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aa seq not available
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. thermoresistible (build 8) | TH_4294 | - | - | 100% (447) | protein of unknown function DUF1023 |
M. thermoresistible (build 8) | TH_2235 | - | 0.0 | 71.46% (445) | CONSERVED HYPOTHETICAL PROTEIN |
M. thermoresistible (build 8) | TH_4075 | - | e-111 | 52.66% (395) | PUTATIVE putative protein of unknown function DUF1023 |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb2105 | - | 1e-127 | 53.85% (442) | hypothetical protein Mb2105 |
M. gilvum PYR-GCK | Mflv_3088 | - | 5e-08 | 26.57% (335) | hypothetical protein Mflv_3088 |
M. tuberculosis H37Rv | Rv2079 | - | 1e-127 | 53.85% (442) | hypothetical protein Rv2079 |
M. leprae Br4923 | - | - | - | - | - |
M. abscessus ATCC 19977 | MAB_0252 | - | 3e-08 | 23.27% (447) | hypothetical protein MAB_0252 |
M. marinum M | MMAR_5468 | - | 1e-133 | 58.05% (441) | hypothetical protein MMAR_5468 |
M. avium 104 | MAV_5292 | - | 1e-115 | 50.43% (464) | hypothetical protein MAV_5292 |
M. smegmatis MC2 155 | MSMEG_6381 | - | 7e-29 | 29.65% (344) | hypothetical protein MSMEG_6381 |
M. ulcerans Agy99 | MUL_5057 | - | 1e-131 | 57.18% (439) | hypothetical protein MUL_5057 |
M. vanbaalenii PYR-1 | Mvan_0049 | - | 1e-136 | 56.83% (454) | hypothetical protein Mvan_0049 |
CLUSTAL 2.0.9 multiple sequence alignment TH_4294|M.thermoresistible__bu -------------------------------------------------- Mvan_0049|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb2105|M.bovis_AF2122/97 --------------------------------------------MQLRHI Rv2079|M.tuberculosis_H37Rv --------------------------------------------MQLRHI MMAR_5468|M.marinum_M MSSADAGYRPRFAVAAGATQRTSHAARINHLERLESRHDAVDGAMQLRYI MUL_5057|M.ulcerans_Agy99 --------------------------------------------MQPRYI MAV_5292|M.avium_104 --------------------------------------------MQLRHL MSMEG_6381|M.smegmatis_MC2_155 -------------------------------------------------- Mflv_3088|M.gilvum_PYR-GCK ---------------------------------------MGVGRLRGRRI MAB_0252|M.abscessus_ATCC_1997 -------------------------------------------------- TH_4294|M.thermoresistible__bu -------------------------------------------------- Mvan_0049|M.vanbaalenii_PYR-1 ---------------MAVSVSTVRDSKPDRLVDAADATGRHRSELQTIIA Mb2105|M.bovis_AF2122/97 NIRALIAEAGGDPWAIEHSLHAGRPAQIAELAEAFHAAGRCTAEANAAFE Rv2079|M.tuberculosis_H37Rv NIRALIAEAGGDPWAIEHSLHAGRPAQIAELAEAFHAAGRYTAEANAAFE MMAR_5468|M.marinum_M SIPLLIAEAGGDPWAINQSLQLGRPAQISDLATAFHDAGRSTTEADTAFE MUL_5057|M.ulcerans_Agy99 SNPLLIAEAGGGPWAINQSLQLGRPAQISDLATAFHDAGRSTTEADTAFE MAV_5292|M.avium_104 SIPFLVAEAGGDPWSIDSGLQAGRPAQIASLARAFHDAGMSTAEADVAFA MSMEG_6381|M.smegmatis_MC2_155 --------------MQLSDIDSWNVGALQSIAFELRDELRTIEGVATDLE Mflv_3088|M.gilvum_PYR-GCK LPRRRRRSRRTVPPPVSPTVSAARRWRPDALLELAEQCDDAARRLCDHID MAB_0252|M.abscessus_ATCC_1997 ---------------MRPTISQLRGWNLDALGKAADAARDNARTLDASLD TH_4294|M.thermoresistible__bu -------------------------------------------------- Mvan_0049|M.vanbaalenii_PYR-1 GQRESLSHLQEHWSG------QAASAALARGLDDIARQDRVAGRLLN--- Mb2105|M.bovis_AF2122/97 EARRRFEASWNRENGEHPINDSAEVQRVTAALGVQSLQLPKIGVDLENIA Rv2079|M.tuberculosis_H37Rv EARRRFEASWNRENGEHPINDSAEVQRVTAALGVQSLQLPKIGVDLENIA MMAR_5468|M.marinum_M QARRRFETSWNRENGAHPINDSPQVQGLTTSLRSQAARLPEIGLQLDNIA MUL_5057|M.ulcerans_Agy99 QARRRFETSWNRENGAHPINDSPQVQGLTTSLRSQAARLPEIGLQLDNIA MAV_5292|M.avium_104 AARGRFEASWNHRNGALPINDSAEVQRVTRALAVEGRQLPRIATDLETIA MSMEG_6381|M.smegmatis_MC2_155 LISR--------LPGWDSPAADAARGRIGTAKANVLDDAAVIG-AVAQLA Mflv_3088|M.gilvum_PYR-GCK DSVTAADASRDYWTGAAADAARGAARGIAADAARAAHRLVNASAAARDGA MAB_0252|M.abscessus_ATCC_1997 SCDRVFNDASG-WYGKTHDAAKIKVDQELDHGREIRNVLNRISDDAEDAA TH_4294|M.thermoresistible__bu -------------------------------------------------- Mvan_0049|M.vanbaalenii_PYR-1 --LESALRNGGLQMGALRDALLDLVSSLERFGFAVADDGTVTPEQWLVGQ Mb2105|M.bovis_AF2122/97 ADLAEAQRAAAGRIATLESQLQRIDDQLDQALELEHDPRLAAAERSELDA Rv2079|M.tuberculosis_H37Rv ADLAEAQRAAAGRIATLESQLQRIDDQLDQALELEHDPRLAAAERSELDA MMAR_5468|M.marinum_M GGLAGAQRSATGQIVGLEAQLRDIDSEIGEVLALEHGAQLTTADRLALEA MUL_5057|M.ulcerans_Agy99 GGLAGAQRSATGQIVGLETQLCDIDSEIGEVLALEHGAQLTTADRLALEA MAV_5292|M.avium_104 AVLAESQRTSTWYIEALEYDLAAIDDEIGQALEEAD------------HC MSMEG_6381|M.smegmatis_MC2_155 DETAAAVAKLQSQLEAVRADVAAQGGLLHLADNGDVTIGGSPDDREQLKH Mflv_3088|M.gilvum_PYR-GCK TQIGAARDDAVGQVDDALEHGFLVADDGTVTVGADPDPLLVALAGGRDTL MAB_0252|M.abscessus_ATCC_1997 RTLKHAKEFTLQDVDGAVSEGFTVTDTGEVSHPDAKKAQAAADHQRRIQS TH_4294|M.thermoresistible__bu ----------------------------------VRRPGAAXXXPRRP-- Mvan_0049|M.vanbaalenii_PYR-1 FLDSLADKFTGFLQKMLQLFTDLDE------NTAAAIDQAAGVDSPNPPV Mb2105|M.bovis_AF2122/97 LITCLEQDAIDDTASALGQLQSIRAGYSDHLQQSLAMLRADGYDGAGLQG Rv2079|M.tuberculosis_H37Rv LITCLEQDAIDDTASALGQLQSIRAGYSDHLQQSLAMLRADGYDGAGLQG MMAR_5468|M.marinum_M LVCALEDQAVGGTQSAVSQLHSIRAGYAGLLHQALTSLSADGFDPAAIQA MUL_5057|M.ulcerans_Agy99 IVCALEDQAVGDTQSAVSQLHSIRAGYAGLLHQAPTSLSADGFDPAVIQA MAV_5292|M.avium_104 AAEELRYSAVTETKAITLVLEQIRESYSRLLHSALARLQADGVDPANVRG MSMEG_6381|M.smegmatis_MC2_155 IAENIEARAKALIHQAEDIDADCAEVFGHIENGDVTARGSSDFASAQEMG Mflv_3088|M.gilvum_PYR-GCK AADLLQLRADELSVRIPAALDRLGAADSDAAADLVRALTDTDRPVTPAPT MAB_0252|M.abscessus_ATCC_1997 GLDELARLDDMYGKKLREAADDLESMRDGQHDVTLPSGERVDPDALVDR- TH_4294|M.thermoresistible__bu ----------------PPPDAPAEDVKQWWDSLSEEERRRLIADHPPELG Mvan_0049|M.vanbaalenii_PYR-1 EVGGQD-------IHIPSPDTDPADVKQWWDSLSEQQRRELIDRHPPMLG Mb2105|M.bovis_AF2122/97 LDAPQSPVKLEEPIQIPPPGTGAPEVHRWWTSLTSEERQRLIAEHPEQIG Rv2079|M.tuberculosis_H37Rv LDAPQSPVKPEEPIQIPPPGTGAPEVHRWWTSLTSEERQRLIAEHPEQIG MMAR_5468|M.marinum_M LDAPQSPAEPAEVIAIPAPTASAEEVKKWWDSLSPQRRGRLIDEHPPELG MUL_5057|M.ulcerans_Agy99 LDAPQSPAEPAEVIAIAAPTASAEEVKKWWDSLSPQQRGRLIDEHPPELG MAV_5292|M.avium_104 VDELS----------IPPADTGPEQVKWWWDSLSAAQQRLLIDQHPQELG MSMEG_6381|M.smegmatis_MC2_155 REQSGLS----APYPPEGEGVSPENVNAWWNALSEEEQAKVISEHPDWIG Mflv_3088|M.gilvum_PYR-GCK VPAGAWPVP-SGDVVDGWPAMSQDRIAAQVAAMTDDQRARLIAEFPHQVG MAB_0252|M.abscessus_ATCC_1997 -----------------VSKMSADERAAFLATLSPETVDAMVIANPEVMG ::: :: * :* TH_4294|M.thermoresistible__bu NLNGIPAEVRHQVNEAVLRDDLDRVRDATEHHGVTPD------------E Mvan_0049|M.vanbaalenii_PYR-1 NLNGIPAEVRDQVNVAVMDDDLDRVQNVADRNGVSTD------------E Mb2105|M.bovis_AF2122/97 NLNGVPVSARSDANIAVMTRDLNRVRDIATRYRTSVD------------D Rv2079|M.tuberculosis_H37Rv NLNGVPVSARSDANIAVMTRDLNRVRDIATRYRTSVD------------D MMAR_5468|M.marinum_M NLNGINAITRDLVNQAVMDDDITRVESVAMQRGVSAD------------D MUL_5057|M.ulcerans_Agy99 NLNGINAITRDLVNQAVMDDDITRVESVAMQRGVSAD------------D MAV_5292|M.avium_104 NLNGIPAEARDSVNRATMTDDLSKVEAVARVRGVSVQALRDNALHNRDID MSMEG_6381|M.smegmatis_MC2_155 NRDGVPVAVRSEVNKAALDRELAEAQAAVDAMPSRDE------------- Mflv_3088|M.gilvum_PYR-GCK NTDGVPWDMRVAANRTNIATAILAESAADAP------------------- MAB_0252|M.abscessus_ATCC_1997 NSDGIPFDTRIAANEINIRNALSDELQKQPP------------------- * :*: * .* : : TH_4294|M.thermoresistible__bu VLADPGAYGLTAADATRYRNAVQTQKGLDAMGGTDTGETR---------- Mvan_0049|M.vanbaalenii_PYR-1 VAGNPGRYGLTDGDVTRYQNAKRTQEGLLHQLGAQDGETRRYSEIGEQER Mb2105|M.bovis_AF2122/97 VLGDPAKYGLSAGDITRYRNADETKKGLDHNARNDP-------------- Rv2079|M.tuberculosis_H37Rv VLGDPAKYGLSAGDITRYRNADETKKGLDHNARNDP-------------- MMAR_5468|M.marinum_M IVNNPRKYGLSGSDVTRYRNAIRTRDGLIYDREHAT-------------- MUL_5057|M.ulcerans_Agy99 IVNNPQKYGLSASDVTRYRNAIRTRDGLIYDREHAT-------------- MAV_5292|M.avium_104 MFRNPAAYGLCATDIVRYQNAVKTNDCLNKACDPG--------------- MSMEG_6381|M.smegmatis_MC2_155 FRREHPGWNGAQLNAAYNKMMFERQGRLDDAKAMKDALSVDG-------- Mflv_3088|M.gilvum_PYR-GCK ----------SRRRIAFYRSLLGEVDDPSGDTRIAR-------------- MAB_0252|M.abscessus_ATCC_1997 ----------DQARVNQLQDMLKPMEDPLVTRPADAG------------- : TH_4294|M.thermoresistible__bu ------PVMLWAYDPLAFNGQGRAAVAIGNPDE-AENTAVVVP--GTGSS Mvan_0049|M.vanbaalenii_PYR-1 RDKNWRPTMLWAYDPQAFDGKGRAAVSIGNPDR-ASNTAVIVP--GTSAS Mb2105|M.bovis_AF2122/97 --RNPSPVYLFAYDPMAFGGKGRAAIAIGNPDT-AKHTAVIVP--GTSSS Rv2079|M.tuberculosis_H37Rv --RNPSPVYLFAYDPMAFGGKGRAAIAIGNPDT-AKHTAVIVP--GTSSS MMAR_5468|M.marinum_M --DDPRPVMLWAYDPLAFNGEGKAAIAIGNPDY-ARNTAVVVP--GTGSS MUL_5057|M.ulcerans_Agy99 --DDPRPVMLWAYDPLAFNGEGKAAIAIGNPDY-ARNTAVIVP--GAGSS MAV_5292|M.avium_104 -----LPLMLWAYDPLAFAGKGRAGIAIGNPDK-SRNTAVVVP--GTNSS MSMEG_6381|M.smegmatis_MC2_155 ---KYDPNKYLMLLEFPEDREPRAAIAVGNPDT-AEHVTVTTPGVGTRPE Mflv_3088|M.gilvum_PYR-GCK --------QILAFDP----GRASLVELHGDLGT-ARSVAVLVP--GVNTT MAB_0252|M.abscessus_ATCC_1997 ---PRDFMVDRKYVMFSTEGNGRMIEMIGDIKPGVRGVGVIVP--GTNTN . *: . * .* *. . TH_4294|M.thermoresistible__bu VAQGWLEG--DNATNLYDQMRLGEPGKP-ASVIAWMGYDAPDSPLD---- Mvan_0049|M.vanbaalenii_PYR-1 VRDGWLSDGHNDAIHLYGQSLKADPADP-TAVISWMGYNTPESFTD---- Mb2105|M.bovis_AF2122/97 VKGGWLHDNHDDALNLFNQAKAADPNNP-TAVIAWMGYDAPNDFTD---- Rv2079|M.tuberculosis_H37Rv VKGGWLHDNHDDALNLFNQAKAADPNNP-TAVIAWMGYDAPNDFTD---- MMAR_5468|M.marinum_M VAQGWMSD-HDDATNLYDQALAADPEHHYTAVIAWMGYDAPNGFSD---- MUL_5057|M.ulcerans_Agy99 VAQGWMSD-HDDATNLYDQALAADPEHHYTAVIAWMGYDAPNGFSD---- MAV_5292|M.avium_104 VRGGWMSDGADDAINLYTQAQRADPHHA-TAVLAWMGYDAP-EFDDSHWE MSMEG_6381|M.smegmatis_MC2_155 SLGGMVSEADALRQEAQTQLDRAGRSGEQVATIAWLGYEPPGTDIS---- Mflv_3088|M.gilvum_PYR-GCK VEG--------SAANAATARRFVSGSDGRLAMITYLGGPFPQVHDP---- MAB_0252|M.abscessus_ATCC_1997 LNG--------SGSNHESAVKLAKESGS--PIFLYLGGDFPQGLDK---- . . : ::* * TH_4294|M.thermoresistible__bu ---------PRIATPWLARDGGELLAADVNGLGVTHEGGD-RTVTVIGHS Mvan_0049|M.vanbaalenii_PYR-1 ---------PNIANTGLARAGGDALAWDVNGLNVTHEAGVPEHVTVIGHS Mb2105|M.bovis_AF2122/97 ---------PRIATPMLARIGGAALAEDVNGLWVTHLGVG-QNVTVLGHS Rv2079|M.tuberculosis_H37Rv ---------PRIATPMLARIGGAALAEDVNGLWVTHLGVG-QNVTVLGHS MMAR_5468|M.marinum_M ---------VRVTEPGLARSGGALLANDVNGLWVTHNSLTPQHVTVIGHS MUL_5057|M.ulcerans_Agy99 ---------VRVTEPGLARSGGALLANDVNGLWVTHNSLTPQHVTVIGHS MAV_5292|M.avium_104 QAVTDPAKLEQVGTPWRARQAGVLLAGDVNGLAATHDAGSRAHVTVIGHS MSMEG_6381|M.smegmatis_MC2_155 --------VAEAGFERRANEAAPDLADFYRGINATNEHGSDVHLSAFGHS Mflv_3088|M.gilvum_PYR-GCK --------VTAVAAADRRYALEMAPRLVAFSEDVARRVPDSVLVTVVGHS MAB_0252|M.abscessus_ATCC_1997 ----------AADPSYAAAMAPKLVDFGHEVDRAVGQNAPGTPVTYVGHS .. :: .*** TH_4294|M.thermoresistible__bu YGSTTVADAFAGSGMQ--ADNAVLIGSP--GTDLARSAADFNLPEGGQVY Mvan_0049|M.vanbaalenii_PYR-1 YGSTTVADAFANSGMQ--ADDAILLGSP--GTDVARSAADFNLD-GGQVY Mb2105|M.bovis_AF2122/97 YGSTTVADAFALGGMH--ANDAVLLGCP--GTDLAHSAASFHLD-GGRVY Rv2079|M.tuberculosis_H37Rv YGSTTVADAFALGGMH--ANDAVLLGCP--GTDLAHSAASFHLD-GGRVY MMAR_5468|M.marinum_M YGSTTVADAFAGSGMH--ANDAILIGCP--GTDLARSAADFHLD-GGQVY MUL_5057|M.ulcerans_Agy99 YGSTTVADAFAGSGMQ--ANDAILIGCP--GTDLARSAADFHFD-GGQVY MAV_5292|M.avium_104 YGSTTVADAFANSGMR--ANDAVLTGCP--GTDLAHSAADFHLD-GGRLY MSMEG_6381|M.smegmatis_MC2_155 YGSLTTAQALYELGETGVVDDAAFYGSP--GLGHTDSTETYISPRGVPIE Mflv_3088|M.gilvum_PYR-GCK YGGSIVGTAETLGLTS---DRTVFLAAAGAGVGVDDPGDWHNRNPHVQRY MAB_0252|M.abscessus_ATCC_1997 YGGAIVGTAEQMGLRA----DRILHASS-AGTGILPGG-YTDPNPNVQRY **. .. * : ... * . TH_4294|M.thermoresistible__bu VGAASSDPVTWLGQGG-AVPDILNHVL----DHPLGSRAGLGTDP----- Mvan_0049|M.vanbaalenii_PYR-1 IGDASTDPVGWLGQMGNTLPGELNDSL----GNMVGPTAGLGADP----- Mb2105|M.bovis_AF2122/97 VGAASTDPISMLGQLDSLSQYVNRGNL--A-GQLQGLAVGLGTDP----- Rv2079|M.tuberculosis_H37Rv VGAASTDPISMLGQLDSLSQYVNRGNL--A-GQLQGLAVGLGTDP----- MMAR_5468|M.marinum_M VGSASTDPVSWIGESSGVPGELLKGKLREY-GVPIPLDAGLGRDP----- MUL_5057|M.ulcerans_Agy99 VGSASTDPVSWIGESSGVPGELLKGKLREY-GVPIPLDAGLGRDP----- MAV_5292|M.avium_104 VGAASTDAISWIGESGSGLPNGLNETL----GGPLGPFAGLGTDP----- MSMEG_6381|M.smegmatis_MC2_155 VMAPIRDESDMFLADGRAFVMSAPGDP-------------ISGDP----- Mflv_3088|M.gilvum_PYR-GCK SMTAPGDFIELVQGIPGGPHGADPDEMD----------GVIGLPT----- MAB_0252|M.abscessus_ATCC_1997 SMTAPGDPIAIVQSLPRDVRLSDVPGVDQIPGIPHNVEGRIGNPLGGLPS . * . :. TH_4294|M.thermoresistible__bu ---AGDGYGSVRFDAEVPGRSGPSF--------GHHSAYYGVGSESLRAM Mvan_0049|M.vanbaalenii_PYR-1 ---AFEDFGATRFRAEVPGADMIDP--------SDHSYYYTVGSESLRSM Mb2105|M.bovis_AF2122/97 ---AGDGFGSVRFRAEVPNSDGINP--------HDHSYYYHRGSEALRSM Rv2079|M.tuberculosis_H37Rv ---AGDGFGSVRFRAEVPNSDGINP--------HDHSYYYHRGSEALRSM MMAR_5468|M.marinum_M ---AGDGFGSVRFHAEVPGSATMDR--------HDHSHYYVMGSESLRSI MUL_5057|M.ulcerans_Agy99 ---AGDGFGSVRFHAEVPGSGTMDR--------HDHSHYYVMGSESLRSI MAV_5292|M.avium_104 ---AHAGFGAARFRAEVAGSHSVMPW------FTDHSDYYDVGSEALHNM MSMEG_6381|M.smegmatis_MC2_155 ---TWN--GVPLPSAGDLGQFGPNP-----------------LTLPLEQL Mflv_3088|M.gilvum_PYR-GCK ---GFYDDGGLVAGWEAHSGMLNRP------------------SGAWRTI MAB_0252|M.abscessus_ATCC_1997 ATDPDKIPGVTRLDTGYYGEFGKHPNQVIVGPDGHGSYWDDPSSDAFHNI * . : . . : TH_4294|M.thermoresistible__bu TDIANGNGAT------LAENGYTAEGRRQVHIGLPDTVNLPFIGEVDLPD Mvan_0049|M.vanbaalenii_PYR-1 TEIVTGNGGR------LDELGLLAQPRTELTVSTPQQLDVPVLGEVPLPH Mb2105|M.bovis_AF2122/97 ADIASGHGDA------LASDGMLAQPRHQPGVEID-IPGLGSV-EIDIP- Rv2079|M.tuberculosis_H37Rv ADIASGHGDA------LASDGMLAQPRHQPGVEID-IPGLGSV-EIDIP- MMAR_5468|M.marinum_M TDIASGHPDR------LASDDLIAEGRRQP--------HVG---PFRVP- MUL_5057|M.ulcerans_Agy99 TDISSGHPDR------LASDDLIAEGRRQP--------HVG---PLRVP- MAV_5292|M.avium_104 TEIVTGRGNE------LAAEGMLAPDRNAARVSILGRVHTPLG-TLSLPR MSMEG_6381|M.smegmatis_MC2_155 SADAAVTPDG------VSREGAVAHADYPRPVELPSGEKVLRTPAYNLA- Mflv_3088|M.gilvum_PYR-GCK LDVLTGDPGT------LSSASSIPAGG----------------------- MAB_0252|M.abscessus_ATCC_1997 AAVIGGGEATGYVERGIQTNYVDINVGDDGNFRAEAWDQSRAAAGAQVPG : TH_4294|M.thermoresistible__bu WDTRIPGTPAVNDPEGDRD--HVTQNHQY------- Mvan_0049|M.vanbaalenii_PYR-1 LEVETP---VIYDPEWNRAGGSVTNDHGY------- Mb2105|M.bovis_AF2122/97 ---GTP---ASIDPEWSRPPGSITDDHVFDAPLHR- Rv2079|M.tuberculosis_H37Rv ---GTP---ASIDPEWSRPPGSITDDHVFDAPLHR- MMAR_5468|M.marinum_M ---GVP---AYIDPESDRPRDTVHDDHHYPAYQPPR MUL_5057|M.ulcerans_Agy99 ---GVP---AYIDPESDRPRDTVHDDHHYPAYQPPR MAV_5292|M.avium_104 VEIRMP---VVVDPEWERPARSVTNEHGF------- MSMEG_6381|M.smegmatis_MC2_155 ----------VIAAGLADVPGPNGEDRLVR------ Mflv_3088|M.gilvum_PYR-GCK ------------------------------------ MAB_0252|M.abscessus_ATCC_1997 LPWDDPGTIDRRHHPWDNPRVTDHPEHGQKIQVK--