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SAVALPRVSGGHDEHGHLEEFRTDPIGLMQRVRDECGDVGTFQLAGKQVVLLSGSHANEFFFRAGDDDLD QAKAYPFMTPIFGEGVVFDASPERRKEMLHNAALRGEQMKGHAATIEDQVRRMIADWGEAGEIDLLDFFA ELTIYTSSACLIGKKFRDQLDGRFAKLYHELERGTDPLAYVDPYLPIESFRRRDEARNGLVALVADIMNG RIANPPTDKSDRDMLDVLIAVKAETGTPRFSADEITGMFISMMFAGHHTSSGTASWTLIELMRHRDAYAA VIDELDELYGDGRSVSFHALRQIPQLENVLKETLRLHPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAI SNRIPEDFPDPHDFVPARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEFEMAQ PPESYRNDHSKMVVQLAQPACVRYRRRTGV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv0764c | cyp51 | - | 100% (451) | CYTOCHROME P450 51 CYP51 (CYPL1) (P450-L1A1) (STEROL 14-ALPHA DEMETHYLASE) (LANOSTEROL 14-ALPHA DEMETHYLASE) (P450-14DM) |
| M. tuberculosis H37Rv | Rv3059 | cyp136 | 5e-32 | 27.43% (401) | cytochrome P450 136 |
| M. tuberculosis H37Rv | Rv1666c | cyp139 | 1e-29 | 26.93% (375) | cytochrome P450 139 CYP139 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0787c | cyp51 | 0.0 | 100.00% (451) | cytochrome P450 sterol 14-alpha demethylase |
| M. gilvum PYR-GCK | Mflv_1596 | - | 0.0 | 79.29% (449) | cytochrome P450 |
| M. leprae Br4923 | MLBr_02088 | - | 1e-07 | 20.72% (333) | putative cytochrome p450 |
| M. abscessus ATCC 19977 | MAB_1214c | - | 0.0 | 80.97% (452) | cytochrome P450 |
| M. marinum M | MMAR_4932 | cyp51B1 | 0.0 | 82.37% (448) | cytochrome P450 51B1 Cyp51B1 |
| M. avium 104 | MAV_0708 | - | 0.0 | 79.87% (447) | cytochrome P450 51 |
| M. smegmatis MC2 155 | MSMEG_5863 | - | 0.0 | 80.14% (443) | cytochrome P450 51 |
| M. thermoresistible (build 8) | TH_4391 | - | 0.0 | 80.14% (443) | PUTATIVE cytochrome P450 |
| M. ulcerans Agy99 | MUL_0473 | cyp51B1 | 0.0 | 81.92% (448) | cytochrome P450 51B1 Cyp51B1 |
| M. vanbaalenii PYR-1 | Mvan_5161 | - | 0.0 | 80.18% (449) | cytochrome P450 |
CLUSTAL 2.0.9 multiple sequence alignment
Rv0764c|M.tuberculosis_H37Rv ------MSAV---ALPRVSGGHD---EHGHLEEFRTDPIGLMQR------
Mb0787c|M.bovis_AF2122/97 ------MSAV---ALPRVSGGHD---EHGHLEEFRTDPIGLMQR------
MAB_1214c|M.abscessus_ATCC_199 ------MTTP---TVPRVSGGED---QYGHLEEFRTDPIALMKR------
MAV_0708|M.avium_104 ------MTTS--TVVPRVSGGEE---EHGHLEEFRTDPIGLMQR------
TH_4391|M.thermoresistible__bu ------MTSQQLKEVPRVSGGEE---EHGHLEEFRTDPIGLMQR------
MMAR_4932|M.marinum_M ------MTTA---IVPRVSGGEE---EHGHLEEFRTDPIGLMQR------
MUL_0473|M.ulcerans_Agy99 ------MTTA---IVPRVSGGEE---EHGHLEEFRTDPIGLMQR------
MSMEG_5863|M.smegmatis_MC2_155 ------MTTL--HDVPRVSGGEE---EHGHLEEFRTDPIGLMKR------
Mvan_5161|M.vanbaalenii_PYR-1 ------MTAV--KEVPRVSGGEE---EHGHLEEFRTDPIGLMKR------
Mflv_1596|M.gilvum_PYR-GCK -------MTT--AIVPRVSGGEDD--EHGHLEEFRTDPIGLMKR------
MLBr_02088|M.leprae_Br4923 MRTCVPTRTCVYAFIEYLSHNRPMGTNPPSLVEAQMLLLRLIDPGTRADP
: : :* .. : * * : : *:.
Rv0764c|M.tuberculosis_H37Rv --VRDECGDVGTFQLAGKQVVLLSGSHANEFFFRAGDDDLDQAKAYPFMT
Mb0787c|M.bovis_AF2122/97 --VRDECGDVGTFQLAGKQVVLLSGSHANEFFFRAGDDDLDQAKAYPFMT
MAB_1214c|M.abscessus_ATCC_199 --IRAECGNVGTFQLADKQVVFLSGAEANEFFFRSSDEDLDQAEAYPFMT
MAV_0708|M.avium_104 --VRDECGDVGWFQLVDKHVILLSGAQANEFFFRSADEDLDQAEAYPFMT
TH_4391|M.thermoresistible__bu --VRDECGDVGYFQLVDKPVILLTGAEANEFFFRAADEDLDQAAAYPFMT
MMAR_4932|M.marinum_M --VRDECGDVGWFQLANKHVVLLSGAKANEFFFRSSDEELDQAEAYPFMT
MUL_0473|M.ulcerans_Agy99 --VRDECGDVGWFQLANKHVVLLSGAKANEFFFRSSDEELDQAEAYPFMT
MSMEG_5863|M.smegmatis_MC2_155 --VRSECGDVGWFQLADKQVVLLSGAEANEFFFRSSDSELNQAEAYPFMT
Mvan_5161|M.vanbaalenii_PYR-1 --VREECGDVGWFQLADKQVILLSGAEANEFFFRSSDSELNQAEAYPFMT
Mflv_1596|M.gilvum_PYR-GCK --IREECGDVGWFQLADKQVVMLSGAEANEFFFRSTDSELNQAEAYPFMT
MLBr_02088|M.leprae_Br4923 FPVYRALIDYGPMQLPGMPLTVFSSFSDCDEALRHPLSASDRLKATLAQQ
: : * :** . : .::. : :* . :: *
Rv0764c|M.tuberculosis_H37Rv PIFGEG----------VVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ
Mb0787c|M.bovis_AF2122/97 PIFGEG----------VVFDASPERRKEMLHNAALRGEQMKGHAATIEDQ
MAB_1214c|M.abscessus_ATCC_199 PIFGKG----------VVFDADPERRKEMLHNAALRGEQMKGHAATIENE
MAV_0708|M.avium_104 PIFGKG----------VVFDASPERRKEMLHNSALRGEQMKGHASTIEGE
TH_4391|M.thermoresistible__bu PIFGKG----------VVFDASPERRKEMLHNSALRGEHMKSHATTIEGE
MMAR_4932|M.marinum_M PIFGKG----------VVFDASPERRKEMLHNSALRGEHMKGHATTIERE
MUL_0473|M.ulcerans_Agy99 PIFGKG----------VVFDASPERRKEMLHNSALRGEHMKGHATTIERE
MSMEG_5863|M.smegmatis_MC2_155 PIFGEG----------VVFDADPERRAEMLHNTALRGEQMKGHAATIENE
Mvan_5161|M.vanbaalenii_PYR-1 PIFGEG----------VVFDADPERRAEMLHNTALRGEHMKGHATTIEAE
Mflv_1596|M.gilvum_PYR-GCK PIFGEG----------VVFDADPERRAEMLHNTALRGEQMKGHAATIENE
MLBr_02088|M.leprae_Br4923 AIAAGAEPRPFYASSFMFLDPPDHTRLRKLVSKAFAPKVVQALEGDIAAL
.* . . :.:*. . * . * . *: : ::. *
Rv0764c|M.tuberculosis_H37Rv VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYH
Mb0787c|M.bovis_AF2122/97 VRRMIADWGEAGEIDLLDFFAELTIYTSSACLIGKKFRDQLDGRFAKLYH
MAB_1214c|M.abscessus_ATCC_199 VRQMISRWGESGEVDLLDFFAELTIYTSSACLIGKKFRDELDGRFAHLYH
MAV_0708|M.avium_104 VKKMIADWGDEGEIELLDFFAELTIYTSTACLIGLKFREQLDHRFAEYYH
TH_4391|M.thermoresistible__bu VRKMIADWGDEGEIDLLDFFAELTIYTSTACLIGLKFRNQLDKRFAEYYH
MMAR_4932|M.marinum_M VHRMIENWGQEGEIDLLEFFAELTIYTSTSCLIGTKFRNQLDSRFAHFYH
MUL_0473|M.ulcerans_Agy99 VHRMIENWGQEGEIDLLEFFAELTSYTSTSCLIGTKFRNQLDSRFAHFCH
MSMEG_5863|M.smegmatis_MC2_155 VRRMVESWGDEGEIDLLEFFAELTIYTSTACLIGVKFRNQLDKRFADYYH
Mvan_5161|M.vanbaalenii_PYR-1 VRKMIEGWGESGEIDLLEFFAELTIYTSTACLIGLKFRNQLDSRFANYYH
Mflv_1596|M.gilvum_PYR-GCK VRRMIENWGEQGEIELLDFFSELTIYTSTACLIGLKFRNQLDSRFAEYYH
MLBr_02088|M.leprae_Br4923 VDSLLDKGAAAGQFDVIADLAFPLAVAVICRLLGVPYEDAP--EFGRVSA
* :: . *:.::: :: : . *:* :.: .*.
Rv0764c|M.tuberculosis_H37Rv ELERGTDPLAYVDPYLPIESFRRRDEARNGLVALVADIMNG---RIANPP
Mb0787c|M.bovis_AF2122/97 ELERGTDPLAYVDPYLPIESFRRRDEARNGLVALVADIMNG---RIANPP
MAB_1214c|M.abscessus_ATCC_199 QLEQGTDPLCYVDPYLEIESFRQRDEARTGLVALVQEIINGRVQRSADSP
MAV_0708|M.avium_104 DLERGTDPLCYVDPYLPIESFKRRDEARVKLVALVQEIMDQ---RLANPP
TH_4391|M.thermoresistible__bu LLERGTDPLCYVDPYLPIESFRLRDEARAKLVELVQEIIDQ---RLANPP
MMAR_4932|M.marinum_M ELERGTDPLCYVDPYLPIESFRRRDEARKGLVALVQDIMHQ---RVANPP
MUL_0473|M.ulcerans_Agy99 ELERGTDPLCYVDPYLPIESFRRRDEARKGLVALVQDIMHQ---RVANPP
MSMEG_5863|M.smegmatis_MC2_155 LLERGTDPLCYVDPYLPIESFRIRDEARANLVELVQEVMNG---RIANPP
Mvan_5161|M.vanbaalenii_PYR-1 LLERGTDPLCYVDPYLPIESFRIRDEARAGLVELVQDVMHG---RIANPP
Mflv_1596|M.gilvum_PYR-GCK LLERGTDPLCYVDPYLPIESFRIRDEARASLVELVQEVMNG---RIANPP
MLBr_02088|M.leprae_Br4923 LLVQSVDPFITITG-EPPEATEERLRAGVWLRDYLEQLVKCR--------
* :..**: : *: . * .* * : :::.
Rv0764c|M.tuberculosis_H37Rv TDKSDRDMLDVLIAVKAETGTPRFSADEITGMFISMMFAGHHTSSGTASW
Mb0787c|M.bovis_AF2122/97 TDKSDRDMLDVLIAVKAETGTPRFSADEITGMFISMMFAGHHTSSGTASW
MAB_1214c|M.abscessus_ATCC_199 TDKSQRDMLDVLIMIKDEHGNPRFTADEITGMFISMMFAGHHTSSGTASW
MAV_0708|M.avium_104 KDKADRDMLDVLVSIKDEDGKPRFSADEITGMFISLMFAGHHTSSGTSAW
TH_4391|M.thermoresistible__bu RSKADRDMLDVLVSIKDENGDPRFSADEITGMFISLMFAGHHTSSGTSAW
MMAR_4932|M.marinum_M TDKRDRDMLDVLVSITDEQGNPRFCADEVTGMFISLMFAGHHTSSGTSAW
MUL_0473|M.ulcerans_Agy99 TDKRDRDMLDVLVSITDEQGNPRFCTDEVTGMFISLMFAGHHTSSGTSAW
MSMEG_5863|M.smegmatis_MC2_155 KDKSDRDLLDVLVSIKDEDGTPRFSANEVTGMFISLMFAGHHTSSGTASW
Mvan_5161|M.vanbaalenii_PYR-1 KDKSDRDMLDVLVSIKDEDGNPRFTANEITGMFISLMFAGHHTSSGTSSW
Mflv_1596|M.gilvum_PYR-GCK TDKSDRDLLDVLVSIKDEDGNPRFSANEVTGMFISLMFAGHHTSSGTSSW
MLBr_02088|M.leprae_Br4923 RGTPGEDLISRLIELDESGD--QLTEEEIIATCGLLLVAGHETTVNLIAN
.. .*::. *: : . . :: :*: . ::.***.*: . :
Rv0764c|M.tuberculosis_H37Rv TLIELMRHRDAYAAVIDELDELYGDGRSVSFHALRQIPQLENVLKETLRL
Mb0787c|M.bovis_AF2122/97 TLIELMRHRDAYAAVIDELDELYGDGRSVSFHALRQIPQLENVLKETLRL
MAB_1214c|M.abscessus_ATCC_199 VLIELLRHPDIQSQVIDELDELYADGSEVSFHALRQIPKLENVLKETLRL
MAV_0708|M.avium_104 TLIELIRHPDVYAEVLAELEELYADGQEVSFHALRSIPKLDNVVKETLRL
TH_4391|M.thermoresistible__bu TLIELIRHPEIYAEVQAELDELYSDGQAVNFHALRQIPKLDNVVKETLRL
MMAR_4932|M.marinum_M TLIELLRHPDAYAAVIDELDELYADGQPVSFHALRQIPRLENVLKETLRL
MUL_0473|M.ulcerans_Agy99 TLIELLRHPDAYAAVIDELDELYADGQLVSFHALRQIPRLENVLKETLRL
MSMEG_5863|M.smegmatis_MC2_155 TLIELLRHPEFYAKVQAELDDLYADGQEISFHALRQIPNLDNALKETLRL
Mvan_5161|M.vanbaalenii_PYR-1 TLIELLRHPEFYAKVQQELDDLYADGQEVSFHALRQIPSLDNALKETLRL
Mflv_1596|M.gilvum_PYR-GCK TLIELLRHPEYYAQVQQELDDLYADGQEVSFHALRQIPKIDNALKETLRL
MLBr_02088|M.leprae_Br4923 AVLAMLRNPSQWKALSSNP------------------QRAPLVVEETLRY
.:: ::*: . : : .::****
Rv0764c|M.tuberculosis_H37Rv HPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPDPHDFVP
Mb0787c|M.bovis_AF2122/97 HPPLIILMRVAKGEFEVQGHRIHEGDLVAASPAISNRIPEDFPDPHDFVP
MAB_1214c|M.abscessus_ATCC_199 HPPLIILMRVAKGEFEVGGFPIHDGDMVAASPAVSNRIAEDFPNPDGFVP
MAV_0708|M.avium_104 HPPLIILMRVAKGEFEVEGFPIHEGDYVAASPAISNRIPEDFPDPDAFKP
TH_4391|M.thermoresistible__bu HPPLIILMRVAQGEFEVCGFPIHKGDYVAASPAISNRIPEDFPDPDAFRP
MMAR_4932|M.marinum_M HPPLIILMRVAKGEFQVEGYPIHEGELVAASPAISNRIAEDFPDPDEFVP
MUL_0473|M.ulcerans_Agy99 HPPLIILMRVAKGEFQVEGYPIHEGELVAASPAISNRIAEDFPDPDEFVP
MSMEG_5863|M.smegmatis_MC2_155 HPPLIILMRVAQDEFEVAGRPIHKGQMVAASPAISNRIPEDFPDPDTFDP
Mvan_5161|M.vanbaalenii_PYR-1 HPPLIILMRVAQDEFEVAGYPIHKGQMVAASPAISNRIPEDFPNPDDFDP
Mflv_1596|M.gilvum_PYR-GCK HPPLIILMRVAQDEFEVAGYPIHKGQMVAASPAISNRIPEDFPYPDAFDP
MLBr_02088|M.leprae_Br4923 DPAIHLIGRVAAKDMTIGQTTLTEGDTMVLLLAAANRDPAVYSRPDEFDP
.*.: :: *** :: : : .*: :. * :** . :. *. * *
Rv0764c|M.tuberculosis_H37Rv ARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEF
Mb0787c|M.bovis_AF2122/97 ARYEQPRQEDLLNRWTWIPFGAGRHRCVGAAFAIMQIKAIFSVLLREYEF
MAB_1214c|M.abscessus_ATCC_199 DRYEKPRQEDIVNRWTWIPFGAGRHRCVGAAFATMQIKAIFSVLLREYEF
MAV_0708|M.avium_104 DRYNKPEQADIVNRWTWIPFGAGRHRCVGAAFAQMQIKAIFSVLLREYDF
TH_4391|M.thermoresistible__bu DRYDKPEQADIVNRWTWIPFGAGRHRCVGAAFAQMQIKAIFSVLLREYEF
MMAR_4932|M.marinum_M ERYQEPRQEDLINRWTWIPFGAGRHRCVGAAFATMQIKAIFSVLLREYEF
MUL_0473|M.ulcerans_Agy99 ERYQEPRQEDLINRWTWIPFGAGRHRCVGAAFATMQIKAIFSVLLREYEF
MSMEG_5863|M.smegmatis_MC2_155 DRYDKPRQEDLINRWTWIPFGAGKHRCVGAAFAQMQIKAIFSVLLRDFEF
Mvan_5161|M.vanbaalenii_PYR-1 DRYEKPRQEDLINRWTWIPFGAGKHRCVGAAFAQMQIKAIFSVLLREYEF
Mflv_1596|M.gilvum_PYR-GCK DRYEKPRQEDLINRWTWIPFGAGKHRCVGAAFAQMQIKAIFSVLLREYEF
MLBr_02088|M.leprae_Br4923 DRPSS----------RHLAFAVGSHFCLGAALARLEATVTLSAISARFP-
* .. :.*..* * *:***:* :: .. :*.: :
Rv0764c|M.tuberculosis_H37Rv EMAQPPESYRNDHSKMVVQLAQPACVRYRRRTGV------
Mb0787c|M.bovis_AF2122/97 EMAQPPESYRNDHSKMVVQLAQPACVRYRRRTGV------
MAB_1214c|M.abscessus_ATCC_199 EMAQPADSYHNDHSKMVVQLAQPAKVRYRKRSA-------
MAV_0708|M.avium_104 EMAQPADSYRNDHSKMVVQLARPAKVRYRKRNA-------
TH_4391|M.thermoresistible__bu EMAQPPESYRNDHSKMVVQLQQPARARYRRRAKAAKAAKE
MMAR_4932|M.marinum_M EMAQPADSYRNDHSKMVVQLARPARVRYRRRKMSDNRGH-
MUL_0473|M.ulcerans_Agy99 EMAQPADSYRNDHSKMVVQLARPARVRYRRRKLSDNRGH-
MSMEG_5863|M.smegmatis_MC2_155 EMAQPSESYRNDHSKMVVQLARPAKVRYRRRVR-------
Mvan_5161|M.vanbaalenii_PYR-1 EMAQPPESYQNDHSKMVVQLARPAKVRYRRRVRD------
Mflv_1596|M.gilvum_PYR-GCK EMAQPAESYQNDHSKMVVQLARPAKVRYRRRVKD------
MLBr_02088|M.leprae_Br4923 QVQLAGELVYKPNVAMRGMSALPVQV--------------
:: . : : : * *. .