For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. thermoresistible (build 8) TH_3817 (-)

annotation: pyridine nucleotide-disulphide oxidoreductase dimerisation region
coordinates: 2627640 - 2629055
length: 472

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_3817--100% (472)pyridine nucleotide-disulphide oxidoreductase dimerisation region
M. thermoresistible (build 8)TH_3945-4e-5834.20% (462) PUTATIVE pyridine nucleotide-disulphide oxidoreductase
M. thermoresistible (build 8)TH_4200-2e-4729.62% (476) PUTATIVE dihydrolipoamide dehydrogenase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2880mtr0.070.59% (459) mycothione reductase
M. gilvum PYR-GCKMflv_4054-0.073.46% (471) mycothione/glutathione reductase
M. tuberculosis H37RvRv2855mtr0.070.59% (459) mycothione reductase
M. leprae Br4923MLBr_02387lpd3e-4327.52% (487) dihydrolipoamide dehydrogenase
M. abscessus ATCC 19977MAB_0062-1e-15660.09% (466) mycothione reductase
M. marinum MMMAR_1875mtr0.069.06% (459) NADPH-dependent mycothiol reductase Mtr
M. avium 104MAV_3710-0.071.24% (459) mycothione/glutathione reductase
M. smegmatis MC2 155MSMEG_2611-0.067.97% (459) mycothione/glutathione reductase
M. ulcerans Agy99MUL_2214lpd3e-4227.57% (486) dihydrolipoamide dehydrogenase
M. vanbaalenii PYR-1Mvan_2298-0.072.82% (471) mycothione/glutathione reductase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_4054|M.gilvum_PYR-GCK          MADFDLAIIGTGSGNSILDERYVDK--RVAICEQGVFG----GTCLNVGC
Mvan_2298|M.vanbaalenii_PYR-1       MADFDIAIIGTGSGNSILDERYVDK--RVAICEEGVFG----GTCLNVGC
TH_3817|M.thermoresistible__bu      MRHFDIAIIGTGSGNSLLDERYADK--KVAICEKAVFG----GTCLNVGC
Mb2880|M.bovis_AF2122/97            METYDIAIIGTGSGNSILDERYASK--RAAICEQGTFG----GTCLNVGC
Rv2855|M.tuberculosis_H37Rv         METYDIAIIGTGSGNSILDERYASK--RAAICEQGTFG----GTCLNVGC
MMAR_1875|M.marinum_M               METYDLAIIGTGSGNSILDERYAGK--RAAICEQGTFG----GTCLNVGC
MAV_3710|M.avium_104                METYDLAIIGTGSGNSLLDARFAGK--RTAICEHGTFG----GTCLNVGC
MSMEG_2611|M.smegmatis_MC2_155      MEHYDLAIIGTGSGNSIVDDRYAGK--KVAICEQGTFG----GTCLNVGC
MAB_0062|M.abscessus_ATCC_1997      --MYDLVIIGSGSANSLPDDRFADQ--EIAIVDRGVYGGAYGGTCLNVGC
MLBr_02387|M.leprae_Br4923          MTHYDVVVLGAGPGGYVAAIRAAQLGLSTAVVEPKYWG----GICLNVGC
MUL_2214|M.ulcerans_Agy99           MTHYDVVVLGAGPAGYVAAIRAAQLGLNTAIVEPKYWG----GVCLNVGC
                                       :*:.::*:*... :   * .      *: :   :*    * ******

Mflv_4054|M.gilvum_PYR-GCK          IPTKMFVYAAGVAEQIRESARFGVDGRLDGVRWPDIVSRVFGRIDPLAGG
Mvan_2298|M.vanbaalenii_PYR-1       IPTKMFVYAAGVAHDIRESSRFGVDSHIDDVRWTDIVSRVFGRIDPLASG
TH_3817|M.thermoresistible__bu      IPTKMFVYTADVAQTVRDASRFGVDAELRAVRWPDIVSRVFGRIDPIAAS
Mb2880|M.bovis_AF2122/97            IPTKMFVYAAEVAKTIRGASRYGIDAHIDRVRWDDVVSRVFGRIDPIALS
Rv2855|M.tuberculosis_H37Rv         IPTKMFVYAAEVAKTIRGASRYGIDAHIDRVRWDDVVSRVFGRIDPIALS
MMAR_1875|M.marinum_M               LPTKMFVYAAEVAQTIRGASRYGVDAHIDRVRWDDIVSRVFGRIDPIAHS
MAV_3710|M.avium_104                IPTKMFVYAADVATTIREAARYGVDAHLDGVRWPDIVSRVFGRIDPIALS
MSMEG_2611|M.smegmatis_MC2_155      IPTKMFVYAAEVAHSVRTSARYGVDAHIDKVRWPDIVERVFGRIDPIAAG
MAB_0062|M.abscessus_ATCC_1997      IPTKMFVYPADLADEAREGARLGVDSSVNGTRWGDIRDRVFGRIDPIAAA
MLBr_02387|M.leprae_Br4923          IPSKVLLHNAELAHIFTKEAKTFGISGDASFDYGIAYDRSR-KVSEGRVA
MUL_2214|M.ulcerans_Agy99           IPSKALLRNAELAHIFTKDAKAFGISGEATFDYGVAFDRSR-KVAEGRVA
                                    :*:* ::  * :*      ::    .      :    .*   ::     .

Mflv_4054|M.gilvum_PYR-GCK          GEQYRRS-SPNVEVFASHTRFAGPDSGDG----YRLHTDDGDEFTAEQVV
Mvan_2298|M.vanbaalenii_PYR-1       GEHYRRS-SPNVEVFASHARFV-PGSGDG----YRLCTADGDEFTAEQVV
TH_3817|M.thermoresistible__bu      GENYRRS-SPNVEVFDTHTRFGEPLGDGR----YVLRTEAGEEFSADQVV
Mb2880|M.bovis_AF2122/97            GEDYRRC-APNIDVYRTHTRFGPVQADGR----YLLRTDAGEEFTAEQVV
Rv2855|M.tuberculosis_H37Rv         GEDYRRC-APNIDVYRTHTRFGPVQADGR----YLLRTDAGEEFTAEQVV
MMAR_1875|M.marinum_M               GEDYRRS-APNIDVYGSHTRFGPTQADGR----YLLRTAAGDEFTADQVV
MAV_3710|M.avium_104                GEEYRRS-SVNIDLYRSHTRFGPVQSDGR----YLLRTDAGEQFTAEQVV
MSMEG_2611|M.smegmatis_MC2_155      GEDYRRS-DPNITVYSSHTRFGPKTDDGR----YTLRTESGEEFTSDQVV
MAB_0062|M.abscessus_ATCC_1997      GLRYRVEDCPNITVFQQEARFIEPGTDADGDSVHRLKLGDGTVLEARQVV
MLBr_02387|M.leprae_Br4923          GVHFLMK-KNKITEIHGYGRFTDANTLSVELS--EGVPETPLKVTFNNVI
MUL_2214|M.ulcerans_Agy99           GVHFLMK-KNKITEIHGYGKFTDANTLSVDLN--DGGTE---KVTFDNAI
                                    *  :      ::       :*                      .   :.:

Mflv_4054|M.gilvum_PYR-GCK          IAAGARATVPQAILECGVPYHTSDTIMRISDLPEHLVIVGGGFVAAEFAH
Mvan_2298|M.vanbaalenii_PYR-1       IAAGARATVPPAIADCGVKFHTSDTIMRISELPEHLVIVGGGFVAAEFAH
TH_3817|M.thermoresistible__bu      IAAGSRAVVPEAIAACGVPYHTSDTIMRIAAIPEHLIIVGGGFVAAEFAH
Mb2880|M.bovis_AF2122/97            IAAGSRPVIPPAILASGVDYHTSDTVMRIAELPEHIVIVGSGFIAAEFAH
Rv2855|M.tuberculosis_H37Rv         IAAGSRPVIPPAILASGVDYHTSDTVMRIAELPEHIVIVGSGFIAAEFAH
MMAR_1875|M.marinum_M               IAAGSRPVVPQAIAESGLKYHTSDTVMRIAELPEHVVIVGSGFVAAEFAH
MAV_3710|M.avium_104                IAAGSRPVIPPAILESGVTYHTSDTIMRIPALPEHLVIVGSGFVAAEFAH
MSMEG_2611|M.smegmatis_MC2_155      IAAGSRTYIPPAVVDCGVKYHTSDDIMRIPELPTDLVIIGGGFVSAEFAH
MAB_0062|M.abscessus_ATCC_1997      IAAGSRPVIPPVIAASGVPYHTNDDIMRLPELPGRVLIVGSGFIAAEFAH
MLBr_02387|M.leprae_Br4923          IATGSKTRLVPGTLLS-TNVITYEEQILTRELPDSIVIVGAGAIGIEFGY
MUL_2214|M.ulcerans_Agy99           IATGSSTRLVPGTSLS-TNVVTYEEQILTRELPKSIIIAGAGAIGMEFGY
                                    **:*: . :      .     * :  :    :*  ::* *.* :. **.:

Mflv_4054|M.gilvum_PYR-GCK          VFSALGSRVTIVLRGTTMLSHCDDTVCERFTDIAGKK-WEIRSRRNIVSG
Mvan_2298|M.vanbaalenii_PYR-1       VFSSLGSRVTIVLRGTTMLSHCDDTVCERFTDIAGKK-WEIRSRRNVVGG
TH_3817|M.thermoresistible__bu      VFSALGSRVSIIIRGNTLLRGHDDDITTRFTDLAAKK-WEIHGQREVVDA
Mb2880|M.bovis_AF2122/97            VFSALGVRVTLVIRGSCLLRHCDDTICERFTRIASTK-WELRTHRNVVDG
Rv2855|M.tuberculosis_H37Rv         VFSALGVRVTLVIRGSCLLRHCDDTICERFTRIASTK-WELRTHRNVVDG
MMAR_1875|M.marinum_M               VFSTLGARVTLVIRGSCLLRHCDDTICERFTRIASTK-WELRTHRNIVGG
MAV_3710|M.avium_104                IFSALGVHVTVVIRSGRMLRQYDDMICERFTRLAAAK-WELRTQRNVVGG
MSMEG_2611|M.smegmatis_MC2_155      VFSALGVHVTIVVRGDGLLTHCDETICHRFNEIAATK-WDIRTHENVIGS
MAB_0062|M.abscessus_ATCC_1997      VFSGLGSKVTVIARGPRLLRAQDETISRRFTEIVGQR-WDVRLNTEAVGL
MLBr_02387|M.leprae_Br4923          VLKNYGVDVTIVEFLPRAMPNEDAEVSKEIEKQFKKMGIKILTGTKVESI
MUL_2214|M.ulcerans_Agy99           VLKNYGVDVTIVEFLPRALPNEDAEVSKEIERQFKKLGVKIRTGTKVESI
                                    ::.  *  *:::      :   *  :  .:         .:    :  . 

Mflv_4054|M.gilvum_PYR-GCK          ESDGSG-VSLRLDDGA--TLRADVLLVATGRVPNGDRLDAHLAGVEVTD-
Mvan_2298|M.vanbaalenii_PYR-1       QSDESG-LTLRLDDDS--TVHADALLVATGRVPNGDLLDAHHAGVEVAD-
TH_3817|M.thermoresistible__bu      RALDGG-VEVRCDDGS--TLRGDVLLVATGRVPNGDLLDAELAGVQVREH
Mb2880|M.bovis_AF2122/97            QQRGSG-VALRLDDGC--TINADLLLVATGRVSNADLLDAEQAGVDVE-D
Rv2855|M.tuberculosis_H37Rv         QQRGSG-VALRLDDGC--TINADLLLVATGRVSNADLLDAEQAGVDVE-D
MMAR_1875|M.marinum_M               ENRGSG-VVLQLDDGS--TIDADLLLVATGRVSNADLIDAEQAGVAVA-D
MAV_3710|M.avium_104                NNRGSG-VTLRLDDGS--TLDADVLLVATGRISNADLLDAGQAGVDVE-N
MSMEG_2611|M.smegmatis_MC2_155      HQDGDR-IVLELDDGK--TVAADTLLVATGRVPNGDLLDAELAGVEVDED
MAB_0062|M.abscessus_ATCC_1997      RETGSGGVEVDLSDGS--TVTGDVLLVATGRTPNGDQLDVAAAGLTLDAK
MLBr_02387|M.leprae_Br4923          SDNGSHVLVAVSKDGQFQELKADKVLQAIGFAPNVDGYGLDKVGVALTAD
MUL_2214|M.ulcerans_Agy99           SDDGSAVTVVVSKGGKSEELKADKVLQAIGFAPNVEGYGLDKAGVALTDR
                                        .       ...    : .* :* * *  .* :  .   .*: :   

Mflv_4054|M.gilvum_PYR-GCK          GLVTVDEFQRTTARNVFALGDVSSPYQLKHVANHEARVVKHNLLQDWDDT
Mvan_2298|M.vanbaalenii_PYR-1       GLVVVDEFQRTTARNIFALGDVSSPYQLKHVANHEARVVRHNLLQGWDDT
TH_3817|M.thermoresistible__bu      GQVVVDEYQRTTARGIYALGDVSSDHQLKHVANHEARVVKHNLLQDWDDT
Mb2880|M.bovis_AF2122/97            GRVIVDEYQRTSARGVFALGDVSSPYLLKHVANHEARVVQHNLLCDWEDT
Rv2855|M.tuberculosis_H37Rv         GRVIVDEYQRTSARGVFALGDVSSPYLLKHVANHEARVVQHNLLCDWEDT
MMAR_1875|M.marinum_M               GRVVVDQYQRTSARGVFALGDVSSPYQLKHVANHEARVVQQNLLCDWDDT
MAV_3710|M.avium_104                GRVVVDEYQRTSARGVFALGDVSSPYQLKHVANHEARVVRHNLLCDWDDT
MSMEG_2611|M.smegmatis_MC2_155      GRVIVDQYQRTTARGVFALGDVSSDYQLKHVANHEARVVKENLLRDWDDT
MAB_0062|M.abscessus_ATCC_1997      GSVPVDQYQRTAVRGIYALGDVSSKYLLKHVANHEARVVQANLLSGWDSP
MLBr_02387|M.leprae_Br4923          KAVDIDDYMQTNVSHIYAIGDVTGKLQLAHVAEAQGVVAAEAIAG----A
MUL_2214|M.ulcerans_Agy99           KAIGIGEYMQTSVGHIYAIGDVTGQLMLAHVAEAMGVVAAETIAG----A
                                      : :.:: :* .  ::*:***:.   * ***:  . *.   :      .

Mflv_4054|M.gilvum_PYR-GCK          EALMPANHDNVPSAVFTEPQIACVGLTENEARAAGYRIRSKVQDYGDVAY
Mvan_2298|M.vanbaalenii_PYR-1       ENLMPANHRNVPSAVFTEPQIACVGLTENEARSAGYRIRSKVQDYGDVAY
TH_3817|M.thermoresistible__bu      AALAASDHRYVPSAVFTDPQIASVGLTENEARSRGLPIKVKIQDYSDVAY
Mb2880|M.bovis_AF2122/97            QSMIVTDHRYVPAAVFTDPQIAAVGLTENQAVAKGLDISVKIQDYGDVAY
Rv2855|M.tuberculosis_H37Rv         QSMIVTDHRYVPAAVFTDPQIAAVGLTENQAVAKGLDISVKIQDYGDVAY
MMAR_1875|M.marinum_M               ESMAVTDHRFVPAAVFTGPQLAGVGLTENEAVAKGLDITVAIQEYADVGY
MAV_3710|M.avium_104                ESMAVTDHRYVPSAVFTDPQLATVGLTENQAIARGFDISVAIQNYGDVAY
MSMEG_2611|M.smegmatis_MC2_155      ASLVASDHRFVPSAVFTDPQVATVGLTEAEARAAGHDIVVKVQNYGDTAY
MAB_0062|M.abscessus_ATCC_1997      T--TASDHRYVPGAVFTRPQVASVGLSEEQARERGLDIAVKVQTYGDIAY
MLBr_02387|M.leprae_Br4923          ETLALSDYRMMPRATFCQPNVASFGLTEQQARDGGYDVVVAKFPFTANAK
MUL_2214|M.ulcerans_Agy99           ETLPLGDYRMLPRATFCQPQVASFGLTEQQARDEGYDVKVAKFPFTANGK
                                          ::  :* *.*  *::* .**:* :*   *  :      :   . 

Mflv_4054|M.gilvum_PYR-GCK          GWAMEDSTGFAKLIVDDETGLLLGAHIMGHQASSIIQPLIQAMAFGLPAQ
Mvan_2298|M.vanbaalenii_PYR-1       GWAMEDSTGFAKLIVDDDTGLLLGAHIMGHQASSIIQPIVQAMAFDLPAQ
TH_3817|M.thermoresistible__bu      GWAMEDTTGFVKVIVDDSTGLIAGAHIMGHQAASLIQPLIQAMSFGLPAR
Mb2880|M.bovis_AF2122/97            GWAMEDTSGIVKLITERGSGRLLGAHIMGYQASSLIQPLIQAMSFGLTAA
Rv2855|M.tuberculosis_H37Rv         GWAMEDTSGIVKLITERGSGRLLGAHIMGYQASSLIQPLIQAMSFGLTAA
MMAR_1875|M.marinum_M               GWAMEDTTGFVKLVGDRATGRLLGAHIMGYHASTVIQPLIQAMSFGLTAA
MAV_3710|M.avium_104                GWAMEDTTGVVKLIAERTSGRLLGAHIMGPQASSIIQPLIQAMSFGLTAA
MSMEG_2611|M.smegmatis_MC2_155      GWAMEDTTGIAKLIGERGTGKLLGAHILGHQASSIIQPLIQAMSLGQTAQ
MAB_0062|M.abscessus_ATCC_1997      GWAMEDTEGLCKLIADRATGLLVGAHIIGYQASALIQSLITAMSFSIPAR
MLBr_02387|M.leprae_Br4923          AHGMGDPSGFVKLVADAKYGELLGGHMIGHNVSELLPELTLAQKWDLTAT
MUL_2214|M.ulcerans_Agy99           AHGLGDPSGFVKLVADGKHGELLGGHLVGHDVSELLPELTLAQKWDLTAT
                                    . .: *. *. *:: :   * : *.*::* ..: ::  :  *   . .* 

Mflv_4054|M.gilvum_PYR-GCK          DMARGQYWIHPALPEVVENALLSLCGEPPWPRPRRH
Mvan_2298|M.vanbaalenii_PYR-1       DMARGQYWIHPALPEVVENALLALCGEPPWPPSKRH
TH_3817|M.thermoresistible__bu      DMARGQYWIHPALPEVVENALLALCGEPPWPPAKRH
Mb2880|M.bovis_AF2122/97            EMARGQYWIHPALPEVVENALLGLR-----------
Rv2855|M.tuberculosis_H37Rv         EMARGQYWIHPALPEVVENALLGLR-----------
MMAR_1875|M.marinum_M               EMARGQYWIHPALPEVIENALLNLR-----------
MAV_3710|M.avium_104                QMARGQYWIHPALPEVVENALLGLY-----------
MSMEG_2611|M.smegmatis_MC2_155      EIARGQYWIHPALPEVIENALLGLQE----------
MAB_0062|M.abscessus_ATCC_1997      EMARGQYWIHPALPELVENALLGLDL----------
MLBr_02387|M.leprae_Br4923          ELVR-NVHTHPTLSEALQECFHGLIGHMINF-----
MUL_2214|M.ulcerans_Agy99           ELAR-NVHTHPTMSEALQECFHGLAGHMINF-----
                                    ::.* :   **::.* :::.:  *