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M. thermoresistible (build 8) TH_1441 ()

annotation: PROBABLE ATP-DEPENDENT DNA HELICASE
coordinates: 2721142 - 2724336
length: 1065

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_1441-100% (1065)PROBABLE ATP-DEPENDENT DNA HELICASE
M. thermoresistible (build 8)TH_1135uvrD28e-3629.92% (498) PROBABLE ATP-DEPENDENT DNA HELICASE II UVRD2
M. thermoresistible (build 8)TH_3022-2e-0624.88% (414) PUTATIVE acyl transferase domain protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3226c-0.072.08% (849) ATP-dependent DNA helicase
M. gilvum PYR-GCKMflv_4665-0.076.79% (840) UvrD/REP helicase
M. tuberculosis H37RvRv3201c-0.072.08% (849) ATP-dependent DNA helicase
M. leprae Br4923MLBr_00153uvrD2e-4025.41% (799) putative ATP-dependent DNA helicase
M. abscessus ATCC 19977MAB_3515c-0.064.47% (836) ATP-dependent DNA helicase
M. marinum MMMAR_1359-0.071.16% (853) ATP-dependent DNA helicase
M. avium 104MAV_4147-0.072.56% (849) superfamily protein I DNA and RNA helicases
M. smegmatis MC2 155MSMEG_1943-0.078.82% (831) ATP-dependent DNA helicase
M. ulcerans Agy99MUL_2520-0.070.81% (853) ATP-dependent DNA helicase
M. vanbaalenii PYR-1Mvan_1802-0.075.58% (860) UvrD/REP helicase

CLUSTAL 2.0.9 multiple sequence alignment


Mb3226c|M.bovis_AF2122/97           --------MTQTAAPARYSPAELACALGLFPPTAEQAAVIAAPPGPLVVI
Rv3201c|M.tuberculosis_H37Rv        --------MTQTAAPARYSPAELACALGLFPPTAEQAAVIAAPPGPLVVI
MMAR_1359|M.marinum_M               -------------MNPRYSPDEIASALGIFPPTDEQAAVIAAPPGPLVVI
MUL_2520|M.ulcerans_Agy99           -------------MNPRYSPDEIASALGIFPPTDEQAAVIAAPPGPLVVI
MAV_4147|M.avium_104                -------------MSDRYSPRELACALGLFPPTEEQAAVIAAPPGPLVVI
Mflv_4665|M.gilvum_PYR-GCK          ------------MSTPLYSPAELSRALGLFEPTEEQAAVIAAPPGPLVVI
Mvan_1802|M.vanbaalenii_PYR-1       ------------MTTPRYSPAELSRALGLFEPTDEQAAVIAAEPGPLVVI
MSMEG_1943|M.smegmatis_MC2_155      -------------MQARYSPVELSAALGLFPPTDEQAAVIAAPPGPLVVI
TH_1441|M.thermoresistible__bu      LSGAGRAGRIGAAVTARHSPADLAEALGLFPPTEEQAAVIAAPPGPLVVI
MAB_3515c|M.abscessus_ATCC_199      --------------MNAYSPAELSRVLGLFEPTDEQAAVIGAPPGPMVVI
MLBr_00153|M.leprae_Br4923          ---------MSVHTTDAKPDSEVDRLLDGLNPQQRQAVVHEGSP--LLIV
                                                      .  ::   *. : *  .**.*  . *  ::::

Mb3226c|M.bovis_AF2122/97           AGAGAGKTETMAARVVWLVANGYAEPGQVLGLTFTRKAAGQLLRRVRSRL
Rv3201c|M.tuberculosis_H37Rv        AGAGAGKTETMAARVVWLVANGYAEPGQVLGLTFTRKAAGQLLRRVRSRL
MMAR_1359|M.marinum_M               AGAGAGKTETMAARVVWLVANGYAEPGQVLGLTFTRKAAGQLLRRVRSRL
MUL_2520|M.ulcerans_Agy99           AGAGAGKTETMAARVVWLVANGYAEPGQVLGLTFTRKAAGQLLRRVRSRL
MAV_4147|M.avium_104                AGAGAGKTETMAARVVWLIANGYAHPGQVLGLTFTRKAAGQLLRRVRSRL
Mflv_4665|M.gilvum_PYR-GCK          AGAGAGKTETMAARVVWLVANGYATPGEVLGLTFTRKAAGQLLRRVRSRL
Mvan_1802|M.vanbaalenii_PYR-1       AGAGAGKTETMAARVVWLVANGYARPGEVLGLTFTRKAAGQLLRRVRARL
MSMEG_1943|M.smegmatis_MC2_155      AGAGAGKTETMAARVVWLVANGFATPSQVLGLTFTRKAAGQLLRRVRTRL
TH_1441|M.thermoresistible__bu      AGAGAGKTETMAARVVWLVANGYARPDQVLGLTFTRKAAGQLLRRVRSRL
MAB_3515c|M.abscessus_ATCC_199      AGAGAGKTETMAARVVWLVANGYATPGQVLGLTFTRKAAAQLLRRVRSRL
MLBr_00153|M.leprae_Br4923          AGAGSGKTTVLARRIAYLIAARSVGVSQILAITFTNKAAAEMRERVARLV
                                    ****:*** .:* *:.:*:*   .  .::*.:***.***.:: .**   :

Mb3226c|M.bovis_AF2122/97           ARLAGIGLGCG------DPAACAPVVSTYHAFAGSLLRDYGLLLPLEPDT
Rv3201c|M.tuberculosis_H37Rv        ARLAGIGLGCG------DPAACAPVVSTYHAFAGSLLRDYGLLLPLEPDT
MMAR_1359|M.marinum_M               ARLAGTTVGVAV-----GEAAGAPTVSTYHAFAGSLLRDHGLLLPIEPDT
MUL_2520|M.ulcerans_Agy99           ARLAGTTVGVAV-----GEAAGAPTVSTYHAFAGSLLRDHGLLLPIEPDT
MAV_4147|M.avium_104                ARLAGVGLGAASPNHGAVDPEAAPVVSTYHAFAGSLLRDYGLLLPVEPDT
Mflv_4665|M.gilvum_PYR-GCK          ARLAGAGLTIPAA--GADLADDPVTIGTYHAFAGTLLREFGLMLPVEPDT
Mvan_1802|M.vanbaalenii_PYR-1       ARLAGAGLMIPTG--GADFADDPVTISTYHAFAGNLLREFGLLLPVEPDT
MSMEG_1943|M.smegmatis_MC2_155      ARLAGAGLAP-----GSGASDESATVSTYHAFAGTLLREHGLLLPVEPDT
TH_1441|M.thermoresistible__bu      ARLAGTGLVPANS--APDWTTESVTVSTYHAFAGTLLREHGLLLPVEPDT
MAB_3515c|M.abscessus_ATCC_199      ARLAGSGILAP-----VAADEPDPVIATYHAYAGTLLREHGLLLPMEPNA
MLBr_00153|M.leprae_Br4923          GDHTGP----------------SMWVSTFHSTCVRILRNQASLIGGLNSN
                                    .  :*                    :.*:*: .  :**: . ::    . 

Mb3226c|M.bovis_AF2122/97           RLLSETELWQLAFDVVSGYDGVLCTDKSPAAVTSIVVRLWGQLGEHLVDT
Rv3201c|M.tuberculosis_H37Rv        RLLSETELWQLAFDVVSGYDGVLCTDKSPAAVTSIVVRLWGQLGEHLVDT
MMAR_1359|M.marinum_M               RLLSETELWQLAFEVVNGYRGELCTQKTPAAVTATVLRLWGQLAEHLVDT
MUL_2520|M.ulcerans_Agy99           RLLSETELWQLAFEVVNGYRGELCTQKTPAAVTATVLRLWGQLAEHLVDT
MAV_4147|M.avium_104                RLLSETELWQLAFDVVNRYRGPLRTDKTPAAVTSMVLRLWGQLAEHLVDT
Mflv_4665|M.gilvum_PYR-GCK          RLLGETELWQLAFRVVCEHPAALDTDKSPASITAMVLRLAGQLSEHLVDT
Mvan_1802|M.vanbaalenii_PYR-1       RLLGETELWQLAFRVVCAHPAALDTEKSPASITDMVLRLAGQLSEHLVDT
MSMEG_1943|M.smegmatis_MC2_155      RLLSETELWQLAYDVVCAHPGHLDTEKTPAAVTAMVLRLSGALAEHLVDT
TH_1441|M.thermoresistible__bu      RLIGETELWQLAYRVVCEHPGPLDTDKTPAAITAMVLRLAGQLAEHLVDT
MAB_3515c|M.abscessus_ATCC_199      RLLTETQLWQLAFRLVCDFDGDLDTEKTPGAVTAQVLALAGQLSEHLVNT
MLBr_00153|M.leprae_Br4923          FSIYDVDDSRSLLQMIGQDMGLDIKRYSPRLMANAISNLKNELIDAESAV
                                      : :.:  :    ::    .   .  :*  ::  :  * . * :    .

Mb3226c|M.bovis_AF2122/97           RALRDTHVELERLVHALPAGRYQRDRGPSQWLLRMLATQTQRAELVPLLD
Rv3201c|M.tuberculosis_H37Rv        RALRDTHVELERLVHALPAGRYQRDRGPSQWLLRMLATQTQRAELVPLLD
MMAR_1359|M.marinum_M               RQLRDTHIELERLVHALPAGPNQRDSGPNQWLLRMLATQTERAELVPLLD
MUL_2520|M.ulcerans_Agy99           RQLRDTHIELERLVHALPAGPNQRDSGPNQWLLRMLVTQTERAELVPLLD
MAV_4147|M.avium_104                SQLRETHLELERLVHALPAGPYQRDRGPSQWLRRLSGTQSERAELVPLLE
Mflv_4665|M.gilvum_PYR-GCK          EQLRDTHVELDRLVHTLPAGRYQRDRGPSQWLLRMLATQTERTMLVPLID
Mvan_1802|M.vanbaalenii_PYR-1       AALRDTHVELERLVLNLPAGRYQRDRGPSQWLLRMLATQTERTMLVPLVD
MSMEG_1943|M.smegmatis_MC2_155      DQLRDTHVELERLVHTLPAGPYQRDRGPSQWLLRMLATQTERTELVPLID
TH_1441|M.thermoresistible__bu      DQLRDTHVELERLVHTLPAGPYQRDRGPSQWLLNMLATQTERAALVPLID
MAB_3515c|M.abscessus_ATCC_199      TDLLSSHDELERLILTLPPGPRQREGGPSAWLLRLIETQRERTQLMAIVE
MLBr_00153|M.leprae_Br4923          ANLSSDTDDLARTVATVYG-------------------------------
                                      * .   :* * :  :                                 

Mb3226c|M.bovis_AF2122/97           ALGERMHAGKVMDFAMQMASAARLAATSPQVGQDLRRRYRVVLLDEYQDT
Rv3201c|M.tuberculosis_H37Rv        ALGERMHAGKVMDFAMQMASAARLAATSPQVGQDLRRRYRVVLLDEYQDT
MMAR_1359|M.marinum_M               ALHERMRAAKVMDFGMQMAAAARLAATCPQVGEELRSRYRVVLLDEYQDT
MUL_2520|M.ulcerans_Agy99           ALHERMRAAKVMDFGMQMAAAARLAATCPQVGGELRSRYRVVLLDEYQDT
MAV_4147|M.avium_104                ALDERMRAVKVMDFGMQMASAARLAAAFPQVGADLRGRYRVVLLDEYQDT
Mflv_4665|M.gilvum_PYR-GCK          ALHRRMREERVMDFGMQMASAARLASTHPAVGEQLRQRYRVVLLDEYQDT
Mvan_1802|M.vanbaalenii_PYR-1       ALHRRMREERVMDFGMQMASAARLAAQFPQVGAQLRQRYRVVLLDEYQDT
MSMEG_1943|M.smegmatis_MC2_155      ALHQRMRAEKVMDFGMQMAAAARLAARFPQVGEQLRQRFRVVLLDEYQDT
TH_1441|M.thermoresistible__bu      AVHRRMRAEKVMDFGMQMAAAARLASEHPQVGAALRQRFRVVLLDEYQDT
MAB_3515c|M.abscessus_ATCC_199      QLIALMRTRGVLDFGAQMALSARLAADHPIVGQTQRERYRVVLLDEYQDT
MLBr_00153|M.leprae_Br4923          EYQRRLRTANALDFDDLIGETVGILQAFPQIAEHYRRRFRHVLVDEYQDT
                                         ::   .:**   :. :. :    * :.   * *:* **:******

Mb3226c|M.bovis_AF2122/97           GHAQRVVLSSLFGGGVDDG------LALTAVGDPIQSIYGWRGASATNLP
Rv3201c|M.tuberculosis_H37Rv        GHAQRVVLSSLFGGGVDDG------LALTAVGDPIQSIYGWRGASATNLP
MMAR_1359|M.marinum_M               GHSQRVALSALFGGGVDDG------LALTAVGDPIQSIYGWRGASATNLP
MUL_2520|M.ulcerans_Agy99           GHSQRIALSALFGGGVDDG------LALTAVGDPIQSIYGWRGASATNLP
MAV_4147|M.avium_104                GHAQRIALSALFGGGVDDG------LALTAVGDPIQSIYGWRGASATNLP
Mflv_4665|M.gilvum_PYR-GCK          GHAQRVALSSLFGGGADDG------LALTAVGDPIQSIYGWRGASATNLP
Mvan_1802|M.vanbaalenii_PYR-1       GHAQRVALSSLFGGGADDG------LALTAVGDPIQSIYGWRGASATNLP
MSMEG_1943|M.smegmatis_MC2_155      GHAQRIALSSLFGGGADDG------LALTAVGDPIQSIYGWRGASATNLP
TH_1441|M.thermoresistible__bu      GHAQRIALSALFGGGVDDD------LALTAVGDPIQSIYGWRGASATNLP
MAB_3515c|M.abscessus_ATCC_199      GHAQRILLSSLFGRGVDPD------LALTAVGDPIQSIYGWRGASATNLP
MLBr_00153|M.leprae_Br4923          NHAQYVLVRELVGHGARNSPDDMPPGELCVVGDADQSIYAFRGSTISNIE
                                    .*:* : :  *.* *.  .        * .***. ****.:**:: :*: 

Mb3226c|M.bovis_AF2122/97           RFTTDFPLSDGTPAPVLELLTSWRNPPQALRVANGISAEARRRSVAVRAL
Rv3201c|M.tuberculosis_H37Rv        RFTTDFPLSDGTPAPVLELLTSWRNPPQALRVANGISAEARRRSVAVRAL
MMAR_1359|M.marinum_M               RFSTDFALSDGAPAPVLELRTSWRNPPRALHLANAISAEARRRSVAVHAL
MUL_2520|M.ulcerans_Agy99           RFSTDFALSDGAPAPVLELRTSWRNPPRALHLANAISAEPRRRSVAVHAL
MAV_4147|M.avium_104                RFTTDFPRSDGTPAPVLELRTSWRNPPRTLRVANAISAEARRRSVAVHAL
Mflv_4665|M.gilvum_PYR-GCK          RFTTDFPLSDGTPAPTLELRTSWRNPPEVLHLANAASVDARRRSVEVRSL
Mvan_1802|M.vanbaalenii_PYR-1       RFTTDFPLSDGTPAPTLELRTSWRNPPEVLHLANEVSVDARRRSVAVRAL
MSMEG_1943|M.smegmatis_MC2_155      RFTTDFPYSDGTPAPTLELRTSWRNPPSTLHVANAVSEEARRRSVAVRAL
TH_1441|M.thermoresistible__bu      RFATDFPHSDGSPAPTLELRTSWRNPPRTLHLANAISAEARRRSVAVRAL
MAB_3515c|M.abscessus_ATCC_199      RFTTDFPLPDGSPAPTRELRTSWRNPPEALHLANSVSEEARRRSVAVRPL
MLBr_00153|M.leprae_Br4923          DFERDYP-----DTTTILLEQNYRSTQNILSAANSVIARNFGR----RDK
                                     *  *:.      :..  *  .:*..   *  **        *    :  

Mb3226c|M.bovis_AF2122/97           RPRPDAPPGAVRCALLPDVQA-EREWIADHLRMRYQRAEADGVKPPTAAV
Rv3201c|M.tuberculosis_H37Rv        RPRPDAPPGAVRCALLPDVQA-EREWIADHLRMRYQRAEADGVKPPTAAV
MMAR_1359|M.marinum_M               RSRPDAPAGTVRCALLADVQA-ERDWIADQLQGHYQRAAADGVSPPTAAV
MUL_2520|M.ulcerans_Agy99           RSRPDAPAGTVRCALLADVQA-ERDWIADQLQGHYQRAAADGVSPPTAAV
MAV_4147|M.avium_104                CPRPDAPPGTVRCALLPDMVA-EREWIADHIDAHYRRARADGVSPPTAAV
Mflv_4665|M.gilvum_PYR-GCK          QPRPNAEPGSVRAALLSDVEA-ERDWVADQVAHRWHGGLAASGTAPTAAV
Mvan_1802|M.vanbaalenii_PYR-1       QPRPGAEPGSVRCALLSDVER-ERDWVADQIARRWHAGIEADGAAPTAAV
MSMEG_1943|M.smegmatis_MC2_155      RPRPDAEPGTIRCALLNNVAA-ERDWVADHLARAYHGAIGRGEAAPTAAV
TH_1441|M.thermoresistible__bu      RPRPDAEPGTIRCALLDDVQS-EREWVAEQLAALYRHARDAGDTPPTAAV
MAB_3515c|M.abscessus_ATCC_199      LPRPDAASGRIACALLGDIAA-EREWVATQLAAVYEQAHREGNRPPSSAV
MLBr_00153|M.leprae_Br4923          RLWTDAGKGELIVGYVSDNEHDEAKFIADEIDALVGGGE---ITYDDVAV
                                       ..*  * :  . : :    * .::* .:      .          **

Mb3226c|M.bovis_AF2122/97           LVRRNADAAAIADTLRARGIPAEVVGLAGLLSIPEVAEVVAMLRLVADPT
Rv3201c|M.tuberculosis_H37Rv        LVRRNADAAAIADTLRARGIPAEVVGLAGLLSIPEVAEVVAMLRLVADPT
MMAR_1359|M.marinum_M               LVRRNADAAPIADALVARGIPVEVVGLAGLLSIPEVADLVAMLRLVGDPT
MUL_2520|M.ulcerans_Agy99           LVRRNADAAPIADALVARGIPVEVVGLAGLLSIPEVADLVAMLRLVGDPT
MAV_4147|M.avium_104                LVRRNADAAPIADALRARGIPVEVVGLAGLLSVPEVAELVAMLRLVADPT
Mflv_4665|M.gilvum_PYR-GCK          LVRRNADAAPMADALSRRGVPVEVVGLAGLLAVPEVADVVAMLRVAVDPT
Mvan_1802|M.vanbaalenii_PYR-1       LVRRNADAAPMADALTRRGVAVEVVGLAGLLAVPEVADVVAMLRLAADPT
MSMEG_1943|M.smegmatis_MC2_155      LVRRNADAAPMAEALTARGVPVEVVGVAGLLAVPEVADLVAMLRLIADPT
TH_1441|M.thermoresistible__bu      LVRRNADAAPMAQALTARGVPVEVVGLAGLLAVPEVADVVAMLRLAADPT
MAB_3515c|M.abscessus_ATCC_199      LVRRNSDAAPMAEALAAQGVPAEVVGLTGLLGLPEVADTVAMLRLVADPT
MLBr_00153|M.leprae_Br4923          LYRANNLSRSLEEVFIPTGIPYKVVGGFCFYESKEIRDLIAYLRVLDNPG
                                    * * *  : .: :.:   *:. :***   :    *: : :* **:  :* 

Mb3226c|M.bovis_AF2122/97           AGAAAMRVLTGPRWRLGARDLAALWRRALTLSG-----ESPSTASPESIA
Rv3201c|M.tuberculosis_H37Rv        AGAAAMRVLTGPRWRLGARDLAALWRRALTLSG-----ESPSTASPESIA
MMAR_1359|M.marinum_M               AGAAAMRVLTGPRWRLGGSDVAALWRRAVALVGGP---QVGASASPGAVA
MUL_2520|M.ulcerans_Agy99           AGAAAMRVLTGPRWRLGGSDVAALWRRAVALVGGP---QVGASVSPGAVA
MAV_4147|M.avium_104                AGAAAMRVLTGPRWRLGARDLAALWQRARALGGAG---TAGGPATAEAIA
Mflv_4665|M.gilvum_PYR-GCK          AGAAAVRVLTGPRWRLGARDLTALWRRAVTLVDTGP-SASDAVSATAEIV
Mvan_1802|M.vanbaalenii_PYR-1       AGAAAVRVLTGPRWRLGARDVAALWRRAVALVEPG--ASSDGESATAGIV
MSMEG_1943|M.smegmatis_MC2_155      AGSAVMRILTGPRWRFGARDIAALWRRAVELDDRP-----KGELGTADIV
TH_1441|M.thermoresistible__bu      AGSAAVRILTGPRWRLGARDLTALWRRAVELGTVEPPGARPDTDGVEQIL
MAB_3515c|M.abscessus_ATCC_199      AGPAALRVLTGPRWRLGAHDLVVLWRRATGFGRGG----------APAVG
MLBr_00153|M.leprae_Br4923          DAVSMRRILNTPRRGIGDR-------------------------AEACVS
                                     . :  *:*. **  :*                               : 

Mb3226c|M.bovis_AF2122/97           MAASA---DADNPCLADAISDPGSAEGYSVAGYGRIGALAGELSALRGRL
Rv3201c|M.tuberculosis_H37Rv        MAASA---DADNPCLADAISDPGSAEGYSVAGYGRIGALAGELSALRGRL
MMAR_1359|M.marinum_M               AAAGP---DTDTACLADAICDPGPADWYSSAGYERIGALAAELNALRGHL
MUL_2520|M.ulcerans_Agy99           AAAGP---DTDTACLADAICDPGPADWYSSAGYERIGALAAELNALRGHL
MAV_4147|M.avium_104                SAADPRNVEADAVCLADAIADPGPAEGYSAAGYARIAALAAELSALRAHL
Mflv_4665|M.gilvum_PYR-GCK          AKLEP---DADDACLADAVCDPGPAAAYSPTGYARIVALGRELTALRAHL
Mvan_1802|M.vanbaalenii_PYR-1       AQLGP---DADAACLADAICDPGPATAYSEAGHARIVALGRELTGLRAHL
MSMEG_1943|M.smegmatis_MC2_155      AQAAP---DADTACVADAICDPGDAERYSPAGYERIVALGRELTMLRAHL
TH_1441|M.thermoresistible__bu      AGIGP---DADEPCLADAICDPGDAAAYSEEGYRRITALAQELTALRAHL
MAB_3515c|M.abscessus_ATCC_199      PDVGE---EADIPCLADAISDPGTPDEYSPEGWKRLTALRRELSALRARL
MLBr_00153|M.leprae_Br4923          VYAEN---TGTSFADALQAVAEGKVPMLNTRSVKAIAGFVALLDDLRCRV
                                                 . *      *     .  .   : .:   *  ** ::

Mb3226c|M.bovis_AF2122/97           GHSLPDLVAEVRRVLGVDCEVRASAPVSGGWAGPEHLDAFADVVAGYAER
Rv3201c|M.tuberculosis_H37Rv        GHSLPDLVAEVRRVLGVDCEVRASAPVSGGWAGPEHLDAFADVVAGYAER
MMAR_1359|M.marinum_M               GHWLPDLVAEVRRVLGLDCDVRAAATASGAWAGAEHLDAFADVVADYAER
MUL_2520|M.ulcerans_Agy99           GHWLPDLVAEVRRVLGLDCDVRAAATASGAWAGAEHLDAFADVVADYAER
MAV_4147|M.avium_104                DHPLGDLVAEVRRVMDLDCEVRAAAAAG--WAGTEHLDAFADVVAGYAER
Mflv_4665|M.gilvum_PYR-GCK          SSPLPDLVAEIRRTLGIDAEVRAAQPISAGWSGTEHLDRFGDVVAEFASR
Mvan_1802|M.vanbaalenii_PYR-1       QSPLPDLLAEVRRVLGIDTEVRAAQPVSAGWSGTEHLDAFGDVVADFAAR
MSMEG_1943|M.smegmatis_MC2_155      GHPLPELVAEVRRVLGLDAEARAARPVAAGWAGTENLDRFSDLVSDFAGH
TH_1441|M.thermoresistible__bu      HHPLPDLIAEIRRILGVDAEARAGQPVAAGWAGTENLDAFADVVAEFAVR
MAB_3515c|M.abscessus_ATCC_199      GMPLTDLIAEVQRVLALDVELVAGRRGE----GLDQLRAFTDVAAGFAES
MLBr_00153|M.leprae_Br4923          DDDLGELVESVLERSGYLRELESS-TDPQELARLDNLNELVSFAHEFSTE
                                       * :*: .: .      :  :.          ::*  : ...  ::  

Mb3226c|M.bovis_AF2122/97           -----ASARSSEASVAGLLAYLDVAEVVENGLPPAELTVACDRVQVLTVH
Rv3201c|M.tuberculosis_H37Rv        -----ASARSSEASVAGLLAYLDVAEVVENGLPPAELTVACDRVQVLTVH
MMAR_1359|M.marinum_M               AAISAGSALSTKASVDGLLAYLDVAAEVENGLPPAQLTVARDRVQVLTVH
MUL_2520|M.ulcerans_Agy99           TAISAGSALSTKASVDGLLAYLDVAAEVENGLPPAQLTVARDGVQVLTVH
MAV_4147|M.avium_104                ADTG-GTDASASASVAGLLAFLDVAESVENGLPAAPLAVARDRVQVLTVH
Mflv_4665|M.gilvum_PYR-GCK          ----------GTPTASGLLAYLDTAEQVENGLAPAEVTVSSDRVQILTVH
Mvan_1802|M.vanbaalenii_PYR-1       ----------GGATVSALLGYLDIAEQVENGLAPAEVTVSADRVQILTVH
MSMEG_1943|M.smegmatis_MC2_155      ----------AGASVSALLAYLDAAVEVENGLAPAELTVSHDRVQILTVH
TH_1441|M.thermoresistible__bu      ----------PNATVPALLGYLSAAMEVENGLAPADVTVATDRVQILTVH
MAB_3515c|M.abscessus_ATCC_199      -----ADQSDPVGVVSAFLQYLDAAWEIEKGLAPVEVAASPGRVQILTVH
MLBr_00153|M.leprae_Br4923          -----------QANAAALAKSLHTPEDED---------------------
                                                  . .:   *  .   :                     

Mb3226c|M.bovis_AF2122/97           AAKGLEWQVVAVAHLSRGVFPSTVSRSSWLTDPAELPPLLRGDRASAG-A
Rv3201c|M.tuberculosis_H37Rv        AAKGLEWQVVAVAHLSRGVFPSTVSRSSWLTDPAELPPLLRGDRASAG-A
MMAR_1359|M.marinum_M               AAKGLEWQVVAVAHLSAGVFPSTASRSSWLTDPGELPPLLRGDRASVG-A
MUL_2520|M.ulcerans_Agy99           AAKGLEWQVVAVAHLSAGVFPSTASRSSWLTDPGELPPLLRGDRASVG-A
MAV_4147|M.avium_104                SAKGLEWQLVAVAHLSGGVFPSTTAKTTWLTDAAELPPLLRGDRARPG-A
Mflv_4665|M.gilvum_PYR-GCK          AAKGLEWQIVAVPHLVGRVFPSTASPRTWLTDAADLPPLLRGDCATVS-A
Mvan_1802|M.vanbaalenii_PYR-1       AAKGLEWQIVAVPHLSGRVFPSTASPRTWLTDAADLPPLLRGDCATVS-E
MSMEG_1943|M.smegmatis_MC2_155      AAKGLEWQVVAVPHLSARVFPSTTQARTWLTDASDLPPLLRGDRATES-E
TH_1441|M.thermoresistible__bu      AAKGLEWEVVAVPHLSRRVFPSTASPRTWLTDAGELPPLLRGDRATTS-E
MAB_3515c|M.abscessus_ATCC_199      SAKGLEWDVVAVPHLSAGVFPSGVAAPTWLTSATELPPLVRGDRASQGDQ
MLBr_00153|M.leprae_Br4923          -------------VPDTGALAAFLEKVSLMSDTDQIPENNSGVVTLMT-L
                                                      .:.:     : ::.. ::*    *  :     

Mb3226c|M.bovis_AF2122/97           HGIPVLDTSAVADRKQLSDKISEHRRLLDRRRVDEERRLLYVAVTRAEDT
Rv3201c|M.tuberculosis_H37Rv        HGIPVLDTSAVADRKQLSDKISEHRRLLDRRRVDEERRLLYVAVTRAEDT
MMAR_1359|M.marinum_M               LGIPVLDTSAVTNRKQLSDTISAHREQLDQRRVDEERRLLYVGVTRAEDT
MUL_2520|M.ulcerans_Agy99           LGIPVLDTSAVTNRKQLSDTISAHREQLDQRRVDEERRLLYVGVTRAEDT
MAV_4147|M.avium_104                LGIPVLDTSDVTNRKQLSDKISEHRRQLEQRRVDEERRLLYVAVTRAEDT
Mflv_4665|M.gilvum_PYR-GCK          HGVPVLDTSDVSDRKGLSDKIAAHKSSLDQRRTDEERRLLYVAITRAEHT
Mvan_1802|M.vanbaalenii_PYR-1       HGVPVLDTSDVSDRKGLSDKIYDHKRSLEQRRTDEERRLLYVAITRAEHT
MSMEG_1943|M.smegmatis_MC2_155      IGVPVLDTSDIYDRKILSDKISDHKKSLDQRRVDEERRLLYVAITRAEDT
TH_1441|M.thermoresistible__bu      HGVPVLDTADVNDRKALSDKIAEHKNRLAQRRTDEERRLLYVAVTRAEDT
MAB_3515c|M.abscessus_ATCC_199      FGVPQLDTEGITNRKQLADAIARHKDSLATRRIDEERRLLYVAVTRCAEQ
MLBr_00153|M.leprae_Br4923          HAAKGLEFPVVFVTGWEDGMLPHMRTLGDPTELSEERRLAYVGITRARQR
                                     .   *:   :       . :   :      . .***** **.:**. . 

Mb3226c|M.bovis_AF2122/97           LLVSGHHWGPTGTKPRGPSEFLCELKDIIDRSAAAGDPCGVVEQWASAPA
Rv3201c|M.tuberculosis_H37Rv        LLVSGHHWGPTGTKPRGPSEFLCELKDIIDRSAAAGDPCGVVEQWASAPA
MMAR_1359|M.marinum_M               VLVSGHHWGATGLKPRGPSDFLCELKDIIERSAAAGDPCGTVDQWDPAPV
MUL_2520|M.ulcerans_Agy99           VLVSGHHWGATGLKPRGPSDFLCELKDIIERSAAAGDPCGTVDQWDRAPV
MAV_4147|M.avium_104                LLVSGHHWAATGIKPRGPSDFLCEIKDVIDASAAAGDPCGTVEQWAPAPA
Mflv_4665|M.gilvum_PYR-GCK          LLVSGHHWGATESKPRGPSTFLTEIKDVIDASIEEGRPCGSIAVWADAPA
Mvan_1802|M.vanbaalenii_PYR-1       LLVSGHHWGATESKPRGPSTFLCELKDVIDASVQSGSPCGAVDVWADAPA
MSMEG_1943|M.smegmatis_MC2_155      LLLSGHHWGATESKPRGPSEFLCELKTILEEATAAGTPCGEIEHWAPDPA
TH_1441|M.thermoresistible__bu      LLVSGHHWGATESKPRGPSEFLLEIKDVIDRSAEAGDPCGTIDLWAPEPP
MAB_3515c|M.abscessus_ATCC_199      LFVSGHHWGQTGLKPKGPSDFLVELRDVIESAAAEGVPCGTVERWAPEPP
MLBr_00153|M.leprae_Br4923          LYLS---------------------------------RAITRSSWGQPIL
                                    : :*                                  .     *     

Mb3226c|M.bovis_AF2122/97           GDERNPLCDNAIEAVWPADPLAARRGDVERGAALVAAAMSADLPGSTTDI
Rv3201c|M.tuberculosis_H37Rv        GDERNPLCDNAIEAVWPADPLAARRGDVERGAALVAAAMSADLPGSTTDI
MMAR_1359|M.marinum_M               AGERNPLLDDVVEAVWPTDPLATRRGDVERGARLVAEAISADA-GVEAPA
MUL_2520|M.ulcerans_Agy99           AGERNPLLDDVVEAVWPTDPLATRRGDVERGARLVAEAISADA-GVEAPA
MAV_4147|M.avium_104                DGERNPLRDNAVEAVWPADPLASRRGEVERGAALVRQAMAAEP-------
Mflv_4665|M.gilvum_PYR-GCK          DGETNPIRDRVVEAVWPVDPVAGRRGPVDRGAHLVAEALSGECPEV----
Mvan_1802|M.vanbaalenii_PYR-1       DGEPNPLRDRVVEAVWPEDPLAGRRAHTDHGARLVTTAMSTAGGAG----
MSMEG_1943|M.smegmatis_MC2_155      PGETNPLRDQVVEALWP--PVASADDHVHRGAQLVAAAMAGEVSA-----
TH_1441|M.thermoresistible__bu      DGTPNPLRDKAFEVLWPAPPXXXPAGPPPPVSPRITTPSAGGA-------
MAB_3515c|M.abscessus_ATCC_199      AGERNPMLDQTVEAQWPADPLAGRRDDIEAGARLVRAALADGAALTME--
MLBr_00153|M.leprae_Br4923          NPESRFLR------EIPPELIDWRR-------------------------
                                        . :         *                                 

Mb3226c|M.bovis_AF2122/97           DHPPRPGDAPWSTDVDALLAERAHAARGAPARGLPNHLSVSSLVELVGDP
Rv3201c|M.tuberculosis_H37Rv        DHPPRPGDAPWSTDVDALLAERAHAARGAPARGLPNHLSVSSLVELVGDP
MMAR_1359|M.marinum_M               GGAAVADIEGWTADVDALLAERARAVG-PPTRALPNQLSVSGLVELARDP
MUL_2520|M.ulcerans_Agy99           GGAAVADIEGWTADVDALLAERARAVG-PPTRALPNQLSVSGLVELARDP
MAV_4147|M.avium_104                -GDPGADVEGWAADVDALLVERARVTG-PPPQVLPGQLSVSSLVGLARDP
Mflv_4665|M.gilvum_PYR-GCK          ---GSDDDHGWVADVDALLAERDLAAQ-RAVPSLPAQLSVSAMVELGRDP
Mvan_1802|M.vanbaalenii_PYR-1       ---PQPDVHGWTADVDALLAERELAAQ-RPVPPLPLQLSVSAMVELGRDP
MSMEG_1943|M.smegmatis_MC2_155      ----EADQEGWAADVDALLAERERPPQ-QEDTELPGQLSVSTLVELSRDP
TH_1441|M.thermoresistible__bu      ----QPNRRRLIAGVAGVAA-----------VAVLGGLAFWLLSPSGTDQ
MAB_3515c|M.abscessus_ATCC_199      ---DDDDTDGWEADVDALLREREQGHR-RPEMTLPQHLSVTSLVELRQDP
MLBr_00153|M.leprae_Br4923          ----------------------------------------SILTDSYSTP
                                                                              :       

Mb3226c|M.bovis_AF2122/97           VGARQRLMCRLPKRPDPHAWLGDAFHAWVQQFYGAELLFDLGDLPGAADR
Rv3201c|M.tuberculosis_H37Rv        VGARQRLMCRLPKRPDPHAWLGDAFHAWVQQFYGAELLFDLGDLPGAADR
MMAR_1359|M.marinum_M               VGARQRLVHRLPTRPDPHAQLGNAFHTWVQQFYGAELLFDLGDLPGAADS
MUL_2520|M.ulcerans_Agy99           VGARQRLVHRLPTRPDPHAQLGNIFHTWVQQFYGAELLFDLGDLPGAADS
MAV_4147|M.avium_104                ARAAQRLRHRLPSRPEPHALLGNAFHAWVQKFYGAECLFELGDLPGAADS
Mflv_4665|M.gilvum_PYR-GCK          EAVAHRLQRRLPRRPDSHALLGTAFHEWVQRYFQAEKLFDLDDLPGAVDA
Mvan_1802|M.vanbaalenii_PYR-1       EAVAQRLQRRLPRRPDAQALLGTAFHEWVQRYFQAEKLFDLDDLPGAVDA
MSMEG_1943|M.smegmatis_MC2_155      KAALTRLRRRLPQRPDPHALLGTTFHEWVQRYFHAERLFDLDDLPGAVDS
TH_1441|M.thermoresistible__bu      ADGARADDTAETTSPPRDTAAENRLLTMLPPGYSAGACGPVPAPEGALAQ
MAB_3515c|M.abscessus_ATCC_199      QALARRLARPRPTRPDLDARRGTAFHSWVQRHYGSVRLIDFEDLPGDGYG
MLBr_00153|M.leprae_Br4923          ASGASRFGRVRPSSIRSG--------------------------------
                                               .                                      

Mb3226c|M.bovis_AF2122/97           E--VGDPEELAALQRAFTASSWAARTPAAVEVPFEMPIGDTVVRGRIDAV
Rv3201c|M.tuberculosis_H37Rv        E--VGDPEELAALQRAFTASSWAARTPAAVEVPFEMPIGDTVVRGRIDAV
MMAR_1359|M.marinum_M               D--VGQVEDLAPLQEAFAGSPWAARTPIAVEVPFEMPVGDTVVRGRIDAV
MUL_2520|M.ulcerans_Agy99           D--VGQVEDLAPLQEAFAGSPWAARTPIAVEVPFEMPVGDTVVRGRIDAV
MAV_4147|M.avium_104                D--VGDTAELAELQAAFLESPWAARTPVAVEVPFEMPIGDTLVRGRIDAV
Mflv_4665|M.gilvum_PYR-GCK          D--RQDRGELDELQTAFAVSPWAARTPIDVEVPFDMMLAGRIVRGRIDAI
Mvan_1802|M.vanbaalenii_PYR-1       D--RQDRGELEELQAAFALSPWAARTPIDVEVPFDMMIAGRVVRGRIDAV
MSMEG_1943|M.smegmatis_MC2_155      DSGRAVEESLAELQDAFVKSPWAARTPVEVEVPFDMVLGETVVRGRIDAV
TH_1441|M.thermoresistible__bu      VVCRENTDPGGPPTATYT----LARDEAAMQRAFDEIIAASATVN--CPN
MAB_3515c|M.abscessus_ATCC_199      S--FEDAEDLAALQSAFLESEWADRTPVEVEVPFEISVAGIVVRGRIDAV
MLBr_00153|M.leprae_Br4923          ----------------------ASKRALLVLAPGDRVTHDKYGLGRVEEV
                                                            :    :  . :         .     

Mb3226c|M.bovis_AF2122/97           FV--DPDGGATVVDWKTGKPPHGPAAMRQAAVQLAVYRLAWAALRGCPTS
Rv3201c|M.tuberculosis_H37Rv        FV--DPDGGATVVDWKTGKPPHGPAAMRQAAVQLAVYRLAWAALRGCPTS
MMAR_1359|M.marinum_M               FE--DPDGGATVVDWKTGEPPRGPEAMRQAAVQLAVYRMAWAALRGCPES
MUL_2520|M.ulcerans_Agy99           FE--DPDGGATVVDWKTGEPPRGPEAMRQAAVQLAVYRMAWAALRGCPES
MAV_4147|M.avium_104                FA--ESDGGATVVDWKTGAPPDSPEAMRQAAVQLAVYRLAWAALAKVPES
Mflv_4665|M.gilvum_PYR-GCK          FA--DGDGSFTVVDWKTGEMPTDPEVLAHNALQLAVYRLAWARLHGCPTS
Mvan_1802|M.vanbaalenii_PYR-1       FA--DGDG-VMVVDWKTGEPPATEEELQHNAVQLAVYRLAWARLHDCPVS
MSMEG_1943|M.smegmatis_MC2_155      FA--EPDGTTMVLDWKTGDPPETPEAKEHAAVQLAVYRLAWAAMRGCPPE
TH_1441|M.thermoresistible__bu      FI--QSPG-----PWRRNATPDRISGTLFCGIQQNEPLVAWTDDANLVVS
MAB_3515c|M.abscessus_ATCC_199      FGPDSAEDTWTVVDWKTGHEPAG-DEMKAAALQLAVYRRAWASLREIDPA
MLBr_00153|M.leprae_Br4923          SG--VGESAISLIDFGSS-----------GRIKLMHNHAPVTKL------
                                           .      :  .             ::      . :        

Mb3226c|M.bovis_AF2122/97           SVRTAFYYVRSGITVVPDELPAPGELAMLLTDCAGRRSDT-----
Rv3201c|M.tuberculosis_H37Rv        SVRTAFYYVRSGITVVPDELPAPGELAMLLTDCAGRRSDT-----
MMAR_1359|M.marinum_M               SVRTAFHYVRTGVTVIPDELPDGMALAELLADSDPPCSC------
MUL_2520|M.ulcerans_Agy99           SVRTAFHYVRTGVTVIPDELPDGMALAELLADSDPPCSC------
MAV_4147|M.avium_104                SVRTAFHYVRARTTVVPEALPTSDQLAGLLAPTAPV---------
Mflv_4665|M.gilvum_PYR-GCK          AVRAAFHYVRSGRTVMPDALPEEDDLIALLADRDDEDAA------
Mvan_1802|M.vanbaalenii_PYR-1       SVRAAFHYVRSGRTVVPDGLPDADDLAALLADPPAA---------
MSMEG_1943|M.smegmatis_MC2_155      SVRAAFHYVRSGQTVIPETLPGAEELVKLLAAAPTETAEEADRIT
TH_1441|M.thermoresistible__bu      AVHSG---------------PQGPTLDELYAWWTTHS--------
MAB_3515c|M.abscessus_ATCC_199      RVRAVFHYVRSGRTVAPTELPDLPHAEELAELTRD----------
MLBr_00153|M.leprae_Br4923          ---------------------------------------------