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ATTRRVHHRHSPQSVAVSLASRLIVKNAVRAWALTPNLHWPLEYVDSFAGLVPRLGSAGTTHPVRLEHCA AEWVRAPGVSGERAILYLHGGAFLTCGLNTHRPMVTRLSKAADAAVLAVAYRKLPAHQITDAIDDGLDGL RWLQDRGFDGDRVVVAGDSAGGYLAFMTTLLAIQNEVMEPAGIATVSPFTDTDPARKLKHRNARKCSMFT CRAFSRFAEYLSNAQVLEGHGDSTVASPVDADLSSLPPVTIHASSDELLVADAELMAKRLEASGIHCDLH LWDGQIHDFPLAADVLPEGRRAIKYLGDFVKDVTAAGTRFSNVRRLRTAAAG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3011 | - | - | 100% (333) | alpha/beta hydrolase domain-containing protein |
| M. avium 104 | MAV_1200 | - | 5e-56 | 39.81% (314) | alpha/beta hydrolase domain-containing protein |
| M. avium 104 | MAV_1798 | - | 9e-24 | 31.47% (251) | alpha/beta hydrolase domain-containing protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1105 | lipU | 4e-51 | 37.58% (298) | putative lipase LIPU |
| M. gilvum PYR-GCK | Mflv_2042 | - | 2e-55 | 38.71% (310) | alpha/beta hydrolase domain-containing protein |
| M. tuberculosis H37Rv | Rv1076 | lipU | 4e-51 | 37.58% (298) | lipase LipU |
| M. leprae Br4923 | MLBr_00314 | - | 3e-52 | 36.39% (305) | putative esterase |
| M. abscessus ATCC 19977 | MAB_4044c | - | 1e-47 | 36.61% (295) | putative hydrolase/esterase/lipase |
| M. marinum M | MMAR_4391 | lipU | 3e-58 | 40.66% (305) | lipase LipU |
| M. smegmatis MC2 155 | MSMEG_0267 | - | 1e-96 | 54.37% (320) | esterase |
| M. thermoresistible (build 8) | TH_1370 | lipF | 3e-58 | 40.33% (305) | PROBABLE ESTERASE/LIPASE LIPF |
| M. ulcerans Agy99 | MUL_0204 | lipU | 4e-55 | 41.11% (287) | lipase LipU |
| M. vanbaalenii PYR-1 | Mvan_4675 | - | 2e-54 | 39.23% (311) | alpha/beta hydrolase domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MAV_3011|M.avium_104 ----------------------------------MATTRRVHHR-HSPQS
MSMEG_0267|M.smegmatis_MC2_155 --------MTSSVSTIDAR-------------PDLSVGKQIMHRRRSAES
MMAR_4391|M.marinum_M MTAPSRVPSNPIHAIRPRDVLKARRLEARRFAISDGAPVEVVESGPSVAA
MUL_0204|M.ulcerans_Agy99 --------------------------------------------------
Mb1105|M.bovis_AF2122/97 --------------------------------------------------
Rv1076|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00314|M.leprae_Br4923 ------------------------------MAISAGAPVEIVESGPSIAA
Mflv_2042|M.gilvum_PYR-GCK MTAPSKVPATPHVAINAARGRKQR-----RFPVSDGAPVEVVEDGPSVAG
Mvan_4675|M.vanbaalenii_PYR-1 MTAPSKVPATPHAAIAAARAGKIR-----RFPVSDGAPVEVVEDGPSIAG
TH_1370|M.thermoresistible__bu MTAPSKVPRTSPLATRAARGHYSR-----TFPVSDGTPSEYVEDGPSLAG
MAB_4044c|M.abscessus_ATCC_199 --------MTANVVP---------------LHVERVEPVRSERGSLTVPL
MAV_3011|M.avium_104 VAVSLASRLIVKNAVRAWALTPNLHWPLEYVDSFAGLVPRLGSAGTTHPV
MSMEG_0267|M.smegmatis_MC2_155 FALAAGCRAFVRNAVRVWAMQPNLAWPLGSIDRMVGLLPHR-VDAKIRSV
MMAR_4391|M.marinum_M RVATLASRLTIRPVLAVGSHVPHLPWPWGLID-HAAKALVPASATVRAAV
MUL_0204|M.ulcerans_Agy99 -------------MLAVGSHVPHLPWPWGLID-HAAKALVPASATVRAAV
Mb1105|M.bovis_AF2122/97 --------MAVRPVLAVGSYLPHAPWPWGVID-QAARVLLPASTTVRAAV
Rv1076|M.tuberculosis_H37Rv --------MAVRPVLAVGSYLPHAPWPWGVID-QAARVLLPASTTVRAAV
MLBr_00314|M.leprae_Br4923 RLASLTSRLTIRPILAVGSYVPQLPWPFGLID-HAARVLLPVTNAARAEV
Mflv_2042|M.gilvum_PYR-GCK RVLGLAAMATIKPFLTVGSYAPKLPWPWGLVD-FAARVLKPAPGTVRATI
Mvan_4675|M.vanbaalenii_PYR-1 RLMGLAAVATVKPFLTVGSYAPKLPWPWGLLD-FAARVLKPAPGTVRATI
TH_1370|M.thermoresistible__bu RLTALAAYLTVRPTLAIGSFAPRLPWPWGLLD-FAARAVRPVPGTVRATI
MAB_4044c|M.abscessus_ATCC_199 RLGRLAVRAVAYPVIALWARFPALPWPYRVVD-LAAAVLRPVRGVRRSRV
: : * ** :* .. :
MAV_3011|M.avium_104 RLEHCAAEWVRAPGVSGE----RAILYLHGGAFLTCGLNTHRPMVTRLSK
MSMEG_0267|M.smegmatis_MC2_155 QLPDCAAELVCANGVSAD----RAILYLHGGAFMTCGINTHRSLVARLSR
MMAR_4391|M.marinum_M SLPNAAAQLVRAPGVLPADGTRRVVLYLHGGAFLTCGANSHGRLVELLSK
MUL_0204|M.ulcerans_Agy99 SLPNAAAQLVRAPGVLPADGTRRVVLYLHGGAFLTCGANSHGRFFELLSK
Mb1105|M.bovis_AF2122/97 SLPNASAQLVRASGVLPADGTRRAVLYLHGGAFLTCGANSHGRLVELLSK
Rv1076|M.tuberculosis_H37Rv SLPNASAQLVRASGVLPADGTRRAVLYLHGGAFLTCGANSHGRLVELLSK
MLBr_00314|M.leprae_Br4923 NLSNTSAQLVRAAGVRPADGSGRIVLYLHGGAFLGCGANSHRRLVETLSK
Mflv_2042|M.gilvum_PYR-GCK KLPHCTAQLVRAAGVLPADGNRTVILYLHGGAFLTCGVNTHGRLVTALSK
Mvan_4675|M.vanbaalenii_PYR-1 GLPHCNAQLVRAAGVLPADGHRSVILYLHGGAFLTCGVNTHGRLVTALSK
TH_1370|M.thermoresistible__bu RLPHCTAQLVRAPGVLPADGRRSVVLYLHGGAFLTCGAHTHGRLVTALSE
MAB_4044c|M.abscessus_ATCC_199 RLRNCEAELMSRADGPSN----GAMLYLHGGAFVVGGLNSHRRLVSRIVT
* . *: : . :********: * ::* :. :
MAV_3011|M.avium_104 AADAAVLAVAYRKLPAHQITDAIDDGLDGLRWLQDRGFDGDRVVVAGDSA
MSMEG_0267|M.smegmatis_MC2_155 EADAAVLNVGYRMLPKYGLAEAIDDAVAGLRWLQEQGYTSDQIVIAGDSA
MMAR_4391|M.marinum_M FADAPVLIVNYRLMPKHSIGMALDDCHDGYRWLRLLGYDPEQIVLAGDSA
MUL_0204|M.ulcerans_Agy99 FADAPVLIVNYRLMPKHSIGMALDDCHDGYRWLRLLGYDPEQIVLAGDSA
Mb1105|M.bovis_AF2122/97 FADSPVLVVDYRLIPKHSIGMALDDCHDGYRWLRLLGYEPEQIVLAGDSA
Rv1076|M.tuberculosis_H37Rv FADSPVLVVDYRLIPKHSIGMALDDCHDGYRWLRLLGYEPEQIVLAGDSA
MLBr_00314|M.leprae_Br4923 LADSPILVVNYRLLPKHSIGMALDDCHDGYQWLRRLGYDPEQIVLAGDSA
Mflv_2042|M.gilvum_PYR-GCK CADAPALVVNYRMIPKHSVGTALDDCYDAYKWLRETGYEPEQIVLAGDSA
Mvan_4675|M.vanbaalenii_PYR-1 CADAPVLVVNYRMIPKHSVGTALDDCFDGYKWLRELGYEPDQIVLAGDSA
TH_1370|M.thermoresistible__bu FADSPVLVVNYRMIPKHSVGTAIDDCYDGYQWLRAKGYEPDQIVLAGDSA
MAB_4044c|M.abscessus_ATCC_199 TAGVTSLAVNYRKLPAHPVSAAVEDALDGFRLLTEMGYRPSEIVIAGDSA
*. . * * ** :* : : *::* . : * *: ..:*:*****
MAV_3011|M.avium_104 GGYLAFMTTLLAIQNE-----VMEPAGIATVSPFTDTDPARKLKHRNARK
MSMEG_0267|M.smegmatis_MC2_155 GGYLALATALQLSSRG-----EVPAAGIAAISPLTDLDPASKLEHPNARK
MMAR_4391|M.marinum_M GGYLALTLAQRLQEE------GEEPAALVAISPLLQLAKEQKKAHPNIKR
MUL_0204|M.ulcerans_Agy99 GGYLALTLAQRLQEE------GEEPAALVAISPLLQLAKEQKKAHPNIKR
Mb1105|M.bovis_AF2122/97 GGYLALALAQRLQEV------GEEPAALVAISPLLQLAKEHKQAHPNIKT
Rv1076|M.tuberculosis_H37Rv GGYLALALAQRLQEV------GEEPAALVAISPLLQLAKEHKQAHPNIKT
MLBr_00314|M.leprae_Br4923 GGYLALALAQRLQDV------GEEPAALVAISPLLQLAKKGKQAHPNAKT
Mflv_2042|M.gilvum_PYR-GCK GGYLALALAEKLQAEGINGYVGETPAAVVTMSPLFEIDNEARADHPNVRT
Mvan_4675|M.vanbaalenii_PYR-1 GGYLALSLAERLQAEGINGFVGETPAAIVTMSPLFEIDNEARADHPNVRT
TH_1370|M.thermoresistible__bu GGYLALSLAQRLLDE------GEEPAALVALSPLFEIDNESRAQHPNIRT
MAB_4044c|M.abscessus_ATCC_199 GGFLSLVTSLIAQRRG-----YGAPGALVCISPLVQRDPAGKLVLAAQSN
**:*:: : ...:. :**: : :
MAV_3011|M.avium_104 CSMFTCRAFSRFAEYLS--NAQVLEGHGDSTVASPVDADLSSLPPVTIHA
MSMEG_0267|M.smegmatis_MC2_155 CAMFTGAALAGFAKYLHRCERRPVSRREAAAFVNPVTADLTKLPPVTVHV
MMAR_4391|M.marinum_M DAMFPPKAFDALGELVASAAAKNKIDGKPEELYEPLEHIRPGLPRTLIHV
MUL_0204|M.ulcerans_Agy99 DAMFPPKAFDALGELVASAAAKNRVDGKPEELYEPLEHIRPGLPRTLIHV
Mb1105|M.bovis_AF2122/97 DAMFPARAFDALDALVASAAARNQVDGEPEELYEPLEHITPGLPRTLIHV
Rv1076|M.tuberculosis_H37Rv DAMFPARAFDALDALVASAAARNQVDGEPEELYEPLEHITPGLPRTLIHV
MLBr_00314|M.leprae_Br4923 DAMFPPKAFDALGRLVASSAAKNKVDDKPEELYEPLDHIAPGLPRTLIHV
Mflv_2042|M.gilvum_PYR-GCK DSMFPPKAFHALVELIEEAAARRMVNGAPEEVYEPLDHIEPGLPRTLIHV
Mvan_4675|M.vanbaalenii_PYR-1 DAMFPPKAFHALVELIEAAAERRMVDGKPEEVYEPLDHIEPGLPRTLIHV
TH_1370|M.thermoresistible__bu DAMFPPRAFSALIELVEEAAERRTTNGRPEEVYEPLDNIEPGLPRTLIHV
MAB_4044c|M.abscessus_ATCC_199 DPLFPESALIAMERLMLSAEKTTAGLEVLDSFVEGCLPTLACLPPTLFQV
.:*. *: : : . . . ** . .:.
MAV_3011|M.avium_104 SSDELLVADAELMAKRLEASGIHCDLHLWDGQIHDFPLAADVLPEGRRAI
MSMEG_0267|M.smegmatis_MC2_155 SADESLYSDSELLAGRLAEAQVPCELHVWHGQVHDFPLAADILPEGRRAL
MMAR_4391|M.marinum_M SGSEVLLHDAQLAARKLAAVGVPAEVRVWPGQVHDFQVAGPLLPEATRSL
MUL_0204|M.ulcerans_Agy99 SGSEVLLHDAQLAARKLAAVGVPAEVRVWPGQVHDFQVAGPLLPEATRSL
Mb1105|M.bovis_AF2122/97 SGSEVLLHDAQLAAAKLAAAGVPAEVRVWPGQVHDFQVAASMLPEAIRSL
Rv1076|M.tuberculosis_H37Rv SGSEVLLHDAQLAAAKLAAAGVPAEVRVWPGQVHDFQVAASMLPEAIRSL
MLBr_00314|M.leprae_Br4923 SGSEVLLHDAQLAATKLAAVGVPAEIRVWPGQVHVFQAAAPMVPEATLSL
Mflv_2042|M.gilvum_PYR-GCK SGSEVLLSDARKAARLLAASGVPVEVRIWPGQMHVFQLGAPMVPEASRSI
Mvan_4675|M.vanbaalenii_PYR-1 SGSEVLLSDARKAARLLAAAGVPVEVRVWPGQMHVFQLGAPAVSEANRSI
TH_1370|M.thermoresistible__bu SGSEALISDARKAARRLAAAGVPVEIRVWPGQMHVFQIAAPFVPEAKRSL
MAB_4044c|M.abscessus_ATCC_199 GSDEILRPDTEFAAARLSEAGVPVELQIWRNQVHVFQIAADVLGDARTAV
...* * *:. * * : ::::* .*:* * .. : :. ::
MAV_3011|M.avium_104 KYLGDFVKDVTAAGTRFSNVRRLRTAAAG
MSMEG_0267|M.smegmatis_MC2_155 RYVGDFVKQTT--GTRLANVS--------
MMAR_4391|M.marinum_M RQIGDYIREATG-----------------
MUL_0204|M.ulcerans_Agy99 RQIGDYIREATG-----------------
Mb1105|M.bovis_AF2122/97 RQIGEYIREATG-----------------
Rv1076|M.tuberculosis_H37Rv RQIGEYIREATG-----------------
MLBr_00314|M.leprae_Br4923 RQISQYIREATASKASRDRQSL-------
Mflv_2042|M.gilvum_PYR-GCK KQIGEYIREATW-----------------
Mvan_4675|M.vanbaalenii_PYR-1 KQIGEYIREATW-----------------
TH_1370|M.thermoresistible__bu RQIGEYIREATW-----------------
MAB_4044c|M.abscessus_ATCC_199 GEIADFVGAHVGGRSA-------------
:.::: .