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M. thermoresistible (build 8) TH_4391 (-)

annotation: cytochrome P450
coordinates: 2401883 - 2403265
length: 461

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_4391--100% (461)cytochrome P450
M. thermoresistible (build 8)TH_2954-3e-3125.35% (434) PUTATIVE cytochrome P450
M. thermoresistible (build 8)TH_0136-3e-3028.65% (363) PROBABLE CYTOCHROME P450 137 CYP137

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0787ccyp510.080.14% (443) cytochrome P450 sterol 14-alpha demethylase
M. gilvum PYR-GCKMflv_1596-0.082.06% (446) cytochrome P450
M. tuberculosis H37RvRv0764ccyp510.080.14% (443) cytochrome P450 sterol 14-alpha demethylase
M. leprae Br4923MLBr_02088-2e-1324.33% (300) putative cytochrome p450
M. abscessus ATCC 19977MAB_1214c-0.078.30% (447) cytochrome P450
M. marinum MMMAR_4932cyp51B10.082.84% (443) cytochrome P450 51B1 Cyp51B1
M. avium 104MAV_0708-0.090.07% (443) cytochrome P450 51
M. smegmatis MC2 155MSMEG_5863-0.082.37% (448) cytochrome P450 51
M. ulcerans Agy99MUL_0473cyp51B10.082.17% (443) cytochrome P450 51B1 Cyp51B1
M. vanbaalenii PYR-1Mvan_5161-0.083.48% (448) cytochrome P450

CLUSTAL 2.0.9 multiple sequence alignment


Mb0787c|M.bovis_AF2122/97           ------MSAV---ALPRVSGGHD---EHGHLEEFRTDPIGLMQR------
Rv0764c|M.tuberculosis_H37Rv        ------MSAV---ALPRVSGGHD---EHGHLEEFRTDPIGLMQR------
MAB_1214c|M.abscessus_ATCC_199      ------MTTP---TVPRVSGGED---QYGHLEEFRTDPIALMKR------
TH_4391|M.thermoresistible__bu      ------MTSQQLKEVPRVSGGEE---EHGHLEEFRTDPIGLMQR------
MAV_0708|M.avium_104                ------MTTS--TVVPRVSGGEE---EHGHLEEFRTDPIGLMQR------
MMAR_4932|M.marinum_M               ------MTTA---IVPRVSGGEE---EHGHLEEFRTDPIGLMQR------
MUL_0473|M.ulcerans_Agy99           ------MTTA---IVPRVSGGEE---EHGHLEEFRTDPIGLMQR------
MSMEG_5863|M.smegmatis_MC2_155      ------MTTL--HDVPRVSGGEE---EHGHLEEFRTDPIGLMKR------
Mvan_5161|M.vanbaalenii_PYR-1       ------MTAV--KEVPRVSGGEE---EHGHLEEFRTDPIGLMKR------
Mflv_1596|M.gilvum_PYR-GCK          -------MTT--AIVPRVSGGEDD--EHGHLEEFRTDPIGLMKR------
MLBr_02088|M.leprae_Br4923          MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
                                            :     :  :* ..    :   * * :   : *:.       

Mb0787c|M.bovis_AF2122/97           --VRDECGDVGTFQLAGKQVVLLSGSHANEFFFRAGDDDLDQAKAYPFMT
Rv0764c|M.tuberculosis_H37Rv        --VRDECGDVGTFQLAGKQVVLLSGSHANEFFFRAGDDDLDQAKAYPFMT
MAB_1214c|M.abscessus_ATCC_199      --IRAECGNVGTFQLADKQVVFLSGAEANEFFFRSSDEDLDQAEAYPFMT
TH_4391|M.thermoresistible__bu      --VRDECGDVGYFQLVDKPVILLTGAEANEFFFRAADEDLDQAAAYPFMT
MAV_0708|M.avium_104                --VRDECGDVGWFQLVDKHVILLSGAQANEFFFRSADEDLDQAEAYPFMT
MMAR_4932|M.marinum_M               --VRDECGDVGWFQLANKHVVLLSGAKANEFFFRSSDEELDQAEAYPFMT
MUL_0473|M.ulcerans_Agy99           --VRDECGDVGWFQLANKHVVLLSGAKANEFFFRSSDEELDQAEAYPFMT
MSMEG_5863|M.smegmatis_MC2_155      --VRSECGDVGWFQLADKQVVLLSGAEANEFFFRSSDSELNQAEAYPFMT
Mvan_5161|M.vanbaalenii_PYR-1       --VREECGDVGWFQLADKQVILLSGAEANEFFFRSSDSELNQAEAYPFMT
Mflv_1596|M.gilvum_PYR-GCK          --IREECGDVGWFQLADKQVVMLSGAEANEFFFRSTDSELNQAEAYPFMT
MLBr_02088|M.leprae_Br4923          FPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPLSASDRLKATLAQQ
                                      :     : * :** .  : .::.    :  :*   .  ::  *     

Mb0787c|M.bovis_AF2122/97           PIFGEG----------VVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ
Rv0764c|M.tuberculosis_H37Rv        PIFGEG----------VVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ
MAB_1214c|M.abscessus_ATCC_199      PIFGKG----------VVFDADPERRKEMLHNAALRGEQMKGHAATIENE
TH_4391|M.thermoresistible__bu      PIFGKG----------VVFDASPERRKEMLHNSALRGEHMKSHATTIEGE
MAV_0708|M.avium_104                PIFGKG----------VVFDASPERRKEMLHNSALRGEQMKGHASTIEGE
MMAR_4932|M.marinum_M               PIFGKG----------VVFDASPERRKEMLHNSALRGEHMKGHATTIERE
MUL_0473|M.ulcerans_Agy99           PIFGKG----------VVFDASPERRKEMLHNSALRGEHMKGHATTIERE
MSMEG_5863|M.smegmatis_MC2_155      PIFGEG----------VVFDADPERRAEMLHNTALRGEQMKGHAATIENE
Mvan_5161|M.vanbaalenii_PYR-1       PIFGEG----------VVFDADPERRAEMLHNTALRGEHMKGHATTIEAE
Mflv_1596|M.gilvum_PYR-GCK          PIFGEG----------VVFDADPERRAEMLHNTALRGEQMKGHAATIENE
MLBr_02088|M.leprae_Br4923          AIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDIAAL
                                    .* . .          :.:*.  . * . * . *:  : ::.    *   

Mb0787c|M.bovis_AF2122/97           VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYH
Rv0764c|M.tuberculosis_H37Rv        VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYH
MAB_1214c|M.abscessus_ATCC_199      VRQMISRWGESGEVDLLDFFAELTIYTSSACLIGKKFRDELDGRFAHLYH
TH_4391|M.thermoresistible__bu      VRKMIADWGDEGEIDLLDFFAELTIYTSTACLIGLKFRNQLDKRFAEYYH
MAV_0708|M.avium_104                VKKMIADWGDEGEIELLDFFAELTIYTSTACLIGLKFREQLDHRFAEYYH
MMAR_4932|M.marinum_M               VHRMIENWGQEGEIDLLEFFAELTIYTSTSCLIGTKFRNQLDSRFAHFYH
MUL_0473|M.ulcerans_Agy99           VHRMIENWGQEGEIDLLEFFAELTSYTSTSCLIGTKFRNQLDSRFAHFCH
MSMEG_5863|M.smegmatis_MC2_155      VRRMVESWGDEGEIDLLEFFAELTIYTSTACLIGVKFRNQLDKRFADYYH
Mvan_5161|M.vanbaalenii_PYR-1       VRKMIEGWGESGEIDLLEFFAELTIYTSTACLIGLKFRNQLDSRFANYYH
Mflv_1596|M.gilvum_PYR-GCK          VRRMIENWGEQGEIELLDFFSELTIYTSTACLIGLKFRNQLDSRFAEYYH
MLBr_02088|M.leprae_Br4923          VDSLLDKGAAAGQFDVIADLAFPLAVAVICRLLGVPYEDAP--EFGRVSA
                                    *  ::   .  *:.:::  ::     :  . *:*  :.:    .*.    

Mb0787c|M.bovis_AF2122/97           ELERGTDPLAYVDPYLPIESFRRRDEARNGLVALVADIMNG---RIANPP
Rv0764c|M.tuberculosis_H37Rv        ELERGTDPLAYVDPYLPIESFRRRDEARNGLVALVADIMNG---RIANPP
MAB_1214c|M.abscessus_ATCC_199      QLEQGTDPLCYVDPYLEIESFRQRDEARTGLVALVQEIINGRVQRSADSP
TH_4391|M.thermoresistible__bu      LLERGTDPLCYVDPYLPIESFRLRDEARAKLVELVQEIIDQ---RLANPP
MAV_0708|M.avium_104                DLERGTDPLCYVDPYLPIESFKRRDEARVKLVALVQEIMDQ---RLANPP
MMAR_4932|M.marinum_M               ELERGTDPLCYVDPYLPIESFRRRDEARKGLVALVQDIMHQ---RVANPP
MUL_0473|M.ulcerans_Agy99           ELERGTDPLCYVDPYLPIESFRRRDEARKGLVALVQDIMHQ---RVANPP
MSMEG_5863|M.smegmatis_MC2_155      LLERGTDPLCYVDPYLPIESFRIRDEARANLVELVQEVMNG---RIANPP
Mvan_5161|M.vanbaalenii_PYR-1       LLERGTDPLCYVDPYLPIESFRIRDEARAGLVELVQDVMHG---RIANPP
Mflv_1596|M.gilvum_PYR-GCK          LLERGTDPLCYVDPYLPIESFRIRDEARASLVELVQEVMNG---RIANPP
MLBr_02088|M.leprae_Br4923          LLVQSVDPFITITG-EPPEATEERLRAGVWLRDYLEQLVKCR--------
                                     * :..**:  :      *: . * .*   *   : :::.          

Mb0787c|M.bovis_AF2122/97           TDKSDRDMLDVLIAVKAETGTPRFSADEITGMFISMMFAGHHTSSGTASW
Rv0764c|M.tuberculosis_H37Rv        TDKSDRDMLDVLIAVKAETGTPRFSADEITGMFISMMFAGHHTSSGTASW
MAB_1214c|M.abscessus_ATCC_199      TDKSQRDMLDVLIMIKDEHGNPRFTADEITGMFISMMFAGHHTSSGTASW
TH_4391|M.thermoresistible__bu      RSKADRDMLDVLVSIKDENGDPRFSADEITGMFISLMFAGHHTSSGTSAW
MAV_0708|M.avium_104                KDKADRDMLDVLVSIKDEDGKPRFSADEITGMFISLMFAGHHTSSGTSAW
MMAR_4932|M.marinum_M               TDKRDRDMLDVLVSITDEQGNPRFCADEVTGMFISLMFAGHHTSSGTSAW
MUL_0473|M.ulcerans_Agy99           TDKRDRDMLDVLVSITDEQGNPRFCTDEVTGMFISLMFAGHHTSSGTSAW
MSMEG_5863|M.smegmatis_MC2_155      KDKSDRDLLDVLVSIKDEDGTPRFSANEVTGMFISLMFAGHHTSSGTASW
Mvan_5161|M.vanbaalenii_PYR-1       KDKSDRDMLDVLVSIKDEDGNPRFTANEITGMFISLMFAGHHTSSGTSSW
Mflv_1596|M.gilvum_PYR-GCK          TDKSDRDLLDVLVSIKDEDGNPRFSANEVTGMFISLMFAGHHTSSGTSSW
MLBr_02088|M.leprae_Br4923          RGTPGEDLISRLIELDESGD--QLTEEEIIATCGLLLVAGHETTVNLIAN
                                     ..  .*::. *: :  . .  ::  :*: .    ::.***.*: .  : 

Mb0787c|M.bovis_AF2122/97           TLIELMRHRDAYAAVIDELDELYGDGRSVSFHALRQIPQLENVLKETLRL
Rv0764c|M.tuberculosis_H37Rv        TLIELMRHRDAYAAVIDELDELYGDGRSVSFHALRQIPQLENVLKETLRL
MAB_1214c|M.abscessus_ATCC_199      VLIELLRHPDIQSQVIDELDELYADGSEVSFHALRQIPKLENVLKETLRL
TH_4391|M.thermoresistible__bu      TLIELIRHPEIYAEVQAELDELYSDGQAVNFHALRQIPKLDNVVKETLRL
MAV_0708|M.avium_104                TLIELIRHPDVYAEVLAELEELYADGQEVSFHALRSIPKLDNVVKETLRL
MMAR_4932|M.marinum_M               TLIELLRHPDAYAAVIDELDELYADGQPVSFHALRQIPRLENVLKETLRL
MUL_0473|M.ulcerans_Agy99           TLIELLRHPDAYAAVIDELDELYADGQLVSFHALRQIPRLENVLKETLRL
MSMEG_5863|M.smegmatis_MC2_155      TLIELLRHPEFYAKVQAELDDLYADGQEISFHALRQIPNLDNALKETLRL
Mvan_5161|M.vanbaalenii_PYR-1       TLIELLRHPEFYAKVQQELDDLYADGQEVSFHALRQIPSLDNALKETLRL
Mflv_1596|M.gilvum_PYR-GCK          TLIELLRHPEYYAQVQQELDDLYADGQEVSFHALRQIPKIDNALKETLRL
MLBr_02088|M.leprae_Br4923          AVLAMLRNPSQWKALSSNP------------------QRAPLVVEETLRY
                                    .:: ::*: .    :  :                        .::**** 

Mb0787c|M.bovis_AF2122/97           HPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPDPHDFVP
Rv0764c|M.tuberculosis_H37Rv        HPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPDPHDFVP
MAB_1214c|M.abscessus_ATCC_199      HPPLIILMRVAKGEFEVGGFPIHDGDMVAASPAVSNRIAEDFPNPDGFVP
TH_4391|M.thermoresistible__bu      HPPLIILMRVAQGEFEVCGFPIHKGDYVAASPAISNRIPEDFPDPDAFRP
MAV_0708|M.avium_104                HPPLIILMRVAKGEFEVEGFPIHEGDYVAASPAISNRIPEDFPDPDAFKP
MMAR_4932|M.marinum_M               HPPLIILMRVAKGEFQVEGYPIHEGELVAASPAISNRIAEDFPDPDEFVP
MUL_0473|M.ulcerans_Agy99           HPPLIILMRVAKGEFQVEGYPIHEGELVAASPAISNRIAEDFPDPDEFVP
MSMEG_5863|M.smegmatis_MC2_155      HPPLIILMRVAQDEFEVAGRPIHKGQMVAASPAISNRIPEDFPDPDTFDP
Mvan_5161|M.vanbaalenii_PYR-1       HPPLIILMRVAQDEFEVAGYPIHKGQMVAASPAISNRIPEDFPNPDDFDP
Mflv_1596|M.gilvum_PYR-GCK          HPPLIILMRVAQDEFEVAGYPIHKGQMVAASPAISNRIPEDFPYPDAFDP
MLBr_02088|M.leprae_Br4923          DPAIHLIGRVAAKDMTIGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDP
                                    .*.: :: ***  :: :    : .*: :.   * :** .  :. *. * *

Mb0787c|M.bovis_AF2122/97           ARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEF
Rv0764c|M.tuberculosis_H37Rv        ARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEF
MAB_1214c|M.abscessus_ATCC_199      DRYEKPRQEDIVNRWTWIPFGAGRHRCVGAAFATMQIKAIFSVLLREYEF
TH_4391|M.thermoresistible__bu      DRYDKPEQADIVNRWTWIPFGAGRHRCVGAAFAQMQIKAIFSVLLREYEF
MAV_0708|M.avium_104                DRYNKPEQADIVNRWTWIPFGAGRHRCVGAAFAQMQIKAIFSVLLREYDF
MMAR_4932|M.marinum_M               ERYQEPRQEDLINRWTWIPFGAGRHRCVGAAFATMQIKAIFSVLLREYEF
MUL_0473|M.ulcerans_Agy99           ERYQEPRQEDLINRWTWIPFGAGRHRCVGAAFATMQIKAIFSVLLREYEF
MSMEG_5863|M.smegmatis_MC2_155      DRYDKPRQEDLINRWTWIPFGAGKHRCVGAAFAQMQIKAIFSVLLRDFEF
Mvan_5161|M.vanbaalenii_PYR-1       DRYEKPRQEDLINRWTWIPFGAGKHRCVGAAFAQMQIKAIFSVLLREYEF
Mflv_1596|M.gilvum_PYR-GCK          DRYEKPRQEDLINRWTWIPFGAGKHRCVGAAFAQMQIKAIFSVLLREYEF
MLBr_02088|M.leprae_Br4923          DRPSS----------RHLAFAVGSHFCLGAALARLEATVTLSAISARFP-
                                     * ..            :.*..* * *:***:* :: .. :*.:   :  

Mb0787c|M.bovis_AF2122/97           EMAQPPESYRNDHSKMVVQLAQPACVRYRRRTGV------
Rv0764c|M.tuberculosis_H37Rv        EMAQPPESYRNDHSKMVVQLAQPACVRYRRRTGV------
MAB_1214c|M.abscessus_ATCC_199      EMAQPADSYHNDHSKMVVQLAQPAKVRYRKRSA-------
TH_4391|M.thermoresistible__bu      EMAQPPESYRNDHSKMVVQLQQPARARYRRRAKAAKAAKE
MAV_0708|M.avium_104                EMAQPADSYRNDHSKMVVQLARPAKVRYRKRNA-------
MMAR_4932|M.marinum_M               EMAQPADSYRNDHSKMVVQLARPARVRYRRRKMSDNRGH-
MUL_0473|M.ulcerans_Agy99           EMAQPADSYRNDHSKMVVQLARPARVRYRRRKLSDNRGH-
MSMEG_5863|M.smegmatis_MC2_155      EMAQPSESYRNDHSKMVVQLARPAKVRYRRRVR-------
Mvan_5161|M.vanbaalenii_PYR-1       EMAQPPESYQNDHSKMVVQLARPAKVRYRRRVRD------
Mflv_1596|M.gilvum_PYR-GCK          EMAQPAESYQNDHSKMVVQLARPAKVRYRRRVKD------
MLBr_02088|M.leprae_Br4923          QVQLAGELVYKPNVAMRGMSALPVQV--------------
                                    ::  . :   : :  *      *. .