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MLFAVGRHRANPSRRSQQLKRASARAAVVTVLSSGTLMGGFGVFAITTPAADAKPGGGSGNDHDHDHGLG GALHKLTGGLLGGGGGGNGGPGSGGARNAPSAPSFGKSLHGGSGSEGAAGGNGDSAKSDKDKDKGPGASV PKPGSAGSTGKTADSAAGSAGSGTGTPGANSSAPGGSNGSSGGGIGGVGTTVGTTLPHSGGAAGVHTPTA EGAAATESSAGTGTHTEEHPSLKGALGSVAGALAPKTETATTPKTETATSPHTSTAPGATAETPTAGTTH PEHESSAEEPKVPGVTVNMGGRTIIIWKKKPSTSTHTPGAGTGTNPGHESEGDRDHVINLPGFPALGGAT NPDAPFGGAAGTRTPGGNPSIHTGPVAPPTVPTPKAPAVAIATPPAPPVLAPLAPVVPPTPPVVTVKQAE GGRGGDVVVTAGGTKQPEAVTKPIQQFVAAETIAPRTGYTDYLRLTKTSEIAAVAIPGAAGIAMMTFVGA ALGYRQAKAGHTVRASAAARFLE
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. abscessus ATCC 19977 | MAB_0112 | - | - | 100% (513) | hypothetical protein MAB_0112 |
M. abscessus ATCC 19977 | MAB_0010c | - | 3e-13 | 29.80% (198) | hypothetical protein MAB_0010c |
M. abscessus ATCC 19977 | MAB_1280c | - | 1e-11 | 32.85% (207) | hypothetical protein MAB_1280c |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb3537 | PE_PGRS53 | 4e-25 | 28.80% (441) | PE-PGRS family protein |
M. gilvum PYR-GCK | Mflv_3843 | - | 7e-21 | 29.11% (371) | hypothetical protein Mflv_3843 |
M. tuberculosis H37Rv | Rv3507 | PE_PGRS53 | 2e-24 | 29.25% (424) | PE-PGRS family protein |
M. leprae Br4923 | MLBr_01828 | PPE | 7e-05 | 40.58% (69) | PPE-family protein |
M. marinum M | MMAR_3303 | - | 2e-24 | 32.54% (335) | PE-PGRS family protein |
M. avium 104 | MAV_4827 | - | 5e-13 | 34.13% (167) | hypothetical protein MAV_4827 |
M. smegmatis MC2 155 | MSMEG_6433 | - | 1e-23 | 29.43% (384) | hypothetical protein MSMEG_6433 |
M. thermoresistible (build 8) | TH_3810 | - | 6e-09 | 33.16% (196) | PUTATIVE - |
M. ulcerans Agy99 | MUL_4280 | - | 3e-17 | 36.32% (190) | PE-PGRS family protein |
M. vanbaalenii PYR-1 | Mvan_5676 | - | 1e-19 | 28.85% (357) | hypothetical protein Mvan_5676 |
CLUSTAL 2.0.9 multiple sequence alignment MSMEG_6433|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_5676|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3537|M.bovis_AF2122/97 -------------------------------------------MSFVLVS Rv3507|M.tuberculosis_H37Rv -------------------------------------------MSFVLVS MUL_4280|M.ulcerans_Agy99 -------------------------------------------MSYVMAV MMAR_3303|M.marinum_M ------------------------------------------MSAFVYAA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_0112|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK MSRTKKSIVVVMMGSAGLFLSAPLLGPAANATPTRGGVPCVGILQQIVTR MAV_4827|M.avium_104 -------------------------------MNIVLGVSMAPSSIQMVVL MLBr_01828|M.leprae_Br4923 -----------------------------------------MSAPIWMAS MSMEG_6433|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_5676|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3537|M.bovis_AF2122/97 PETVAAVATDLKRIGASLAHENASAAASTTAVVSAAADEVSTAVAALFSQ Rv3507|M.tuberculosis_H37Rv PETVAAVATDLKRIGASLAHENASAAASTTAVVSAAADEVSTAVAALFSQ MUL_4280|M.ulcerans_Agy99 PEIIEAAAS-------------TAAASQTAQTVAAAEDEVSAAIATVLSS MMAR_3303|M.marinum_M PEELAAASSSLSSLGSSIREAHAASAGLTTSIAAAAEDEVSAAVAKLFGG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_0112|M.abscessus_ATCC_1997 ------------------------------------MLFAVGRHRANPSR Mflv_3843|M.gilvum_PYR-GCK PGEIPQALTDTARSFTEPPKPAPPVVRPPASSSSSAGTPPVPGRPPASVV MAV_4827|M.avium_104 EGEYADGATVEEDAIDVTGADDAATASAPDRVISAILGTREGAADAGLQL MLBr_01828|M.leprae_Br4923 PPEVHSALLSRGPGSGPLLVAAEAWRSLSSVYAEMADELVALLVVVPVSS MSMEG_6433|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_5676|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3537|M.bovis_AF2122/97 HAQGYQAAAAQVAAFHSRFVQALTAGAGAYAFAEAANASPLQSAMGAVS- Rv3507|M.tuberculosis_H37Rv HAQGYQAAAAQVAAFHSRFVQALTAGAGAYAFAEAANASPLQSAMGAVS- MUL_4280|M.ulcerans_Agy99 HGQGYQVLSARALEFHTRLAQALSAGAGAYSGAEASSAG----LLAAVN- MMAR_3303|M.marinum_M YAQQFQALGAQASLFHDQFVQALNGGGFLYAATEAASASPLQAAAAAAVG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_0112|M.abscessus_ATCC_1997 RSQQLKRASARAAVVTVLSSGTLMGGFGVFAITTP--------------- Mflv_3843|M.gilvum_PYR-GCK TPSSGATPPVPPSPGTPASTSTRGGTPPVPPAPPAPAGTPASGATPPAPP MAV_4827|M.avium_104 SSIGVTWTDQLEAAALRDALAARRIDNVMLVSAFLAAAALAQNVGGAMGY MLBr_01828|M.leprae_Br4923 WDGSAAEAYVIAYLPYLGWLRQASVDSAVMAAHYETMATAYITTLAMMPT MSMEG_6433|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_5676|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3537|M.bovis_AF2122/97 ------ASAQTLLSRPLIGNGANATT-PGGNGGDGGWLFGSGGNGAPG-- Rv3507|M.tuberculosis_H37Rv ------ASAQTLLSRPLIGNGANATT-PGGNGGDGGWLFGSGGNGAPG-- MUL_4280|M.ulcerans_Agy99 ------EPIAALTGRPLIGNGANGTPGLGTDGAPGGWLIGNDGAGGSG-- MMAR_3303|M.marinum_M VQDAINAPFLQFTGRPLVGPGTDGAPGTGQAGGPGGWLWGDGGDGGSGTP TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_0112|M.abscessus_ATCC_1997 ----------AADAKPGGGSGNDHDHDHGLGGALHKLTGG---------- Mflv_3843|M.gilvum_PYR-GCK VPGVPAVTSTGGGTPPVPPVPGAPVGAPVANPGLPTPPVPGAPVFGDGGA MAV_4827|M.avium_104 ERTAVLLVEPDTATLAVVETSDGSIPDVYKQQIRAESYGDAAGQLSAMVA MLBr_01828|M.leprae_Br4923 LAELAANRTAHTVLVTTNFFGINTIPIARNEIDYVRMWVEAAIAMG---- MSMEG_6433|M.smegmatis_MC2_155 -MRSRVRVAASACLVTSGLFMAGLGGALAFANPDAGS------------- Mvan_5676|M.vanbaalenii_PYR-1 --------------MASGLLVGGWTTATASADTDTGT------------- Mb3537|M.bovis_AF2122/97 -----AAGQSGGNGGSAGLWGNGGAGGAGGSGGAAGGNGGNGGWLFGAGG Rv3507|M.tuberculosis_H37Rv -----AAGQSGGNGGSAGLWGNGGAGGAGGSGGAAGGNGGNGGWLFGAGG MUL_4280|M.ulcerans_Agy99 -----AAGSAGGAGGAAGLIGAGGAGGAGGAGGSSTG------------- MMAR_3303|M.marinum_M GTATSPAGGAGGAGGSAFLFGSGGHGGSGGTAYAGSG------------- TH_3810|M.thermoresistible__bu ------VDGDGGSGGRTGLFSKLSRGGDGGDG------------------ MAB_0112|M.abscessus_ATCC_1997 -----LLGGGGGGNGGPGSGGARNAPSAPSFGKSLHG------------- Mflv_3843|M.gilvum_PYR-GCK VLPPLPPAPAGPAGGPAGLVAPPAPPVPGGPAAVPAG------------- MAV_4827|M.avium_104 GLEKLESLPGGLLLVGSGVDVAPLKQVLQTTTFLDVS------------- MLBr_01828|M.leprae_Br4923 -----TYQEVSTVVVDSAPEAIAAPQIMASDALEASS------------- . MSMEG_6433|M.smegmatis_MC2_155 -------------------------------------------DTAGQGP Mvan_5676|M.vanbaalenii_PYR-1 -------------------------------------------AANADAT Mb3537|M.bovis_AF2122/97 TGGIGGTGAPGAMGGTGGNGGNGALLIGGGGLGGAGGMGGTGGGTGGTGG Rv3507|M.tuberculosis_H37Rv TGGIGGTGAPGAMGGTGGNGGNGALLIGGGGLGGAGGMGGTGGGTGGTGG MUL_4280|M.ulcerans_Agy99 -------------------------------------------GAGGTGG MMAR_3303|M.marinum_M -------------------------------------------AVGGTGG TH_3810|M.thermoresistible__bu -------------------------------------------GLGGNGG MAB_0112|M.abscessus_ATCC_1997 -------------------------------------------GSGSEGA Mflv_3843|M.gilvum_PYR-GCK ---------------------------VALPPAPPGAPGAPVFGEAGAAP MAV_4827|M.avium_104 -----------------------------------------VAEEPETAL MLBr_01828|M.leprae_Br4923 ------------------------------------------DQPSPTAP . MSMEG_6433|M.smegmatis_MC2_155 AG--------------------------ADSGAPQVAGPRGTHGQR---- Mvan_5676|M.vanbaalenii_PYR-1 GGGA------------------------DDRARPDTAAAAGGGTDRD--- Mb3537|M.bovis_AF2122/97 NGGNGALLIGAGGVGGAGGIGGQGTGAGGAAGAGGTGGNGGAGGLFMNGG Rv3507|M.tuberculosis_H37Rv NGGNGALLIGAGGVGGAGGIGGQGTGAGGAAGAGGTGGNGGAGGLFMNGG MUL_4280|M.ulcerans_Agy99 AGGAGEWLFGPGGVGGAG---------GSSSSAGGAGGVGGAGGLFG--- MMAR_3303|M.marinum_M NGGAGGLIFGGGGAGGVGGLG----AAGSATAAPGMGGHGGAGGTSY--- TH_3810|M.thermoresistible__bu HGGGTGIIS--------------------LLSLAGNGGNGGNG------- MAB_0112|M.abscessus_ATCC_1997 AGGN------------------------GDSAKSDKDKDKGPGASVP--- Mflv_3843|M.gilvum_PYR-GCK SGAAAPVAPAAGSGGAG-----------GAGGGSGIGGPGGGGAPVEGTG MAV_4827|M.avium_104 ARGAALAAANAP-------------LFASSTAALAYAQDPGTGAVDQYSL MLBr_01828|M.leprae_Br4923 SQSP------------------------QVQNWLQWLQKIGYTDFYN--- * MSMEG_6433|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_5676|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3537|M.bovis_AF2122/97 DGGAGGQGGDGAAGDAAASAGGTGGKGGQGGDGGTGGAGGAGPVLFGHGG Rv3507|M.tuberculosis_H37Rv DGGAGGQGGDGAAGDAAASAGGTGGKGGQGGDGGTGGAGGAGPVLFGHGG MUL_4280|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3303|M.marinum_M -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_0112|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK GAVPAGAPLAAAGG------------------------------------ MAV_4827|M.avium_104 P------------------------------------------------- MLBr_01828|M.leprae_Br4923 -------------------------------------------------- MSMEG_6433|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_5676|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3537|M.bovis_AF2122/97 AGGMGGQGGTGGMGGAGGDGTTVIAAGTGGEGGTG--------------- Rv3507|M.tuberculosis_H37Rv AGGMGGQGGTGGMGGAGGDGTTVIAAGTGGEGGTGGAAGAGGAAGARGAL MUL_4280|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3303|M.marinum_M -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_0112|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01828|M.leprae_Br4923 -------------------------------------------------- MSMEG_6433|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_5676|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3537|M.bovis_AF2122/97 ---------------GTGGTGGNGADAAAVVGFGANGDPGFAGGKGGNGG Rv3507|M.tuberculosis_H37Rv TSGGLAGGVGAGGTGGTGGTGGNGADAAAVVGFGANGDPGFAGGKGGNGG MUL_4280|M.ulcerans_Agy99 -------------------------------------------------- MMAR_3303|M.marinum_M -------------------------------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_0112|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK -------------------------------------------------- MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01828|M.leprae_Br4923 -------------------------------------------------- MSMEG_6433|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_5676|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3537|M.bovis_AF2122/97 IGGAAVTGGVAGDGGTGGKGGTGGAGGAGNDAGSTGNPGGKGGDGGIGGA Rv3507|M.tuberculosis_H37Rv IGGAAVTGGVAGDGGTGGKGGTGGAGGAGNDAGSTGNPGGKGGDGGIGGA MUL_4280|M.ulcerans_Agy99 --------------------------------------------GGLGGA MMAR_3303|M.marinum_M ------------------------------------------QLGGAAGA TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_0112|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK --------------------------------------EVPPPAPPIPGA MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01828|M.leprae_Br4923 -------------------------------------------------- MSMEG_6433|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_5676|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3537|M.bovis_AF2122/97 GGAGGAAGTGNGGHAGNTGDGGDGGTGGNGGNGTGGVNGADNTLNPDTPG Rv3507|M.tuberculosis_H37Rv GGAGGAAGTGNGGHAGNTGDGGDGGTGGNGGNGTGGVNGADNTLNPDTPG MUL_4280|M.ulcerans_Agy99 GGAG---------------------------------------------- MMAR_3303|M.marinum_M GGAGGQGGLGYDAAADPMAAAG---------------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_0112|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK PVIGEAGVVPPPAPPAPAPPAGGLGGAVPPPVPGAPGVPVVDEAGVVTPP MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01828|M.leprae_Br4923 -------------------------------------------------- MSMEG_6433|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_5676|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3537|M.bovis_AF2122/97 GAGEPGGAGGAGGAGGAAGGPGGTGGTGGNGGN----------------- Rv3507|M.tuberculosis_H37Rv GAGEPGGAGGAGGAGGAAGGPGGTGGTGGNGGNGGNGGNGGNGGNGGNGG MUL_4280|M.ulcerans_Agy99 -VSASGGAGGAGGAGGALAGFLGAGGS----------------------- MMAR_3303|M.marinum_M ASGGHGGPGGVGGVGGRVVGLFGSGGGGG--------------------- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_0112|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK APGGPGVPTGGEGGVVTPPAPGAPGVPVVDEAGVVTPPAPGGPGVPTGGE MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01828|M.leprae_Br4923 -------------------------------------------------- MSMEG_6433|M.smegmatis_MC2_155 ------------------------------------------PSPRPGGP Mvan_5676|M.vanbaalenii_PYR-1 ------------------------------------------PDVEPADG Mb3537|M.bovis_AF2122/97 -AGNNSTNAPVGGEGGAGGDGGAGGAGGAANGGTAGSQGTGGVGGDGGAG Rv3507|M.tuberculosis_H37Rv NAGNNSTNAPVGGEGGAGGDGGAGGAGGAANGGTAGSQGTGGVGGDGGAG MUL_4280|M.ulcerans_Agy99 -------------------DGGAGGTG---------------VNHEGGAG MMAR_3303|M.marinum_M ----------------AGGDGGVGGTGAQG--------APGTQSFSAGTG TH_3810|M.thermoresistible__bu ---------------------------------------------YRTTD MAB_0112|M.abscessus_ATCC_1997 ------------------------------------------KPGSAGST Mflv_3843|M.gilvum_PYR-GCK GGVVTPPAPGAPGAPVVDEAGVVTPPAPGGPGVPAVGDTAVVTPPAPGAP MAV_4827|M.avium_104 ------------------------------------DYLYVPVDPEPGDD MLBr_01828|M.leprae_Br4923 --------------------------------------TLVQPLITSLTN MSMEG_6433|M.smegmatis_MC2_155 GHTGQA-------------------PTHGHSRPPMHTGTRHP-------- Mvan_5676|M.vanbaalenii_PYR-1 GAVAES-------------------DDAGDITG--RDTDPEP-------- Mb3537|M.bovis_AF2122/97 GNGGGGKAGTGNSGNFGVDGEAGFSGGAGGNGGVGGAAGANGGTGGSGGN Rv3507|M.tuberculosis_H37Rv GNGGGGKAGTGNSGNFGVDGEAGFSGGAGGNGGVGGAAGANGGTGGSGGN MUL_4280|M.ulcerans_Agy99 GAGGAG----------------GLIAGTGGNGGAGGTDAYS--------R MMAR_3303|M.marinum_M GNGGDG--------------GSGGVAGAGGSGGFLGSAGATG-------G TH_3810|M.thermoresistible__bu NNALDG--------------------GHGGNGGNVGFFSLFN-------- MAB_0112|M.abscessus_ATCC_1997 GKTADS--------------------AAGSAGSGTGTPGANS-------- Mflv_3843|M.gilvum_PYR-GCK GTPAVNSVETFSPPAPPAATPPSSGSVETFSPPAPPAPGTGTNSTVEIST MAV_4827|M.avium_104 ELAYSAVG-----------------EEDAESPTVVIEKLFLPEDSEPRRR MLBr_01828|M.leprae_Br4923 HPFFQG-------------------MFSGFDPWLPSLGNPLSFLSPFNIA MSMEG_6433|M.smegmatis_MC2_155 -GKPPRPGPPRPG------------------------HGHPTKTGHPD-- Mvan_5676|M.vanbaalenii_PYR-1 -LPDPADGEPQPS------------------------EDAPVADKEPE-- Mb3537|M.bovis_AF2122/97 GGDGGAGGIGGAGGNGIPGTGTEPAGGTGAKGGDGGDGGAGGAGGNAGGA Rv3507|M.tuberculosis_H37Rv GGDGGAGGIGGAGGNGIPGTGTEPAGGTGAKGGDGGDGGAGGAGGNAG-- MUL_4280|M.ulcerans_Agy99 GGAGGAGGTGGTGGTDMSDS-----------------GGTGGAGGNAG-- MMAR_3303|M.marinum_M AGDGGRGGTGGLGGVGTSTNG----------------GAAGGTGGRGG-- TH_3810|M.thermoresistible__bu --LGGAGGWGGSG-----------------------VDGVDVVGGNPD-- MAB_0112|M.abscessus_ATCC_1997 SAPGGSNGSSGGGIGGVGTTVG---------------TTLPHSGGAAG-- Mflv_3843|M.gilvum_PYR-GCK PPPPGTPGLPSEGSTTYTTPPTPEITLNPANSG--IDIATPPAPGLPG-- MAV_4827|M.avium_104 PVLLVGSGLAVVGISAVLALEIALAIG-------IRTTGTVALQPTPN-- MLBr_01828|M.leprae_Br4923 FALGTPMDIGSYVGYLSQTFAFIG-----------ADLAAAFASGNPVTI . MSMEG_6433|M.smegmatis_MC2_155 -------------------------------------PPQQTDPSHTPTR Mvan_5676|M.vanbaalenii_PYR-1 -------------------------------------EPR-------PPC Mb3537|M.bovis_AF2122/97 GGNGGAGGQGGNAGQGGAGGAGGNAVIPGDGVGKAPHGGAGGSGGDGGKG Rv3507|M.tuberculosis_H37Rv ----GAGGQGGNAGQGGAGGAGGNAVIPGDGVGKAPHGDAGGSGGDGGKG MUL_4280|M.ulcerans_Agy99 ----------LLFGSGGAGGAGGAAVALND------VGGAGGAGGNAGLF MMAR_3303|M.marinum_M ----------LSGGVGGTDGAGG-------------DGGQGGSGGAVGTG TH_3810|M.thermoresistible__bu ---------------GGTPGAHG---------------ESHTPGVYTDRQ MAB_0112|M.abscessus_ATCC_1997 -------------------------------------VHTPTAEGAAATE Mflv_3843|M.gilvum_PYR-GCK APLEATANITTPGTPGVPGAPVNSSIDVATPGEVGVPAAPIERSMTVTTP MAV_4827|M.avium_104 ---------------------------------QHLIVPTEQAPAPPPVQ MLBr_01828|M.leprae_Br4923 G--------------------------------FTLLFTTIEAIGTIITD MSMEG_6433|M.smegmatis_MC2_155 PSHTRPTRP----------------------------------------- Mvan_5676|M.vanbaalenii_PYR-1 CKDGDKDCE----------------------------------------- Mb3537|M.bovis_AF2122/97 GQGGSGGTGGSGAPIGGGAGGTGGSGGHAGKGGAGGIGAQGTTITVPGNG Rv3507|M.tuberculosis_H37Rv GQGGSGGTGGSGAPIGGGAGGTGGSGGHAGKGGAGGIGAQGTTITVPGNG MUL_4280|M.ulcerans_Agy99 GNGGVGGVGGVGA-------GDGGAGGRAG--------------LVIGNG MMAR_3303|M.marinum_M ATAGAGGAGGAGAAATSGGPGYGGGGGGGGGGAR----------VLPTSG TH_3810|M.thermoresistible__bu GEDGEDGTG----------------------------------------- MAB_0112|M.abscessus_ATCC_1997 SSAGTGTHTEEHPSLKG--------------------------------- Mflv_3843|M.gilvum_PYR-GCK DTPGAPGAPANAAVDVATPPAPGVPGAPVVGEAGVTTPGAPGAPGAPANA MAV_4827|M.avium_104 ASAPQPKISVPEPVAAPKPLSP---------------------------- MLBr_01828|M.leprae_Br4923 TIALVKTMIEQSFVLLP--------------------------------- MSMEG_6433|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_5676|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3537|M.bovis_AF2122/97 GNAGDGGNGGGGGAGGTGGDGATGTPAGNGGNGGNAGDGGNGGSGDFGGN Rv3507|M.tuberculosis_H37Rv GNAGDGGNGG------------------------NAGAGGNGGSGDFGGN MUL_4280|M.ulcerans_Agy99 GAGGAG-----------------------------------GESFGFG-- MMAR_3303|M.marinum_M GITSGTATGG------------------------------EGGVGGAG-- TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_0112|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK AVDVATPPAPG------------------------VPGAPVVGEAAVTTP MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01828|M.leprae_Br4923 -------------------------------------------------- MSMEG_6433|M.smegmatis_MC2_155 --PGWPGWPGWPPHHGHWPTKPTKPTKPTEPTEPTEPTEP---------- Mvan_5676|M.vanbaalenii_PYR-1 --PGWP-WP-WP-----WPDDPDDRPKPDDGYGEGRPEG----------- Mb3537|M.bovis_AF2122/97 TTSGASGSGGNGGNAGTAGSGGAGGTGGTGLSGGNGGNGG------DGGN Rv3507|M.tuberculosis_H37Rv TTSGASGSGGNGGNAGTAGSGGAGGTGGTGLSGGNGGNGGNGGNGGDGGN MUL_4280|M.ulcerans_Agy99 --AGVGGAGGNGGNGVLIGNGGNAGTGGTGLSTGSTGAGG---------- MMAR_3303|M.marinum_M TTVAAGGVGGHGGNATLAASDAGSSADGT-ATGGAGGAGG---------- TH_3810|M.thermoresistible__bu --TGIGGRGGNGGSSSGTHPMAEDGEHVKALDGRPGLDGG---------- MAB_0112|M.abscessus_ATCC_1997 -ALGSVAGALAPKTETATTPKTETATSPHTSTAPGATAETP--------- Mflv_3843|M.gilvum_PYR-GCK GAPGVPGVPAGGDAGVVTPPAPGVPGAPVVGEAGVTTPGAPG-------- MAV_4827|M.avium_104 -PVAAPLPAAPPPAAPPLPEAPPIPAAPPVVPVPVVVPPVP--------- MLBr_01828|M.leprae_Br4923 --MILPLLTAPLAVATAGAAGSFAGLSELAGLVGVAPPGLP--------- MSMEG_6433|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_5676|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3537|M.bovis_AF2122/97 GAHGTVGAQFVPATSLPTPNGGAGGNGGTGSNGGAPGPAGAPGPTTGGNA Rv3507|M.tuberculosis_H37Rv GAHGTVGAQFVPATSLPTPNGGAGGNGGTGSNGGAPGPAGAPGPTTGGNA MUL_4280|M.ulcerans_Agy99 ---------------------------ISGLLLGLDGFNAPASTSALHNL MMAR_3303|M.marinum_M ----------------------------TNHASGGRGGDATISTSGGGTI TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_0112|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK -----------VPGVPAGGDAGVVTPPAPGVPGAPAATEAGLATPPGPGA MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01828|M.leprae_Br4923 -------------------------------------------------- MSMEG_6433|M.smegmatis_MC2_155 -------------------------------------------------- Mvan_5676|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3537|M.bovis_AF2122/97 GSQGIGGDGGNGGDGGKGGDGADAVNVVFMPTEPQAATGTAGSAGDPTGG Rv3507|M.tuberculosis_H37Rv GSQGIGGDGGNGGDGGKGGDGADAVNVVFMPTEPQAATGTAGSAGDPTGG MUL_4280|M.ulcerans_Agy99 QQQALG----------------------VINEPTQALTGR------PLIG MMAR_3303|M.marinum_M TG----------------------------GTATGGVGGAG-----TTGG TH_3810|M.thermoresistible__bu -------------------------------------------------- MAB_0112|M.abscessus_ATCC_1997 -------------------------------------------------- Mflv_3843|M.gilvum_PYR-GCK PGAPVVGDAGVATPPGPGVPGAPIVDEAGLATPPAPVAPVEGAGGAVPPA MAV_4827|M.avium_104 -------------------------------------------------- MLBr_01828|M.leprae_Br4923 -------------------------------------------------- MSMEG_6433|M.smegmatis_MC2_155 -----------------------------------------------TRP Mvan_5676|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb3537|M.bovis_AF2122/97 NGGPGTPGSPMVAPPPPTPITQVQQGGDGGAGGTGSTNANDGTATGGKGG Rv3507|M.tuberculosis_H37Rv NGGPGTPGSPMVAPPPPTPITQVQQGGDGGAGGTGSTNANDGTATGGKGG MUL_4280|M.ulcerans_Agy99 NGTPGAAGS-----------------------------GTDGTPGGWLLG MMAR_3303|M.marinum_M SGGGGGSGALFAN------------------------GAGSSASGSAIGG TH_3810|M.thermoresistible__bu NGSHG-----------------------------------------GNGG MAB_0112|M.abscessus_ATCC_1997 ---------------------------------------TAGTTHPEHES Mflv_3843|M.gilvum_PYR-GCK GPPPAPVFGDAGAPVEAAAGGAPVEAAAGVTGGGSVAGAGAGGGAGGAAG MAV_4827|M.avium_104 ---------------------------------------------VPVPV MLBr_01828|M.leprae_Br4923 -------------------------------------------------S MSMEG_6433|M.smegmatis_MC2_155 TPTTTVIPG-----GVDVGGGNGVGPNEAPEVPRPQVPDMQL-------- Mvan_5676|M.vanbaalenii_PYR-1 VPSVRPLPG-----GVIR-------PGIEPPVAEPEDPGVLD-------- Mb3537|M.bovis_AF2122/97 EGGVGSILGGPGGNGGTGGNASATGTNGVANAGNGGKGGDGGQFGAGGNG Rv3507|M.tuberculosis_H37Rv EGGVGSILGGPGGNGGTGGNASATGTNGVANAGNGGKGGDGGQFGAGGNG MUL_4280|M.ulcerans_Agy99 DGGAAGLLG----TGGTGG-AGARLAGGAG--GTGGAGGAGG-WLLGDGG MMAR_3303|M.marinum_M YGGAGTTGG----LGGVGGYAQVSASNGGTATGTVS-GGYGGAGTTGGHG TH_3810|M.thermoresistible__bu HGGRGGFLG----IGGSGG--------------WGGHGGNGG-------- MAB_0112|M.abscessus_ATCC_1997 SAEEPKVPGVTVNMGGRTIIIWKKKPSTSTHTPGAGTGTNPG-------- Mflv_3843|M.gilvum_PYR-GCK GAGVEGASGAVGAAGGPGAGAAPAAAGGAAPGGAPGGPVAGGGPVGGPGA MAV_4827|M.avium_104 RIPVPDPVSPPQLLAPPRLSVPQPVQPPVRVPQPPSPPQVGG-------- MLBr_01828|M.leprae_Br4923 APPVAAVAPVVPPSMPTLASIPTPTPMPAPAASTAPVVTPPG-------- MSMEG_6433|M.smegmatis_MC2_155 ---------------PGPRVVQNSG------------GGAAAEPPGAAAE Mvan_5676|M.vanbaalenii_PYR-1 ---------------TVPGIGVAAG------------NGPEA-------- Mb3537|M.bovis_AF2122/97 GAGGSVTD---GSAGSTAGNGGNGGNATNGTIAGQPAGGNGSAGGKGGDG Rv3507|M.tuberculosis_H37Rv GAGGSVTD---GSAGSTAGNGGNGGNATNGTIAGQPAGGNGSAGGKGGDG MUL_4280|M.ulcerans_Agy99 GGGGGASG---GGGGASGGTGGTGG-----------AGGLLSAGGAGGVG MMAR_3303|M.marinum_M GGGGNAFLR-ANGAGSSASGISIGG-----------AGGAGTAGGYGGSG TH_3810|M.thermoresistible__bu ---------------DTDADGGNGG-----------DGGNGGSAGRGGTG MAB_0112|M.abscessus_ATCC_1997 ----------HESEGDRDHVINLPG-------FPALGGATNPDAPFGGAA Mflv_3843|M.gilvum_PYR-GCK LPAPGAPIVGEAGVVSPPAPGVPGGAAAVPAGAVTPPAPGVPGAPVFGEA MAV_4827|M.avium_104 -----------TVPQSPPQHQTPPG------------EGTPPKPDGPGNY MLBr_01828|M.leprae_Br4923 ----------------PPPVTAPPS------------VTGAGVESFGYLV . MSMEG_6433|M.smegmatis_MC2_155 AVAPPVLLPVVVAPVIVPPALAAPQPDGGGGPGGTEP------------- Mvan_5676|M.vanbaalenii_PYR-1 ----PISVPILVTVPTGGGASAGPSVAGSGGASASPR------------- Mb3537|M.bovis_AF2122/97 GNIAAGATGTAGNGGNGGNGNDGAVNAGTGGSGGNGGNAGGGGANGGDGG Rv3507|M.tuberculosis_H37Rv GNIAAGATGTAGNGGNGGNGNDGAVNAGTGGSGGNGGNAGGGGANGGDGG MUL_4280|M.ulcerans_Agy99 G---AGGYNTSGPGGNGGSGGNAGTLFGSGG-GGNGG-----------SG MMAR_3303|M.marinum_M N--YASIRGYSGATVTDGTATGGGGGAGTGGRGGLGG-----------SA TH_3810|M.thermoresistible__bu G-----LRGVFG--INGGNGR-----AGLGGRGXXXX------------- MAB_0112|M.abscessus_ATCC_1997 GTRTPGGNPSIHTGPVAPPTVPTPKAPAVAIATPPAP------------P Mflv_3843|M.gilvum_PYR-GCK GVVTPPAPGVPGGAAAVPAGVVTPPAPGVPGGAAAVPAGAVTPPAPGVPG MAV_4827|M.avium_104 GGGHVPTPGAGGSGGSGGGHVPTPGAGGSGGSGGGHVP---------TPG MLBr_01828|M.leprae_Br4923 GRLPSTARGVVGTSVRQQSSAPDRIEAPDAAATPQEQ------------- MSMEG_6433|M.smegmatis_MC2_155 ----RRPAATPTLKFQTPATGQPQAVGALDAGAPP--------------- Mvan_5676|M.vanbaalenii_PYR-1 ----QIVESTPPRQLSPAPAGR-------DFAVPP--------------- Mb3537|M.bovis_AF2122/97 AGGAGGAGGRGGKGIDGGFGGDGGNGGSNNGTGAGGNGGNGGTGGVGSVG Rv3507|M.tuberculosis_H37Rv AGGAGGAGGRGGKGIDGGFGGDGGNGGSNNGTGAGGNGGNGGTGGVGSVG MUL_4280|M.ulcerans_Agy99 YSGIGGTGGTGGNAVLLGGGGAGGAGG-ISFTGAGGQGGAGGTG-----G MMAR_3303|M.marinum_M TLFANGAGSSVATGAATG--GVGGAGSTGGIGGAGNIARITAIGG-GTVT TH_3810|M.thermoresistible__bu -GGGVGAAVRSGNGVFSGGGGTPSAGFGVPTT------------------ MAB_0112|M.abscessus_ATCC_1997 VLAPLAPVVPPTPPVVTVKQAEGGRGGDVVVTAGGTKQPEAVTKP----- Mflv_3843|M.gilvum_PYR-GCK APVFGDAGVATPPVPGVPGGGTTVPAASVTPPAPGVPGGASTVPGNAGTP MAV_4827|M.avium_104 TGGPGGTGGSGGGHVPTPGAGTPGGSGGGHLPFPGAGSTPGGSGG----- MLBr_01828|M.leprae_Br4923 ---ARSRWRRRAKVTPFDSSGSPNPKAAPTASDQGAG------------- . MSMEG_6433|M.smegmatis_MC2_155 ----------------ASFRAGYTDYLRTAEVFDIVAVAVPGTAG----- Mvan_5676|M.vanbaalenii_PYR-1 ----------------SVNRAGYGDYLRSAGISQVAALAVPGLAG----- Mb3537|M.bovis_AF2122/97 AAGGDGGNGGTGGFAGFGGTAGNGGSGGTGGAGGDGGTGGGGGNGGTGVI Rv3507|M.tuberculosis_H37Rv AAGGDGGNGGTGGFAGFGGTAGNGGSGGTGGAGGDGGTGGDGGNG---VI MUL_4280|M.ulcerans_Agy99 QLSGNGGSGGTG---GEGDYVGGADSGGAGGAGGNAGLTGDGGNG----- MMAR_3303|M.marinum_M SSATNGGAGGDGITDGIGG-NGGGSTFTANTGGTIDTSTGTGGNG----- TH_3810|M.thermoresistible__bu ----------------IQFPAGSCTSRAVSREGIMPSSRAASARA----- MAB_0112|M.abscessus_ATCC_1997 -------IQQFVAAETIAPRTGYTDYLRLTKTSEIAAVAIPGAAG----- Mflv_3843|M.gilvum_PYR-GCK STPGLPPGSTDTYINYPAPPVPPTPPNSTGVSAGTPGSPAPGTPGSTLTL MAV_4827|M.avium_104 --------------GHLPTPGAGTPGGGLGGFGGGHAPAPGGGLG----- MLBr_01828|M.leprae_Br4923 ----------------TLGLAGTARQASSGPATGLVTLSNGTFSD----- MSMEG_6433|M.smegmatis_MC2_155 -----------LLGLTGLGGLVG-------------------YRQAKAGV Mvan_5676|M.vanbaalenii_PYR-1 -----------ILILTGVGGYVG-------------------YRQAKAGQ Mb3537|M.bovis_AF2122/97 AGGGGTGGNGGASGAGGAGGTGGFAGNGNAGGNGGTGGASEDGDNGNAGS Rv3507|M.tuberculosis_H37Rv AGGGGTGGNGGASGAGGAGGTGGFAGNGNAGGNGGTGGASEDGDNGNAGS MUL_4280|M.ulcerans_Agy99 -------GSGGTPGSPGGGGTG----------------GALIGQDGLARL MMAR_3303|M.marinum_M ---------GSGTGLGNTGGNGG--------------AADLTAPPDWMGV TH_3810|M.thermoresistible__bu -------------GAACASSTSR-------------------SRRSFCCS MAB_0112|M.abscessus_ATCC_1997 -----------IAMMTFVGAALG-------------------YRQAKAGH Mflv_3843|M.gilvum_PYR-GCK TDLLTPPGIARTLQNTASSVMGATPPGTPPVPGGSGSVSLAVPGTPSPIA MAV_4827|M.avium_104 --------GGGGHAPAPGGGLGG-------------------FGGGHSGG MLBr_01828|M.leprae_Br4923 -----------SPRAPMLPRTWG-------------------ADPTFCYN MSMEG_6433|M.smegmatis_MC2_155 VVRSS-ASRFMP-------------------------------------- Mvan_5676|M.vanbaalenii_PYR-1 GVRASGIARFMN-------------------------------------- Mb3537|M.bovis_AF2122/97 GATGGTGGNGGTGGDGGAAGLGGVA------------------------- Rv3507|M.tuberculosis_H37Rv GATGGTGGNGGTGGDGGAAGLGGVA------------------------- MUL_4280|M.ulcerans_Agy99 AVTGR--------------------------------------------- MMAR_3303|M.marinum_M DLFGTPGANVP--------------------------------------- TH_3810|M.thermoresistible__bu RA------------------------------------------------ MAB_0112|M.abscessus_ATCC_1997 TVRASAAARFLE-------------------------------------- Mflv_3843|M.gilvum_PYR-GCK PLAATGLSNLVSPPSLTIPSIPGLPVPLPNTVPVPSDLLCVGTDWSASQG MAV_4827|M.avium_104 GLGGLGGGHK---------------------------------------- MLBr_01828|M.leprae_Br4923 AADIGPAGGWDDE------------------------------------- MSMEG_6433|M.smegmatis_MC2_155 ------------------------------- Mvan_5676|M.vanbaalenii_PYR-1 ------------------------------- Mb3537|M.bovis_AF2122/97 ------------------------------- Rv3507|M.tuberculosis_H37Rv ------------------------------- MUL_4280|M.ulcerans_Agy99 ------------------------------- MMAR_3303|M.marinum_M ------------------------------- TH_3810|M.thermoresistible__bu ------------------------------- MAB_0112|M.abscessus_ATCC_1997 ------------------------------- Mflv_3843|M.gilvum_PYR-GCK DSAATPPAAEVPRVVTGAAPTGDRRDRWGNR MAV_4827|M.avium_104 ------------------------------- MLBr_01828|M.leprae_Br4923 -------------------------------