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VYNYIVTSPGQGVQKPGMLDPWLTLSAARDRIAIWSDAVKFDLVTASRDENSLRDTAVAQPVIIAAALLS LSVLREKVDISGDGALFAGHSVGELAAGVGAGYLTDEAALTLAGVRGGAMSSACALAATGMAAVMPTKRG GASDDEIVAKTHEHGLSTANRNGCNQFVVAGPLDAVERFADAPPEGMRVMKLDVAGAFHTSAMDTAISPF AEAVNSCPVLTPSSPMIGNRDGAIIEGPMDFKKRLIAQINSVVRWDLCAATIASAATADTVVIELAPSGP LTRLAERLNAEFQTVAIREPGDVELLSGEFAID
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2034 | - | - | 100% (313) | malonyl CoA-acyl carrier protein transacylase |
| M. abscessus ATCC 19977 | MAB_1879c | - | 3e-52 | 39.03% (310) | putative malonyl CoA-ACP transacylase FabD |
| M. abscessus ATCC 19977 | MAB_2256 | - | 2e-16 | 30.77% (286) | polyketide synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2267 | fabD | 4e-56 | 40.13% (304) | acyl-carrier-protein S-malonyltransferase |
| M. gilvum PYR-GCK | Mflv_2779 | - | 5e-53 | 38.89% (306) | (acyl-carrier protein) S-malonyltransferase |
| M. tuberculosis H37Rv | Rv2243 | fabD | 4e-56 | 40.13% (304) | acyl-carrier-protein S-malonyltransferase |
| M. leprae Br4923 | MLBr_01653 | fabD | 6e-57 | 41.83% (306) | malonyl CoA- |
| M. marinum M | MMAR_3336 | fabD | 8e-56 | 40.13% (304) | malonyl CoA-acyl carrier protein transacylase FabD |
| M. avium 104 | MAV_2194 | - | 1e-55 | 39.80% (304) | malonyl CoA-acyl carrier protein transacylase |
| M. smegmatis MC2 155 | MSMEG_4325 | - | 4e-49 | 38.14% (291) | malonyl CoA-acyl carrier protein transacylase |
| M. thermoresistible (build 8) | TH_1510 | fabD | 1e-08 | 35.44% (79) | MALONYL CoA-ACYL CARRIER PROTEIN TRANSACYLASE FABD (Malonyl |
| M. ulcerans Agy99 | MUL_1306 | fabD | 9e-56 | 40.13% (304) | malonyl CoA-acyl carrier protein transacylase FabD |
| M. vanbaalenii PYR-1 | Mvan_3754 | - | 8e-52 | 38.26% (311) | (acyl-carrier protein) S-malonyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3336|M.marinum_M -----MIALLAPGQGSQTQGMLSPWLELPGAADQIASWSQASGLDLARLG
MUL_1306|M.ulcerans_Agy99 -----MIALLAPGQGSQTQGMLSPWLELPGAADQIASWSQASGLDLARLG
Mb2267|M.bovis_AF2122/97 -----MIALLAPGQGSQTEGMLSPWLQLPGAADQIAAWSKAADLDLARLG
Rv2243|M.tuberculosis_H37Rv -----MIALLAPGQGSQTEGMLSPWLQLPGAADQIAAWSKAADLDLARLG
MLBr_01653|M.leprae_Br4923 -----MIALLAPGQGSQTEGMLSPWLGLPGAADQIATWSKASGLDLVRLG
MAV_2194|M.avium_104 -----MIALLAPGQGSQTEGMLSPWLELDGAADQLALWSKASGLDLVRLG
Mflv_2779|M.gilvum_PYR-GCK MPQTTVLAFLAPGQGSQTPGMLTEWLELPGAAERIASWSEISGLDLARLG
Mvan_3754|M.vanbaalenii_PYR-1 MPQTTVLAFLAPGQGSQTPGMLAEWLELPGAAQRIQAWSEISGLDLAALG
MSMEG_4325|M.smegmatis_MC2_155 --------------------MLTPWLELPGAADRLAAWSQISGLDLTTLG
TH_1510|M.thermoresistible__bu --------------------------------------------------
MAB_2034|M.abscessus_ATCC_1997 ---MYNYIVTSPGQGVQKPGMLDPWLTLSAARDRIAIWSDAVKFDLVTAS
MMAR_3336|M.marinum_M TTATTEEITDTAVAQPLIVAATLLAHQELIRRGLLND----QEVIVAGHS
MUL_1306|M.ulcerans_Agy99 TTATTEEITDTAVAQPLIVAATLLAHQELIRRGLLND----QEVIVAGHS
Mb2267|M.bovis_AF2122/97 TTASTEEITDTAVAQPLIVAATLLAHQELARRCVLAG----KDVIVAGHS
Rv2243|M.tuberculosis_H37Rv TTASTEEITDTAVAQPLIVAATLLAHQELARRCVLAG----KDVIVAGHS
MLBr_01653|M.leprae_Br4923 TTASTEEITDTAVAQPLIVATTLLAHQELAKHALFENAL--DNLIVAGHS
MAV_2194|M.avium_104 TTASTEEITDTAVTQPLVVAATLLAHQELTRRGLLAD----ADLVVAGHS
Mflv_2779|M.gilvum_PYR-GCK TTATAEEITDTAVTQPLVVAATLLAYEELNKRDVLTGDE---KIIAAGHS
Mvan_3754|M.vanbaalenii_PYR-1 TTASAEEITDTAVTQPLVVAATLLAYEELTKRDVLGGIEGPVDIVAAGHS
MSMEG_4325|M.smegmatis_MC2_155 TTATAEEITDTAVTQPLVVAATLLAHEELTKRGHSAAET-----IVAGHS
TH_1510|M.thermoresistible__bu --------------------------------------------------
MAB_2034|M.abscessus_ATCC_1997 RDE--NSLRDTAVAQPVIIAAALLSLSVLREKVDISG----DGALFAGHS
MMAR_3336|M.marinum_M VGEIAAYAIAGVMAANDAVSLAATRGAEMAKACATEPTGMSALLGG----
MUL_1306|M.ulcerans_Agy99 VGEIAAYAIAGVMAANDAVSLAATRGAEMAKACATEPTGMSALLGG----
Mb2267|M.bovis_AF2122/97 VGEIAAYAIAGVIAADDAVALAATRGAEMAKACATEPTGMSAVLGG----
Rv2243|M.tuberculosis_H37Rv VGEIAAYAIAGVIAADDAVALAATRGAEMAKACATEPTGMSAVLGG----
MLBr_01653|M.leprae_Br4923 VGEIAAYSIAGVIAADDAVALAATRGAEMAKACAIEPTGMSAVLGG----
MAV_2194|M.avium_104 VGEIAAYAIAGVMAADDAVALAATRGAEMAKACAVEPTGMSAVLGG----
Mflv_2779|M.gilvum_PYR-GCK VGEIAAYAIAGVISADDAVSLAATRGKEMAKACALEPTGMSALLGG----
Mvan_3754|M.vanbaalenii_PYR-1 VGEIAAYAIAGVISADEAVSLAATRGKEMAKACALEPTGMSALLGG----
MSMEG_4325|M.smegmatis_MC2_155 VGEIAAYAIAGVISADDAVKLAATRGAEMAKACAVEPTGMAAVLGG----
TH_1510|M.thermoresistible__bu --------------------------------VVVDP----AVVG-----
MAB_2034|M.abscessus_ATCC_1997 VGELAAGVGAGYLTDEAALTLAGVRGGAMSSACALAATGMAAVMPTKRGG
. . *::
MMAR_3336|M.marinum_M -TEDEVLSRLEQLDLVPANRNAAGQIVAAGRLTALEKLAEDPPARARVRA
MUL_1306|M.ulcerans_Agy99 -TEDEVLSRLEQLDLVPANRNAAGQIVAAGRLTALEKLAEDPPARARVRA
Mb2267|M.bovis_AF2122/97 -DETEVLSRLEQLDLVPANRNAAGQIVAAGRLTALEKLAEDPPAKARVRA
Rv2243|M.tuberculosis_H37Rv -DETEVLSRLEQLDLVPANRNAAGQIVAAGRLTALEKLAEDPPAKARVRA
MLBr_01653|M.leprae_Br4923 -DEADVLNRLEELDLVPANRNAAGQIVAAGRLTALEKLAEDPPARARVRA
MAV_2194|M.avium_104 -DEAEVLARLEQLDLFPANRNAAGQIVAAGSLAALEKLAEDPPAKARVRA
Mflv_2779|M.gilvum_PYR-GCK -DEAEVLARLEALDLVPANRNAAGQIVAAGAVAALEKLAEDPPARARVRP
Mvan_3754|M.vanbaalenii_PYR-1 -DEAEVLARLEALDLIPANRNAAGQIVAAGAVSALEKLAEDPPSRARVRP
MSMEG_4325|M.smegmatis_MC2_155 -DEAEVLARLEALDLVPANRNAAGQIVAAGAVAALDKLAEDPPAKARVRK
TH_1510|M.thermoresistible__bu ---------------FPGHRGVG---------------------------
MAB_2034|M.abscessus_ATCC_1997 ASDDEIVAKTHEHGLSTANRNGCNQFVVAGPLDAVERFADAPPEGMRVMK
..:*.
MMAR_3336|M.marinum_M LGVAGAFHTQFMAPALEGYAAAAEAIATAEPTATLLSNRDGKPVTSAAAA
MUL_1306|M.ulcerans_Agy99 LGVAGAFHTQFMAPALEGYAAAAEAIATAEPTATLLSNRDGKPVTPAAAA
Mb2267|M.bovis_AF2122/97 LGVAGAFHTEFMAPALDGFAAAAANIATADPTATLLSNRDGKPVTSAAAA
Rv2243|M.tuberculosis_H37Rv LGVAGAFHTEFMAPALDGFAAAAANIATADPTATLLSNRDGKPVTSAAAA
MLBr_01653|M.leprae_Br4923 LDVAGAFHTEFMTAALDGFAEAAASITIAEPIAMLLSNRDGKPVASAATG
MAV_2194|M.avium_104 LGVAGAFHTKYMASALDGYAAAAAAVQTAEPTATLLSNRDGKPVASAAAA
Mflv_2779|M.gilvum_PYR-GCK LATAGAFHTRYMAPALDEYTRVADRIDPQEPAVTLLSNSDGRPVSGGADA
Mvan_3754|M.vanbaalenii_PYR-1 LATAGAFHTRYMAPALDGYATVADRIDPAEPTVTLLSNSDGRPVSSAADA
MSMEG_4325|M.smegmatis_MC2_155 LATAGAFHTHYMASALDGYAAAAQSVTTSEPTATLLSNADGQPVASAADA
TH_1510|M.thermoresistible__bu ----------------DGDQXXX--------------NADGQPVASAADA
MAB_2034|M.abscessus_ATCC_1997 LDVAGAFHTSAMDTAISPFAEAVNSCPVLTPSSPMIGNRDGAIIEGPMDF
. * ** :
MMAR_3336|M.marinum_M MQTLVSQLTQPVRWDLCTATIRE----HSVTAIVEFPPAGTLTGIAKREL
MUL_1306|M.ulcerans_Agy99 MQTLVSQLTQPVRWDLCTATIRE----HSVTAIVEFPPAGTLTGIAKREL
Mb2267|M.bovis_AF2122/97 MDTLVSQLTQPVRWDLCTATLRE----HTVTAIVEFPPAGTLSGIAKREL
Rv2243|M.tuberculosis_H37Rv MDTLVSQLTQPVRWDLCTATLRE----HTVTAIVEFPPAGTLSGIAKREL
MLBr_01653|M.leprae_Br4923 METLISQLTHPARWDLCNVTLRE----HNVTAIVELPPAGALTGIAKREL
MAV_2194|M.avium_104 MEALVAQLTQPVRWDLCTATLRE----LEVAAAVEFPPAGTLTGIAKREL
Mflv_2779|M.gilvum_PYR-GCK LAKLVAQMTRPVRWDLCTAAMKD----LGVTALVEFPPAGTLTGIAKREL
Mvan_3754|M.vanbaalenii_PYR-1 MAKLVAQMTRPVRWDLCTASMKD----LGVTAIVEFPPAGTLTGIAKREL
MSMEG_4325|M.smegmatis_MC2_155 MEKLVAQLTKPVRWDLCTATLRDRFQNAESAGIVEFPPAGTLVGIAKREL
TH_1510|M.thermoresistible__bu MEKLVAQLTRPVRWDLCTATMRE----RSVAALVEFPPAGTLTGIAKREL
MAB_2034|M.abscessus_ATCC_1997 KKRLIAQINSVVRWDLCAATIAS--AATADTVVIELAPSGPLTRLAERLN
*::*:. .***** .:: . : :*:.*:*.* :*:*
MMAR_3336|M.marinum_M RGVPTHAVKSPADLDELANL----
MUL_1306|M.ulcerans_Agy99 RGVPTHAVKSPADLDELANL----
Mb2267|M.bovis_AF2122/97 RGVPARAVKSPADLDELANL----
Rv2243|M.tuberculosis_H37Rv RGVPARAVKSPADLDELANL----
MLBr_01653|M.leprae_Br4923 REVTTCAVKSPTDLDKLANL----
MAV_2194|M.avium_104 RGVSARAVKSPADLDALAEL----
Mflv_2779|M.gilvum_PYR-GCK RGTPTHAVKSPADLDGLRGAW---
Mvan_3754|M.vanbaalenii_PYR-1 RGVPTHAVKSPADLDGLAASFRA-
MSMEG_4325|M.smegmatis_MC2_155 KGTPTRAIKSPEDLDGLDQL----
TH_1510|M.thermoresistible__bu RGVPTRAVKAPNDLDGLTELA---
MAB_2034|M.abscessus_ATCC_1997 AEFQTVAIREPGDVELLSGEFAID
: *:: * *:: *