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TLSSTELDDLVGAVDRYPVYKDLRDNQPVLPVEVNGHEAYLLTRYADVSRVLKTASARVQPRAGEFPAHI GTGPASEFYRFSLPSMDAPSHTRLRKLAAAAFSPRAVAAMRSWVEEIIGAGIDRLMDFDGEFDFVGEFAS RVPAEIACRLLHAPMSDAHSVLERMPDLNPILSHGGITAEQLAAADAAAQFYIDYIGDLVDTLQGKLDSD DAVGALLEAEADGSKMTRTELIITLVGLFIASYHTTMVALTNAVYGFSSHPAQMRTLADNPDLAPKAWEE SLRYRSPVHVVHRYAGEDMVLHDQSIPEGAQLLLGLASANRDERFFDSPDTLDITRGTNRHLAFTGGGHY CLGAPLSRLEGDYFMRVLPQRLPNIRVTSDRPDWGTDLSFAFMRSMMVSSGR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0917c | - | - | 100% (403) | cytochrome P450 |
| M. abscessus ATCC 19977 | MAB_0276 | - | 2e-51 | 33.00% (397) | cytochrome P450 |
| M. abscessus ATCC 19977 | MAB_1216c | - | 1e-39 | 30.83% (373) | cytochrome P450 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0789c | cyp123 | 7e-42 | 32.07% (368) | cytochrome P450 123 |
| M. gilvum PYR-GCK | Mflv_1229 | - | 1e-42 | 29.21% (404) | cytochrome P450 |
| M. tuberculosis H37Rv | Rv0766c | cyp123 | 7e-42 | 32.07% (368) | cytochrome P450 123 |
| M. leprae Br4923 | MLBr_02088 | - | 2e-49 | 31.91% (376) | putative cytochrome p450 |
| M. marinum M | MMAR_5268 | cyp164A3 | 1e-52 | 32.92% (407) | cytochrome P450 164A3 Cyp164A3 |
| M. avium 104 | MAV_0358 | - | 1e-50 | 32.51% (403) | cytochrome P450 |
| M. smegmatis MC2 155 | MSMEG_6312 | - | 2e-46 | 31.58% (418) | cytochrome P450 107B1 |
| M. thermoresistible (build 8) | TH_4410 | - | 1e-63 | 35.77% (369) | PUTATIVE putative cytochrome P450 107B1 |
| M. ulcerans Agy99 | MUL_2979 | cyp140A5 | 1e-37 | 33.11% (299) | cytochrome P450 140A5 Cyp140A5 |
| M. vanbaalenii PYR-1 | Mvan_0317 | - | 1e-47 | 34.21% (380) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1229|M.gilvum_PYR-GCK ----------------------------------MTTAAEPQSLLLQMLD
MSMEG_6312|M.smegmatis_MC2_155 ------------------------MHNGWMS--TAATAQEAQGLLLQLLD
MMAR_5268|M.marinum_M MLRGPVTAATHFDHTFFMRRHNVSMTTRPIEPIEFTEQVEPQAFLFQLLD
MAV_0358|M.avium_104 ------------------------MTTAP------TESAESQGLLLQLLD
MLBr_02088|M.leprae_Br4923 -MRTCVPTRTCVYAFIEYLSHNRPMGTNP------PSLVEAQMLLLRLID
MUL_2979|M.ulcerans_Agy99 ----------------MKDKLHWFAMHGVIRGMANIGLRRGELEARLIAD
Mb0789c|M.bovis_AF2122/97 ----------------------------------MTVRVGDPELVLDPYD
Rv0766c|M.tuberculosis_H37Rv ----------------------------------MTVRVGDPELVLDPYD
Mvan_0317|M.vanbaalenii_PYR-1 --------------------------------------MVSVQIRYDPFD
MAB_0917c|M.abscessus_ATCC_199 ----------------------------------------MTLSSTELDD
TH_4410|M.thermoresistible__bu ----------------------------------------VTVLFDPLDE
:
Mflv_1229|M.gilvum_PYR-GCK PANRADPYPLYARIRAQGPVQLP-ANN--LTVFSTYAACDEILR----HP
MSMEG_6312|M.smegmatis_MC2_155 PATRADPYPIYDRIRRGGPLALP-EAN--LAVFSSFSDCDDVLR----HP
MMAR_5268|M.marinum_M PAIRADPYPLCARLRDHGPLHLP-EAN--FVLFSSFGDCDEVLR----HP
MAV_0358|M.avium_104 PANRADPYRLYAQFRERGALQLP-EAN--LAVFLSYRDCDEVLR----HP
MLBr_02088|M.leprae_Br4923 PGTRADPFPVYRALIDYGPMQLP-GMP--LTVFSSFSDCDEALR----HP
MUL_2979|M.ulcerans_Agy99 PAVAANPGPFHDELRRHGRMVRT-RVN--YLTVD-YQLAHDVLRSDDFHT
Mb0789c|M.bovis_AF2122/97 YDFHEDPYPYYRRLRDEAPLYRNEERN--FWAVSRHHDVLQGFR------
Rv0766c|M.tuberculosis_H37Rv YDFHEDPYPYYRRLRDEAPLYRNEERN--FWAVSRHHDVLQGFR------
Mvan_0317|M.vanbaalenii_PYR-1 ASILNDPYPTYRLLRDVAPVYRAEESH--TWVLSRHADVQAAAL------
MAB_0917c|M.abscessus_ATCC_199 LVGAVDRYPVYKDLRDNQPVLPVEVNGHEAYLLTRYADVSRVLK------
TH_4410|M.thermoresistible__bu EQ-LADPIPTYRALREQDPVQRIPVGG-GTWVVSRYEDVRRLLR------
: : : . .
Mflv_1229|M.gilvum_PYR-GCK HASSDRLKSTLAQRAIAD-GAQPRPFGPPGFLFLDPPDHTRLRRLVSKAF
MSMEG_6312|M.smegmatis_MC2_155 SSCSDRTKSTIFQRQLAA-ETQPRPQGPASFLFLDPPDHTRLRGLVSKAF
MMAR_5268|M.marinum_M SSCSDQTKSTVAQRRVEE-EPALGRDFPPGFLFLDPPDHTRLRKLVSKAF
MAV_0358|M.avium_104 SSSSDNVNSTVAKRQAAA-GTAPVRQGPPGFLFLDPPDHTRLRRLVSKAF
MLBr_02088|M.leprae_Br4923 LSASDRLKATLAQQAIAA-GAEPRPFYASSFMFLDPPDHTRLRKLVSKAF
MUL_2979|M.ulcerans_Agy99 ISFGENLPGPLRWLERRTRDEQLHPLRPPSLLAVEPPDHTRYRKTVSAVF
Mb0789c|M.bovis_AF2122/97 ---DSTALSNAYGVSLDPSSRTSEAYRVMSMLAMDDPAHLRMRTLVSKGF
Rv0766c|M.tuberculosis_H37Rv ---DSTALSNAYGVSLDPSSRTSEAYRVMSMLAMDDPAHLRMRTLVSKGF
Mvan_0317|M.vanbaalenii_PYR-1 ---DHSTYSSVDGIFPTPPGSDFIGSFLPMMIVMDPPRHDQLRALVSRAF
MAB_0917c|M.abscessus_ATCC_199 -TASARVQPRAGEFPAHIGTGPASEFYRFSLPSMDAPSHTRLRKLAAAAF
TH_4410|M.thermoresistible__bu -TTAGLMQPPGATVPVELAGGPAERIYRGLMVLNDPPVHTRLRKLTEKAM
: : * * : * . :
Mflv_1229|M.gilvum_PYR-GCK VPKVVKALEPEIVALVDALLADAGG---TFDAIEGLAYPLPVAVICRLLG
MSMEG_6312|M.smegmatis_MC2_155 APRVIKRLEPEITALVDQLLDAVDGP--EFNLIDNLAYPLPVAVICRLLG
MMAR_5268|M.marinum_M APKVVNALRPEISSLVDGLLDRIAEQ-GRFDVVSDFAYPLPVAVICRLLG
MAV_0358|M.avium_104 APRVVAALEPDIRSLVDGLLDRAADR-GELEIVEDFAYPLPVAVICRLLG
MLBr_02088|M.leprae_Br4923 APKVVQALEGDIAALVDSLLDKGAAA-GQFDVIADLAFPLAVAVICRLLG
MUL_2979|M.ulcerans_Agy99 TSRAVAALRDRVEQTANSLLDQLAQRPGVVDVVGQYCSQLPIMVISEILG
Mb0789c|M.bovis_AF2122/97 TPRRIRELEPQVLELARIHLDSALQ-TESFDFVAEFAGKLPMDVISELIG
Rv0766c|M.tuberculosis_H37Rv TPRRIRELEPQVLELARIHLDSALQ-TESFDFVAEFAGKLPMDVISELIG
Mvan_0317|M.vanbaalenii_PYR-1 TPRRVAGLQGTITQMAAELFERLDEGSGSADFVTDFAAILPAAVIADLLG
MAB_0917c|M.abscessus_ATCC_199 SPRAVAAMRSWVEEIIGAGIDRLMDFDGEFDFVGEFASRVPAEIACRLLH
TH_4410|M.thermoresistible__bu TRGAVEKLRADVERVASEALDAMLEQ-GEADAMTELAFTVPLRVICGMLG
: :. : : : : . :. : . ::
Mflv_1229|M.gilvum_PYR-GCK VPLADEPEFSAASALLAQSLDPFATVTGSAGDGFEERMEAARWLRGYLRE
MSMEG_6312|M.smegmatis_MC2_155 VPIEDEPKFSRASALLAAALDPFLALTGETSDLFDEQMKAGMWLRDYLRA
MMAR_5268|M.marinum_M VPLEDEPQFSQASALLAQALDPFFAFTGQNAENLNDSLEAGQWLRGYLRD
MAV_0358|M.avium_104 VPLDDEPQFSRASALLAQALDPFSTITGVPAEVASERQQAGTWLRDYFHQ
MLBr_02088|M.leprae_Br4923 VPYEDAPEFGRVSALLVQSVDPFITITGEPPEATEERLRAGVWLRDYLEQ
MUL_2979|M.ulcerans_Agy99 VPEQDRGRVLEYGELAAPSLD-----IGVTYRQYRRIQQGITGFNSWLTA
Mb0789c|M.bovis_AF2122/97 VPDTDRARIRALADAVLHRED-------GVADVPPPAMAASIELMRYYAD
Rv0766c|M.tuberculosis_H37Rv VPDTDRARIRALADAVLHRED-------GVADVPPPAMAASIELMRYYAD
Mvan_0317|M.vanbaalenii_PYR-1 VPATDRDQFRLWSSQLVQVDV-------NHGQTT-DALAAAAAIYAYFTD
MAB_0917c|M.abscessus_ATCC_199 APMSDAHSVLERMPDLNPILSH----GGITAEQLAAADAAAQFYIDYIGD
TH_4410|M.thermoresistible__bu IPEADRAQMLDWTPDFFRIFLP----QANDADGIAACHRACQNFIDYLSE
* * . . :
Mflv_1229|M.gilvum_PYR-GCK LISQRR-RDPGEDLMSGLIQVEESGDQ---LTEDEIVATCNLLLVAGHET
MSMEG_6312|M.smegmatis_MC2_155 LIDERR-RTPGEDLMSGLVAVEESGDQ---LTEDEIIATCNLLLIAGHET
MMAR_5268|M.marinum_M LIALRR-SQPGEDLMSGLVAVEESGDQ---LTEDEIVSTCVLLLVAGHET
MAV_0358|M.avium_104 LIEARR-SRPGDDLLSGLIAVEESGDQ---LTEEEIVSTCNLLLIAGHET
MLBr_02088|M.leprae_Br4923 LVKCRR-GTPGEDLISRLIELDESGDQ---LTEEEIIATCGLLLVAGHET
MUL_2979|M.ulcerans_Agy99 HLEQLR-RNPGDDLMSQLIRVAESGDAGTYLDKSELRAIAGLVLVAGFET
Mb0789c|M.bovis_AF2122/97 LIAEFR-RRPANNLTSALLAAELDGDR---LSDQEIMAFLFLMVIAGNET
Rv0766c|M.tuberculosis_H37Rv LIAEFR-RRPANNLTSALLAAELDGDR---LSDQEIMAFLFLMVIAGNET
Mvan_0317|M.vanbaalenii_PYR-1 FLADRR-KNPREDLMSALANATVDGIG---LTDEEVLGFCALLLVAGYET
MAB_0917c|M.abscessus_ATCC_199 LVDTLQGKLDSDDAVGALLEAEADGSK---MTRTELIITLVGLFIASYHT
TH_4410|M.thermoresistible__bu QIEYRR-RTPADDIFSALVSAEDEGDR---LSRDELVATVLSLLTGGFDT
: : :: . * .* : *: :. .. .*
Mflv_1229|M.gilvum_PYR-GCK TVNLIANAILALLSNDGQWSALAADPA-RVGAVVEETLRYDPPVQLVGRI
MSMEG_6312|M.smegmatis_MC2_155 TVNLIANAALAMLRTPGQWAALAADGS-RASAVIEETMRYDPPVQLVSRY
MMAR_5268|M.marinum_M TVNLIGNAILAMLRDRRQWAQLGADPD-RAAAVVEETMRYDPPVQLIGRI
MAV_0358|M.avium_104 TVNLIGNAVLAMLRDPGQWAALGADPG-RAPAIVEETLRYDPPVQLAGQI
MLBr_02088|M.leprae_Br4923 TVNLIANAVLAMLRNPSQWKALSSNPQ-RAPLVVEETLRYDPAIHLIGRV
MUL_2979|M.ulcerans_Agy99 TVNLLGNGIRMLLDAPEQLETLRQRPE-LWPNAVEEILRLDSPVQLTARV
Mb0789c|M.bovis_AF2122/97 TTKLLANAVYWAAHHPGQLARVFADHS-RIPMWVEETLRYDTSSQILART
Rv0766c|M.tuberculosis_H37Rv TTKLLANAVYWAAHHPGQLARVFADHS-RIPMWVEETLRYDTSSQILART
Mvan_0317|M.vanbaalenii_PYR-1 TTNLLGNSAVVLAQHRQTRRRLAADRT-LLGPAVEELLRYDSPAQGLSRT
MAB_0917c|M.abscessus_ATCC_199 TMVALTNAVYGFSSHPAQMRTLADNPD-LAPKAWEESLRYRSPVHVVHRY
TH_4410|M.thermoresistible__bu TMGMIGAGVFGLARQPEQLAALREDPAGLARTAVEEFIRWESPVAVTYRH
* : . : ** :* .. :
Mflv_1229|M.gilvum_PYR-GCK AAEDMTVGTTTVPKGDNMLLLTAAAHRDPDAVDRPDEFDPDRESF-RHLG
MSMEG_6312|M.smegmatis_MC2_155 AGDDLTIGTHTVPKGDTMLLLLAAAHRDPTIVGAPDRFDPDRAQI-RHLG
MMAR_5268|M.marinum_M AGADMVIGDVEVAKGDVMMMLVAAAHRDPAEYDRPEEFDPDRGAL-RHLG
MAV_0358|M.avium_104 ALDDMVIGGVEVPAGDVMMLLLAAANRDPAEFDRPDTFDPDRKSL-RHLG
MLBr_02088|M.leprae_Br4923 AAKDMTIGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDPDRPSS-RHLA
MUL_2979|M.ulcerans_Agy99 ARTDVEIASWPINRGEMVVAYLAGANRDPAVFPNPHRFDVERANAGRHLA
Mb0789c|M.bovis_AF2122/97 VAHDLTLYDTTIPEGEVLLLLPGSANRDDRVFDDPDDYRIGREIGCKLVS
Rv0766c|M.tuberculosis_H37Rv VAHDLTLYDTTIPEGEVLLLLPGSANRDDRVFDDPDDYRIGREIGCKLVS
Mvan_0317|M.vanbaalenii_PYR-1 LTRDVTLHDTTMRQGEKVLLLFGSANRDERAFPDPDVFDIERTS-EHQVA
MAB_0917c|M.abscessus_ATCC_199 AGEDMVLHDQSIPEGAQLLLGLASANRDERFFDSPDTLDITRGTN-RHLA
TH_4410|M.thermoresistible__bu FVEDVTIADTTIPAGEPIWLLLLSANRDDTRFHDPDGFDVRRKPN-QHVA
*: : : * : .*:** *. * : :.
Mflv_1229|M.gilvum_PYR-GCK FGKGPHFCIGAPLARLEAAVALTALTSRFPGAQLAGEPSYKQ-NVTLRGM
MSMEG_6312|M.smegmatis_MC2_155 FGKGAHFCLGAPLARLEATVALPALAARFPEARLSGEPEYKR-NLTLRGM
MMAR_5268|M.marinum_M FGRGAHYCLGAPLARLEASVALSAIAARFPQARLDGEPQYKT-NVTLRGL
MAV_0358|M.avium_104 FGRGVHYCLGAPLARLEAGVALSAVTARFPRARLDGEPQYKT-NVTLRGL
MLBr_02088|M.leprae_Br4923 FAVGSHFCLGAALARLEATVTLSAISARFPQVQLAGELVYKP-NVAMRGM
MUL_2979|M.ulcerans_Agy99 FSTGRHFCLGAALARAEGEVGLRTFFERFPDVRAAGAGSRRD-TRVLRGW
Mb0789c|M.bovis_AF2122/97 FGSGAHFCLGAHLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGF
Rv0766c|M.tuberculosis_H37Rv FGSGAHFCLGAHLARMEARVALGALLRRIRNYEVDDDNVVRVHSSNVRGF
Mvan_0317|M.vanbaalenii_PYR-1 FGRGIHFCLGAALARMEARIALNALLDKVPDWEVDLESARRLRSGPIRGY
MAB_0917c|M.abscessus_ATCC_199 FTGGGHYCLGAPLSRLEGDYFMRVLPQRLPNIRVTSDRPDWG-TDLSFAF
TH_4410|M.thermoresistible__bu FGGGRHHCIGSHLARLEGEVVFAEIARRIETIEITGDSPRRP-NFQFRSF
* * *.*:*: *:* *. : . :. . . .
Mflv_1229|M.gilvum_PYR-GCK SELPITL---------
MSMEG_6312|M.smegmatis_MC2_155 STLSIAV---------
MMAR_5268|M.marinum_M ESMTVALS--------
MAV_0358|M.avium_104 SRLVVAV---------
MLBr_02088|M.leprae_Br4923 SALPVQV---------
MUL_2979|M.ulcerans_Agy99 STLPVTLGPARALAAS
Mb0789c|M.bovis_AF2122/97 AHLPISVQAR------
Rv0766c|M.tuberculosis_H37Rv AHLPISVQAR------
Mvan_0317|M.vanbaalenii_PYR-1 TSLPITWTTPV-----
MAB_0917c|M.abscessus_ATCC_199 MRSMMVSSGR------
TH_4410|M.thermoresistible__bu TTLPVKMTGRSR----
: