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QPRYISNPLLIAEAGGGPWAINQSLQLGRPAQISDLATAFHDAGRSTTEADTAFEQARRRFETSWNRENG AHPINDSPQVQGLTTSLRSQAARLPEIGLQLDNIAGGLAGAQRSATGQIVGLETQLCDIDSEIGEVLALE HGAQLTTADRLALEAIVCALEDQAVGDTQSAVSQLHSIRAGYAGLLHQAPTSLSADGFDPAVIQALDAPQ SPAEPAEVIAIAAPTASAEEVKKWWDSLSPQQRGRLIDEHPPELGNLNGINAITRDLVNQAVMDDDITRV ESVAMQRGVSADDIVNNPQKYGLSASDVTRYRNAIRTRDGLIYDREHATDDPRPVMLWAYDPLAFNGEGK AAIAIGNPDYARNTAVIVPGAGSSVAQGWMSDHDDATNLYDQALAADPEHHYTAVIAWMGYDAPNGFSDV RVTEPGLARSGGALLANDVNGLWVTHNSLTPQHVTVIGHSYGSTTVADAFAGSGMQANDAILIGCPGTDL ARSAADFHFDGGQVYVGSASTDPVSWIGESSGVPGELLKGKLREYGVPIPLDAGLGRDPAGDGFGSVRFH AEVPGSGTMDRHDHSHYYVMGSESLRSITDISSGHPDRLASDDLIAEGRRQPHVGPLRVPGVPAYIDPES DRPRDTVHDDHHYPAYQPPR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_5057 | - | - | 100% (651) | hypothetical protein MUL_5057 |
| M. ulcerans Agy99 | MUL_2305 | - | 2e-50 | 42.48% (266) | hypothetical protein MUL_2305 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2105 | - | 0.0 | 56.86% (656) | hypothetical protein Mb2105 |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. tuberculosis H37Rv | Rv2079 | - | 0.0 | 57.01% (656) | hypothetical protein Rv2079 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0252 | - | 2e-07 | 21.60% (463) | hypothetical protein MAB_0252 |
| M. marinum M | MMAR_5468 | - | 0.0 | 96.93% (651) | hypothetical protein MMAR_5468 |
| M. avium 104 | MAV_5292 | - | 1e-170 | 50.80% (687) | hypothetical protein MAV_5292 |
| M. smegmatis MC2 155 | MSMEG_6381 | - | 6e-27 | 26.44% (522) | hypothetical protein MSMEG_6381 |
| M. thermoresistible (build 8) | TH_4294 | - | 1e-131 | 57.18% (439) | PUTATIVE protein of unknown function DUF1023 |
| M. vanbaalenii PYR-1 | Mvan_0049 | - | 1e-131 | 49.19% (553) | hypothetical protein Mvan_0049 |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_5057|M.ulcerans_Agy99 --------------------------------------------MQPRYI
MMAR_5468|M.marinum_M MSSADAGYRPRFAVAAGATQRTSHAARINHLERLESRHDAVDGAMQLRYI
Mb2105|M.bovis_AF2122/97 --------------------------------------------MQLRHI
Rv2079|M.tuberculosis_H37Rv --------------------------------------------MQLRHI
MAV_5292|M.avium_104 --------------------------------------------MQLRHL
TH_4294|M.thermoresistible__bu --------------------------------------------------
Mvan_0049|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6381|M.smegmatis_MC2_155 --------------------------------------------------
MAB_0252|M.abscessus_ATCC_1997 --------------------------------------------------
MUL_5057|M.ulcerans_Agy99 SNPLLIAEAGGGPWAINQSLQLGRPAQISDLATAFHDAGRSTTEADTAFE
MMAR_5468|M.marinum_M SIPLLIAEAGGDPWAINQSLQLGRPAQISDLATAFHDAGRSTTEADTAFE
Mb2105|M.bovis_AF2122/97 NIRALIAEAGGDPWAIEHSLHAGRPAQIAELAEAFHAAGRCTAEANAAFE
Rv2079|M.tuberculosis_H37Rv NIRALIAEAGGDPWAIEHSLHAGRPAQIAELAEAFHAAGRYTAEANAAFE
MAV_5292|M.avium_104 SIPFLVAEAGGDPWSIDSGLQAGRPAQIASLARAFHDAGMSTAEADVAFA
TH_4294|M.thermoresistible__bu --------------------------------------------------
Mvan_0049|M.vanbaalenii_PYR-1 ---------------MAVSVSTVRDSKPDRLVDAADATGRHRSELQTIIA
MSMEG_6381|M.smegmatis_MC2_155 --------------MQLSDIDSWNVGALQSIAFELRDELRTIEGVATDLE
MAB_0252|M.abscessus_ATCC_1997 ---------------MRPTISQLRGWNLDALGKAADAARDNARTLDASLD
MUL_5057|M.ulcerans_Agy99 QARRRFETSWNRENGAHPINDSPQVQGLTTSLRSQAARLPEIGLQLDNIA
MMAR_5468|M.marinum_M QARRRFETSWNRENGAHPINDSPQVQGLTTSLRSQAARLPEIGLQLDNIA
Mb2105|M.bovis_AF2122/97 EARRRFEASWNRENGEHPINDSAEVQRVTAALGVQSLQLPKIGVDLENIA
Rv2079|M.tuberculosis_H37Rv EARRRFEASWNRENGEHPINDSAEVQRVTAALGVQSLQLPKIGVDLENIA
MAV_5292|M.avium_104 AARGRFEASWNHRNGALPINDSAEVQRVTRALAVEGRQLPRIATDLETIA
TH_4294|M.thermoresistible__bu --------------------------------------------------
Mvan_0049|M.vanbaalenii_PYR-1 GQRESLSHLQEHWSG------QAASAALARGLDDIARQDRVAGRLLN---
MSMEG_6381|M.smegmatis_MC2_155 LISR--------LPGWDSPAADAARGRIGTAKANVLDDAAVIG-AVAQLA
MAB_0252|M.abscessus_ATCC_1997 SCDRVFNDASGWYGKTHDAAKIKVDQELDHGREIRN-VLNRISDDAEDAA
MUL_5057|M.ulcerans_Agy99 GGLAGAQRSATGQIVGLETQLCDIDSEIGEVLALEHGAQLTTADRLALEA
MMAR_5468|M.marinum_M GGLAGAQRSATGQIVGLEAQLRDIDSEIGEVLALEHGAQLTTADRLALEA
Mb2105|M.bovis_AF2122/97 ADLAEAQRAAAGRIATLESQLQRIDDQLDQALELEHDPRLAAAERSELDA
Rv2079|M.tuberculosis_H37Rv ADLAEAQRAAAGRIATLESQLQRIDDQLDQALELEHDPRLAAAERSELDA
MAV_5292|M.avium_104 AVLAESQRTSTWYIEALEYDLAAIDDEIGQALEEAD------------HC
TH_4294|M.thermoresistible__bu --------------------------------------------------
Mvan_0049|M.vanbaalenii_PYR-1 --LESALRNGGLQMGALRDALLDLVSSLERFGFAVADDGTVTPEQWLVGQ
MSMEG_6381|M.smegmatis_MC2_155 DETAAAVAKLQSQLEAVRADVAAQGGLLHLADNGDVTIGGSPDDREQLKH
MAB_0252|M.abscessus_ATCC_1997 RTLKHAKEFTLQDVDGAVSEGFTVTDTGEVSHPDAKKAQAAADHQRRIQS
MUL_5057|M.ulcerans_Agy99 IVCALEDQAVGDTQSAVSQLHSIRAGYAGLLHQAPTSLSADGFDPAVIQA
MMAR_5468|M.marinum_M LVCALEDQAVGGTQSAVSQLHSIRAGYAGLLHQALTSLSADGFDPAAIQA
Mb2105|M.bovis_AF2122/97 LITCLEQDAIDDTASALGQLQSIRAGYSDHLQQSLAMLRADGYDGAGLQG
Rv2079|M.tuberculosis_H37Rv LITCLEQDAIDDTASALGQLQSIRAGYSDHLQQSLAMLRADGYDGAGLQG
MAV_5292|M.avium_104 AAEELRYSAVTETKAITLVLEQIRESYSRLLHSALARLQADGVDPANVRG
TH_4294|M.thermoresistible__bu ----------------------------------VRRPGAAXXXPRRP--
Mvan_0049|M.vanbaalenii_PYR-1 FLDSLADKFTGFLQKMLQLFTDLDE------NTAAAIDQAAGVDSPNPPV
MSMEG_6381|M.smegmatis_MC2_155 IAENIEARAKALIHQAEDIDADCAEVFGHIENGDVTARGSSDFASAQEMG
MAB_0252|M.abscessus_ATCC_1997 GLDELARLDDMYGKKLREAADDLESMRDG--QHDVTLPSGERVDPDALVD
.
MUL_5057|M.ulcerans_Agy99 LDAPQSPAEPAEVIAIAAPTASAEEVKKWWDSLSPQQRGRLIDEHPPELG
MMAR_5468|M.marinum_M LDAPQSPAEPAEVIAIPAPTASAEEVKKWWDSLSPQRRGRLIDEHPPELG
Mb2105|M.bovis_AF2122/97 LDAPQSPVKLEEPIQIPPPGTGAPEVHRWWTSLTSEERQRLIAEHPEQIG
Rv2079|M.tuberculosis_H37Rv LDAPQSPVKPEEPIQIPPPGTGAPEVHRWWTSLTSEERQRLIAEHPEQIG
MAV_5292|M.avium_104 VDELS----------IPPADTGPEQVKWWWDSLSAAQQRLLIDQHPQELG
TH_4294|M.thermoresistible__bu ----------------PPPDAPAEDVKQWWDSLSEEERRRLIADHPPELG
Mvan_0049|M.vanbaalenii_PYR-1 EVGGQD-------IHIPSPDTDPADVKQWWDSLSEQQRRELIDRHPPMLG
MSMEG_6381|M.smegmatis_MC2_155 REQSGLS----APYPPEGEGVSPENVNAWWNALSEEEQAKVISEHPDWIG
MAB_0252|M.abscessus_ATCC_1997 R----------------VSKMSADERAAFLATLSPETVDAMVIANPEVMG
. : : :*: :: :* :*
MUL_5057|M.ulcerans_Agy99 NLNGINAITRDLVNQAVMDDDITRVESVAMQRGVSAD------------D
MMAR_5468|M.marinum_M NLNGINAITRDLVNQAVMDDDITRVESVAMQRGVSAD------------D
Mb2105|M.bovis_AF2122/97 NLNGVPVSARSDANIAVMTRDLNRVRDIATRYRTSVD------------D
Rv2079|M.tuberculosis_H37Rv NLNGVPVSARSDANIAVMTRDLNRVRDIATRYRTSVD------------D
MAV_5292|M.avium_104 NLNGIPAEARDSVNRATMTDDLSKVEAVARVRGVSVQALRDNALHNRDID
TH_4294|M.thermoresistible__bu NLNGIPAEVRHQVNEAVLRDDLDRVRDATEHHGVTPD------------E
Mvan_0049|M.vanbaalenii_PYR-1 NLNGIPAEVRDQVNVAVMDDDLDRVQNVADRNGVSTD------------E
MSMEG_6381|M.smegmatis_MC2_155 NRDGVPVAVRSEVNKAALDRELAEAQAAVDAMPSRDE-------------
MAB_0252|M.abscessus_ATCC_1997 NSDGIPFDTRIAANEINIRNALSDELQKQPPDQARVN-------------
* :*: .* .* : : :
MUL_5057|M.ulcerans_Agy99 IVNNPQKYGLSASDVTRYRNAIRTRDGLIYDREHAT--------------
MMAR_5468|M.marinum_M IVNNPRKYGLSGSDVTRYRNAIRTRDGLIYDREHAT--------------
Mb2105|M.bovis_AF2122/97 VLGDPAKYGLSAGDITRYRNADETKKGLDHNARNDP--------------
Rv2079|M.tuberculosis_H37Rv VLGDPAKYGLSAGDITRYRNADETKKGLDHNARNDP--------------
MAV_5292|M.avium_104 MFRNPAAYGLCATDIVRYQNAVKTNDCLNKACDPG---------------
TH_4294|M.thermoresistible__bu VLADPGAYGLTAADATRYRNAVQTQKGLDAMGGTDTGETR----------
Mvan_0049|M.vanbaalenii_PYR-1 VAGNPGRYGLTDGDVTRYQNAKRTQEGLLHQLGAQDGETRRYSEIGEQER
MSMEG_6381|M.smegmatis_MC2_155 FRREHPGWNGAQLNAAYNKMMFERQGRLDDAKAMKDALSVDG--------
MAB_0252|M.abscessus_ATCC_1997 -QLQDMLKPMEDPLVTRPADAGPRDFMVDR--------------------
: . :
MUL_5057|M.ulcerans_Agy99 --DDPRPVMLWAYDPLAFNGEGKAAIAIGNPDY-ARNTAVIVP--GAGSS
MMAR_5468|M.marinum_M --DDPRPVMLWAYDPLAFNGEGKAAIAIGNPDY-ARNTAVVVP--GTGSS
Mb2105|M.bovis_AF2122/97 --RNPSPVYLFAYDPMAFGGKGRAAIAIGNPDT-AKHTAVIVP--GTSSS
Rv2079|M.tuberculosis_H37Rv --RNPSPVYLFAYDPMAFGGKGRAAIAIGNPDT-AKHTAVIVP--GTSSS
MAV_5292|M.avium_104 -----LPLMLWAYDPLAFAGKGRAGIAIGNPDK-SRNTAVVVP--GTNSS
TH_4294|M.thermoresistible__bu ------PVMLWAYDPLAFNGQGRAAVAIGNPDE-AENTAVVVP--GTGSS
Mvan_0049|M.vanbaalenii_PYR-1 RDKNWRPTMLWAYDPQAFDGKGRAAVSIGNPDR-ASNTAVIVP--GTSAS
MSMEG_6381|M.smegmatis_MC2_155 ---KYDPNKYLMLLEFPEDREPRAAIAVGNPDT-AEHVTVTTPGVGTRPE
MAB_0252|M.abscessus_ATCC_1997 -----------KYVMFSTEGNGRMIEMIGDIKPGVRGVGVIVP--GTNTN
. : : :*: . . * .* *: ..
MUL_5057|M.ulcerans_Agy99 VAQGWMSD-HDDATNLYDQALAADPEHHYTAVIAWMGYDAPNGFSD----
MMAR_5468|M.marinum_M VAQGWMSD-HDDATNLYDQALAADPEHHYTAVIAWMGYDAPNGFSD----
Mb2105|M.bovis_AF2122/97 VKGGWLHDNHDDALNLFNQAKAADPNNP-TAVIAWMGYDAPNDFTD----
Rv2079|M.tuberculosis_H37Rv VKGGWLHDNHDDALNLFNQAKAADPNNP-TAVIAWMGYDAPNDFTD----
MAV_5292|M.avium_104 VRGGWMSDGADDAINLYTQAQRADPHHA-TAVLAWMGYDAP-EFDDSHWE
TH_4294|M.thermoresistible__bu VAQGWLEG--DNATNLYDQMRLGEPGKP-ASVIAWMGYDAPDSPLD----
Mvan_0049|M.vanbaalenii_PYR-1 VRDGWLSDGHNDAIHLYGQSLKADPADP-TAVISWMGYNTPESFTD----
MSMEG_6381|M.smegmatis_MC2_155 SLGGMVSEADALRQEAQTQLDRAGRSGEQVATIAWLGYEPPGTDIS----
MAB_0252|M.abscessus_ATCC_1997 LNG--------SGSNHESAVKLAKESGS--PIFLYLGGDFPQGLDK----
. . . : ::* : * .
MUL_5057|M.ulcerans_Agy99 ---------VRVTEPGLARSGGALLANDVNGLWVTHNSLTPQHVTVIGHS
MMAR_5468|M.marinum_M ---------VRVTEPGLARSGGALLANDVNGLWVTHNSLTPQHVTVIGHS
Mb2105|M.bovis_AF2122/97 ---------PRIATPMLARIGGAALAEDVNGLWVTHLGVG-QNVTVLGHS
Rv2079|M.tuberculosis_H37Rv ---------PRIATPMLARIGGAALAEDVNGLWVTHLGVG-QNVTVLGHS
MAV_5292|M.avium_104 QAVTDPAKLEQVGTPWRARQAGVLLAGDVNGLAATHDAGSRAHVTVIGHS
TH_4294|M.thermoresistible__bu ---------PRIATPWLARDGGELLAADVNGLGVTHEGGD-RTVTVIGHS
Mvan_0049|M.vanbaalenii_PYR-1 ---------PNIANTGLARAGGDALAWDVNGLNVTHEAGVPEHVTVIGHS
MSMEG_6381|M.smegmatis_MC2_155 --------VAEAGFERRANEAAPDLADFYRGINATNEHGSDVHLSAFGHS
MAB_0252|M.abscessus_ATCC_1997 ----------AADPSYAAAMAPKLVDFGHEVDRAVGQNAPGTPVTYVGHS
* . : . .. :: .***
MUL_5057|M.ulcerans_Agy99 YGSTTVADAFAGSGMQ--ANDAILIGC---PG--TDLARSAADFHFD--G
MMAR_5468|M.marinum_M YGSTTVADAFAGSGMH--ANDAILIGC---PG--TDLARSAADFHLD--G
Mb2105|M.bovis_AF2122/97 YGSTTVADAFALGGMH--ANDAVLLGC---PG--TDLAHSAASFHLD--G
Rv2079|M.tuberculosis_H37Rv YGSTTVADAFALGGMH--ANDAVLLGC---PG--TDLAHSAASFHLD--G
MAV_5292|M.avium_104 YGSTTVADAFANSGMR--ANDAVLTGC---PG--TDLAHSAADFHLD--G
TH_4294|M.thermoresistible__bu YGSTTVADAFAGSGMQ--ADNAVLIGS---PG--TDLARSAADFNLPE-G
Mvan_0049|M.vanbaalenii_PYR-1 YGSTTVADAFANSGMQ--ADDAILLGS---PG--TDVARSAADFNLD--G
MSMEG_6381|M.smegmatis_MC2_155 YGSLTTAQALYELGETGVVDDAAFYGS---PG--LGHTDSTETYISPR-G
MAB_0252|M.abscessus_ATCC_1997 YGGAIVGTAEQMGLRADRILHASSAGTGILPGGYTDPNPNVQRYSMTAPG
**. .. * .* * ** . .. : *
MUL_5057|M.ulcerans_Agy99 GQVYVGSASTDPVSWIGESSGVPGELLKGKLREYGVPIPLDAGLGRDPAG
MMAR_5468|M.marinum_M GQVYVGSASTDPVSWIGESSGVPGELLKGKLREYGVPIPLDAGLGRDPAG
Mb2105|M.bovis_AF2122/97 GRVYVGAASTDPISMLGQLDSLSQYVNRGNL--AGQLQGLAVGLGTDPAG
Rv2079|M.tuberculosis_H37Rv GRVYVGAASTDPISMLGQLDSLSQYVNRGNL--AGQLQGLAVGLGTDPAG
MAV_5292|M.avium_104 GRLYVGAASTDAISWIGESGSGLPNGLNETL---GGPLGPFAGLGTDPAH
TH_4294|M.thermoresistible__bu GQVYVGAASSDPVTWLGQGG-AVPDILNHVL---DHPLGSRAGLGTDPAG
Mvan_0049|M.vanbaalenii_PYR-1 GQVYIGDASTDPVGWLGQMGNTLPGELNDSL---GNMVGPTAGLGADPAF
MSMEG_6381|M.smegmatis_MC2_155 VPIEVMAPIRDESDMFLADGRAFVMSAPGDP------------ISGDPTW
MAB_0252|M.abscessus_ATCC_1997 DPIAIVQSLPRDVRLSDVPGVDQIPGIPHNV--EGRIGNPLGGLPSATDP
: : . . : .
MUL_5057|M.ulcerans_Agy99 DGF-GSVRFHAEVPGSGTMDR--------HDHSHYYVMGSESLRSITDIS
MMAR_5468|M.marinum_M DGF-GSVRFHAEVPGSATMDR--------HDHSHYYVMGSESLRSITDIA
Mb2105|M.bovis_AF2122/97 DGF-GSVRFRAEVPNSDGINP--------HDHSYYYHRGSEALRSMADIA
Rv2079|M.tuberculosis_H37Rv DGF-GSVRFRAEVPNSDGINP--------HDHSYYYHRGSEALRSMADIA
MAV_5292|M.avium_104 AGF-GAARFRAEVAGSHSVMPW------FTDHSDYYDVGSEALHNMTEIV
TH_4294|M.thermoresistible__bu DGY-GSVRFDAEVPGRSGPSF--------GHHSAYYGVGSESLRAMTDIA
Mvan_0049|M.vanbaalenii_PYR-1 EDF-GATRFRAEVPGADMIDP--------SDHSYYYTVGSESLRSMTEIV
MSMEG_6381|M.smegmatis_MC2_155 N---GVPLPSAGDLGQFGPNP-----------------LTLPLEQLSADA
MAB_0252|M.abscessus_ATCC_1997 DKIPGVTRLDTGYYGEFGKHPNQVIVGPDGHGSYWDDPSSDAFHNIAAVI
* : . : .:. ::
MUL_5057|M.ulcerans_Agy99 SGHPDR------LASDDLIAEGRRQP--------HVG---PLRVP----G
MMAR_5468|M.marinum_M SGHPDR------LASDDLIAEGRRQP--------HVG---PFRVP----G
Mb2105|M.bovis_AF2122/97 SGHGDA------LASDGMLAQPRHQPGVEID-IPGLGSV-EIDIP----G
Rv2079|M.tuberculosis_H37Rv SGHGDA------LASDGMLAQPRHQPGVEID-IPGLGSV-EIDIP----G
MAV_5292|M.avium_104 TGRGNE------LAAEGMLAPDRNAARVSILGRVHTPLG-TLSLPRVEIR
TH_4294|M.thermoresistible__bu NGNGAT------LAENGYTAEGRRQVHIGLPDTVNLPFIGEVDLPDWDTR
Mvan_0049|M.vanbaalenii_PYR-1 TGNGGR------LDELGLLAQPRTELTVSTPQQLDVPVLGEVPLPHLEVE
MSMEG_6381|M.smegmatis_MC2_155 AVTPDG------VSREGAVAHADYPRPVELPSGEKVLRTPAYNLA-----
MAB_0252|M.abscessus_ATCC_1997 GGGEATGYVERGIQTNYVDINVGDDGNFRAEAWDQSRAAAGAQVPGLPWD
: :.
MUL_5057|M.ulcerans_Agy99 VP---AYIDPESDRPRDTVHDDHHYPAYQPPR
MMAR_5468|M.marinum_M VP---AYIDPESDRPRDTVHDDHHYPAYQPPR
Mb2105|M.bovis_AF2122/97 TP---ASIDPEWSRPPGSITDDHVFDAPLHR-
Rv2079|M.tuberculosis_H37Rv TP---ASIDPEWSRPPGSITDDHVFDAPLHR-
MAV_5292|M.avium_104 MP---VVVDPEWERPARSVTNEHGF-------
TH_4294|M.thermoresistible__bu IPGTPAVNDPEGDRD--HVTQNHQY-------
Mvan_0049|M.vanbaalenii_PYR-1 TP---VIYDPEWNRAGGSVTNDHGY-------
MSMEG_6381|M.smegmatis_MC2_155 ------VIAAGLADVPGPNGEDRLVR------
MAB_0252|M.abscessus_ATCC_1997 DPGTIDRRHHPWDNPRVTDHPEHGQKIQVK--
::