.marinum_M PCPVEIKKQMMDWWG--PIIDEYYASSEAIGSTLITAEDW-----LEHPG
MLBr_02546|M.leprae_Br4923 QLGAELATRALEELG-PVIYNMYGSTEIAFATIAGPKDLQ------INSA
MUL_1191|M.ulcerans_Agy99 QLGAELASRALKDLG-PVIYNMYGSTEIAFATIAGPEDLQ------RNAA
Mb3116|M.bovis_AF2122/97 SAGRATMFTDVAVRGDDG--VIREHGEGEVVIKSDILLKEYWNRPEATRD
Rv3089|M.tuberculosis_H37Rv SAGRATMFTDVAVRGDDG--VIREHGEGEVVIKSDILLKEYWNRPEATRD
MAB_2062c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_4616|M.gilvum_PYR-GCK SIGRVAMHVDARIVDADD-RDVPADTVGELLVRGPNVFVGYWMKPATTAE
MSMEG_0131|M.smegmatis_MC2_155 SVGRVIPTVSARVVDDNM-NDVPVGEVGEIVYRGPNLMVGYWNNPKATAE
TH_2878|M.thermoresistible__bu SVGKVIPTVAARIVDDTM-NDVPVGEVGEIVYRAPTLMAGYWNNPQATAE
MAV_3523|M.avium_104 SAGKAVQGCEIRIVDPNNCAELPAGRSGEVWVRSNQNMSGYLNRAEATAE
Mvan_0943|M.vanbaalenii_PYR-1 SCGRPYPWVQIRIVDETG-ADAVAGTVGEVWTRSEQNMLGYWNNPDATAS
MMAR_0452|M.marinum_M SVGKPMQG-GVHILGADG-VELPPGQAGEIYFEGG-YSFEYLNDPSKTAA
MLBr_02546|M.leprae_Br4923 TVGPVVKGVKVKILDDSG-KEVPRGQVGRIFVGNAFPFEGYTGG----GG
MUL_1191|M.ulcerans_Agy99 TVGPVVKGVKVKILDDNG-NEVSQGQVGRIFVGNAFPFEGYTGG----GH
Mb3116|M.bovis_AF2122/97 AFDN-GWFRTGDIGEIDDEGYLYIKDRLKDMIISGGENVYPAEIESVIIG
Rv3089|M.tuberculosis_H37Rv AFDN-GWFRTGDIGEIDDEGYLYIKDRLKDMIISGGENVYPAEIESVIIG
MAB_2062c|M.abscessus_ATCC_199 ---------------MDAEGFITLVDRKKDMIISGGENVYPIEVEQVLFR
Mflv_4616|M.gilvum_PYR-GCK AFRG-GWFHTGDLGRIDADGYITLVDRKKDMIISGGENVYPIEVEQVLFR
MSMEG_0131|M.smegmatis_MC2_155 AFAG-GWFHSGDLVRQDEEGYVWVVDRKKDMIISGGENIYCAEVENVLAA
TH_2878|M.thermoresistible__bu AFAG-GWFHSGDLVRQDEEGYIWVVDRKKDMIISGGENIYCAEVENVLAA
MAV_3523|M.avium_104 TITADGWVRTGDVGRLDADGYVYIEDRLKDMIITGGENVYGPEVESVLIE
Mvan_0943|M.vanbaalenii_PYR-1 TLTADGWLKTGDAGYVDDDGYLFLHDRIKDMIVSGGENVYPVEVENVLMT
MMAR_0452|M.marinum_M SRDKHGWVTVGDVGYLDDQGYLFLTDRRHHMIISGGVNIYPQEAENILVT
MLBr_02546|M.leprae_Br4923 KQIIDGLLSSGDVGYFDEHDLLYISGRDDEMIVSGGENVFPAEVEDLISG
MUL_1191|M.ulcerans_Agy99 KQIIDGLMSSGDVGYFDEHGLLYVSGRDDEMIVSGGENVFPAEVEALISG
* .. : : .* ..**::** *:: * * ::
Mb3116|M.bovis_AF2122/97 VPGVSEVAVIGLPDEKWGEIAAAIVVADQ---NEVSEQ-QIVEYCGTRLA
Rv3089|M.tuberculosis_H37Rv VPGVSEVAVIGLPDEKWGEIAAAIVVADQ---NEVSEQ-QIVEYCGTRLA
MAB_2062c|M.abscessus_ATCC_199 HPAVFDAAVIGGKDAKWGERVVAVVVADPAT-QAPSAE-EIVAWCRERLA
Mflv_4616|M.gilvum_PYR-GCK HPGVLDAAVVGGPDDKWGERVVAVVVADPAAEQEPSAD-ELIAWCRERLA
MSMEG_0131|M.smegmatis_MC2_155 HPAIMEVAVIGRPHEKWGEVPVAVVALNSATAESISLG-ELDSFLTERLA
TH_2878|M.thermoresistible__bu HPAVAEVAVVGRPHEKWGEVPVAVVALN--PDAELTMA-ELEEFLADRLA
MAV_3523|M.avium_104 HPAVVDAAVIGVPDDFWGESVKAIVVADG----DVDAA-DVIEFCRRHLA
Mvan_0943|M.vanbaalenii_PYR-1 HPAVADAAVIGVPDRRWGEAVKAVVVAARGA--QLTEA-ELIAFARDRIG
MMAR_0452|M.marinum_M HPKVMDAAVFGVPDDEMGQRVMAVVQTVDPADATSQFGDELMEWLRDRLS
MLBr_02546|M.leprae_Br4923 HPEVVEATAIGVDDKEWGARLRAFVVKKQ---DATIDEDAIKAYVRDHLA
MUL_1191|M.ulcerans_Agy99 HPDVVEATALGVDDKEWGARLRAFVVKKP---DTDLDEETVKHYVRDHLA
* : :.:..* . * *.* : : ::.
Mb3116|M.bovis_AF2122/97 RYKLPKKVIFAEAIPRNPTGKILKTVLREQYSAT--VPK-----------
Rv3089|M.tuberculosis_H37Rv RYKLPKKVIFAEAIPRNPTGKILKTVLREQYSAT--VPK-----------
MAB_2062c|M.abscessus_ATCC_199 HFKCPRDVHFVAELPRNATGKLLKTELRAQFTG---IEGGVVLR------
Mflv_4616|M.gilvum_PYR-GCK HFKCPREVHLLPELPRNATGKLLKTELRKRFTG---VEGGVVQR------
MSMEG_0131|M.smegmatis_MC2_155 RYKHPKALEVVDALPRNPSGKVLKTELRERFGRATSLDGGESNSATTVSA
TH_2878|M.thermoresistible__bu RYKHPKVLEIVDALPRNPAGKVLKTELRARFAAGPSAEKEQSSSGATTSA
MAV_3523|M.avium_104 GFKCPRTVDFVAELPRNASGKILKTQLREPFWRD--RDRRV---------
Mvan_0943|M.vanbaalenii_PYR-1 GFKLPKSVDFVDVLPRNPSGKLLKRALREPYWDG--ADRHIG--------
MMAR_0452|M.marinum_M HFKCPRSVAFEAQLPRTDTGKLYKNGLIEKYSG-----------------
MLBr_02546|M.leprae_Br4923 RYKVPREVIFLEELPRNPTGKVLKRELRDFEVH-----------------
MUL_1191|M.ulcerans_Agy99 RYKVPREVIFLEELPRNPTGKILKRELREMEIE-----------------
:* *: : . :**. :**: * *
Mb3116|M.bovis_AF2122/97 ---
Rv3089|M.tuberculosis_H37Rv ---
MAB_2062c|M.abscessus_ATCC_199 ---
Mflv_4616|M.gilvum_PYR-GCK ---
MSMEG_0131|M.smegmatis_MC2_155 G--
TH_2878|M.thermoresistible__bu GSS
MAV_3523|M.avium_104 ---
Mvan_0943|M.vanbaalenii_PYR-1 ---
MMAR_0452|M.marinum_M ---
MLBr_02546|M.leprae_Br4923 ---
MUL_1191|M.ulcerans_Agy99 ---