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SEHRRTSISVDGHRLAYRQFGSGDRVVVLSHAFLTSHYLEHAWAQELAARGFRVICLDLLGTTADERPLE PDRYNSQALGRQLIGALDALGIERAVLGGTSVGANISIEAAALAPERVAGLLLEGPFLEHGIGAAGYLWS AGLTLFTLGRPLVWLAGAVARSFPETEQPTLGLIRAFLTAPPARSAAFMRGMLVGRMAPPRAVRRSVNVP TMILSLTADPLHPASDAHSLAVDIVGAQVVSAGTLATLRFWPRRVTPAIVSFLVETFGIDVTARQADA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_1875c | - | - | 100% (279) | putative hydrolase (alpha/beta fold) |
| M. abscessus ATCC 19977 | MAB_0528c | - | 6e-11 | 34.92% (126) | epoxide hydrolase EphA |
| M. abscessus ATCC 19977 | MAB_1169 | - | 9e-10 | 33.33% (120) | putative hydrolase, alpha/beta fold |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1973 | ephB | 1e-07 | 31.48% (108) | epoxide hydrolase EphB |
| M. gilvum PYR-GCK | Mflv_1415 | - | 1e-09 | 36.52% (115) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv3617 | ephA | 8e-08 | 33.04% (115) | epoxide hydrolase EphA |
| M. leprae Br4923 | - | - | - | - | - |
| M. marinum M | MMAR_3948 | - | 3e-10 | 26.67% (225) | hydrolase |
| M. avium 104 | MAV_0539 | - | 2e-08 | 34.95% (103) | hydrolase, alpha/beta fold family protein |
| M. smegmatis MC2 155 | MSMEG_3289 | - | 2e-10 | 26.67% (240) | gp61 protein |
| M. thermoresistible (build 8) | TH_0992 | ephA | 1e-08 | 32.77% (119) | PROBABLE EPOXIDE HYDROLASE EPHA (EPOXIDE HYDRATASE) |
| M. ulcerans Agy99 | MUL_4193 | ephA | 2e-09 | 30.00% (200) | epoxide hydrolase EphA |
| M. vanbaalenii PYR-1 | Mvan_5373 | - | 7e-10 | 35.48% (124) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3617|M.tuberculosis_H37Rv -------------------MGAPTERLVDTNGVRLRVVEAG--EPGAPVV
MUL_4193|M.ulcerans_Agy99 ------------------MVATSTERLVDTNGVRLRVTEAG--ERGAPVV
MAV_0539|M.avium_104 --------------------------------MRLRVTEAG--DRGAPVV
TH_0992|M.thermoresistible__bu -------------------VITPSERSVETNGVRLRLVEAG--ERGDPLV
Mflv_1415|M.gilvum_PYR-GCK ----------------------MQSRMVHTNGITLRVFEAG--ERSAPVV
Mvan_5373|M.vanbaalenii_PYR-1 MNSRWCFRAVRDRGCPFGESGAMRSRMVQTNGVTLRVTEAG--EPGAPVV
Mb1973|M.bovis_AF2122/97 --------------------MSQVHRILNCRGTRIHAVADSPPDQQGPLV
MMAR_3948|M.marinum_M ------------------------MPIATINGQKIHYTDAG----AGPPV
MAB_1875c|M.abscessus_ATCC_199 -------------------MSEHRRTSISVDGHRLAYRQFG---SGDRVV
MSMEG_3289|M.smegmatis_MC2_155 -------MDAVNSGRAARRVRLTHHVVELDDGHQVGVSVGG----VGVPM
: . :
Rv3617|M.tuberculosis_H37Rv ILAHGFPELAYSWRHQIPALADAGYHVLAPDQRGYGGSSRPEAIEAYDIH
MUL_4193|M.ulcerans_Agy99 ILAHGFPELAYSWRHQIPVLAEAGYHVLAPDQRGYGGSSRPEAIEDYDIH
MAV_0539|M.avium_104 ILAHGFPELAYSWRHQIDVLADAGYHVLAPDQRGYGGSDRPDAVEAYDIH
TH_0992|M.thermoresistible__bu VLAHGFPELAYSWRHQIPALVDAGYHVMAPDQRGYGGSSAPEAIEAYDIT
Mflv_1415|M.gilvum_PYR-GCK VLCHGFPELAFTWRHQISALAAAGFHVLAPDQRGYGGSDKPGDAGVYNVA
Mvan_5373|M.vanbaalenii_PYR-1 VLCHGFPELAFTWRHQVRALADAGFHVLAPDQRGYGGSDKPDAVDSYNVA
Mb1973|M.bovis_AF2122/97 VLLHGFPESWYSWRHQIPALAGAGYRVVAIDQRGYGRSSKYRVQKAYRIK
MMAR_3948|M.marinum_M LATHATLMDLISLEPVTTKLVDAGYRVIAFDLRGHG--ETVYDQQPYTYV
MAB_1875c|M.abscessus_ATCC_199 VLSHAFLTSHYLEHAWAQELAARGFRVICLDLLGTTADERPLEPDRYNSQ
MSMEG_3289|M.smegmatis_MC2_155 VFLHGLGLNRRVYIRLLSRVAGLGFRIVAIDAPGHGDTGDLP-PDADGFS
: *. :. *::::. * *
Rv3617|M.tuberculosis_H37Rv RLTADLVGLLDDVGAERAVWVGHDWGAVVVWNAPLLHADRVAAVAALSVP
MUL_4193|M.ulcerans_Agy99 QLTADLVGLLDDVGAERAAWVGHDWGAVVVWNAPLLHPDRVAAVAGLSVP
MAV_0539|M.avium_104 QLTADLVGLLDDVGAQRAVWVGHDWGAAVVWNAPLLHPDRVAAVAAMSVP
TH_0992|M.thermoresistible__bu RLTADLMGLLDDIGAEKAAFIGHDWGALVVWNAALLYPDRVAAVAGLSVP
Mflv_1415|M.gilvum_PYR-GCK ELTADVVGLLDDVGAERAALVGHDFGAVVAWGAPLLEPDRFSAVAGLSLP
Mvan_5373|M.vanbaalenii_PYR-1 ELTADVVGLLDDLGAERAALVGHDFGAVVAWAAPLLQPDRFSSVAGLSLP
Mb1973|M.bovis_AF2122/97 ELVGDVVGVLDSYGAEQAFVVGHDWGAPVAWTFAWLHPDRCAGVVGISVP
MMAR_3948|M.marinum_M DVAGDVIGLADYLGVDRFIFVAEGQGAVVALRTALLAPQRVRALALIGP-
MAB_1875c|M.abscessus_ATCC_199 ALGRQLIGALDALGIERAVLGGTSVGANISIEAAALAPERVAGLLLEGPF
MSMEG_3289|M.smegmatis_MC2_155 ERTALVLRTMDALGVEKAVLAGHSMGGRTAIHLAAVAPQRVLAAILVDAA
:: * * :: . . *. . : .:* . .
Rv3617|M.tuberculosis_H37Rv ALPR----------AQVPPTQAFRSRFG-ENFFYILYFQEPGIADAELNG
MUL_4193|M.ulcerans_Agy99 VLPR----------AQVPPIQAFRQRFG-EHFFYILYFQQPGVADAELNG
MAV_0539|M.avium_104 VTPR----------PRLAPTQAWRKMFG-ENFFYILYFQEPGVADAELNA
TH_0992|M.thermoresistible__bu PVPR----------SLTRPTEAFRALVGEDNFFYILYFQEPGVADAELDG
Mflv_1415|M.gilvum_PYR-GCK PVPR----------PQVPTTQAFRRVFG-DRFMYILYFQEPGPADAELAR
Mvan_5373|M.vanbaalenii_PYR-1 PVPR----------PKVPTTQAFRRIFA-DRFFYILYFQDRGPADAELAR
Mb1973|M.bovis_AF2122/97 FAGRGVIGLPGSPFGERRPSDYHLELAGPGRVWYQDYFAVQDGIITEIEE
MMAR_3948|M.marinum_M ------------------------------------------TAEAALDG
MAB_1875c|M.abscessus_ATCC_199 LEHG------------------------------------IGAAGYLWSA
MSMEG_3289|M.smegmatis_MC2_155 AGSSFDATIS---TVTRSPRQMLNSVLGAIYDMHSDPLHMQIGALNRYLR
Rv3617|M.tuberculosis_H37Rv DPARTMR---------RMIGGLRPPGDQSAAMRMLA------PGPDGFID
MUL_4193|M.ulcerans_Agy99 DPARTMR---------RMIGGQRSPTDQGAALRMVA------PGPEGFID
MAV_0539|M.avium_104 DPAQVMR---------RMMGSLRTDGDKAAGLRMVA------PGPEGFLE
TH_0992|M.thermoresistible__bu DPARTMR---------RMFGGLTSDPD--AAHRMLQ------PGPAGFID
Mflv_1415|M.gilvum_PYR-GCK DPATTFR---------RLFA--LTTG---GAEMVGD------AGPQGFLD
Mvan_5373|M.vanbaalenii_PYR-1 DPAGTFR---------RLFA--MDVADEQSALRMTE------PGPAGFLD
Mb1973|M.bovis_AF2122/97 DLRGWLLGLTYTVSGEGMMAATKAAVDAGVDLESMDPIDVIRAGPLCMAE
MMAR_3948|M.marinum_M ENAALTA-----------------------AMEIWCT-----QGPLPDIY
MAB_1875c|M.abscessus_ATCC_199 GLTLFTLG-----------------------------------RPLVWLA
MSMEG_3289|M.smegmatis_MC2_155 MVAAVTMG-----------KSFASRGFTGAARAIMQS-----GACAALLA
Rv3617|M.tuberculosis_H37Rv --RLPE----PAGLPAWISQEELDHYIGEFTRTGFTGGLNWYRNFDRNWE
MUL_4193|M.ulcerans_Agy99 --RLPE----PDAPPSWISRDELDHYISEFTRTGFTGGLNWYRNFDRNWE
MAV_0539|M.avium_104 --RLPE----PDGLPEWISQDELDHYIAEFSRTGFTGGLNWYRNFDRNWE
TH_0992|M.thermoresistible__bu --RLPE----PEALPDWLTAEELDHYIAEFTRTGFTGGLNWYRNMDRNWE
Mflv_1415|M.gilvum_PYR-GCK --RIPE----PGGLPDWISQADFDVYVDEFTRGGFTGPLNWYRCFDRNWE
Mvan_5373|M.vanbaalenii_PYR-1 --RIPD----PGRLPDWISPPDFAVYVDEFRRGGFTAPLNWYRCFDLNWE
Mb1973|M.bovis_AF2122/97 GARLKDAFVYPETMPAWFTEADLDFYTGEFERSGFGGPLSFYHNIDNDWH
MMAR_3948|M.marinum_M R---------PTAAMATPTPDAADALMERWRCSAWREYRAAADALATRPT
MAB_1875c|M.abscessus_ATCC_199 G---------AVARSFPETEQPTLGLIRAFLTAPPARSAAFMRGMLVGRM
MSMEG_3289|M.smegmatis_MC2_155 AMREHR----IPTIVLHGEHDSIVPFDNACDVADVVDATLYRVRGACHSW
Rv3617|M.tuberculosis_H37Rv TTADLAGKTISVPSLFIAGTADP--VLTFTR--------TDRAAEVISGP
MUL_4193|M.ulcerans_Agy99 TTADLEGATITVPSLFMAGTKDP--VLSFAR--------SDRASEVITGP
MAV_0539|M.avium_104 TTPELDGAKIAVPCLFIGGTADP--VLSFTR--------ADRAAEVISGP
TH_0992|M.thermoresistible__bu LTEHLAGATITAPALFLAGAADP--VLGFMR--------PERATEVAVGP
Mflv_1415|M.gilvum_PYR-GCK LTAETPAPTIEVPALFVGGTEDA--TLAYTP--------RDRVREVVTGD
Mvan_5373|M.vanbaalenii_PYR-1 LTADPPAPTIGVPALFVGGTADA--TLAYTP--------RHRVREVVTGD
Mb1973|M.bovis_AF2122/97 DLADQQGKPLTPPALFIGGQYDVGTIWGAQA--------IERAHEVMPNY
MMAR_3948|M.marinum_M FIAELS--TVACPALVVHSTQDV--FVPMFL--------GKEVADSLGGP
MAB_1875c|M.abscessus_ATCC_199 APPRAVRRSVNVPTMILSLTADPLHPASDAH--------SLAVDIVGAQV
MSMEG_3289|M.smegmatis_MC2_155 LIGNPRRGADSIRQLLHGELGDVLREAATTLGIDDWRDAEDWDRTLVTSA
:. *
Rv3617|M.tuberculosis_H37Rv YREVLIDGAGHWLQQERPGEVTAALLEFLTGLELR-----------
MUL_4193|M.ulcerans_Agy99 YREVMVEGAGHWLQQERPDEVNATLLDFLKGVQW------------
MAV_0539|M.avium_104 YRHVMIDGAGHWLQQERPAEVNAALLDFLNGLELR-----------
TH_0992|M.thermoresistible__bu YRQVLLDGAGHWVQQERPQEVNAALIDFLRGLELQ-----------
Mflv_1415|M.gilvum_PYR-GCK YREVMIDGAGHWLTEERPDEVSRVLVDFLTTVR-------------
Mvan_5373|M.vanbaalenii_PYR-1 YREVMIDGAGHWLTEERPDEVSRILLEFLTAAR-------------
Mb1973|M.bovis_AF2122/97 RGTHMIADVGHWIQQEAPEETNRLLLDFLGGLRP------------
MMAR_3948|M.marinum_M TAFVPVDTGHHAITCAFHPQIGAEILAWLPSVEDHPE---------
MAB_1875c|M.abscessus_ATCC_199 VSAGTLATLRFWPRRVTPAIVSFLVETFGIDVTARQADA-------
MSMEG_3289|M.smegmatis_MC2_155 AQVRTLAGAGVVIGPDSRERVEMDLVRRPGPTRAEAVPETPERATA
: :