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M. thermoresistible (build 8) TH_4527 (-)

annotation: acyl-CoA dehydrogenase domain protein
coordinates: 3840244 - 3841386
length: 381

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_4527--100% (381)acyl-CoA dehydrogenase domain protein
M. thermoresistible (build 8)TH_2583-e-13057.45% (376) PUTATIVE peptidase S1 and S6, chymotrypsin/Hap
M. thermoresistible (build 8)TH_4630-e-12354.09% (379) PUTATIVE isovaleryl-CoA dehydrogenase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2743cfadE201e-12958.84% (379) acyl-CoA dehydrogenase FADE20
M. gilvum PYR-GCKMflv_2118-0.087.11% (380) acyl-CoA dehydrogenase domain-containing protein
M. tuberculosis H37RvRv2724cfadE201e-13159.37% (379) acyl-CoA dehydrogenase FADE20
M. leprae Br4923MLBr_00737fadE257e-5432.80% (372) putative acyl-CoA dehydrogenase
M. abscessus ATCC 19977MAB_3040c-1e-13259.42% (377) acyl-CoA dehydrogenase
M. marinum MMMAR_1989fadE201e-13258.58% (379) acyl-CoA dehydrogenase FadE20
M. avium 104MAV_2600-0.085.26% (380) acyl-CoA dehydrogenase
M. smegmatis MC2 155MSMEG_5197-0.086.58% (380) long-chain specific acyl-CoA dehydrogenase
M. ulcerans Agy99MUL_3367fadE201e-12957.78% (379) acyl-CoA dehydrogenase FadE20
M. vanbaalenii PYR-1Mvan_4587-0.088.16% (380) acyl-CoA dehydrogenase domain-containing protein

CLUSTAL 2.0.9 multiple sequence alignment


Mb2743c|M.bovis_AF2122/97           ---MGSATKYQRTLFEPEHELFRESYRAFLDRHVAAYHDEWEKTKIVDRG
Rv2724c|M.tuberculosis_H37Rv        ---MGSATKYQRTLFEPEHELFRESYRAFLDRHVAPYHDEWEKTKIVDRG
MMAR_1989|M.marinum_M               ---MGSAIKYQRTLFEPEHDLFRESYRGFLERHVAPYHDEWEKAKIVDRG
MUL_3367|M.ulcerans_Agy99           ---MGSAIKYQRTLFEPEHDLFRESYRGFLERHVALYHDEWEKAKIVDRG
MAB_3040c|M.abscessus_ATCC_199      ---MAGAVKFKRTIFEPEHELFRESFKTFLDRHAEPYKEEWEKNKIVDRA
Mflv_2118|M.gilvum_PYR-GCK          ---------MKRTIYDAEHEAFRDTVKEYIERELVPNSEKWETERIVDRS
Mvan_4587|M.vanbaalenii_PYR-1       ---------MKRTIYDAEHEAFRETVKEYIERELVPNSEKWETERIVDRS
MSMEG_5197|M.smegmatis_MC2_155      ---------MKRLIYNEEHEAFRQTVKEYIERELVPHSEKWEAERIVDRS
TH_4527|M.thermoresistible__bu      ---------MKRTVYEPEHEAFRETVREYIERELVPHAEKWETERIVDRS
MAV_2600|M.avium_104                ---------MKRLVLEPEHEAFRETVRQFIERELVPNAERWEADRIVDRS
MLBr_00737|M.leprae_Br4923          MVGWSGNPLFDLFKLPEEHNELRATIRALAEKEIAPHAADVDQRARFPEE
                                              .      **: :* : :   ::.        :    . . 

Mb2743c|M.bovis_AF2122/97           VWLEAGKQGFLGMAVPEEYGGGGNADFRYNTVITEETCAGRYSGIGFGLH
Rv2724c|M.tuberculosis_H37Rv        VWLEAGKQGFLGMAVPEEYGGGGNADFRYNTVITEETCAGRYSGIGFGLH
MMAR_1989|M.marinum_M               VWLEAGKQGFLGMAVPEEYGGGGNPDFRYNTIITEETSAGRYSGIGFGLH
MUL_3367|M.ulcerans_Agy99           VWLEAGKQGFLGMAVPEEYGGGGNPDFRYNTIITEETSAGRYSGIGFGLH
MAB_3040c|M.abscessus_ATCC_199      LWVEAGKQGFLGTDMPEEFGGGGLIDFRYNTIITEEVTKGRHTGVGFSLH
Mflv_2118|M.gilvum_PYR-GCK          AYTAAGKYGLIGFNMPEEFGGGGTDDFRFNAIIDEEIAKAGVHGPALSLH
Mvan_4587|M.vanbaalenii_PYR-1       AYTAAGKYGLIGFNMPEEYGGGGSEDFRFNAIIDEEMAKSGVHGPALSLH
MSMEG_5197|M.smegmatis_MC2_155      AYTAAGKYGLIGFNMPEEFGGGGSDDFRFNAIIDEEIAKSGVHGPALSLH
TH_4527|M.thermoresistible__bu      AYVAAGKYGLIGFNMPEKYGGGGTDDFRFNAVIDEEMAKAGVPGPALSLH
MAV_2600|M.avium_104                AFVAAGKYGLIGFNMPEQYGGGGVDDFRFNAVIDEEIARYGGPSPSLSLQ
MLBr_00737|M.leprae_Br4923          ALAALNASGFNAIHVPEEYGGQG-ADSVAACIVIEEVARVDASASLIPAV
                                         .  *: .  :**::** *  *     :: **       .  :   

Mb2743c|M.bovis_AF2122/97           NDIVAPYLLALATEEQKRRWFPNFCTGELTTAIAMTEPGTGSDLQGITTR
Rv2724c|M.tuberculosis_H37Rv        NDIVAPYLLALATEEQKRRWFPNFCTGELITAIAMTEPGTGSDLQGITTR
MMAR_1989|M.marinum_M               NDIVAPYLLALATEEQKQRWLPKFCTGEFITAIAMTEPGTGSDLQGIKTR
MUL_3367|M.ulcerans_Agy99           NEIVAPYLLALATEEQKQRRLPKFCTGEFITAIAMTEPGTGSDLQGIKTR
MAB_3040c|M.abscessus_ATCC_199      NDVAGPYFRDLANDEQKARWFPGFCSGELISAIAMTEPGTGSDLQGIKTR
Mflv_2118|M.gilvum_PYR-GCK          NDVVGPYFKDLTNDEQKKRWLPGVTSGETIIAVAMTEPGAGSDLAGIRTS
Mvan_4587|M.vanbaalenii_PYR-1       NDVVGPYFKDLTNDEQKKRWLPGIASGETIIAVAMTEPGAGSDLAGIRTS
MSMEG_5197|M.smegmatis_MC2_155      NDVVGPYFKELANDEQRRRWLPGITSGELIIAIAMTEPGAGSDLAGIRTS
TH_4527|M.thermoresistible__bu      NDVVAPYFNNLCTEEQKERWMPGIASGETIIAIAMTEPGAGSDLAGIRTS
MAV_2600|M.avium_104                NDVVGPYFSSLANDEQKERWLPGIVSGELIVAVAMTEPGAGSDLAGIRTS
MLBr_00737|M.leprae_Br4923          NKLGTMGLILRGSEELKKQVLPSLAAEGAMASYALSEREAGSDAASMRTR
                                    *.:    :    .:* : : :* . :     : *::*  :***  .: * 

Mb2743c|M.bovis_AF2122/97           AVKHGDHYVLNGSKTFITNGINSDLVIVVAQTDPEKGAQGFSLLVVERGM
Rv2724c|M.tuberculosis_H37Rv        AVKHGDHYVLNGSKTFITNGINSDLVIVVAQTDPEKGAQGFSLLVVERGM
MMAR_1989|M.marinum_M               AVKQGDHYLLNGSKTFITNGINADLVIVVAQTDPEKGAQGFSLLVVERGM
MUL_3367|M.ulcerans_Agy99           AVKQGDHYLLNGSKTFITNGINADLVIVVAQTDPEKGAQGFSLLVVERGM
MAB_3040c|M.abscessus_ATCC_199      AVKDGDHYILNGAKTFITNGINADLVIVVAQTDPEKGALGFSLIVVERGM
Mflv_2118|M.gilvum_PYR-GCK          AVRDGDDWIINGSKTFISSGINCDLCVVVARTDPEAGHKGFSLFVVERDM
Mvan_4587|M.vanbaalenii_PYR-1       AVRDGDDWIINGSKTFISSGINCDLCVVVARTDPEAGHKGFSLFVVERGM
MSMEG_5197|M.smegmatis_MC2_155      AVRDGDDWIINGSKTFISSGINCDLCVVVARTDPEAGHKGFSLFVVERGM
TH_4527|M.thermoresistible__bu      AVRDGDDWIINGSKTFISSGINCDLVVVVCRTDPEAGHKGFTLFVVERGM
MAV_2600|M.avium_104                AVRDGDDWIINGAKTFISSGINCDLVVVVCRTDPEAGHKGFTLLVVEAGM
MLBr_00737|M.leprae_Br4923          AKADGDDWILNGFKCWITNGGKSTWYTVMAVTDPDKGANGISAFIVHKDD
                                    *  .**.:::** * :*:.* :.    *:. ***: *  *:: ::*. . 

Mb2743c|M.bovis_AF2122/97           AGFERGRQLDKIGLDAQDTAELSFTDVAVPAENLLGQEGMGFIYLMQNLP
Rv2724c|M.tuberculosis_H37Rv        AGFERGRQLDKIGLDAQDTAELSFTDVAVPAENLLGQEGMGFIYLMQNLP
MMAR_1989|M.marinum_M               EGFERGRHLDKIGLDAQDTAELSFSDVQVPVENLLGQEGMGFIYLMQNLP
MUL_3367|M.ulcerans_Agy99           EGFERGRHLDKIGLDAQDTAELSFSDVQVPVENLLGQEGMGFIYLMQNLP
MAB_3040c|M.abscessus_ATCC_199      EGFERGRKLDKVGLDAQDTAELSFTDVRVPAANLLGEEGQGFIYLMKNLP
Mflv_2118|M.gilvum_PYR-GCK          EGFTRGRKLDKMGLHSQDTSELHFENVRVPNANLLGKEGRGFYHLMTNLP
Mvan_4587|M.vanbaalenii_PYR-1       EGFTRGRKLDKMGLHSQDTSELHFENVRVPNANLLGKEGRGFYHLMTNLP
MSMEG_5197|M.smegmatis_MC2_155      EGFTRGRKLDKMGLHSQDTSELHFENVRVPHANLLGKEGRGFYHLMTNLP
TH_4527|M.thermoresistible__bu      EGFTRGRKLDKMGLHAQDTAELHFENVRVPHANLLGKEGHGFYHLMQNLP
MAV_2600|M.avium_104                EGFSRGRKLEKMGLHYQDTAELAFENVRVPSANLLGKEGRGFYHLMHNLP
MLBr_00737|M.leprae_Br4923          EGFSIGPKEKKLGIKGSPTTELYFDKCRIPGDRIIGEPGTGFKTALATLD
                                     **  * : .*:*:. . *:** * .  :*  .::*: * **   : .* 

Mb2743c|M.bovis_AF2122/97           QERISIAIMAAAGMESVLEQTLQYAKERKAFGRSIGSFQNSRFLLAELAT
Rv2724c|M.tuberculosis_H37Rv        QERISIAIMAAAGMESVLEQTLQYAKERKAFGRSIGSFQNSRFLLAELAT
MMAR_1989|M.marinum_M               QERISIAIMAAAGMESVLDQTLQYTKERKAFGRSIGNFQNSRFVLAELAT
MUL_3367|M.ulcerans_Agy99           QERISIAIMAAAGMESVLDQTLQYTKERKAFGRSIGNFQNSRFVLAELAT
MAB_3040c|M.abscessus_ATCC_199      QERMSIAVMAAAAMESVLEETIAYTTERKAFGKPIKSFQNSRFLLAELAT
Mflv_2118|M.gilvum_PYR-GCK          SERLSIAISAIAGARAVFDETLQYSKDRKAFGQSIGSFQHNRFLLAEMET
Mvan_4587|M.vanbaalenii_PYR-1       SERLSIAISAIAGARAVFQETLQYAKDRKAFGQPIGSFQHNRFLLAEMET
MSMEG_5197|M.smegmatis_MC2_155      SERLSIAISAIAGARAVFDETLQYCKDRKAFGQPIGSFQHNRFLLAEMET
TH_4527|M.thermoresistible__bu      SERLSIAISAIAGARATWRETLQYAKDRKAFGKPIGSFQHNRFLLAEMDT
MAV_2600|M.avium_104                SERLSIAISAIAGARETWRQTLQYAKDRKAFGQSIGSFQHNRFLLAEMDT
MLBr_00737|M.leprae_Br4923          HTRPTIGAQAVGIAQGALDAAIVYTKDRKQFGESISTFQSIQFMLADMAM
                                      * :*.  * .  . .   :: * .:** **..* .**  :*:**::  

Mb2743c|M.bovis_AF2122/97           EATVVRIMVDEFIKLHLAGK-LTAEQAAMAKWYATEKQVYLNDRCLQLHG
Rv2724c|M.tuberculosis_H37Rv        EATVVRIMVDEFIKLHLAGK-LTAEQAAMAKWYATEKQVYLNDRCLQLHG
MMAR_1989|M.marinum_M               EATMVRIMVDEFIELHLDGK-LTAEQAAMAKWYSTEKQVSLNDRCLQLHG
MUL_3367|M.ulcerans_Agy99           EATMVRIMVDESIELHLDGK-LTAEQAAMAKWYSTEKQVSLNDRCLQLHG
MAB_3040c|M.abscessus_ATCC_199      DATVIRVMVDEFISLLNKEE-LSVEQAAMAKWYSTEKQVHLIDRCLQLHG
Mflv_2118|M.gilvum_PYR-GCK          ELEVTETYIDRCLQGVVDGE-LTAVEAAKAKWWATEVAKKVVDQCVQLHG
Mvan_4587|M.vanbaalenii_PYR-1       ELEVTENYIDRCLQGVVDGE-LTAVEAAKAKWWATETAKKVVDQCVQLHG
MSMEG_5197|M.smegmatis_MC2_155      ELEVTENYIDRCLQGVVDGE-LTAVEAAKAKWWATETAKKIVDNCVQLHG
TH_4527|M.thermoresistible__bu      ELEVSEQYIDRCLQAVVDGE-LTAVEAAKAKWWCTEVAKKVVDQCVQLHG
MAV_2600|M.avium_104                ELEIGEQYIDRCLRAVVDGE-LTAVEASKAKWWCTETAKKVIDGCVQLHG
MLBr_00737|M.leprae_Br4923          KVEAARLIVYAAAARAERGEPDLGFISAASKCFASDIAMEVTTDAVQLFG
                                    .    .  :          :      :: :* :.::    :   .:**.*

Mb2743c|M.bovis_AF2122/97           GYGYMREYPVARAYLDSRVQTIYGGTTEIMKEIIGRGLGV
Rv2724c|M.tuberculosis_H37Rv        GYGYMREYPVARAYLDSRVQTIYGGTTEIMKEIIGRGLGV
MMAR_1989|M.marinum_M               GYGYMREYPVARAYLDSRVQTIYGGTTEIMKEIIGRSLGI
MUL_3367|M.ulcerans_Agy99           GYGYMREYPVARAYLDSRVQTIYGGTTEIMKEIIGRSLGI
MAB_3040c|M.abscessus_ATCC_199      GYGFMREYPVARAYMDSRIQTIYGGTTEIMKEIIGRSL--
Mflv_2118|M.gilvum_PYR-GCK          GYGYMLEYRVARAYVDGRIQTIFGGTTEIMKEIIGRELGV
Mvan_4587|M.vanbaalenii_PYR-1       GYGYMLEYRVARAYVDGRIQTIFGGTTEIMKEIIGRELGV
MSMEG_5197|M.smegmatis_MC2_155      GYGYMMEYRVARAYVDGRIQTIFGGTTEIMKEIIGRDLGV
TH_4527|M.thermoresistible__bu      GYGYMMEYRVARDFVDGRIQTIFGGTTEIMKEIIGRDLGL
MAV_2600|M.avium_104                GYGYMTEYRVARDYMDNRIMTIFGGTTEIMKDIIGRDLGL
MLBr_00737|M.leprae_Br4923          GAGYTSDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR
                                    * *:  :: * *   * ::  *: **.:* : ::.* *