For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
VIALLAPGQGSQTEGMLSPWLQLPGAADQIAAWSKAADLDLARLGTTASTEEITDTAVAQPLIVAATLLA HQELARRCVLAGKDVIVAGHSVGEIAAYAIAGVIAADDAVALAATRGAEMAKACATEPTGMSAVLGGDET EVLSRLEQLDLVPANRNAAGQIVAAGRLTALEKLAEDPPAKARVRALGVAGAFHTEFMAPALDGFAAAAA NIATADPTATLLSNRDGKPVTSAAAAMDTLVSQLTQPVRWDLCTATLREHTVTAIVEFPPAGTLSGIAKR ELRGVPARAVKSPADLDELANL
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv2243 | fabD | - | 100% (302) | acyl-carrier-protein S-malonyltransferase |
| M. tuberculosis H37Rv | Rv1662 | pks8 | 2e-20 | 32.06% (287) | polyketide synthase pks8 |
| M. tuberculosis H37Rv | Rv2946c | pks1 | 2e-18 | 30.13% (302) | polyketide synthase PKS1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2267 | fabD | 1e-166 | 100.00% (302) | acyl-carrier-protein S-malonyltransferase |
| M. gilvum PYR-GCK | Mflv_2779 | - | 1e-120 | 72.67% (300) | (acyl-carrier protein) S-malonyltransferase |
| M. leprae Br4923 | MLBr_01653 | fabD | 1e-136 | 82.57% (304) | malonyl CoA- |
| M. abscessus ATCC 19977 | MAB_1879c | - | 1e-119 | 71.29% (310) | putative malonyl CoA-ACP transacylase FabD |
| M. marinum M | MMAR_3336 | fabD | 1e-148 | 89.07% (302) | malonyl CoA-acyl carrier protein transacylase FabD |
| M. avium 104 | MAV_2194 | - | 1e-142 | 85.76% (302) | malonyl CoA-acyl carrier protein transacylase |
| M. smegmatis MC2 155 | MSMEG_4325 | - | 1e-117 | 74.57% (291) | malonyl CoA-acyl carrier protein transacylase |
| M. thermoresistible (build 8) | TH_1510 | fabD | 3e-29 | 74.68% (79) | MALONYL CoA-ACYL CARRIER PROTEIN TRANSACYLASE FABD (Malonyl |
| M. ulcerans Agy99 | MUL_1306 | fabD | 1e-148 | 88.74% (302) | malonyl CoA-acyl carrier protein transacylase FabD |
| M. vanbaalenii PYR-1 | Mvan_3754 | - | 1e-124 | 74.01% (304) | (acyl-carrier protein) S-malonyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2779|M.gilvum_PYR-GCK MPQTTVLAFLAPGQGSQTPGMLTEWLELPGAAERIASWSEISGLDLARLG
Mvan_3754|M.vanbaalenii_PYR-1 MPQTTVLAFLAPGQGSQTPGMLAEWLELPGAAQRIQAWSEISGLDLAALG
Rv2243|M.tuberculosis_H37Rv -----MIALLAPGQGSQTEGMLSPWLQLPGAADQIAAWSKAADLDLARLG
Mb2267|M.bovis_AF2122/97 -----MIALLAPGQGSQTEGMLSPWLQLPGAADQIAAWSKAADLDLARLG
MMAR_3336|M.marinum_M -----MIALLAPGQGSQTQGMLSPWLELPGAADQIASWSQASGLDLARLG
MUL_1306|M.ulcerans_Agy99 -----MIALLAPGQGSQTQGMLSPWLELPGAADQIASWSQASGLDLARLG
MLBr_01653|M.leprae_Br4923 -----MIALLAPGQGSQTEGMLSPWLGLPGAADQIATWSKASGLDLVRLG
MAV_2194|M.avium_104 -----MIALLAPGQGSQTEGMLSPWLELDGAADQLALWSKASGLDLVRLG
MAB_1879c|M.abscessus_ATCC_199 -----MIALLAPGQGSQTPGMLTPWLELPGATDQVEQWSKASGLDLVRLG
MSMEG_4325|M.smegmatis_MC2_155 --------------------MLTPWLELPGAADRLAAWSQISGLDLTTLG
TH_1510|M.thermoresistible__bu --------------------------------------------------
Mflv_2779|M.gilvum_PYR-GCK TTATAEEITDTAVTQPLVVAATLLAYEELNKRDVLTGDE---KIIAAGHS
Mvan_3754|M.vanbaalenii_PYR-1 TTASAEEITDTAVTQPLVVAATLLAYEELTKRDVLGGIEGPVDIVAAGHS
Rv2243|M.tuberculosis_H37Rv TTASTEEITDTAVAQPLIVAATLLAHQELARRCVLAG----KDVIVAGHS
Mb2267|M.bovis_AF2122/97 TTASTEEITDTAVAQPLIVAATLLAHQELARRCVLAG----KDVIVAGHS
MMAR_3336|M.marinum_M TTATTEEITDTAVAQPLIVAATLLAHQELIRRGLLND----QEVIVAGHS
MUL_1306|M.ulcerans_Agy99 TTATTEEITDTAVAQPLIVAATLLAHQELIRRGLLND----QEVIVAGHS
MLBr_01653|M.leprae_Br4923 TTASTEEITDTAVAQPLIVATTLLAHQELAKHALFENAL--DNLIVAGHS
MAV_2194|M.avium_104 TTASTEEITDTAVTQPLVVAATLLAHQELTRRGLLAD----ADLVVAGHS
MAB_1879c|M.abscessus_ATCC_199 TTATAEEITDTSITQPLVVALTLLAYDELNKRGHLNGKIASGEVIVAGHS
MSMEG_4325|M.smegmatis_MC2_155 TTATAEEITDTAVTQPLVVAATLLAHEELTKRGHSAA-----ETIVAGHS
TH_1510|M.thermoresistible__bu --------------------------------------------------
Mflv_2779|M.gilvum_PYR-GCK VGEIAAYAIAGVISADDAVSLAATRGKEMAKACALEPTGMSALLGGDEAE
Mvan_3754|M.vanbaalenii_PYR-1 VGEIAAYAIAGVISADEAVSLAATRGKEMAKACALEPTGMSALLGGDEAE
Rv2243|M.tuberculosis_H37Rv VGEIAAYAIAGVIAADDAVALAATRGAEMAKACATEPTGMSAVLGGDETE
Mb2267|M.bovis_AF2122/97 VGEIAAYAIAGVIAADDAVALAATRGAEMAKACATEPTGMSAVLGGDETE
MMAR_3336|M.marinum_M VGEIAAYAIAGVMAANDAVSLAATRGAEMAKACATEPTGMSALLGGTEDE
MUL_1306|M.ulcerans_Agy99 VGEIAAYAIAGVMAANDAVSLAATRGAEMAKACATEPTGMSALLGGTEDE
MLBr_01653|M.leprae_Br4923 VGEIAAYSIAGVIAADDAVALAATRGAEMAKACAIEPTGMSAVLGGDEAD
MAV_2194|M.avium_104 VGEIAAYAIAGVMAADDAVALAATRGAEMAKACAVEPTGMSAVLGGDEAE
MAB_1879c|M.abscessus_ATCC_199 VGEIAAYAIAGVISADEAITLAATRGAEMAKACALDPTGMSAVLGGDEAE
MSMEG_4325|M.smegmatis_MC2_155 VGEIAAYAIAGVISADDAVKLAATRGAEMAKACAVEPTGMAAVLGGDEAE
TH_1510|M.thermoresistible__bu --------------------------------VVVDP----AVVG-----
. :* *::*
Mflv_2779|M.gilvum_PYR-GCK VLARLEALDLVPANRNAAGQIVAAGAVAALEKLAEDPPARARVRPLATAG
Mvan_3754|M.vanbaalenii_PYR-1 VLARLEALDLIPANRNAAGQIVAAGAVSALEKLAEDPPSRARVRPLATAG
Rv2243|M.tuberculosis_H37Rv VLSRLEQLDLVPANRNAAGQIVAAGRLTALEKLAEDPPAKARVRALGVAG
Mb2267|M.bovis_AF2122/97 VLSRLEQLDLVPANRNAAGQIVAAGRLTALEKLAEDPPAKARVRALGVAG
MMAR_3336|M.marinum_M VLSRLEQLDLVPANRNAAGQIVAAGRLTALEKLAEDPPARARVRALGVAG
MUL_1306|M.ulcerans_Agy99 VLSRLEQLDLVPANRNAAGQIVAAGRLTALEKLAEDPPARARVRALGVAG
MLBr_01653|M.leprae_Br4923 VLNRLEELDLVPANRNAAGQIVAAGRLTALEKLAEDPPARARVRALDVAG
MAV_2194|M.avium_104 VLARLEQLDLFPANRNAAGQIVAAGSLAALEKLAEDPPAKARVRALGVAG
MAB_1879c|M.abscessus_ATCC_199 VLERLEALELVPANRNAVGQIVAAGRITALEKLAEDPPAKARVRQLATAG
MSMEG_4325|M.smegmatis_MC2_155 VLARLEALDLVPANRNAAGQIVAAGAVAALDKLAEDPPAKARVRKLATAG
TH_1510|M.thermoresistible__bu ----------FPGHRG-----VGDGDQXX---------------------
.*.:*. *. *
Mflv_2779|M.gilvum_PYR-GCK AFHTRYMAPALDEYTRVADRIDPQEPAVTLLSNSDGRPVSGGADALAKLV
Mvan_3754|M.vanbaalenii_PYR-1 AFHTRYMAPALDGYATVADRIDPAEPTVTLLSNSDGRPVSSAADAMAKLV
Rv2243|M.tuberculosis_H37Rv AFHTEFMAPALDGFAAAAANIATADPTATLLSNRDGKPVTSAAAAMDTLV
Mb2267|M.bovis_AF2122/97 AFHTEFMAPALDGFAAAAANIATADPTATLLSNRDGKPVTSAAAAMDTLV
MMAR_3336|M.marinum_M AFHTQFMAPALEGYAAAAEAIATAEPTATLLSNRDGKPVTSAAAAMQTLV
MUL_1306|M.ulcerans_Agy99 AFHTQFMAPALEGYAAAAEAIATAEPTATLLSNRDGKPVTPAAAAMQTLV
MLBr_01653|M.leprae_Br4923 AFHTEFMTAALDGFAEAAASITIAEPIAMLLSNRDGKPVASAATGMETLI
MAV_2194|M.avium_104 AFHTKYMASALDGYAAAAAAVQTAEPTATLLSNRDGKPVASAAAAMEALV
MAB_1879c|M.abscessus_ATCC_199 AFHTHFMAPAQEAYAAAAAAITPSEPTVTLLSNLDGSPVTSGADAMAKLV
MSMEG_4325|M.smegmatis_MC2_155 AFHTHYMASALDGYAAAAQSVTTSEPTATLLSNADGQPVASAADAMEKLV
TH_1510|M.thermoresistible__bu -------------------------------XNADGQPVASAADAMEKLV
* ** **: .* .: *:
Mflv_2779|M.gilvum_PYR-GCK AQMTRPVRWDLCTAAMKDLG----VTALVEFPPAGTLTGIAKRELRGTPT
Mvan_3754|M.vanbaalenii_PYR-1 AQMTRPVRWDLCTASMKDLG----VTAIVEFPPAGTLTGIAKRELRGVPT
Rv2243|M.tuberculosis_H37Rv SQLTQPVRWDLCTATLREHT----VTAIVEFPPAGTLSGIAKRELRGVPA
Mb2267|M.bovis_AF2122/97 SQLTQPVRWDLCTATLREHT----VTAIVEFPPAGTLSGIAKRELRGVPA
MMAR_3336|M.marinum_M SQLTQPVRWDLCTATIREHS----VTAIVEFPPAGTLTGIAKRELRGVPT
MUL_1306|M.ulcerans_Agy99 SQLTQPVRWDLCTATIREHS----VTAIVEFPPAGTLTGIAKRELRGVPT
MLBr_01653|M.leprae_Br4923 SQLTHPARWDLCNVTLREHN----VTAIVELPPAGALTGIAKRELREVTT
MAV_2194|M.avium_104 AQLTQPVRWDLCTATLRELE----VAAAVEFPPAGTLTGIAKRELRGVSA
MAB_1879c|M.abscessus_ATCC_199 NQMTSPVRWDLCTEYFKTANDTPAATAVVELPPSGALSGIAKREMRGVPN
MSMEG_4325|M.smegmatis_MC2_155 AQLTKPVRWDLCTATLRDRFQNAESAGIVEFPPAGTLVGIAKRELKGTPT
TH_1510|M.thermoresistible__bu AQLTRPVRWDLCTATMRERS----VAALVEFPPAGTLTGIAKRELRGVPT
*:* *.*****. :: :. **:**:*:* ******:: ..
Mflv_2779|M.gilvum_PYR-GCK HAVKSPADLDGLRGAW--
Mvan_3754|M.vanbaalenii_PYR-1 HAVKSPADLDGLAASFRA
Rv2243|M.tuberculosis_H37Rv RAVKSPADLDELANL---
Mb2267|M.bovis_AF2122/97 RAVKSPADLDELANL---
MMAR_3336|M.marinum_M HAVKSPADLDELANL---
MUL_1306|M.ulcerans_Agy99 HAVKSPADLDELANL---
MLBr_01653|M.leprae_Br4923 CAVKSPTDLDKLANL---
MAV_2194|M.avium_104 RAVKSPADLDALAEL---
MAB_1879c|M.abscessus_ATCC_199 HALKTPEDLEALAEL---
MSMEG_4325|M.smegmatis_MC2_155 RAIKSPEDLDGLDQL---
TH_1510|M.thermoresistible__bu RAVKAPNDLDGLTELA--
*:*:* **: *