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M. thermoresistible (build 8) TH_4249 (-)

annotation: dihydrodipicolinate reductase
coordinates: 3248231 - 3249289
length: 353

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_4249--100% (353)dihydrodipicolinate reductase
M. thermoresistible (build 8)TH_2632-3e-6635.90% (351) PUTATIVE dihydrodipicolinate reductase, N-terminus domain
M. thermoresistible (build 8)TH_1493-1e-4634.08% (355) CONSERVED HYPOTHETICAL PROTEIN

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1088-1e-3833.14% (347) hypothetical protein Mb1088
M. gilvum PYR-GCKMflv_1277-1e-15674.86% (350) dihydrodipicolinate reductase
M. tuberculosis H37RvRv1059-1e-3833.14% (347) hypothetical protein Rv1059
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_0727-2e-6837.46% (347) putative dihydrodipicolinate reductase
M. marinum MMMAR_5250-1e-15071.71% (350) hypothetical protein MMAR_5250
M. avium 104MAV_0371dapB1e-15071.88% (352) dihydrodipicolinate reductase
M. smegmatis MC2 155MSMEG_0560dapB1e-15472.65% (351) dihydrodipicolinate reductase N-terminus domain-containing
M. ulcerans Agy99MUL_3685-3e-7443.70% (341) hypothetical protein MUL_3685
M. vanbaalenii PYR-1Mvan_5538-1e-15975.92% (353) dihydrodipicolinate reductase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_1277|M.gilvum_PYR-GCK          MPNNAPHRVVQWTTGNVGKSSVAAITANPTLELVGCYAWSDDKVGRDVGE
Mvan_5538|M.vanbaalenii_PYR-1       MPNTASYRVVQWTTGNVGKSSVAAIAGNPTLELVGCYAWSDDKVGRDAGE
TH_4249|M.thermoresistible__bu      VPN-TPYRVVQWTTGNVGKSSVQALAANPLYELVGVYAWSPDKVGRDAGE
MMAR_5250|M.marinum_M               MPNS--YRVVQWTTGNVGKSSLQAIATHPALELVGCYAWSQEKAGRDAGE
MAV_0371|M.avium_104                MPNT--YRVVQWNTGNVGKSSLKSIVTNPTLELVGCYAWSAEKVGRDAGE
MSMEG_0560|M.smegmatis_MC2_155      MPDTTGYRVVQWTTGNVGKSSVAAIAKNPTLELVGCYAWSGDKVGKDVGE
MAB_0727|M.abscessus_ATCC_1997      ---MSVIRVFQVATGNVGTEMIRRIASHPDLELAGLHCYSPEKVGRDAGE
MUL_3685|M.ulcerans_Agy99           MSTARPLRVIQWTTGNIGRRSLHAIIGRPDLELVGVYAHGPDKVGVDAAE
Mb1088|M.bovis_AF2122/97            --MTMSLRVIQWATGSVGVAAIKGVLQHPELELVGCWVHSAAKSGKDVGE
Rv1059|M.tuberculosis_H37Rv         --MTMSLRVIQWATGSVGVAAIKGVLQHPELELVGCWVHSAAKSGKDVGE
                                           **.*  **.:*   :  :  .*  **.*    .  * * *..*

Mflv_1277|M.gilvum_PYR-GCK          LVGIE-PLGVAATNDVDALLALKPDAVVYNPMWIDVDELVRILEAGVNVV
Mvan_5538|M.vanbaalenii_PYR-1       LAGIE-PVGVTATNNVDALLALKPDVVVYNPMWIDVDELVRILEAGVNVV
TH_4249|M.thermoresistible__bu      LAGIE-PLGVKATNDVDELLALKPDVVVYNPMWIDVDELVRILSAGINVV
MMAR_5250|M.marinum_M               LCGMA-PLGITASNDVEALLALKPDCVVYNPMWIDVDELVRILSAGVNVV
MAV_0371|M.avium_104                LVGIP-PLGVAATNDVDELLALKPDCVVYNPMWIDVDELVRILSAGVNVV
MSMEG_0560|M.smegmatis_MC2_155      LCGIE-PLGVSATDDVDALLALKPDVVVYNPMWIDVDELVRILESGVNVV
MAB_0727|M.abscessus_ATCC_1997      LVGLE-PNGVIATGTVEEIVAAKPDVLTFHGVFPDEDLYVKVLEAGIDIV
MUL_3685|M.ulcerans_Agy99           LAGWPDPTGVRATSDIGALLALGADACCYNPLWPNIDELVGLLESGVNVC
Mb1088|M.bovis_AF2122/97            IIGSP-PLGVIATNSIDDVLALDADAVIYAPLLPSVDEVAALLRSGKNVV
Rv1059|M.tuberculosis_H37Rv         IIGSP-PLGVIATNSIDDVLALDADAVIYAPLLPSVDEVAALLRSGKNVV
                                    : *   * *: *:. :  ::*  .*   :  :  . *  . :* :* :: 

Mflv_1277|M.gilvum_PYR-GCK          ASASFITGHNLG------DGR---AKLADACERGGSTLFGSGVSPG-FAE
Mvan_5538|M.vanbaalenii_PYR-1       ASASFITGRNLG------DGR---DKLADACQRGGSTLFGSGVSPG-FAE
TH_4249|M.thermoresistible__bu      SSASFITGHNLR------DGR---DRIEEACRQGGSTMFGSGISPG-FAE
MMAR_5250|M.marinum_M               TTAAFITGHNLG------AGR---DRILAACRHGGSTIFGSGVSPG-FAE
MAV_0371|M.avium_104                TTASFITGGNLG------DGR---DRILQACQQGGSTIFGSGVSPG-FAE
MSMEG_0560|M.smegmatis_MC2_155      STASFITGHNQG------TGR---DRIAEACTRGGSSMFGSGISPG-YVN
MAB_0727|M.abscessus_ATCC_1997      TTADWITGHHRDQNHPHPSGRPTTEVLQQACERGGSTFYGTGMNPG-LTQ
MUL_3685|M.ulcerans_Agy99           TSAAWITGGKQTP-----RDR---ERILAACERGGATIFGSDAHPG-MTN
Mb1088|M.bovis_AF2122/97            TPLGWFYPSEKE-----------AAPLEVAAQAGNATLHGAGIGPGAVTE
Rv1059|M.tuberculosis_H37Rv         TPLGWFYPSEKE-----------AAPLEVAAQAGNATLHGAGIGPGAVTE
                                    :.  ::   .                :  *.  *.:::.*:.  **  .:

Mflv_1277|M.gilvum_PYR-GCK          LLAIVAGTACDRIDKVVISESADTTLYDSPDTER-PVGFDMAIDDPALQP
Mvan_5538|M.vanbaalenii_PYR-1       LLAIVAGTACDRIDKITIAESADTTLYDSPDTER-PVGFGTAIDDPNLQP
TH_4249|M.thermoresistible__bu      LLAIIGTQMCDRVDKVTICEQSDTTFYDSPATEK-PVGFGTPIDDPNLPQ
MMAR_5250|M.marinum_M               LLAIVSAMVCNRIDKVTVNEAADTTFYDSPATER-PVGFGQPIDHPQLQA
MAV_0371|M.avium_104                LLAIVSAMVCNRIDKVTVNEAADTTFYDSPETEK-PVGFGQPIDHPDLPA
MSMEG_0560|M.smegmatis_MC2_155      QLSVVAAGICDRVDKITVNEAADTTFYDSPATEK-PVGFGQPIDHPDLQA
MAB_0727|M.abscessus_ATCC_1997      ILGVIHSCDVAEIENVTVIESVDVSCHHSVDSWE-MVGYGLPVGDPSIPA
MUL_3685|M.ulcerans_Agy99           MVGMVLSGSCERVDEIRITESVDCSTYESAATQT-AMGFSQHPDTPGLAE
Mb1088|M.bovis_AF2122/97            LFPLLLSVMSTGVTFVRSEEFSDLRSYGAPDVLRYVMGFGGTPDSALTGP
Rv1059|M.tuberculosis_H37Rv         LFPLLLSVMSTGVTFVRSEEFSDLRSYGAPDVLRYVMGFGGTPDSALTGP
                                     . ::       :  :   *  *   : :       :*:.   . .    

Mflv_1277|M.gilvum_PYR-GCK          MAAQGTAVFAEAVQLVADALGIELD-EITCVSEYAQTTEDLPMASWTIKA
Mvan_5538|M.vanbaalenii_PYR-1       MAANGTAVFAEAVQLVADALAIELD-EIKCVSEYAQTTEDLVMASWTIPA
TH_4249|M.thermoresistible__bu      MASQGTAIFAEAVQLIADSLGVELD-EIVCEAEYAQTTEDLDLGSWKIGA
MMAR_5250|M.marinum_M               MTAQGTAIFGEAVRLVADALGVELD-EVRCVAEHAQTTADLDLGSWTIAA
MAV_0371|M.avium_104                MAAKGTAIFGEAVRLVGDALGVELD-DVRCVAEFAQTTEDLVMASWTIPA
MSMEG_0560|M.smegmatis_MC2_155      MTAQGTGVFGEAVRMIADALGIELD-EVRCDAEYAQTTEDLDLGSWTIPA
MAB_0727|M.abscessus_ATCC_1997      LLEKGTRVFADGVYLMADCFGLELD-DVTFSYELGACTEDIDLGWYRLPK
MUL_3685|M.ulcerans_Agy99           SVRVESEVFAESAAMMADAIGATLD-KMTFDVTFTAATADTDLGFMKIPA
Mb1088|M.bovis_AF2122/97            MQKILDGGFLQSVRLCVDRLGFAADPQIRTSQEVAVATAPIDSPIGVIEP
Rv1059|M.tuberculosis_H37Rv         MQKILDGGFLQSVRLCVDRLGFAADPQIRTSQEVAVATAPIDSPIGVIEP
                                            * :.. :  * :.   * .:         *         :  

Mflv_1277|M.gilvum_PYR-GCK          GHVAGVFASWQGIYQGRTVIDINVRWKKG-QTLEPDW--QLDGDGWKITI
Mvan_5538|M.vanbaalenii_PYR-1       GHVAGVYASWQGIANGKTVIDINVRWKKG-QTLDPDW--QLDGDGWKITI
TH_4249|M.thermoresistible__bu      GCVAGVYASWQGRIGGRTLIDLNVRWKKG-QTLEPNW--QLEREGWKITV
MMAR_5250|M.marinum_M               GCVAGVHASWQGVAGGRTIVELNVRWRKG-QTLEPDW--QIDQDGWVIQV
MAV_0371|M.avium_104                GHVAGTYISWQGIVGDQVLIDLNVRWRKG-QTLDPDW--KIEQDGWVIQI
MSMEG_0560|M.smegmatis_MC2_155      GCVAGVYASWKGIVAGHTRVEINVRWRKG-QTLQPDW--KIDQDGWVIEV
MAB_0727|M.abscessus_ATCC_1997      GSLGANYLKYQGIVGGVPKVEVHVEWQMT-PKTEPHW--NVKG-CYITKI
MUL_3685|M.ulcerans_Agy99           GTVGSVYGYHRGWVGDRNVVSVGFNWTMG-NHVVPPK--PLKH-GHVIQV
Mb1088|M.bovis_AF2122/97            GQVAGRRFHWEALVEDTVVVQIAVNWLMGSENLDPPWSFGPAGERYEIEV
Rv1059|M.tuberculosis_H37Rv         GQVAGRRFHWEALVEDTVVVQIAVNWLMGSENLDPPWSFGPAGERYEIEV
                                    * :..     ..   .   :.: ..*        *              :

Mflv_1277|M.gilvum_PYR-GCK          EGRPTVNMSVGFLPPQDMIENAKTLEDFFVLGHIMTALPPIHAIPAVVAA
Mvan_5538|M.vanbaalenii_PYR-1       DGRPTVNMQVGFLPPQDMIENAKTLEDFFVLGHIMTAMPPIHAIPAVVAA
TH_4249|M.thermoresistible__bu      DGRPTVNMEIGFLPPPDFG--ATTMEEFMVLGHIMTAMPPIHMIPAVVAA
MMAR_5250|M.marinum_M               DGTPTVTTKVSFLPPPYFQ--AETIADFMVLGHIMTAMPTINAIPAVVAA
MAV_0371|M.avium_104                DGQPTVTTKVGFLPPPYFE--ATTIEEFMDLGHIMTAMPAINAIPAVVAA
MSMEG_0560|M.smegmatis_MC2_155      AGRPTVTMKVGFLPPPDFE--ATTLEEFMVLGHIMTATPPLNAIPAVVAA
MAB_0727|M.abscessus_ATCC_1997      QGDPCVYSKHMVIPKPGTD--FTDPAAFASVGMTVTGLPALNAIRSVIDA
MUL_3685|M.ulcerans_Agy99           FGLPNMRTVLHCLPPKDWT-----ESGFMGLGMIYTAMPVTNAVPAVVAA
Mb1088|M.bovis_AF2122/97            RGSPDTCVTIKGWQPQTVA-----AGLKSNPGIVATAAHCVNAIPATCAA
Rv1059|M.tuberculosis_H37Rv         RGSPDTCVTIKGWQPQTVA-----AGLKSNPGIVATAAHCVNAIPATCAA
                                     * *                           *   *.    : : :.  *

Mflv_1277|M.gilvum_PYR-GCK          APGIATYNDLPLPLPRGVVPTR-------------
Mvan_5538|M.vanbaalenii_PYR-1       APGIATYNDLPLPTPRGVVPTA-------------
TH_4249|M.thermoresistible__bu      EPGIATYNDLPLPQARGVVRV--------------
MMAR_5250|M.marinum_M               APGIVTYSDLALTLPRGMVPTDRNSDPKLGASRTP
MAV_0371|M.avium_104                APGIASYADLPLTLPRGNAHVAGQP----------
MSMEG_0560|M.smegmatis_MC2_155      PPGIVTYNDLPLILPRGVVPTP-------------
MAB_0727|M.abscessus_ATCC_1997      PPGILTSADLPLRGFAGRFK---------------
MUL_3685|M.ulcerans_Agy99           KPGIVTLADLPPITGRAAL----------------
Mb1088|M.bovis_AF2122/97            PAGIQSFFDLPLITGRAAPGLAR------------
Rv1059|M.tuberculosis_H37Rv         PAGIQSFFDLPLITGRAAPGLAR------------
                                     .** :  **.     .