For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
TANVVPLHVERVEPVRSERGSLTVPLRLGRLAVRAVAYPVIALWARFPALPWPYRVVDLAAAVLRPVRGV RRSRVRLRNCEAELMSRADGPSNGAMLYLHGGAFVVGGLNSHRRLVSRIVTTAGVTSLAVNYRKLPAHPV SAAVEDALDGFRLLTEMGYRPSEIVIAGDSAGGFLSLVTSLIAQRRGYGAPGALVCISPLVQRDPAGKLV LAAQSNDPLFPESALIAMERLMLSAEKTTAGLEVLDSFVEGCLPTLACLPPTLFQVGSDEILRPDTEFAA ARLSEAGVPVELQIWRNQVHVFQIAADVLGDARTAVGEIADFVGAHVGGRSA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_4044c | - | - | 100% (333) | putative hydrolase/esterase/lipase |
| M. abscessus ATCC 19977 | MAB_1194 | - | 1e-50 | 36.31% (325) | putative lipase LipU |
| M. abscessus ATCC 19977 | MAB_0141c | - | 4e-48 | 36.28% (317) | putative esterase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1105 | lipU | 2e-50 | 40.00% (295) | putative lipase LIPU |
| M. gilvum PYR-GCK | Mflv_2042 | - | 3e-50 | 36.70% (327) | alpha/beta hydrolase domain-containing protein |
| M. tuberculosis H37Rv | Rv1076 | lipU | 2e-50 | 40.00% (295) | lipase LipU |
| M. leprae Br4923 | MLBr_00314 | - | 3e-55 | 39.44% (322) | putative esterase |
| M. marinum M | MMAR_4391 | lipU | 2e-51 | 39.01% (323) | lipase LipU |
| M. avium 104 | MAV_1200 | - | 3e-51 | 38.58% (324) | alpha/beta hydrolase domain-containing protein |
| M. smegmatis MC2 155 | MSMEG_0267 | - | 6e-52 | 38.46% (299) | esterase |
| M. thermoresistible (build 8) | TH_1370 | lipF | 2e-51 | 40.00% (310) | PROBABLE ESTERASE/LIPASE LIPF |
| M. ulcerans Agy99 | MUL_2832 | lipU_1 | 2e-47 | 37.24% (333) | lipase LipU_1 |
| M. vanbaalenii PYR-1 | Mvan_4675 | - | 4e-51 | 36.70% (327) | alpha/beta hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1105|M.bovis_AF2122/97 --------------------------------------------------
Rv1076|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_4391|M.marinum_M ---MTAPSRVPSNPIHAIRPRDVLKARRLEARRFAISDGAPVEVVESGPS
MAV_1200|M.avium_104 ---MTAPSEVSGSQ-SPVRVHDVLKARRARIRKFAISDGAPVEVLESGPS
MLBr_00314|M.leprae_Br4923 ---------------------------------MAISAGAPVEIVESGPS
MUL_2832|M.ulcerans_Agy99 MSGVTTFDKLFGPPYDAIRPRRNRRVG----RRAASGHGAHVEVVESGPS
Mflv_2042|M.gilvum_PYR-GCK ---MTAPSKVPATPHVAINAARGRKQ-----RRFPVSDGAPVEVVEDGPS
Mvan_4675|M.vanbaalenii_PYR-1 ---MTAPSKVPATPHAAIAAARAGKI-----RRFPVSDGAPVEVVEDGPS
TH_1370|M.thermoresistible__bu ---MTAPSKVPRTSPLATRAARGHYS-----RTFPVSDGTPSEYVEDGPS
MSMEG_0267|M.smegmatis_MC2_155 ---MTS-------SVSTIDARP------------DLSVGK--QIMHRRRS
MAB_4044c|M.abscessus_ATCC_199 ---------------MTANVVP-----------LHVERVEPVRSERGSLT
Mb1105|M.bovis_AF2122/97 -----------MAVRPVLAVGSYLPHAPWPWGVIDQAARVLLPASTTVRA
Rv1076|M.tuberculosis_H37Rv -----------MAVRPVLAVGSYLPHAPWPWGVIDQAARVLLPASTTVRA
MMAR_4391|M.marinum_M VAARVATLASRLTIRPVLAVGSHVPHLPWPWGLIDHAAKALVPASATVRA
MAV_1200|M.avium_104 VAARLANLTSRLTIRPILAVGSHAPNLPWPWGLIDLTARVLLPVSATVRE
MLBr_00314|M.leprae_Br4923 IAARLASLTSRLTIRPILAVGSYVPQLPWPFGLIDHAARVLLPVTNAARA
MUL_2832|M.ulcerans_Agy99 IAARVVSLASRLTVRPVIAVASHFPHLPWPWSLVDFALLPITWASGIIGE
Mflv_2042|M.gilvum_PYR-GCK VAGRVLGLAAMATIKPFLTVGSYAPKLPWPWGLVDFAARVLKPAPGTVRA
Mvan_4675|M.vanbaalenii_PYR-1 IAGRLMGLAAVATVKPFLTVGSYAPKLPWPWGLLDFAARVLKPAPGTVRA
TH_1370|M.thermoresistible__bu LAGRLTALAAYLTVRPTLAIGSFAPRLPWPWGLLDFAARAVRPVPGTVRA
MSMEG_0267|M.smegmatis_MC2_155 AESFALAAGCRAFVRNAVRVWAMQPNLAWPLGSIDRMVGLLPHRVDAKIR
MAB_4044c|M.abscessus_ATCC_199 VPLRLGRLAVRAVAYPVIALWARFPALPWPYRVVDLAAAVLRPVRGVRRS
: : : * .** :* :
Mb1105|M.bovis_AF2122/97 AVSLPNASAQLVRASGVLPADGTRRAVLYLHGGAFLTCGANSHGRLVELL
Rv1076|M.tuberculosis_H37Rv AVSLPNASAQLVRASGVLPADGTRRAVLYLHGGAFLTCGANSHGRLVELL
MMAR_4391|M.marinum_M AVSLPNAAAQLVRAPGVLPADGTRRVVLYLHGGAFLTCGANSHGRLVELL
MAV_1200|M.avium_104 TVALPHASAQLVRAPGVLPADGTRRVVVYLHGGAFLTCGANSHGRLVEAL
MLBr_00314|M.leprae_Br4923 EVNLSNTSAQLVRAAGVRPADGSGRIVLYLHGGAFLGCGANSHRRLVETL
MUL_2832|M.ulcerans_Agy99 RVSLPNASGHLVRASGVPPPDGSRRVVLYMHGGAFLKGGIHSHARLAGTL
Mflv_2042|M.gilvum_PYR-GCK TIKLPHCTAQLVRAAGVLPADGNRTVILYLHGGAFLTCGVNTHGRLVTAL
Mvan_4675|M.vanbaalenii_PYR-1 TIGLPHCNAQLVRAAGVLPADGHRSVILYLHGGAFLTCGVNTHGRLVTAL
TH_1370|M.thermoresistible__bu TIRLPHCTAQLVRAPGVLPADGRRSVVLYLHGGAFLTCGAHTHGRLVTAL
MSMEG_0267|M.smegmatis_MC2_155 SVQLPDCAAELVCANGVS-AD---RAILYLHGGAFMTCGINTHRSLVARL
MAB_4044c|M.abscessus_ATCC_199 RVRLRNCEAELMSRADGPSNG----AMLYLHGGAFVVGGLNSHRRLVSRI
: * . ..*: . . ::*:*****: * ::* *. :
Mb1105|M.bovis_AF2122/97 SKFADSPVLVVDYRLIPKHSIGMALDDCHDGYRWLRLLGYEPEQIVLAGD
Rv1076|M.tuberculosis_H37Rv SKFADSPVLVVDYRLIPKHSIGMALDDCHDGYRWLRLLGYEPEQIVLAGD
MMAR_4391|M.marinum_M SKFADAPVLIVNYRLMPKHSIGMALDDCHDGYRWLRLLGYDPEQIVLAGD
MAV_1200|M.avium_104 STFADAPVLVVNYRLLPKNSVGMALQDCHDAYQWLRLRGYQPDQIVLAGD
MLBr_00314|M.leprae_Br4923 SKLADSPILVVNYRLLPKHSIGMALDDCHDGYQWLRRLGYDPEQIVLAGD
MUL_2832|M.ulcerans_Agy99 SKFADSPLLVVNYRLVPKHTVGMALEDCHDAYLWLRLRGHAPEQIVLAGD
Mflv_2042|M.gilvum_PYR-GCK SKCADAPALVVNYRMIPKHSVGTALDDCYDAYKWLRETGYEPEQIVLAGD
Mvan_4675|M.vanbaalenii_PYR-1 SKCADAPVLVVNYRMIPKHSVGTALDDCFDGYKWLRELGYEPDQIVLAGD
TH_1370|M.thermoresistible__bu SEFADSPVLVVNYRMIPKHSVGTAIDDCYDGYQWLRAKGYEPDQIVLAGD
MSMEG_0267|M.smegmatis_MC2_155 SREADAAVLNVGYRMLPKYGLAEAIDDAVAGLRWLQEQGYTSDQIVIAGD
MAB_4044c|M.abscessus_ATCC_199 VTTAGVTSLAVNYRKLPAHPVSAAVEDALDGFRLLTEMGYRPSEIVIAGD
*. . * *.** :* :. *::*. . * *: ..:**:***
Mb1105|M.bovis_AF2122/97 SAGGYLALALAQRLQEV------GEEPAA-LVAISPLLQLAKEHKQAHPN
Rv1076|M.tuberculosis_H37Rv SAGGYLALALAQRLQEV------GEEPAA-LVAISPLLQLAKEHKQAHPN
MMAR_4391|M.marinum_M SAGGYLALTLAQRLQEE------GEEPAA-LVAISPLLQLAKEQKKAHPN
MAV_1200|M.avium_104 SAGGYLALTLAQRLQRD------GEEPAA-LVMISPLLQLAKEPKQAHPN
MLBr_00314|M.leprae_Br4923 SAGGYLALALAQRLQDV------GEEPAA-LVAISPLLQLAKKGKQAHPN
MUL_2832|M.ulcerans_Agy99 SAGGYLAFALAQRLRAR------GEEPAA-LVAISPLLQLAMRSKKAHPN
Mflv_2042|M.gilvum_PYR-GCK SAGGYLALALAEKLQAEGINGYVGETPAA-VVTMSPLFEIDNEARADHPN
Mvan_4675|M.vanbaalenii_PYR-1 SAGGYLALSLAERLQAEGINGFVGETPAA-IVTMSPLFEIDNEARADHPN
TH_1370|M.thermoresistible__bu SAGGYLALSLAQRLLDE------GEEPAA-LVALSPLFEIDNESRAQHPN
MSMEG_0267|M.smegmatis_MC2_155 SAGGYLALATALQLSSR------GEVPAAGIAAISPLTDLDPASKLEHPN
MAB_4044c|M.abscessus_ATCC_199 SAGGFLSLVTSLIAQRR------GYGAPGALVCISPLVQRDPAGKLVLAA
****:*:: : * ... :. :*** : : .
Mb1105|M.bovis_AF2122/97 IKTDAMFPARAFDALDALVASAAARNQVDGEPEELYEPLEHITPGLPRTL
Rv1076|M.tuberculosis_H37Rv IKTDAMFPARAFDALDALVASAAARNQVDGEPEELYEPLEHITPGLPRTL
MMAR_4391|M.marinum_M IKRDAMFPPKAFDALGELVASAAAKNKIDGKPEELYEPLEHIRPGLPRTL
MAV_1200|M.avium_104 IDTDAMFGAGAFDALAELVAGAAAKNIVDGKPEEIYEPLEHIEPGLPRTL
MLBr_00314|M.leprae_Br4923 AKTDAMFPPKAFDALGRLVASSAAKNKVDDKPEELYEPLDHIAPGLPRTL
MUL_2832|M.ulcerans_Agy99 IKSDAMFPARAFDALVAIVAGAAARNETAGRREEIYEPLEHIAPGLPPTL
Mflv_2042|M.gilvum_PYR-GCK VRTDSMFPPKAFHALVELIEEAAARRMVNGAPEEVYEPLDHIEPGLPRTL
Mvan_4675|M.vanbaalenii_PYR-1 VRTDAMFPPKAFHALVELIEAAAERRMVDGKPEEVYEPLDHIEPGLPRTL
TH_1370|M.thermoresistible__bu IRTDAMFPPRAFSALIELVEEAAERRTTNGRPEEVYEPLDNIEPGLPRTL
MSMEG_0267|M.smegmatis_MC2_155 ARKCAMFTGAALAGFAKYLHRCERRPVSRREAAAFVNPVTADLTKLPPVT
MAB_4044c|M.abscessus_ATCC_199 QSNDPLFPESALIAMERLMLSAEKTTAGLEVLDSFVEGCLPTLACLPPTL
.:* *: .: : . . : . ** .
Mb1105|M.bovis_AF2122/97 IHVSGSEVLLHDAQLAAAKLAAAGVPAEVRVWPGQVHDFQVAASMLPEAI
Rv1076|M.tuberculosis_H37Rv IHVSGSEVLLHDAQLAAAKLAAAGVPAEVRVWPGQVHDFQVAASMLPEAI
MMAR_4391|M.marinum_M IHVSGSEVLLHDAQLAARKLAAVGVPAEVRVWPGQVHDFQVAGPLLPEAT
MAV_1200|M.avium_104 IHVSGSEVLLHDARLAASRLAAAGVPAEVRVWPGQIHDFQLAAPMVPEAR
MLBr_00314|M.leprae_Br4923 IHVSGSEVLLHDAQLAATKLAAVGVPAEIRVWPGQVHVFQAAAPMVPEAT
MUL_2832|M.ulcerans_Agy99 IHVSGAEALLHDARLAAGKLAAAGVRAEVRVWPGQLHDFQVAAPMLPEAT
Mflv_2042|M.gilvum_PYR-GCK IHVSGSEVLLSDARKAARLLAASGVPVEVRIWPGQMHVFQLGAPMVPEAS
Mvan_4675|M.vanbaalenii_PYR-1 IHVSGSEVLLSDARKAARLLAAAGVPVEVRVWPGQMHVFQLGAPAVSEAN
TH_1370|M.thermoresistible__bu IHVSGSEALISDARKAARRLAAAGVPVEIRVWPGQMHVFQIAAPFVPEAK
MSMEG_0267|M.smegmatis_MC2_155 VHVSADESLYSDSELLAGRLAEAQVPCELHVWHGQVHDFPLAADILPEGR
MAB_4044c|M.abscessus_ATCC_199 FQVGSDEILRPDTEFAAARLSEAGVPVELQIWRNQVHVFQIAADVLGDAR
.:*.. * * *:. * *: * *:::* .*:* * .. : :.
Mb1105|M.bovis_AF2122/97 RSLRQIGEYIREATG----------
Rv1076|M.tuberculosis_H37Rv RSLRQIGEYIREATG----------
MMAR_4391|M.marinum_M RSLRQIGDYIREATG----------
MAV_1200|M.avium_104 RSLRQIGDYIREATG----------
MLBr_00314|M.leprae_Br4923 LSLRQISQYIREATASKASRDRQSL
MUL_2832|M.ulcerans_Agy99 YSLRQIGEYIRQATG----------
Mflv_2042|M.gilvum_PYR-GCK RSIKQIGEYIREATW----------
Mvan_4675|M.vanbaalenii_PYR-1 RSIKQIGEYIREATW----------
TH_1370|M.thermoresistible__bu RSLRQIGEYIREATW----------
MSMEG_0267|M.smegmatis_MC2_155 RALRYVGDFVKQTTGTRLANVS---
MAB_4044c|M.abscessus_ATCC_199 TAVGEIADFVGAHVGGRSA------
:: :.::: .