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M. thermoresistible (build 8) TH_2466 (-)

annotation: putative protein of unknown function DUF1023
coordinates: 1825603 - 1827168
length: 522

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_2466--100% (522)putative protein of unknown function DUF1023
M. thermoresistible (build 8)TH_2235-7e-6134.23% (523) CONSERVED HYPOTHETICAL PROTEIN
M. thermoresistible (build 8)TH_2578-6e-5330.65% (558) PUTATIVE putative conserved hypothetical protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2820c-3e-3331.59% (421) hypothetical protein Mb2820c
M. gilvum PYR-GCKMflv_3088-3e-2525.58% (516) hypothetical protein Mflv_3088
M. tuberculosis H37RvRv2797c-3e-3331.59% (421) hypothetical protein Rv2797c
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_0252-5e-1423.74% (396) hypothetical protein MAB_0252
M. marinum MMMAR_1913-1e-3028.36% (550) hypothetical protein MMAR_1913
M. avium 104MAV_5292-1e-2423.62% (470) hypothetical protein MAV_5292
M. smegmatis MC2 155MSMEG_6381-6e-4830.12% (581) hypothetical protein MSMEG_6381
M. ulcerans Agy99MUL_5057-1e-2227.45% (357) hypothetical protein MUL_5057
M. vanbaalenii PYR-1Mvan_0049-1e-4927.44% (594) hypothetical protein Mvan_0049

CLUSTAL 2.0.9 multiple sequence alignment


Mb2820c|M.bovis_AF2122/97           --------------------------MPLTVADIDRWNAQAVREVFHAA-
Rv2797c|M.tuberculosis_H37Rv        --------------------------MPLTVADIDRWNAQAVREVFHAA-
MMAR_1913|M.marinum_M               --------------------------MSLTVADIDRWDAQAVREVFHAA-
MAV_5292|M.avium_104                -----MQLRHLSIPFLVAEAGGDPWSIDSGLQAGRPAQIASLARAFHDAG
MUL_5057|M.ulcerans_Agy99           -----MQPRYISNPLLIAEAGGGPWAINQSLQLGRPAQISDLATAFHDAG
Mvan_0049|M.vanbaalenii_PYR-1       --------------------------MAVSVSTVRDSKPDRLVDAADATG
MSMEG_6381|M.smegmatis_MC2_155      ----------------------------MQLSDIDSWNVGALQSIAFELR
TH_2466|M.thermoresistible__bu      -----------------------VWVMSATISLVEAADPQGLTAAAAQLQ
Mflv_3088|M.gilvum_PYR-GCK          MGVGRLRGRRILPRRRRRSRRTVPPPVSPTVSAARRWRPDALLELAEQCD
MAB_0252|M.abscessus_ATCC_1997      --------------------------MRPTISQLRGWNLDALGKAADAAR
                                                                  :          :        

Mb2820c|M.bovis_AF2122/97           --SARAEVTFEASRQLAALSIFANSGGKTAEAAAHHNAGIRRDLDAHGNE
Rv2797c|M.tuberculosis_H37Rv        --SARAEVTFEASRQLAALSIFANSGGKTAEAAAHHNAGIRRDLDAHGNE
MMAR_1913|M.marinum_M               --IARAQVSLEVSRQLATLSIFANSGGKTAEAAAHQNAGLRRDLDAHGNE
MAV_5292|M.avium_104                MSTAEADVAFAAARGRFEASWNHRNGALPINDSAE-VQRVTRALAVEGRQ
MUL_5057|M.ulcerans_Agy99           RSTTEADTAFEQARRRFETSWNRENGAHPINDSPQ-VQGLTTSLRSQAAR
Mvan_0049|M.vanbaalenii_PYR-1       RHRSELQTIIAGQRESLSHLQEHWSGQAASAALARGLDDIARQDRVAG-R
MSMEG_6381|M.smegmatis_MC2_155      ---DELRTIEGVATDLELISRLPGWDSPAADAARGRIGTAKANVLDDAAV
TH_2466|M.thermoresistible__bu      TKXTHLDTIITAERSALAALAGGWEGTAADAALARGEQHLAQQ-EQLRTR
Mflv_3088|M.gilvum_PYR-GCK          DAARRLCDHIDDSVTAADASRDYWTG-AAADAARGAARGIAADAARAAHR
MAB_0252|M.abscessus_ATCC_1997      DNARTLDASLDSCDRVFNDASG-WYGKTHDAAKIKVDQELDHG-REIRNV
                                                             .                        

Mb2820c|M.bovis_AF2122/97           ALAVARAADRAADGIVKVQSELAALRHAAAAAELTIDALIN---------
Rv2797c|M.tuberculosis_H37Rv        ALAVARAADRAADGIVKVQSELAALRHAAAAAELTIDALIN---------
MMAR_1913|M.marinum_M               ALAVARAADRAADGIVKVQSELAALRKAAAAAELQIDALSS---------
MAV_5292|M.avium_104                LPRIATDLETIAAVLAESQRTSTWYIEALEYDLAAIDDEIG--------Q
MUL_5057|M.ulcerans_Agy99           LPEIGLQLDNIAGGLAGAQRSATGQIVGLETQLCDIDSEIGEVLALEHGA
Mvan_0049|M.vanbaalenii_PYR-1       LLNLESALRNGGLQMGALRDALLDLVSSLERFGFAVADDGT---------
MSMEG_6381|M.smegmatis_MC2_155      IGAVAQLADETAAAVAKLQSQLEAVRADVAAQGGLLHLADN---------
TH_2466|M.thermoresistible__bu      LTSLQATLADAGANLSALRTRILDVAAQARSLGGLVRDDGT---------
Mflv_3088|M.gilvum_PYR-GCK          LVNASAAARDGATQIGAARDDAVGQVDDALEHGFLVADDGTVTVGADPDP
MAB_0252|M.abscessus_ATCC_1997      LNRISDDAEDAARTLKHAKEFTLQDVDGAVSEGFTVTDTGE---------
                                               .  :   :                :              

Mb2820c|M.bovis_AF2122/97           RVVPIPGLRSTEAQWARTLAKQTELQAELDAIMAEANAVDEELASAVNMA
Rv2797c|M.tuberculosis_H37Rv        RVVPIPGLRSTEAQWARTLAKQTELQAELDAIMAEANAVDEELASAVNMA
MMAR_1913|M.marinum_M               RVVPIAGLRHTESEWARVLAKQAELQADLGAIVVEANTIDEELASAVNMA
MAV_5292|M.avium_104                ALEEADHCAAEELRYS----AVTETKAITLVLEQIRESYSRLLHSALARL
MUL_5057|M.ulcerans_Agy99           QLTTADRLALEAIVCALEDQAVGDTQSAVSQLHSIRAGYAGLLHQAPTSL
Mvan_0049|M.vanbaalenii_PYR-1       --VTPEQWLVGQFLDSLADKFTGFLQKMLQLFTDLDENTAAAIDQAAGVD
MSMEG_6381|M.smegmatis_MC2_155      GDVTIGGSPDDREQLKHIAENIEARAKALIHQAEDIDADCAEVFGHIENG
TH_2466|M.thermoresistible__bu      ---VIALTSGGLMTPDVAAAYTTTLKTLLQTFDRVDQQSSQSVIQALGDG
Mflv_3088|M.gilvum_PYR-GCK          LLVALAGGRDTLAADLLQLRADELSVRIPAALDRLGAADSDAAADLVRAL
MAB_0252|M.abscessus_ATCC_1997      --VSHPDAKKAQAAADHQRRIQSGLDELARLDDMYGKKLREAADDLESMR
                                                                                      

Mb2820c|M.bovis_AF2122/97           DGDAPIPADSGPPVG-------------PEGLTP-------TQLASDANE
Rv2797c|M.tuberculosis_H37Rv        DGDAPIPADSGPPVG-------------PEGLTP-------TQLASDANE
MMAR_1913|M.marinum_M               DGDSPIPAEAGAPVG-------------PEGLTP-------TQRASDANE
MAV_5292|M.avium_104                QADGVDPANVRGVDE----------LSIPPADTG-------PEQVKWWWD
MUL_5057|M.ulcerans_Agy99           SADGFDPAVIQALDAPQSPAEPAEVIAIAAPTAS-------AEEVKKWWD
Mvan_0049|M.vanbaalenii_PYR-1       SPN--PPVEVG-GQD----------IHIPSPDTD-------PADVKQWWD
MSMEG_6381|M.smegmatis_MC2_155      DVTARGSSDFASAQEMGREQSGLSAPYPPEGEGVS------PENVNAWWN
TH_2466|M.thermoresistible__bu      ADTGAEAPPEPDIDD------------LKPPEGAT------DTEVNQWWD
Mflv_3088|M.gilvum_PYR-GCK          TDTDRPVTPAPTVPAG--------AWPVPSGDVVDGWPAMSQDRIAAQVA
MAB_0252|M.abscessus_ATCC_1997      DGQHDVTLPSGERVDP-------DALVDRVSKMS-------ADERAAFLA
                                                                                      

Mb2820c|M.bovis_AF2122/97           ERLREERARLQAHLERLQAEYDQLSVRAARDYHNGILDGDAVGRLAALTD
Rv2797c|M.tuberculosis_H37Rv        ERLREERARLQAHLERLQAEYDQLSVRAARDYHNGILDGDAVGRLAALTD
MMAR_1913|M.marinum_M               ELLREERAKLRARIGQLQGRYDQLAARAACDYNNGILDSDAMGQLAALGD
MAV_5292|M.avium_104                SLSAAQQRLLIDQHPQELGNLNGIPAEARDSVNRATMTDDLSKVEAVARV
MUL_5057|M.ulcerans_Agy99           SLSPQQRGRLIDEHPPELGNLNGINAITRDLVNQAVMDDDITRVESVAMQ
Mvan_0049|M.vanbaalenii_PYR-1       SLSEQQRRELIDRHPPMLGNLNGIPAEVRDQVNVAVMDDDLDRVQNVADR
MSMEG_6381|M.smegmatis_MC2_155      ALSEEEQAKVISEHPDWIGNRDGVPVAVRSEVNKAALDRELAEAQAAVDA
TH_2466|M.thermoresistible__bu      GLSEEDRQRLIHERPEWIGNLDGVPASARDQANRNRLEGLRDDPGLTVEE
Mflv_3088|M.gilvum_PYR-GCK          AMTDDQRARLIAEFPHQVGNTDGVPWDMRVAANRTNIATAILAESAADAP
MAB_0252|M.abscessus_ATCC_1997      TLSPETVDAMVIANPEVMGNSDGIPFDTRIAANEINIRNALSDELQKQPP
                                             :        .. : :        :   :             

Mb2820c|M.bovis_AF2122/97           ELSAARGRLG----------------------ELDAVDEALSR-------
Rv2797c|M.tuberculosis_H37Rv        ELSAARGRLG----------------------ELDAVDEALSR-------
MMAR_1913|M.marinum_M               QLTAAKGRLG----------------------DLDAVDQALRN-------
MAV_5292|M.avium_104                RGVSVQALRDNALHNRDIDMFRNPAAYGLCATDIVRYQNAVKTNDCLN--
MUL_5057|M.ulcerans_Agy99           RGVSADDIVN------------NPQKYGLSASDVTRYRNAIRTRDGLIYD
Mvan_0049|M.vanbaalenii_PYR-1       NGVSTDEVAG------------NPGRYGLTDGDVTRYQNAKRTQEGLLHQ
MSMEG_6381|M.smegmatis_MC2_155      MPSRDEFRREHPGWNG---AQLNAAYNKMMFERQGRLDDAKAMKDALSVD
TH_2466|M.thermoresistible__bu      RD------------------------------TIAAIDDALEG-------
Mflv_3088|M.gilvum_PYR-GCK          SRRRIAFYRS----------------------LLGEVDDPSGD-------
MAB_0252|M.abscessus_ATCC_1997      DQARVNQLQD----------------------MLKPMEDPLVTRPADAG-
                                                                          :.          

Mb2820c|M.bovis_AF2122/97           ----------------------APETYLTQLQIPEDPNQQVLAAVAVGNP
Rv2797c|M.tuberculosis_H37Rv        ----------------------APETYLTQLQIPEDPNQQVLAAVAVGNP
MMAR_1913|M.marinum_M               ----------------------APETYLAQLRVPDDPHQQVLAAVAVGNP
MAV_5292|M.avium_104                ------------------KACDPGLPLMLWAYDPLAFAGKGRAGIAIGNP
MUL_5057|M.ulcerans_Agy99           R----------------EHATDDPRPVMLWAYDPLAFNGEGKAAIAIGNP
Mvan_0049|M.vanbaalenii_PYR-1       LGAQDGETRRYSEIGEQERRDKNWRPTMLWAYDPQAFDGKGRAAVSIGNP
MSMEG_6381|M.smegmatis_MC2_155      G-------------------KYDPNKYLMLLEFPED--REPRAAIAVGNP
TH_2466|M.thermoresistible__bu      ----------------------EERQLLVLDFDGEHP----KVAVALGDV
Mflv_3088|M.gilvum_PYR-GCK          ----------------------TRIARQILAFDPGR----ASLVELHGDL
MAB_0252|M.abscessus_ATCC_1997      ----------------------PRDFMVDRKYVMFSTEGNGRMIEMIGDI
                                                                                   *: 

Mb2820c|M.bovis_AF2122/97           DT-AANVSVTVPGVGSTTR------GALPGMVTEARDLRSEVIRQLNAAG
Rv2797c|M.tuberculosis_H37Rv        DT-AANVSVTVPGVGSTTR------GALPGMVTEARDLRSEVIRQLNAAG
MMAR_1913|M.marinum_M               DT-AANVSVTVPGVGSTTR------GTLPGMVTEARNLQSEEMRQLKNAG
MAV_5292|M.avium_104                DK-SRNTAVVVPGTNSSVRG-----GWMSDGADDAINLYT---QAQRADP
MUL_5057|M.ulcerans_Agy99           DY-ARNTAVIVPGAGSSVAQ-----GWMSD-HDDATNLYD---QALAADP
Mvan_0049|M.vanbaalenii_PYR-1       DR-ASNTAVIVPGTSASVRD-----GWLSDGHNDAIHLYG---QSLKADP
MSMEG_6381|M.smegmatis_MC2_155      DT-AEHVTVTTPGVG--TRP-----ESLGGMVSEADALRQEAQTQLDRAG
TH_2466|M.thermoresistible__bu      ET-ADHVSVYVPGTGSVTYDKPDAGNDLPTYVEQSGWLKAETERVLEQAG
Mflv_3088|M.gilvum_PYR-GCK          GT-ARSVAVLVPGVNTTVEG-------SAANAATARRFVS------GSDG
MAB_0252|M.abscessus_ATCC_1997      KPGVRGVGVIVPGTNTNLNG-------SGSNHESAVKLAK-------ESG
                                          . * .**..                   :  :            

Mb2820c|M.bovis_AF2122/97           K-PASVATIAWMGYHPPP-----NPLDTGSAGDLWQTMTDGQAHAGAADL
Rv2797c|M.tuberculosis_H37Rv        K-PASVATIAWMGYHPPP-----NPLDTGSAGDLWQTMTDGQAHAGAADL
MMAR_1913|M.marinum_M               K-PTSVAAIAWMGYEPPP-----NPLDTATAGDLWQTMTDGQARAGAGDL
MAV_5292|M.avium_104                --HHATAVLAWMGYDAPEFDDSHWEQAVTDPAKLEQVGTPWRARQAGVLL
MUL_5057|M.ulcerans_Agy99           E-HHYTAVIAWMGYDAPN---GFSDVRVTEPG---------LARSGGALL
Mvan_0049|M.vanbaalenii_PYR-1       --ADPTAVISWMGYNTPE---SFTDPNIANTG---------LARAGGDAL
MSMEG_6381|M.smegmatis_MC2_155      RSGEQVATIAWLGYEPPG-----TDISVAEAG------FERRANEAAPDL
TH_2466|M.thermoresistible__bu      RSDETVATVAWLGYEPPA--------NVAQAG------SPHYADDNAPKL
Mflv_3088|M.gilvum_PYR-GCK          R----LAMITYLGGPFPQVHDPVTAVAAADRR---------YALEMAPRL
MAB_0252|M.abscessus_ATCC_1997      S-----PIFLYLGGDFPQG-----LDKAADPS---------YAAAMAPKL
                                          . . ::*   *                         *   .  *

Mb2820c|M.bovis_AF2122/97           SRYLQQVRANN-PSG---HLTVLGHSYGSLTASLALQDLDAQSAHPVNDV
Rv2797c|M.tuberculosis_H37Rv        SRYLQQVRANN-PSG---HLTVLGHSYGSLTASLALQDLDAQSAHPVNDV
MMAR_1913|M.marinum_M               SRYLQQVRANN-PSG---HLTVLGHSYGSLTASLALQDLNAHGAHPVNDV
MAV_5292|M.avium_104                AGDVNGLAATH-DAGSRAHVTVIGHSYG----STTVADAFANSGMRANDA
MUL_5057|M.ulcerans_Agy99           ANDVNGLWVTH-NSLTPQHVTVIGHSYG----STTVADAFAGSGMQANDA
Mvan_0049|M.vanbaalenii_PYR-1       AWDVNGLNVTH-EAGVPEHVTVIGHSYG----STTVADAFANSGMQADDA
MSMEG_6381|M.smegmatis_MC2_155      ADFYRGINATN-EHGSDVHLSAFGHSYGSLTTAQALYELGETG--VVDDA
TH_2466|M.thermoresistible__bu      ASFINGLNSSR-DTDP--NLTVLGHSYG-----SLVASEALQRGTAADNV
Mflv_3088|M.gilvum_PYR-GCK          VAFSEDVARRV-PDS--VLVTVVGHSYG-----GSIVGTAETLGLTSDRT
MAB_0252|M.abscessus_ATCC_1997      VDFGHEVDRAVGQNAPGTPVTYVGHSYG-----GAIVGTAEQMGLRADRI
                                        . :            :: .*****       :           :  

Mb2820c|M.bovis_AF2122/97           VFYGSPGLELY---------------------SPAQLGLDHGHAYVMQAP
Rv2797c|M.tuberculosis_H37Rv        VFYGSPGLELY---------------------SPAQLGLDHGHAYVMQAP
MMAR_1913|M.marinum_M               VFYGSPGLELY---------------------SPAQLGLEHGHAYVMQAP
MAV_5292|M.avium_104                VLTGCPGTDLAH--------------------SAADFHLDGGRLYVGAAS
MUL_5057|M.ulcerans_Agy99           ILIGCPGTDLAR--------------------SAADFHFDGGQVYVGSAS
Mvan_0049|M.vanbaalenii_PYR-1       ILLGSPGTDVAR--------------------SAADFNLDGGQVYIGDAS
MSMEG_6381|M.smegmatis_MC2_155      AFYGSPGLGHTDSTETYISPRGVPIEVMAPIRDESDMFLADGRAFVMSAP
TH_2466|M.thermoresistible__bu      VFMGSPGLETNVWEWHKN-------------VTPEKLHLSEGHVFVQHAD
Mflv_3088|M.gilvum_PYR-GCK          VFLAAAGAGVGVD-------------------DPGDWHNRNPHVQRYSMT
MAB_0252|M.abscessus_ATCC_1997      LHASSAGTGILP--------------------GGYTDPNPNVQRYSMTAP
                                       ...*                                   :       

Mb2820c|M.bovis_AF2122/97           HD-------------------LITNLVAPLAPLHGW---------GLDPY
Rv2797c|M.tuberculosis_H37Rv        HD-------------------LITNLVAPLAPLHGW---------GLDPY
MMAR_1913|M.marinum_M               HD-------------------LITGVVAPLAPLHGW---------GPDPY
MAV_5292|M.avium_104                TDAISWIGESGSGLP----NGLNETLGGPLGPFAGL---------GTDP-
MUL_5057|M.ulcerans_Agy99           TDPVSWIGES-SGVPGELLKGKLREYGVPIPLDAGL---------GRDP-
Mvan_0049|M.vanbaalenii_PYR-1       TDPVGWLGQMGNTLP----GELNDSLGNMVGPTAGL---------GADP-
MSMEG_6381|M.smegmatis_MC2_155      GDPISGD------------PTWNGVPLPSAGDLGQF---------GPNP-
TH_2466|M.thermoresistible__bu      ND-----------------------IVANLGRYG-----------AVIPS
Mflv_3088|M.gilvum_PYR-GCK          APG-------------------DFIELVQGIPGGPH---------GADPD
MAB_0252|M.abscessus_ATCC_1997      GDPIAIVQSLPRDVRLSDVPGVDQIPGIPHNVEGRIGNPLGGLPSATDPD
                                                                                 .  * 

Mb2820c|M.bovis_AF2122/97           LTPGFTELSS----QAGFDPGGIWRDGVYAHGDYPRSFLDAAGQPQLRMS
Rv2797c|M.tuberculosis_H37Rv        LTPGFTELSS----QAGFDPGGIWRDGVYAHGDYPRSFLDAAGQPQLRMS
MMAR_1913|M.marinum_M               LTPGLTELSS----QAGFDPGGIWRDGVYAHGDYPRVFQDAAGQPQLRMS
MAV_5292|M.avium_104                AHAGFGAARF----RAEVAGSHSVMPWFTDHSDYYDVGSEALHNMTEIVT
MUL_5057|M.ulcerans_Agy99           AGDGFGSVRF----HAEVPGSGTMD--RHDHSHYYVMGSESLRSITDISS
Mvan_0049|M.vanbaalenii_PYR-1       AFEDFGATRF----RAEVPGADMIDP--SDHSYYYTVGSESLRSMTEIVT
MSMEG_6381|M.smegmatis_MC2_155      LTLPLEQLSA----DAAVTPDGVSREGAVAHADYPRPVELPSGEKVLRTP
TH_2466|M.thermoresistible__bu      ELPGFIDLST----NAESTPLGPRD-ASSGHSEYSFINKTALYNQAVVVA
Mflv_3088|M.gilvum_PYR-GCK          EMDGVIGLP------TGFYDDGGLVAGWEAHSGMLNRPSGAWRTILDVLT
MAB_0252|M.abscessus_ATCC_1997      KIPGVTRLDTGYYGEFGKHPNQVIVGPDGHGSYWDDPSSDAFHNIAAVIG
                                        .                          .        .         

Mb2820c|M.bovis_AF2122/97           GYNLAAIAAGLPDN----------------TVGPPLLP------PILGGG
Rv2797c|M.tuberculosis_H37Rv        GYNLAAIAAGLPDN----------------TVGPPLLP------PILGGG
MMAR_1913|M.marinum_M               GYNLAAIAAGLPDN----------------KVGAPLLP------PVLGGG
MAV_5292|M.avium_104                GRGNELAAEGMLAPDRNAARVSILGRVHT-PLGTLSLPRVEIRMPVVVDP
MUL_5057|M.ulcerans_Agy99           GHPDRLASDDLIAE----------GRRQP-HVGPLRVP----GVPAYIDP
Mvan_0049|M.vanbaalenii_PYR-1       GNGGRLDELGLLAQPRTELTVSTPQQLDVPVLGEVPLPHLEVETPVIYDP
MSMEG_6381|M.smegmatis_MC2_155      AYNLAVIAAGLADV-----------------------------------P
TH_2466|M.thermoresistible__bu      GLGQDDRFIRVED-------------------------------------
Mflv_3088|M.gilvum_PYR-GCK          GDPGTLSSASSIPAGG----------------------------------
MAB_0252|M.abscessus_ATCC_1997      GGEATGYVERGIQTNYVDINVGDDGNFRAEAWDQSRAAAGAQVPGLPWDD
                                    .                                                 

Mb2820c|M.bovis_AF2122/97           MPAAPGPALRGGR----------------
Rv2797c|M.tuberculosis_H37Rv        MPAAPGPALRGGR----------------
MMAR_1913|M.marinum_M               MPAAPGHVLAGGH----------------
MAV_5292|M.avium_104                EWERPARSVTNEHGF--------------
MUL_5057|M.ulcerans_Agy99           ESDRPRDTVHDDHHYPAYQPPR-------
Mvan_0049|M.vanbaalenii_PYR-1       EWNRAGGSVTNDHGY--------------
MSMEG_6381|M.smegmatis_MC2_155      GPNGEDRLVR-------------------
TH_2466|M.thermoresistible__bu      -----------------------------
Mflv_3088|M.gilvum_PYR-GCK          -----------------------------
MAB_0252|M.abscessus_ATCC_1997      PGTIDRRHHPWDNPRVTDHPEHGQKIQVK