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MTSARHAADSRLAAVTYAGPEWMGKANWHSVAETYLFKALGKPGLYALTRLMLAVNRRFPDVLLNRRYDG LERLMGWVPGVSGTRTERVQLPNCPAEWTWNVKNESASSASSDAPVVIYFHGSAFIALGINSHRPLVSHI ARDSGARALSVGYRLCPRNLVEDAIADGVDAYRYVLSQGVDPDNIVLAGDSAGGFLAAMTAIAVRDQGLT PPAGCVLISAATSNDMEPKYAVGKRVGDAMFPVDFLRMINDVFLLRNGAREPGACPVDADLTGLGPFLLQ VGSQEALRPDSELLAERLVAAGVPVRLQIFDRAIHVFQVFAMTNPDARRAVAEITDFIKVLPGLAKARQR PGEMATGLGS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_0846 | - | - | 100% (360) | putative lipase/esterase |
| M. abscessus ATCC 19977 | MAB_0141c | - | 2e-44 | 40.39% (255) | putative esterase |
| M. abscessus ATCC 19977 | MAB_4044c | - | 2e-43 | 37.25% (306) | putative hydrolase/esterase/lipase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1105 | lipU | 3e-31 | 35.07% (268) | putative lipase LIPU |
| M. gilvum PYR-GCK | Mflv_2042 | - | 3e-34 | 33.96% (268) | alpha/beta hydrolase domain-containing protein |
| M. tuberculosis H37Rv | Rv1076 | lipU | 3e-31 | 35.07% (268) | lipase LipU |
| M. leprae Br4923 | MLBr_00314 | - | 2e-31 | 33.33% (279) | putative esterase |
| M. marinum M | MMAR_4391 | lipU | 2e-32 | 34.33% (268) | lipase LipU |
| M. avium 104 | MAV_3011 | - | 4e-41 | 35.27% (275) | alpha/beta hydrolase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_0267 | - | 5e-41 | 37.28% (279) | esterase |
| M. thermoresistible (build 8) | TH_1370 | lipF | 4e-35 | 35.09% (265) | PROBABLE ESTERASE/LIPASE LIPF |
| M. ulcerans Agy99 | MUL_2832 | lipU_1 | 3e-32 | 36.26% (273) | lipase LipU_1 |
| M. vanbaalenii PYR-1 | Mvan_4675 | - | 2e-31 | 32.09% (268) | alpha/beta hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1105|M.bovis_AF2122/97 --------------------------------------------------
Rv1076|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4391|M.marinum_M ---MTAPSRVPSNPIHAIRPRDVLKARRLEARRFAISDGAPVEVVESGPS
MLBr_00314|M.leprae_Br4923 ---------------------------------MAISAGAPVEIVESGPS
MUL_2832|M.ulcerans_Agy99 MSGVTTFDKLFGPPYDAIRPRRNRRVG----RRAASGHGAHVEVVESGPS
Mflv_2042|M.gilvum_PYR-GCK ---MTAPSKVPATPHVAINAARGRKQ-----RRFPVSDGAPVEVVEDGPS
Mvan_4675|M.vanbaalenii_PYR-1 ---MTAPSKVPATPHAAIAAARAGKI-----RRFPVSDGAPVEVVEDGPS
TH_1370|M.thermoresistible__bu ---MTAPSKVPRTSPLATRAARGHYS-----RTFPVSDGTPSEYVEDGPS
MAV_3011|M.avium_104 -------------------------------------MATTRRVHHR-HS
MSMEG_0267|M.smegmatis_MC2_155 ----------MTSSVSTIDAR--------------PDLSVGKQIMHRRRS
MAB_0846|M.abscessus_ATCC_1997 ---MTSARHAADSRLAAVTYAG------------PEWMGKANWHSVAETY
Mb1105|M.bovis_AF2122/97 -----------MAVRPVLAVGSYLPHAPWPWGVID-QAARVLLPASTTVR
Rv1076|M.tuberculosis_H37Rv -----------MAVRPVLAVGSYLPHAPWPWGVID-QAARVLLPASTTVR
MMAR_4391|M.marinum_M VAARVATLASRLTIRPVLAVGSHVPHLPWPWGLID-HAAKALVPASATVR
MLBr_00314|M.leprae_Br4923 IAARLASLTSRLTIRPILAVGSYVPQLPWPFGLID-HAARVLLPVTNAAR
MUL_2832|M.ulcerans_Agy99 IAARVVSLASRLTVRPVIAVASHFPHLPWPWSLVD-FALLPITWASGIIG
Mflv_2042|M.gilvum_PYR-GCK VAGRVLGLAAMATIKPFLTVGSYAPKLPWPWGLVD-FAARVLKPAPGTVR
Mvan_4675|M.vanbaalenii_PYR-1 IAGRLMGLAAVATVKPFLTVGSYAPKLPWPWGLLD-FAARVLKPAPGTVR
TH_1370|M.thermoresistible__bu LAGRLTALAAYLTVRPTLAIGSFAPRLPWPWGLLD-FAARAVRPVPGTVR
MAV_3011|M.avium_104 PQSVAVSLASRLIVKNAVRAWALTPNLHWPLEYVDSFAGLVPRLGSAGTT
MSMEG_0267|M.smegmatis_MC2_155 AESFALAAGCRAFVRNAVRVWAMQPNLAWPLGSIDRMVGLLPHR-VDAKI
MAB_0846|M.abscessus_ATCC_1997 LFKALGKPGLYALTRLMLAVNRRFPDVLLNRRYDGLERLMGWVPGVSGTR
: : * .
Mb1105|M.bovis_AF2122/97 -AAVSLPNASAQLVR---ASGVLPADGTRRAVLYLHGGAFLTCGANSHGR
Rv1076|M.tuberculosis_H37Rv -AAVSLPNASAQLVR---ASGVLPADGTRRAVLYLHGGAFLTCGANSHGR
MMAR_4391|M.marinum_M -AAVSLPNAAAQLVR---APGVLPADGTRRVVLYLHGGAFLTCGANSHGR
MLBr_00314|M.leprae_Br4923 -AEVNLSNTSAQLVR---AAGVRPADGSGRIVLYLHGGAFLGCGANSHRR
MUL_2832|M.ulcerans_Agy99 -ERVSLPNASGHLVR---ASGVPPPDGSRRVVLYMHGGAFLKGGIHSHAR
Mflv_2042|M.gilvum_PYR-GCK -ATIKLPHCTAQLVR---AAGVLPADGNRTVILYLHGGAFLTCGVNTHGR
Mvan_4675|M.vanbaalenii_PYR-1 -ATIGLPHCNAQLVR---AAGVLPADGHRSVILYLHGGAFLTCGVNTHGR
TH_1370|M.thermoresistible__bu -ATIRLPHCTAQLVR---APGVLPADGRRSVVLYLHGGAFLTCGAHTHGR
MAV_3011|M.avium_104 -HPVRLEHCAAEWVR---APGVS----GERAILYLHGGAFLTCGLNTHRP
MSMEG_0267|M.smegmatis_MC2_155 -RSVQLPDCAAELVC---ANGVS----ADRAILYLHGGAFMTCGINTHRS
MAB_0846|M.abscessus_ATCC_1997 TERVQLPNCPAEWTWNVKNESASSASSDAPVVIYFHGSAFIALGINSHRP
: * . .. . .. ::*:**.**: * ::*
Mb1105|M.bovis_AF2122/97 LVELLSKFADSPVLVVDYRLIPKHSIGMALDDCHDGYRWLRLLGYEPEQI
Rv1076|M.tuberculosis_H37Rv LVELLSKFADSPVLVVDYRLIPKHSIGMALDDCHDGYRWLRLLGYEPEQI
MMAR_4391|M.marinum_M LVELLSKFADAPVLIVNYRLMPKHSIGMALDDCHDGYRWLRLLGYDPEQI
MLBr_00314|M.leprae_Br4923 LVETLSKLADSPILVVNYRLLPKHSIGMALDDCHDGYQWLRRLGYDPEQI
MUL_2832|M.ulcerans_Agy99 LAGTLSKFADSPLLVVNYRLVPKHTVGMALEDCHDAYLWLRLRGHAPEQI
Mflv_2042|M.gilvum_PYR-GCK LVTALSKCADAPALVVNYRMIPKHSVGTALDDCYDAYKWLRETGYEPEQI
Mvan_4675|M.vanbaalenii_PYR-1 LVTALSKCADAPVLVVNYRMIPKHSVGTALDDCFDGYKWLRELGYEPDQI
TH_1370|M.thermoresistible__bu LVTALSEFADSPVLVVNYRMIPKHSVGTAIDDCYDGYQWLRAKGYEPDQI
MAV_3011|M.avium_104 MVTRLSKAADAAVLAVAYRKLPAHQITDAIDDGLDGLRWLQDRGFDGDRV
MSMEG_0267|M.smegmatis_MC2_155 LVARLSREADAAVLNVGYRMLPKYGLAEAIDDAVAGLRWLQEQGYTSDQI
MAB_0846|M.abscessus_ATCC_1997 LVSHIARDSGARALSVGYRLCPRNLVEDAIADGVDAYRYVLSQGVDPDNI
:. ::. :.: * * ** * : *: * . :: * :.:
Mb1105|M.bovis_AF2122/97 VLAGDSAGGYLALALAQRLQEV------GEEPAALVAISPLLQLAKEHKQ
Rv1076|M.tuberculosis_H37Rv VLAGDSAGGYLALALAQRLQEV------GEEPAALVAISPLLQLAKEHKQ
MMAR_4391|M.marinum_M VLAGDSAGGYLALTLAQRLQEE------GEEPAALVAISPLLQLAKEQKK
MLBr_00314|M.leprae_Br4923 VLAGDSAGGYLALALAQRLQDV------GEEPAALVAISPLLQLAKKGKQ
MUL_2832|M.ulcerans_Agy99 VLAGDSAGGYLAFALAQRLRAR------GEEPAALVAISPLLQLAMRSKK
Mflv_2042|M.gilvum_PYR-GCK VLAGDSAGGYLALALAEKLQAEGINGYVGETPAAVVTMSPLFEIDNEARA
Mvan_4675|M.vanbaalenii_PYR-1 VLAGDSAGGYLALSLAERLQAEGINGFVGETPAAIVTMSPLFEIDNEARA
TH_1370|M.thermoresistible__bu VLAGDSAGGYLALSLAQRLLDE------GEEPAALVALSPLFEIDNESRA
MAV_3011|M.avium_104 VVAGDSAGGYLAFMTTLLAIQNE-----VMEPAGIATVSPFTDTDPARKL
MSMEG_0267|M.smegmatis_MC2_155 VIAGDSAGGYLALATALQLSSRG-----EVPAAGIAAISPLTDLDPASKL
MAB_0846|M.abscessus_ATCC_1997 VLAGDSAGGFLAAMTAIAVRDQG-----LTPPAGCVLISAATSNDMEPKY
*:*******:** : .*. . :*. . :
Mb1105|M.bovis_AF2122/97 AHPNIKTDAMFPARAFDALDALVASAAARNQVDGEPEELYEPLEHITPGL
Rv1076|M.tuberculosis_H37Rv AHPNIKTDAMFPARAFDALDALVASAAARNQVDGEPEELYEPLEHITPGL
MMAR_4391|M.marinum_M AHPNIKRDAMFPPKAFDALGELVASAAAKNKIDGKPEELYEPLEHIRPGL
MLBr_00314|M.leprae_Br4923 AHPNAKTDAMFPPKAFDALGRLVASSAAKNKVDDKPEELYEPLDHIAPGL
MUL_2832|M.ulcerans_Agy99 AHPNIKSDAMFPARAFDALVAIVAGAAARNETAGRREEIYEPLEHIAPGL
Mflv_2042|M.gilvum_PYR-GCK DHPNVRTDSMFPPKAFHALVELIEEAAARRMVNGAPEEVYEPLDHIEPGL
Mvan_4675|M.vanbaalenii_PYR-1 DHPNVRTDAMFPPKAFHALVELIEAAAERRMVDGKPEEVYEPLDHIEPGL
TH_1370|M.thermoresistible__bu QHPNIRTDAMFPPRAFSALIELVEEAAERRTTNGRPEEVYEPLDNIEPGL
MAV_3011|M.avium_104 KHRNARKCSMFTCRAFSRFAEYLS--NAQVLEGHGDSTVASPVDADLSSL
MSMEG_0267|M.smegmatis_MC2_155 EHPNARKCAMFTGAALAGFAKYLHRCERRPVSRREAAAFVNPVTADLTKL
MAB_0846|M.abscessus_ATCC_1997 AVGKRVGDAMFPVDFLRMINDVFLLRNGAREPG------ACPVDADLTGL
: :**. : : . *: . *
Mb1105|M.bovis_AF2122/97 PRTLIHVSGSEVLLHDAQLAAAKLAAAGVPAEVRVWPGQVHDFQVAASML
Rv1076|M.tuberculosis_H37Rv PRTLIHVSGSEVLLHDAQLAAAKLAAAGVPAEVRVWPGQVHDFQVAASML
MMAR_4391|M.marinum_M PRTLIHVSGSEVLLHDAQLAARKLAAVGVPAEVRVWPGQVHDFQVAGPLL
MLBr_00314|M.leprae_Br4923 PRTLIHVSGSEVLLHDAQLAATKLAAVGVPAEIRVWPGQVHVFQAAAPMV
MUL_2832|M.ulcerans_Agy99 PPTLIHVSGAEALLHDARLAAGKLAAAGVRAEVRVWPGQLHDFQVAAPML
Mflv_2042|M.gilvum_PYR-GCK PRTLIHVSGSEVLLSDARKAARLLAASGVPVEVRIWPGQMHVFQLGAPMV
Mvan_4675|M.vanbaalenii_PYR-1 PRTLIHVSGSEVLLSDARKAARLLAAAGVPVEVRVWPGQMHVFQLGAPAV
TH_1370|M.thermoresistible__bu PRTLIHVSGSEALISDARKAARRLAAAGVPVEIRVWPGQMHVFQIAAPFV
MAV_3011|M.avium_104 PPVTIHASSDELLVADAELMAKRLEASGIHCDLHLWDGQIHDFPLAADVL
MSMEG_0267|M.smegmatis_MC2_155 PPVTVHVSADESLYSDSELLAGRLAEAQVPCELHVWHGQVHDFPLAADIL
MAB_0846|M.abscessus_ATCC_1997 GPFLLQVGSQEALRPDSELLAERLVAAGVPVRLQIFDRAIHVFQVFAMTN
::... * * *:. * * : :::: :* * .
Mb1105|M.bovis_AF2122/97 PEAIRSLRQIGEYIREATG-----------------
Rv1076|M.tuberculosis_H37Rv PEAIRSLRQIGEYIREATG-----------------
MMAR_4391|M.marinum_M PEATRSLRQIGDYIREATG-----------------
MLBr_00314|M.leprae_Br4923 PEATLSLRQISQYIREATASKASRDRQSL-------
MUL_2832|M.ulcerans_Agy99 PEATYSLRQIGEYIRQATG-----------------
Mflv_2042|M.gilvum_PYR-GCK PEASRSIKQIGEYIREATW-----------------
Mvan_4675|M.vanbaalenii_PYR-1 SEANRSIKQIGEYIREATW-----------------
TH_1370|M.thermoresistible__bu PEAKRSLRQIGEYIREATW-----------------
MAV_3011|M.avium_104 PEGRRAIKYLGDFVKDVTAAGTRFSNVRRLRTAAAG
MSMEG_0267|M.smegmatis_MC2_155 PEGRRALRYVGDFVKQTT--GTRLANVS--------
MAB_0846|M.abscessus_ATCC_1997 PDARRAVAEITDFIKVLPGLAKARQRPGEMATGLGS
.:. :: : :::: .