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PQTTVLAFLAPGQGSQTPGMLTEWLELPGAAERIASWSEISGLDLARLGTTATAEEITDTAVTQPLVVAA TLLAYEELNKRDVLTGDEKIIAAGHSVGEIAAYAIAGVISADDAVSLAATRGKEMAKACALEPTGMSALL GGDEAEVLARLEALDLVPANRNAAGQIVAAGAVAALEKLAEDPPARARVRPLATAGAFHTRYMAPALDEY TRVADRIDPQEPAVTLLSNSDGRPVSGGADALAKLVAQMTRPVRWDLCTAAMKDLGVTALVEFPPAGTLT GIAKRELRGTPTHAVKSPADLDGLRGAW*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2779 | - | - | 100% (309) | (acyl-carrier protein) S-malonyltransferase |
| M. gilvum PYR-GCK | Mflv_3390 | - | 2e-19 | 32.45% (302) | beta-ketoacyl synthase |
| M. gilvum PYR-GCK | Mflv_0405 | - | 2e-13 | 26.53% (294) | beta-ketoacyl synthase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2267 | fabD | 1e-120 | 72.67% (300) | acyl-carrier-protein S-malonyltransferase |
| M. tuberculosis H37Rv | Rv2243 | fabD | 1e-120 | 72.67% (300) | acyl-carrier-protein S-malonyltransferase |
| M. leprae Br4923 | MLBr_01653 | fabD | 1e-112 | 68.11% (301) | malonyl CoA- |
| M. abscessus ATCC 19977 | MAB_1879c | - | 1e-122 | 72.31% (307) | putative malonyl CoA-ACP transacylase FabD |
| M. marinum M | MMAR_3336 | fabD | 1e-125 | 75.33% (300) | malonyl CoA-acyl carrier protein transacylase FabD |
| M. avium 104 | MAV_2194 | - | 1e-121 | 73.67% (300) | malonyl CoA-acyl carrier protein transacylase |
| M. smegmatis MC2 155 | MSMEG_4325 | - | 1e-120 | 76.82% (289) | malonyl CoA-acyl carrier protein transacylase |
| M. thermoresistible (build 8) | TH_1510 | fabD | 1e-29 | 76.32% (76) | MALONYL CoA-ACYL CARRIER PROTEIN TRANSACYLASE FABD (Malonyl |
| M. ulcerans Agy99 | MUL_1306 | fabD | 1e-125 | 75.33% (300) | malonyl CoA-acyl carrier protein transacylase FabD |
| M. vanbaalenii PYR-1 | Mvan_3754 | - | 1e-154 | 89.42% (312) | (acyl-carrier protein) S-malonyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2779|M.gilvum_PYR-GCK MPQTTVLAFLAPGQGSQTPGMLTEWLELPGAAERIASWSEISGLDLARLG
Mvan_3754|M.vanbaalenii_PYR-1 MPQTTVLAFLAPGQGSQTPGMLAEWLELPGAAQRIQAWSEISGLDLAALG
MMAR_3336|M.marinum_M -----MIALLAPGQGSQTQGMLSPWLELPGAADQIASWSQASGLDLARLG
MUL_1306|M.ulcerans_Agy99 -----MIALLAPGQGSQTQGMLSPWLELPGAADQIASWSQASGLDLARLG
Mb2267|M.bovis_AF2122/97 -----MIALLAPGQGSQTEGMLSPWLQLPGAADQIAAWSKAADLDLARLG
Rv2243|M.tuberculosis_H37Rv -----MIALLAPGQGSQTEGMLSPWLQLPGAADQIAAWSKAADLDLARLG
MLBr_01653|M.leprae_Br4923 -----MIALLAPGQGSQTEGMLSPWLGLPGAADQIATWSKASGLDLVRLG
MAV_2194|M.avium_104 -----MIALLAPGQGSQTEGMLSPWLELDGAADQLALWSKASGLDLVRLG
MAB_1879c|M.abscessus_ATCC_199 -----MIALLAPGQGSQTPGMLTPWLELPGATDQVEQWSKASGLDLVRLG
MSMEG_4325|M.smegmatis_MC2_155 --------------------MLTPWLELPGAADRLAAWSQISGLDLTTLG
TH_1510|M.thermoresistible__bu --------------------------------------------------
Mflv_2779|M.gilvum_PYR-GCK TTATAEEITDTAVTQPLVVAATLLAYEELNKRDVLTGDE---KIIAAGHS
Mvan_3754|M.vanbaalenii_PYR-1 TTASAEEITDTAVTQPLVVAATLLAYEELTKRDVLGGIEGPVDIVAAGHS
MMAR_3336|M.marinum_M TTATTEEITDTAVAQPLIVAATLLAHQELIRRGLLND----QEVIVAGHS
MUL_1306|M.ulcerans_Agy99 TTATTEEITDTAVAQPLIVAATLLAHQELIRRGLLND----QEVIVAGHS
Mb2267|M.bovis_AF2122/97 TTASTEEITDTAVAQPLIVAATLLAHQELARRCVLAG----KDVIVAGHS
Rv2243|M.tuberculosis_H37Rv TTASTEEITDTAVAQPLIVAATLLAHQELARRCVLAG----KDVIVAGHS
MLBr_01653|M.leprae_Br4923 TTASTEEITDTAVAQPLIVATTLLAHQELAKHALFENAL--DNLIVAGHS
MAV_2194|M.avium_104 TTASTEEITDTAVTQPLVVAATLLAHQELTRRGLLAD----ADLVVAGHS
MAB_1879c|M.abscessus_ATCC_199 TTATAEEITDTSITQPLVVALTLLAYDELNKRGHLNGKIASGEVIVAGHS
MSMEG_4325|M.smegmatis_MC2_155 TTATAEEITDTAVTQPLVVAATLLAHEELTKRGHSAA-----ETIVAGHS
TH_1510|M.thermoresistible__bu --------------------------------------------------
Mflv_2779|M.gilvum_PYR-GCK VGEIAAYAIAGVISADDAVSLAATRGKEMAKACALEPTGMSALLGGDEAE
Mvan_3754|M.vanbaalenii_PYR-1 VGEIAAYAIAGVISADEAVSLAATRGKEMAKACALEPTGMSALLGGDEAE
MMAR_3336|M.marinum_M VGEIAAYAIAGVMAANDAVSLAATRGAEMAKACATEPTGMSALLGGTEDE
MUL_1306|M.ulcerans_Agy99 VGEIAAYAIAGVMAANDAVSLAATRGAEMAKACATEPTGMSALLGGTEDE
Mb2267|M.bovis_AF2122/97 VGEIAAYAIAGVIAADDAVALAATRGAEMAKACATEPTGMSAVLGGDETE
Rv2243|M.tuberculosis_H37Rv VGEIAAYAIAGVIAADDAVALAATRGAEMAKACATEPTGMSAVLGGDETE
MLBr_01653|M.leprae_Br4923 VGEIAAYSIAGVIAADDAVALAATRGAEMAKACAIEPTGMSAVLGGDEAD
MAV_2194|M.avium_104 VGEIAAYAIAGVMAADDAVALAATRGAEMAKACAVEPTGMSAVLGGDEAE
MAB_1879c|M.abscessus_ATCC_199 VGEIAAYAIAGVISADEAITLAATRGAEMAKACALDPTGMSAVLGGDEAE
MSMEG_4325|M.smegmatis_MC2_155 VGEIAAYAIAGVISADDAVKLAATRGAEMAKACAVEPTGMAAVLGGDEAE
TH_1510|M.thermoresistible__bu --------------------------------VVVDP----AVVG-----
. :* *::*
Mflv_2779|M.gilvum_PYR-GCK VLARLEALDLVPANRNAAGQIVAAGAVAALEKLAEDPPARARVRPLATAG
Mvan_3754|M.vanbaalenii_PYR-1 VLARLEALDLIPANRNAAGQIVAAGAVSALEKLAEDPPSRARVRPLATAG
MMAR_3336|M.marinum_M VLSRLEQLDLVPANRNAAGQIVAAGRLTALEKLAEDPPARARVRALGVAG
MUL_1306|M.ulcerans_Agy99 VLSRLEQLDLVPANRNAAGQIVAAGRLTALEKLAEDPPARARVRALGVAG
Mb2267|M.bovis_AF2122/97 VLSRLEQLDLVPANRNAAGQIVAAGRLTALEKLAEDPPAKARVRALGVAG
Rv2243|M.tuberculosis_H37Rv VLSRLEQLDLVPANRNAAGQIVAAGRLTALEKLAEDPPAKARVRALGVAG
MLBr_01653|M.leprae_Br4923 VLNRLEELDLVPANRNAAGQIVAAGRLTALEKLAEDPPARARVRALDVAG
MAV_2194|M.avium_104 VLARLEQLDLFPANRNAAGQIVAAGSLAALEKLAEDPPAKARVRALGVAG
MAB_1879c|M.abscessus_ATCC_199 VLERLEALELVPANRNAVGQIVAAGRITALEKLAEDPPAKARVRQLATAG
MSMEG_4325|M.smegmatis_MC2_155 VLARLEALDLVPANRNAAGQIVAAGAVAALDKLAEDPPAKARVRKLATAG
TH_1510|M.thermoresistible__bu ----------FPGHRG-----VGDGDQXX---------------------
.*.:*. *. *
Mflv_2779|M.gilvum_PYR-GCK AFHTRYMAPALDEYTRVADRIDPQEPAVTLLSNSDGRPVSGGADALAKLV
Mvan_3754|M.vanbaalenii_PYR-1 AFHTRYMAPALDGYATVADRIDPAEPTVTLLSNSDGRPVSSAADAMAKLV
MMAR_3336|M.marinum_M AFHTQFMAPALEGYAAAAEAIATAEPTATLLSNRDGKPVTSAAAAMQTLV
MUL_1306|M.ulcerans_Agy99 AFHTQFMAPALEGYAAAAEAIATAEPTATLLSNRDGKPVTPAAAAMQTLV
Mb2267|M.bovis_AF2122/97 AFHTEFMAPALDGFAAAAANIATADPTATLLSNRDGKPVTSAAAAMDTLV
Rv2243|M.tuberculosis_H37Rv AFHTEFMAPALDGFAAAAANIATADPTATLLSNRDGKPVTSAAAAMDTLV
MLBr_01653|M.leprae_Br4923 AFHTEFMTAALDGFAEAAASITIAEPIAMLLSNRDGKPVASAATGMETLI
MAV_2194|M.avium_104 AFHTKYMASALDGYAAAAAAVQTAEPTATLLSNRDGKPVASAAAAMEALV
MAB_1879c|M.abscessus_ATCC_199 AFHTHFMAPAQEAYAAAAAAITPSEPTVTLLSNLDGSPVTSGADAMAKLV
MSMEG_4325|M.smegmatis_MC2_155 AFHTHYMASALDGYAAAAQSVTTSEPTATLLSNADGQPVASAADAMEKLV
TH_1510|M.thermoresistible__bu -------------------------------XNADGQPVASAADAMEKLV
* ** **: .* .: *:
Mflv_2779|M.gilvum_PYR-GCK AQMTRPVRWDLCTAAMKDLG----VTALVEFPPAGTLTGIAKRELRGTPT
Mvan_3754|M.vanbaalenii_PYR-1 AQMTRPVRWDLCTASMKDLG----VTAIVEFPPAGTLTGIAKRELRGVPT
MMAR_3336|M.marinum_M SQLTQPVRWDLCTATIREHS----VTAIVEFPPAGTLTGIAKRELRGVPT
MUL_1306|M.ulcerans_Agy99 SQLTQPVRWDLCTATIREHS----VTAIVEFPPAGTLTGIAKRELRGVPT
Mb2267|M.bovis_AF2122/97 SQLTQPVRWDLCTATLREHT----VTAIVEFPPAGTLSGIAKRELRGVPA
Rv2243|M.tuberculosis_H37Rv SQLTQPVRWDLCTATLREHT----VTAIVEFPPAGTLSGIAKRELRGVPA
MLBr_01653|M.leprae_Br4923 SQLTHPARWDLCNVTLREHN----VTAIVELPPAGALTGIAKRELREVTT
MAV_2194|M.avium_104 AQLTQPVRWDLCTATLRELE----VAAAVEFPPAGTLTGIAKRELRGVSA
MAB_1879c|M.abscessus_ATCC_199 NQMTSPVRWDLCTEYFKTANDTPAATAVVELPPSGALSGIAKREMRGVPN
MSMEG_4325|M.smegmatis_MC2_155 AQLTKPVRWDLCTATLRDRFQNAESAGIVEFPPAGTLVGIAKRELKGTPT
TH_1510|M.thermoresistible__bu AQLTRPVRWDLCTATMRERS----VAALVEFPPAGTLTGIAKRELRGVPT
*:* *.*****. :: :. **:**:*:* ******:: ..
Mflv_2779|M.gilvum_PYR-GCK HAVKSPADLDGLRGAW--
Mvan_3754|M.vanbaalenii_PYR-1 HAVKSPADLDGLAASFRA
MMAR_3336|M.marinum_M HAVKSPADLDELANL---
MUL_1306|M.ulcerans_Agy99 HAVKSPADLDELANL---
Mb2267|M.bovis_AF2122/97 RAVKSPADLDELANL---
Rv2243|M.tuberculosis_H37Rv RAVKSPADLDELANL---
MLBr_01653|M.leprae_Br4923 CAVKSPTDLDKLANL---
MAV_2194|M.avium_104 RAVKSPADLDALAEL---
MAB_1879c|M.abscessus_ATCC_199 HALKTPEDLEALAEL---
MSMEG_4325|M.smegmatis_MC2_155 RAIKSPEDLDGLDQL---
TH_1510|M.thermoresistible__bu RAVKAPNDLDGLTELA--
*:*:* **: *