For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
aa seq not available
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. thermoresistible (build 8) | TH_2598 | - | - | 100% (564) | AMP-dependent synthetase and ligase |
| M. thermoresistible (build 8) | TH_4443 | - | e-174 | 59.16% (546) | PUTATIVE AMP-dependent synthetase and ligase |
| M. thermoresistible (build 8) | TH_4377 | - | 2e-96 | 38.52% (553) | PUTATIVE AMP-dependent synthetase and ligase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3544c | fadD19 | 4e-89 | 34.93% (564) | acyl-CoA synthetase |
| M. gilvum PYR-GCK | Mflv_4335 | - | 1e-162 | 54.14% (543) | acyl-CoA synthetase |
| M. tuberculosis H37Rv | Rv3515c | fadD19 | 4e-89 | 34.93% (564) | acyl-CoA synthetase |
| M. leprae Br4923 | MLBr_02546 | fadD2 | 9e-25 | 24.04% (545) | acyl-CoA synthetase |
| M. abscessus ATCC 19977 | MAB_4163c | - | 2e-92 | 35.62% (553) | acyl-CoA synthetase |
| M. marinum M | MMAR_4007 | fadD19_2 | 1e-169 | 56.62% (544) | fatty-acid-CoA ligase FadD19_2 |
| M. avium 104 | MAV_1600 | - | 1e-169 | 55.84% (548) | acyl-CoA synthetase |
| M. smegmatis MC2 155 | MSMEG_3687 | - | 0.0 | 77.80% (545) | acyl-CoA synthetase |
| M. ulcerans Agy99 | MUL_3870 | fadD19_2 | 1e-166 | 55.88% (544) | acyl-CoA synthetase |
| M. vanbaalenii PYR-1 | Mvan_2010 | - | 1e-165 | 55.06% (543) | acyl-CoA synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3544c|M.bovis_AF2122/97 -----------------------------------------MAVALNIAD
Rv3515c|M.tuberculosis_H37Rv -----------------------------------------MAVALNIAD
MAB_4163c|M.abscessus_ATCC_199 -------------------------------------------MALNIAD
TH_2598|M.thermoresistible__bu --------------------------------MDPTGKDVHNATTFDLST
MSMEG_3687|M.smegmatis_MC2_155 -----------------------------------------MSVSFDLST
MMAR_4007|M.marinum_M -----------------------------------------MTTQFTVPA
MUL_3870|M.ulcerans_Agy99 -----------------------------------------MTTQFTVPA
MAV_1600|M.avium_104 --------------------------------------MSDTTTAFTVPA
Mflv_4335|M.gilvum_PYR-GCK ---------------------------------------MTEPNQFTVPA
Mvan_2010|M.vanbaalenii_PYR-1 ---------------------------------------MTESIQFTVPA
MLBr_02546|M.leprae_Br4923 MTKLRHYLERGAAEVHYLRSIFESGALGFEPPLTYAAMAVAMRKWGDLAM
:.
Mb3544c|M.bovis_AF2122/97 LAEHAIDAVPDRVAVICGDEQLTYAQLEDKANRLAHHLIDQGVQKD----
Rv3515c|M.tuberculosis_H37Rv LAEHAIDAVPDRVAVICGDEQLTYAQLEDKANRLAHHLIDQGVQKD----
MAB_4163c|M.abscessus_ATCC_199 LIEHAIDTMPDRVAIISGDRKLTYAELEEQSNRLGHYLQSQGVGPG----
TH_2598|M.thermoresistible__bu VFRTVAQTAPEHPFLVWRDRRLSYGETDARIDGFARYLVSRGLGCHTERA
MSMEG_3687|M.smegmatis_MC2_155 VFSTVAAAVPDQTFVVWRDRRLTYAQFDAHVDGFAHFLVSAGLGVHTERA
MMAR_4007|M.marinum_M VASAVTAAIGDRELIVGGDRRHTYRQIHQRSNRLASYLHSQGLGCHTERS
MUL_3870|M.ulcerans_Agy99 VASAVTAAIGDRELVVQGDRRHTYRQIHQRSNRLASYLHSQGLGCHTERS
MAV_1600|M.avium_104 VAKAVAAAIPDRELIIQGDRRYSYRQVIERSNRLAAYLHSQGLGCHTERE
Mflv_4335|M.gilvum_PYR-GCK AADAVAAVIGDREFIIQGERRYTYAQIVERSNRLAAFLHAQGLGCHTERS
Mvan_2010|M.vanbaalenii_PYR-1 AADAVAAAIGDREFIVQGDRRYTYTQIVERSNRLAAYLHAQGLGCHTERT
MLBr_02546|M.leprae_Br4923 LPAMPARRSPHRAALIDEEGTLTYKELDRAAHALANGLIAKGVRGG----
.: :: : :* : . :. * *:
Mb3544c|M.bovis_AF2122/97 ---------DKVGLYCRNRIEIVIAMLGIVKAGAILVNVNFRYVEGELRY
Rv3515c|M.tuberculosis_H37Rv ---------DKVGLYCRNRIEIVIAMLGIVKAGAILVNVNFRYVEGELRY
MAB_4163c|M.abscessus_ATCC_199 ---------DKVGLYCRNGIEIVIALTAIVKIRAISVNVNYRYVEAELHY
TH_2598|M.thermoresistible__bu ALAGHESGQDHLGLYLRNGNQYLEAMIGSYRARVAPFNVNFRYVDEELVY
MSMEG_3687|M.smegmatis_MC2_155 ALAGHESGQDHLGIYLRNGNEYLEAMIGSYRARVAPFNVSYRYVEEELLY
MMAR_4007|M.marinum_M ELAGHEVGQDLLGIYAYNGNEFVEALFGSFAARVAPFNVNFRYVKNELQY
MUL_3870|M.ulcerans_Agy99 ELAGHEVGQNLLGIYAYNGNEFVEALFGSFAARVAPFNVNFRYVKNEPQY
MAV_1600|M.avium_104 ALAGHEVGQDLLGLYAYNGNEFVEALLGAFAARVAPFNVNFRYVKSELHY
Mflv_4335|M.gilvum_PYR-GCK ELPGHEVGQDLLGIYAYNGPEYVEGMLGAWRARVAPFNVNYRYVKSELQY
Mvan_2010|M.vanbaalenii_PYR-1 ALPGHEVGQDLLGIYSHNGPEYVEGMLGAWRARVAPFNVNYRYVKSELHY
MLBr_02546|M.leprae_Br4923 ---------DGIAILARNHRWFVIANYGCARVGARIILLNSEFSGPQIKE
: :.: * : . . . . :. .: :
Mb3544c|M.bovis_AF2122/97 LFDNSDMVALVHERRYADRVANVLPDTPHVRTILVVEDGSDQDYRRYGGV
Rv3515c|M.tuberculosis_H37Rv LFDNSDMVALVHERRYADRVANVLPDTPHVRTILVVEDGSDQDYRRYGGV
MAB_4163c|M.abscessus_ATCC_199 LFENSDMAALVHERRYSDKVANVLPSTPNVKTAIVVEDGADGSFDSYGGV
TH_2598|M.thermoresistible__bu LLTDARARALVYSAEFAPQVAAIRDRLPDLELLIQVADDSGNALLP-GAV
MSMEG_3687|M.smegmatis_MC2_155 LLTDSNARALVYNAEFAPRVAAIRDRLPNLAVLIQVADDSGNELLP-GAV
MMAR_4007|M.marinum_M LLADAGATALIYHATFAPRVAEVLPELPRLRVLIQIADDSGNGLLD-GAV
MUL_3870|M.ulcerans_Agy99 LLADAGATALIYHATFAPRVAEVLPELPRLRVLIQIADDSGNGLLD-GAV
MAV_1600|M.avium_104 LLADSEATALIYHAAFAPRVAEILPDLPRLRVLIQIADESGNELLD-GAV
Mflv_4335|M.gilvum_PYR-GCK LLADAGATALLYHSAFAPRLAEVLADLPSLKVLIQIADDSGNELLP-GAV
Mvan_2010|M.vanbaalenii_PYR-1 LLADSGATALLYHAAFAPRLAEVLADLPNLKVLIQIADDSGNELLP-GAV
MLBr_02546|M.leprae_Br4923 VSEREGAKVIIYDDEYTKVVSKAEPALGKLRALGVNPDEEEPPGST--DE
: .::: :: :: : *
Mb3544c|M.bovis_AF2122/97 EFYSAIAAGSPERDFGERSADAIYLLYTGGTTGFPKGVMWRHEDIYRVLF
Rv3515c|M.tuberculosis_H37Rv EFYSAIAAGSPERDFGERSADAIYLLYTGGTTGFPKGVMWRHEDIYRVLF
MAB_4163c|M.abscessus_ATCC_199 PFADALAQGSPERDFEERSPDDIFLIYTGGTTGFPKGVMWRHEDIYRSLF
TH_2598|M.thermoresistible__bu DYEEVLRTPEPAGGMPTPSGEDLYILYTGGTTGMPKGVLWRQHDIFISAM
MSMEG_3687|M.smegmatis_MC2_155 DYEAILGTPEPEGGMPVPSGDDLYILYTGGTTGMPKGVLWRQHDIFLSSM
MMAR_4007|M.marinum_M DYESIIANSSPEPLPVQPSPDDLYVLYTGGTTGMPKGVLWRQHDIFMTSF
MUL_3870|M.ulcerans_Agy99 DYESIIANSSPEPLPVQPSPDDLYVLYTGGTTGMTKGVLWRQHDIFMTSF
MAV_1600|M.avium_104 DYEDALASVSAEPPPVRHCPDDLYVLYTGGTTGMPKGVLWRQHDIFMTSF
Mflv_4335|M.gilvum_PYR-GCK DYESIVAEGPAEVPPVQPSPDDLYVLYTGGTTGMPKGVLWRQHDIFMASF
Mvan_2010|M.vanbaalenii_PYR-1 DYESIVAEGPADVPPVEPSPDDLYVLYTGGTTGMPKGVLWRQHDIFMTSF
MLBr_02546|M.leprae_Br4923 TLAELIARSSSAPAPKVRKRASIIILTSG-TTGTPKGAN-RNTPASLAPL
: . : :: :* *** .**. *: :
Mb3544c|M.bovis_AF2122/97 GGTDFATGEFVKDEYDLAKAAAANPPMI-RYPIPPMIHGATQSATWMALF
Rv3515c|M.tuberculosis_H37Rv GGTDFATGEFVKDEYDLAKAAAANPPMI-RYPIPPMIHGATQSATWMALF
MAB_4163c|M.abscessus_ATCC_199 GGINYVTGEYIEGEWDLAKQGAEAAPFI-GFPIPPMIHGATQAATFMALF
TH_2598|M.thermoresistible__bu GGRPFGSDTAMTSYQELAERARASAGSMGMLMIPPFMHGAAQWAAFNAVT
MSMEG_3687|M.smegmatis_MC2_155 GGRPFGAENFLSSYEELADKARASAGAMSMLMIPPFMHGAAQWASYTAIT
MMAR_4007|M.marinum_M GGRDLYSGQPVNSVDEIVARTTAGPGTK-LLVLPPLIHGAAQWTVMTALT
MUL_3870|M.ulcerans_Agy99 GGRDLYSGQPVNSVDEIVARTTAGPGTK-LLVLPPLIHGAAQWTVMTALT
MAV_1600|M.avium_104 GGRNLMTGEPSSSIDEIVQRAASGPGTK-LMILPPLIHGAAQWSVMTAIT
Mflv_4335|M.gilvum_PYR-GCK GGRSLYTGELISSLDDVAQRCVESPGTT-LMVLPPLMHGAAQWAVFTAMN
Mvan_2010|M.vanbaalenii_PYR-1 GGRSLYTGELVSTYDDIAARCSESPGTK-LMVLPPLMHGAAQWAVFTAMN
MLBr_02546|M.leprae_Br4923 GG-------------ILSKVPFRAHEVT--LLPAPMFHALGYLHATLAMF
** : .*::*. *:
Mb3544c|M.bovis_AF2122/97 SGQTTVLAP---EFNADEVWRTIHKHKVNLLFFTGDAMARPLVDAL--VK
Rv3515c|M.tuberculosis_H37Rv SGQTTVLAP---EFNADEVWRTIHKHKVNLLFFTGDAMARPLVDAL--VK
MAB_4163c|M.abscessus_ATCC_199 QGRTTVLAP---EFNPEEVWELIEKHKINMLFFAGDAIGRPLIDALDTET
TH_2598|M.thermoresistible__bu MAGKIVLPDRVDRLHPADALRAAARERVLSIPVVGDAVARPLLEEIE---
MSMEG_3687|M.smegmatis_MC2_155 MGGKLVIPDDVVRLRPDAALRLAERERVMSIPVVGDAIARPLIDEIE---
MMAR_4007|M.marinum_M TGQTVVFASVVDHLDPRDVVRTIERERVSVVTVVGDAIARPLVASIE---
MUL_3870|M.ulcerans_Agy99 TGQTVVFASVVDHLDPRDVVRTIERERVSVVTVVGNAIARPLVASIE---
MAV_1600|M.avium_104 TGQTVVFPTVVDHLDAEDVVRTIEREKVMVVTVVGDAMARPLVAAIE---
Mflv_4335|M.gilvum_PYR-GCK TGQSVVFSPVTEHLDVDDVVATIEREKVLAVTVVGDAMARPLADAFE---
Mvan_2010|M.vanbaalenii_PYR-1 TGQTVVFSPVTSHLDVDDVVATIEREQILAVTVVGDAMARPLAEAFE---
MLBr_02546|M.leprae_Br4923 LGSTLVLRR---RFKPATVLEDIEKHQATAMVVVPVMLSRILDTLEN--L
. . *: .: . :.: : .. :.* *
Mb3544c|M.bovis_AF2122/97 GNDYDLSSLFLLASTAALFSPSIKEKLLELLPNRVITDSIGSSETGFGGT
Rv3515c|M.tuberculosis_H37Rv GNDYDLSSLFLLASTAALFSPSIKEKLLELLPNRVITDSIGSSETGFGGT
MAB_4163c|M.abscessus_ATCC_199 GRARDLSSLWVLASSAALFSQTVKERYLELLPNRVITDAIGASETGTGGL
TH_2598|M.thermoresistible__bu TGNHDLSGLVTITNGGAPLSPTVRDRLLKALPHVLVMDAVGASESGAQMS
MSMEG_3687|M.smegmatis_MC2_155 GGNYDLSGLVTISNGGAPLSPTVRSRILAALPHLLLLDAVGASESGAQMS
MMAR_4007|M.marinum_M KGTADVSSLVAVANGGALLTPYVKQRLIEALPNAVITDGVGSSETGAQMH
MUL_3870|M.ulcerans_Agy99 KGTADVSSLVAVANGGALLTPYVKQRLIAALPNAVIIDGVGSSETGAQMH
MAV_1600|M.avium_104 KGIADVSSLAVVANGGALLTPFVKQRLIEVLPNAVVVDGVGSSETGAQMH
Mflv_4335|M.gilvum_PYR-GCK RTTADLSALAVVANGGAQLTPSAKQRLIDVKKNLMVVDGVGSSETGAQMT
Mvan_2010|M.vanbaalenii_PYR-1 RTSADLSSLAVVANGGAQLTPTAKQRLIDAKQNLMVVDGVGSSETGAQMT
MLBr_02546|M.leprae_Br4923 ETKSDLSSLRVVFVSGSQLGAELATRALEELG-PVIYNMYGSTEIAFATI
*:*.* : .: : : : :: : *::* .
Mb3544c|M.bovis_AF2122/97 SVVAAGQAHGGGPRVRIDHRTVVLDDDGNEVKPGSGMRGVIAKKGNIPVG
Rv3515c|M.tuberculosis_H37Rv SVVAAGQAHGGGPRVRIDHRTVVLDDDGNEVKPGSGMRGVIAKKGNIPVG
MAB_4163c|M.abscessus_ATCC_199 STVTKGQMHPGGPTVKISSTTTVLDEEGNPVQPGSGVRGLIAKSGHIPVG
TH_2598|M.thermoresistible__bu SYTGSGGATATATFQPQPDTAVLAPDLSRMLTPG-EGEGWLARRDFIPLG
MSMEG_3687|M.smegmatis_MC2_155 AYTTSGAETQPATFTPQPDTAVVSEDLTRVLGPG-EGGGWLARRDLIPLG
MMAR_4007|M.marinum_M HLSASG-AVSTGTFNAGPDTNVAAEDLSAILPAGHEGIGWLAQRGYVPLG
MUL_3870|M.ulcerans_Agy99 HLSASG-AISTGTFNAGPDINVAAEDLSAILPAGHEGIGWLAQRGYVPLG
MAV_1600|M.avium_104 HMSTPG-AVATGTFNAGPDTFVAAEDLSAILPPGHEGMGWLAQRGYVPLG
Mflv_4335|M.gilvum_PYR-GCK HMSAPG-AVSTGKFTAGPDTFVASEDLSTILEPGHDGMGWLAQRGYVPLG
Mvan_2010|M.vanbaalenii_PYR-1 HMSAPG-AVSTGKFNAGPDTFVAAEDLGSILEPGHDGIGWLAQRGYVPLG
MLBr_02546|M.leprae_Br4923 AGPKDLQINSATVGPVVKGVKVKILDDSGKEVPRGQVGRIFVGNAFPFEG
. : . :. *
Mb3544c|M.bovis_AF2122/97 YYKDEKKTAETFRTINGVRYAIPGDYAQVEEDGTVTMLGRGSVSINSGGE
Rv3515c|M.tuberculosis_H37Rv YYKDEKKTAETFRTINGVRYAIPGDYAQVEEDGTVTMLGRGSVSINSGGE
MAB_4163c|M.abscessus_ATCC_199 YFKDEKKTAETFKTFNGVRYAIPGDWATVEADGTVTMLGRGSVSINTGGE
TH_2598|M.thermoresistible__bu YLGDADKTARTFPTIDGVRWSVPGDRARYLPDGQIELLGRDSVTINSGGE
MSMEG_3687|M.smegmatis_MC2_155 YLGDAEKTARTFPTVDGVRWSVPGDRANVLPDGRIQLLGRDSVTINSGGE
MMAR_4007|M.marinum_M YKGDAAKTAATFPVINGVRYAVPGDRARHRADECIELLGRDSATINSGGE
MUL_3870|M.ulcerans_Agy99 YKGDAAKTATTFPVINGVRYAVPGDRARHRADGCIELLGRDSATINSGGE
MAV_1600|M.avium_104 YKGDAAKTAKTFPVIDGVRYAVPGDRARHHADGHIELLGRDSVCINSGGE
Mflv_4335|M.gilvum_PYR-GCK YKGDATKTAATFPVIEGVRYSVPGDRARHLADGAVELLGRDSVTINSGGE
Mvan_2010|M.vanbaalenii_PYR-1 YKGDAAKTAATFPVIGGVRYSVPGDRARHLADGAVELLGRDSVTINSGGE
MLBr_02546|M.leprae_Br4923 YTGGGGK-----QIIDGLLS--SGDVGYFDEHDLLYISGRDDEMIVSGGE
* . * . *: .** . . : : **.. * :***
Mb3544c|M.bovis_AF2122/97 KVYPEEVEAALKGHPDVFDALVVGVPDPRYGQQVAAVVQARPGCRPSLAE
Rv3515c|M.tuberculosis_H37Rv KVYPEEVEAALKGHPDVFDALVVGVPDPRYGQQVAAVVQARPGCRPSLAE
MAB_4163c|M.abscessus_ATCC_199 KVFPEEVESVLKGHPAVFDAVVVGVPDEKWGQHVGAVIAVREGVELTFED
TH_2598|M.thermoresistible__bu KIFAEEVERAVAAHPAVYDVVVVGRPSERWGQEVVAVVQFAEGASASDEE
MSMEG_3687|M.smegmatis_MC2_155 KIFVEEVERAIAAHPAVYDVVVVGRPSERWGSEVVAIVQFAEGASATDDE
MMAR_4007|M.marinum_M KIFAEEVETAIASHPAVADVVVAGRPSERWGQEVVAVVALDPDAAADAEE
MUL_3870|M.ulcerans_Agy99 KIFAEEVETAIASHPAVADVVVAGRPSERWGQEVVAVVALDPDAAADAEE
MAV_1600|M.avium_104 KIFVEEVETAIASHPAVADVVVAGRPSERWGQEVVAVVALSDGAAVDAGE
Mflv_4335|M.gilvum_PYR-GCK KIFAEEVESAIASHPAVADVVVAGRPSERWGQEVVAVVALDSGATATAEE
Mvan_2010|M.vanbaalenii_PYR-1 KIFAEEVESAIASHPAVADVVVAGRPSDRWGQEVVAVVALADGAQATADE
MLBr_02546|M.leprae_Br4923 NVFPAEVEDLISGHPEVVEATAIGVDDKEWGARLRAFVVKKQDATIDEDA
::: *** : .** * :. . * . .:* .: *.: .
Mb3544c|M.bovis_AF2122/97 LDSFVRSEIAGYKVPRSLWFVDEVKRSPAGKPDYRWAKEQTEARPADDVH
Rv3515c|M.tuberculosis_H37Rv LDSFVRSEIAGYKVPRSLWFVDEVKRSPAGKPDYRWAKEQTEARPADDVH
MAB_4163c|M.abscessus_ATCC_199 LDAHARKEIAGYKVPRSIWIVDSVKRNPAGKADYRWAKEVSETEKVDLVN
TH_2598|M.thermoresistible__bu LAAVCRQHIADYKVPKAFIRTAQILRSPAGKADYRWAKRVATGHLQPSGA
MSMEG_3687|M.smegmatis_MC2_155 LVEVCERSIARYKIPKAFIRSPEIVRSPAGKADYRWAKQIATEAVST---
MMAR_4007|M.marinum_M LVAHAAKSLARYKLPKAIVFRAGIQRSPSGKADYRWAKEQAADG------
MUL_3870|M.ulcerans_Agy99 LVAHAAKSLARYKLPKAIVFRAGIQRSPSGKADYRWAKEQAADG------
MAV_1600|M.avium_104 LIAHASNSLARYKLPKAIVFRPVIERSPSGKADYRWAREQAVDG------
Mflv_4335|M.gilvum_PYR-GCK LIDHASAVIARYKLPKAVVFRPAIERSPAGKADYRWAREQAISGS-----
Mvan_2010|M.vanbaalenii_PYR-1 LVEHASSVIARYKLPKAVVFRPVIERSPAGKADYRWAREQAISGS-----
MLBr_02546|M.leprae_Br4923 IKAYVRDHLARYKVPREVIFLEELPRNPTGKVLKRELRDFEVH-------
: :* **:*: . : *.*:** * :
Mb3544c|M.bovis_AF2122/97 AGHVTSGG
Rv3515c|M.tuberculosis_H37Rv AGHVTSGG
MAB_4163c|M.abscessus_ATCC_199 SKHVNTGA
TH_2598|M.thermoresistible__bu --------
MSMEG_3687|M.smegmatis_MC2_155 --------
MMAR_4007|M.marinum_M --------
MUL_3870|M.ulcerans_Agy99 --------
MAV_1600|M.avium_104 --------
Mflv_4335|M.gilvum_PYR-GCK --------
Mvan_2010|M.vanbaalenii_PYR-1 --------
MLBr_02546|M.leprae_Br4923 --------