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TQTAAPARYSPAELACALGLFPPTAEQAAVIAAPPGPLVVIAGAGAGKTETMAARVVWLVANGYAEPGQV LGLTFTRKAAGQLLRRVRSRLARLAGIGLGCGDPAACAPVVSTYHAFAGSLLRDYGLLLPLEPDTRLLSE TELWQLAFDVVSGYDGVLCTDKSPAAVTSIVVRLWGQLGEHLVDTRALRDTHVELERLVHALPAGRYQRD RGPSQWLLRMLATQTQRAELVPLLDALGERMHAGKVMDFAMQMASAARLAATSPQVGQDLRRRYRVVLLD EYQDTGHAQRVVLSSLFGGGVDDGLALTAVGDPIQSIYGWRGASATNLPRFTTDFPLSDGTPAPVLELLT SWRNPPQALRVANGISAEARRRSVAVRALRPRPDAPPGAVRCALLPDVQAEREWIADHLRMRYQRAEADG VKPPTAAVLVRRNADAAAIADTLRARGIPAEVVGLAGLLSIPEVAEVVAMLRLVADPTAGAAAMRVLTGP RWRLGARDLAALWRRALTLSGESPSTASPESIAMAASADADNPCLADAISDPGSAEGYSVAGYGRIGALA GELSALRGRLGHSLPDLVAEVRRVLGVDCEVRASAPVSGGWAGPEHLDAFADVVAGYAERASARSSEASV AGLLAYLDVAEVVENGLPPAELTVACDRVQVLTVHAAKGLEWQVVAVAHLSRGVFPSTVSRSSWLTDPAE LPPLLRGDRASAGAHGIPVLDTSAVADRKQLSDKISEHRRLLDRRRVDEERRLLYVAVTRAEDTLLVSGH HWGPTGTKPRGPSEFLCELKDIIDRSAAAGDPCGVVEQWASAPAGDERNPLCDNAIEAVWPADPLAARRG DVERGAALVAAAMSADLPGSTTDIDHPPRPGDAPWSTDVDALLAERAHAARGAPARGLPNHLSVSSLVEL VGDPVGARQRLMCRLPKRPDPHAWLGDAFHAWVQQFYGAELLFDLGDLPGAADREVGDPEELAALQRAFT ASSWAARTPAAVEVPFEMPIGDTVVRGRIDAVFVDPDGGATVVDWKTGKPPHGPAAMRQAAVQLAVYRLA WAALRGCPTSSVRTAFYYVRSGITVVPDELPAPGELAMLLTDCAGRRSDT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3201c | - | - | 100% (1101) | PROBABLE ATP-DEPENDENT DNA HELICASE |
| M. tuberculosis H37Rv | Rv0949 | uvrD1 | 6e-44 | 26.19% (817) | ATP-dependent DNA helicase II UVRD1 |
| M. tuberculosis H37Rv | Rv3202c | - | 3e-43 | 27.88% (1069) | ATP-dependent DNA helicase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3226c | - | 0.0 | 100.00% (1101) | ATP-dependent DNA helicase |
| M. gilvum PYR-GCK | Mflv_4665 | - | 0.0 | 68.04% (1092) | UvrD/REP helicase |
| M. leprae Br4923 | MLBr_00153 | uvrD | 5e-41 | 25.57% (794) | putative ATP-dependent DNA helicase |
| M. abscessus ATCC 19977 | MAB_3515c | - | 0.0 | 60.56% (1080) | ATP-dependent DNA helicase |
| M. marinum M | MMAR_1359 | - | 0.0 | 79.62% (1094) | ATP-dependent DNA helicase |
| M. avium 104 | MAV_4147 | - | 0.0 | 77.50% (1102) | superfamily protein I DNA and RNA helicases |
| M. smegmatis MC2 155 | MSMEG_1943 | - | 0.0 | 68.91% (1087) | ATP-dependent DNA helicase |
| M. thermoresistible (build 8) | TH_1441 | - | 0.0 | 72.08% (849) | PROBABLE ATP-DEPENDENT DNA HELICASE |
| M. ulcerans Agy99 | MUL_2520 | - | 0.0 | 78.98% (1094) | ATP-dependent DNA helicase |
| M. vanbaalenii PYR-1 | Mvan_1802 | - | 0.0 | 68.98% (1093) | UvrD/REP helicase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3201c|M.tuberculosis_H37Rv --------MTQTAAPARYSPAELACALGLFPPTAEQAAVIAAPPGPLVVI
Mb3226c|M.bovis_AF2122/97 --------MTQTAAPARYSPAELACALGLFPPTAEQAAVIAAPPGPLVVI
MMAR_1359|M.marinum_M -------------MNPRYSPDEIASALGIFPPTDEQAAVIAAPPGPLVVI
MUL_2520|M.ulcerans_Agy99 -------------MNPRYSPDEIASALGIFPPTDEQAAVIAAPPGPLVVI
MAV_4147|M.avium_104 -------------MSDRYSPRELACALGLFPPTEEQAAVIAAPPGPLVVI
Mflv_4665|M.gilvum_PYR-GCK ------------MSTPLYSPAELSRALGLFEPTEEQAAVIAAPPGPLVVI
Mvan_1802|M.vanbaalenii_PYR-1 ------------MTTPRYSPAELSRALGLFEPTDEQAAVIAAEPGPLVVI
MSMEG_1943|M.smegmatis_MC2_155 -------------MQARYSPVELSAALGLFPPTDEQAAVIAAPPGPLVVI
TH_1441|M.thermoresistible__bu LSGAGRAGRIGAAVTARHSPADLAEALGLFPPTEEQAAVIAAPPGPLVVI
MAB_3515c|M.abscessus_ATCC_199 --------------MNAYSPAELSRVLGLFEPTDEQAAVIGAPPGPMVVI
MLBr_00153|M.leprae_Br4923 ---------MSVHTTDAKPDSEVDRLLDGLNPQQRQAVVHEGSP--LLIV
. :: *. : * .**.* . * ::::
Rv3201c|M.tuberculosis_H37Rv AGAGAGKTETMAARVVWLVANGYAEPGQVLGLTFTRKAAGQLLRRVRSRL
Mb3226c|M.bovis_AF2122/97 AGAGAGKTETMAARVVWLVANGYAEPGQVLGLTFTRKAAGQLLRRVRSRL
MMAR_1359|M.marinum_M AGAGAGKTETMAARVVWLVANGYAEPGQVLGLTFTRKAAGQLLRRVRSRL
MUL_2520|M.ulcerans_Agy99 AGAGAGKTETMAARVVWLVANGYAEPGQVLGLTFTRKAAGQLLRRVRSRL
MAV_4147|M.avium_104 AGAGAGKTETMAARVVWLIANGYAHPGQVLGLTFTRKAAGQLLRRVRSRL
Mflv_4665|M.gilvum_PYR-GCK AGAGAGKTETMAARVVWLVANGYATPGEVLGLTFTRKAAGQLLRRVRSRL
Mvan_1802|M.vanbaalenii_PYR-1 AGAGAGKTETMAARVVWLVANGYARPGEVLGLTFTRKAAGQLLRRVRARL
MSMEG_1943|M.smegmatis_MC2_155 AGAGAGKTETMAARVVWLVANGFATPSQVLGLTFTRKAAGQLLRRVRTRL
TH_1441|M.thermoresistible__bu AGAGAGKTETMAARVVWLVANGYARPDQVLGLTFTRKAAGQLLRRVRSRL
MAB_3515c|M.abscessus_ATCC_199 AGAGAGKTETMAARVVWLVANGYATPGQVLGLTFTRKAAAQLLRRVRSRL
MLBr_00153|M.leprae_Br4923 AGAGSGKTTVLARRIAYLIAARSVGVSQILAITFTNKAAAEMRERVARLV
****:*** .:* *:.:*:* . .::*.:***.***.:: .** :
Rv3201c|M.tuberculosis_H37Rv ARLAGIGLGCG------DPAACAPVVSTYHAFAGSLLRDYGLLLPLEPDT
Mb3226c|M.bovis_AF2122/97 ARLAGIGLGCG------DPAACAPVVSTYHAFAGSLLRDYGLLLPLEPDT
MMAR_1359|M.marinum_M ARLAGTTVGVAV-----GEAAGAPTVSTYHAFAGSLLRDHGLLLPIEPDT
MUL_2520|M.ulcerans_Agy99 ARLAGTTVGVAV-----GEAAGAPTVSTYHAFAGSLLRDHGLLLPIEPDT
MAV_4147|M.avium_104 ARLAGVGLGAASPNHGAVDPEAAPVVSTYHAFAGSLLRDYGLLLPVEPDT
Mflv_4665|M.gilvum_PYR-GCK ARLAGAGLTIPAA--GADLADDPVTIGTYHAFAGTLLREFGLMLPVEPDT
Mvan_1802|M.vanbaalenii_PYR-1 ARLAGAGLMIPTG--GADFADDPVTISTYHAFAGNLLREFGLLLPVEPDT
MSMEG_1943|M.smegmatis_MC2_155 ARLAGAGLAP-----GSGASDESATVSTYHAFAGTLLREHGLLLPVEPDT
TH_1441|M.thermoresistible__bu ARLAGTGLVPANS--APDWTTESVTVSTYHAFAGTLLREHGLLLPVEPDT
MAB_3515c|M.abscessus_ATCC_199 ARLAGSGILAP-----VAADEPDPVIATYHAYAGTLLREHGLLLPMEPNA
MLBr_00153|M.leprae_Br4923 GDHTGP----------------SMWVSTFHSTCVRILRNQASLIGGLNSN
. :* :.*:*: . :**: . :: .
Rv3201c|M.tuberculosis_H37Rv RLLSETELWQLAFDVVSGYDGVLCTDKSPAAVTSIVVRLWGQLGEHLVDT
Mb3226c|M.bovis_AF2122/97 RLLSETELWQLAFDVVSGYDGVLCTDKSPAAVTSIVVRLWGQLGEHLVDT
MMAR_1359|M.marinum_M RLLSETELWQLAFEVVNGYRGELCTQKTPAAVTATVLRLWGQLAEHLVDT
MUL_2520|M.ulcerans_Agy99 RLLSETELWQLAFEVVNGYRGELCTQKTPAAVTATVLRLWGQLAEHLVDT
MAV_4147|M.avium_104 RLLSETELWQLAFDVVNRYRGPLRTDKTPAAVTSMVLRLWGQLAEHLVDT
Mflv_4665|M.gilvum_PYR-GCK RLLGETELWQLAFRVVCEHPAALDTDKSPASITAMVLRLAGQLSEHLVDT
Mvan_1802|M.vanbaalenii_PYR-1 RLLGETELWQLAFRVVCAHPAALDTEKSPASITDMVLRLAGQLSEHLVDT
MSMEG_1943|M.smegmatis_MC2_155 RLLSETELWQLAYDVVCAHPGHLDTEKTPAAVTAMVLRLSGALAEHLVDT
TH_1441|M.thermoresistible__bu RLIGETELWQLAYRVVCEHPGPLDTDKTPAAITAMVLRLAGQLAEHLVDT
MAB_3515c|M.abscessus_ATCC_199 RLLTETQLWQLAFRLVCDFDGDLDTEKTPGAVTAQVLALAGQLSEHLVNT
MLBr_00153|M.leprae_Br4923 FSIYDVDDSRSLLQMIGQDMGLDIKRYSPRLMANAISNLKNELIDAESAV
: :.: : :: . . :* :: : * . * : .
Rv3201c|M.tuberculosis_H37Rv RALRDTHVELERLVHALPAGRYQRDRGPSQWLLRMLATQTQRAELVPLLD
Mb3226c|M.bovis_AF2122/97 RALRDTHVELERLVHALPAGRYQRDRGPSQWLLRMLATQTQRAELVPLLD
MMAR_1359|M.marinum_M RQLRDTHIELERLVHALPAGPNQRDSGPNQWLLRMLATQTERAELVPLLD
MUL_2520|M.ulcerans_Agy99 RQLRDTHIELERLVHALPAGPNQRDSGPNQWLLRMLVTQTERAELVPLLD
MAV_4147|M.avium_104 SQLRETHLELERLVHALPAGPYQRDRGPSQWLRRLSGTQSERAELVPLLE
Mflv_4665|M.gilvum_PYR-GCK EQLRDTHVELDRLVHTLPAGRYQRDRGPSQWLLRMLATQTERTMLVPLID
Mvan_1802|M.vanbaalenii_PYR-1 AALRDTHVELERLVLNLPAGRYQRDRGPSQWLLRMLATQTERTMLVPLVD
MSMEG_1943|M.smegmatis_MC2_155 DQLRDTHVELERLVHTLPAGPYQRDRGPSQWLLRMLATQTERTELVPLID
TH_1441|M.thermoresistible__bu DQLRDTHVELERLVHTLPAGPYQRDRGPSQWLLNMLATQTERAALVPLID
MAB_3515c|M.abscessus_ATCC_199 TDLLSSHDELERLILTLPPGPRQREGGPSAWLLRLIETQRERTQLMAIVE
MLBr_00153|M.leprae_Br4923 ANLSSDTDDLARTVATVYG-------------------------------
* . :* * : :
Rv3201c|M.tuberculosis_H37Rv ALGERMHAGKVMDFAMQMASAARLAATSPQVGQDLRRRYRVVLLDEYQDT
Mb3226c|M.bovis_AF2122/97 ALGERMHAGKVMDFAMQMASAARLAATSPQVGQDLRRRYRVVLLDEYQDT
MMAR_1359|M.marinum_M ALHERMRAAKVMDFGMQMAAAARLAATCPQVGEELRSRYRVVLLDEYQDT
MUL_2520|M.ulcerans_Agy99 ALHERMRAAKVMDFGMQMAAAARLAATCPQVGGELRSRYRVVLLDEYQDT
MAV_4147|M.avium_104 ALDERMRAVKVMDFGMQMASAARLAAAFPQVGADLRGRYRVVLLDEYQDT
Mflv_4665|M.gilvum_PYR-GCK ALHRRMREERVMDFGMQMASAARLASTHPAVGEQLRQRYRVVLLDEYQDT
Mvan_1802|M.vanbaalenii_PYR-1 ALHRRMREERVMDFGMQMASAARLAAQFPQVGAQLRQRYRVVLLDEYQDT
MSMEG_1943|M.smegmatis_MC2_155 ALHQRMRAEKVMDFGMQMAAAARLAARFPQVGEQLRQRFRVVLLDEYQDT
TH_1441|M.thermoresistible__bu AVHRRMRAEKVMDFGMQMAAAARLASEHPQVGAALRQRFRVVLLDEYQDT
MAB_3515c|M.abscessus_ATCC_199 QLIALMRTRGVLDFGAQMALSARLAADHPIVGQTQRERYRVVLLDEYQDT
MLBr_00153|M.leprae_Br4923 EYQRRLRTANALDFDDLIGETVGILQAFPQIAEHYRRRFRHVLVDEYQDT
:: .:** :. :. : * :. * *:* **:******
Rv3201c|M.tuberculosis_H37Rv GHAQRVVLSSLFGGGVDDG------LALTAVGDPIQSIYGWRGASATNLP
Mb3226c|M.bovis_AF2122/97 GHAQRVVLSSLFGGGVDDG------LALTAVGDPIQSIYGWRGASATNLP
MMAR_1359|M.marinum_M GHSQRVALSALFGGGVDDG------LALTAVGDPIQSIYGWRGASATNLP
MUL_2520|M.ulcerans_Agy99 GHSQRIALSALFGGGVDDG------LALTAVGDPIQSIYGWRGASATNLP
MAV_4147|M.avium_104 GHAQRIALSALFGGGVDDG------LALTAVGDPIQSIYGWRGASATNLP
Mflv_4665|M.gilvum_PYR-GCK GHAQRVALSSLFGGGADDG------LALTAVGDPIQSIYGWRGASATNLP
Mvan_1802|M.vanbaalenii_PYR-1 GHAQRVALSSLFGGGADDG------LALTAVGDPIQSIYGWRGASATNLP
MSMEG_1943|M.smegmatis_MC2_155 GHAQRIALSSLFGGGADDG------LALTAVGDPIQSIYGWRGASATNLP
TH_1441|M.thermoresistible__bu GHAQRIALSALFGGGVDDD------LALTAVGDPIQSIYGWRGASATNLP
MAB_3515c|M.abscessus_ATCC_199 GHAQRILLSSLFGRGVDPD------LALTAVGDPIQSIYGWRGASATNLP
MLBr_00153|M.leprae_Br4923 NHAQYVLVRELVGHGARNSPDDMPPGELCVVGDADQSIYAFRGSTISNIE
.*:* : : *.* *. . * .***. ****.:**:: :*:
Rv3201c|M.tuberculosis_H37Rv RFTTDFPLSDGTPAPVLELLTSWRNPPQALRVANGISAEARRRSVAVRAL
Mb3226c|M.bovis_AF2122/97 RFTTDFPLSDGTPAPVLELLTSWRNPPQALRVANGISAEARRRSVAVRAL
MMAR_1359|M.marinum_M RFSTDFALSDGAPAPVLELRTSWRNPPRALHLANAISAEARRRSVAVHAL
MUL_2520|M.ulcerans_Agy99 RFSTDFALSDGAPAPVLELRTSWRNPPRALHLANAISAEPRRRSVAVHAL
MAV_4147|M.avium_104 RFTTDFPRSDGTPAPVLELRTSWRNPPRTLRVANAISAEARRRSVAVHAL
Mflv_4665|M.gilvum_PYR-GCK RFTTDFPLSDGTPAPTLELRTSWRNPPEVLHLANAASVDARRRSVEVRSL
Mvan_1802|M.vanbaalenii_PYR-1 RFTTDFPLSDGTPAPTLELRTSWRNPPEVLHLANEVSVDARRRSVAVRAL
MSMEG_1943|M.smegmatis_MC2_155 RFTTDFPYSDGTPAPTLELRTSWRNPPSTLHVANAVSEEARRRSVAVRAL
TH_1441|M.thermoresistible__bu RFATDFPHSDGSPAPTLELRTSWRNPPRTLHLANAISAEARRRSVAVRAL
MAB_3515c|M.abscessus_ATCC_199 RFTTDFPLPDGSPAPTRELRTSWRNPPEALHLANSVSEEARRRSVAVRPL
MLBr_00153|M.leprae_Br4923 DFERDYP-----DTTTILLEQNYRSTQNILSAANSVIARNFGR----RDK
* *:. :.. * .:*.. * ** * :
Rv3201c|M.tuberculosis_H37Rv RPRPDAPPGAVRCALLPDVQA-EREWIADHLRMRYQRAEADGVKPPTAAV
Mb3226c|M.bovis_AF2122/97 RPRPDAPPGAVRCALLPDVQA-EREWIADHLRMRYQRAEADGVKPPTAAV
MMAR_1359|M.marinum_M RSRPDAPAGTVRCALLADVQA-ERDWIADQLQGHYQRAAADGVSPPTAAV
MUL_2520|M.ulcerans_Agy99 RSRPDAPAGTVRCALLADVQA-ERDWIADQLQGHYQRAAADGVSPPTAAV
MAV_4147|M.avium_104 CPRPDAPPGTVRCALLPDMVA-EREWIADHIDAHYRRARADGVSPPTAAV
Mflv_4665|M.gilvum_PYR-GCK QPRPNAEPGSVRAALLSDVEA-ERDWVADQVAHRWHGGLAASGTAPTAAV
Mvan_1802|M.vanbaalenii_PYR-1 QPRPGAEPGSVRCALLSDVER-ERDWVADQIARRWHAGIEADGAAPTAAV
MSMEG_1943|M.smegmatis_MC2_155 RPRPDAEPGTIRCALLNNVAA-ERDWVADHLARAYHGAIGRGEAAPTAAV
TH_1441|M.thermoresistible__bu RPRPDAEPGTIRCALLDDVQS-EREWVAEQLAALYRHARDAGDTPPTAAV
MAB_3515c|M.abscessus_ATCC_199 LPRPDAASGRIACALLGDIAA-EREWVATQLAAVYEQAHREGNRPPSSAV
MLBr_00153|M.leprae_Br4923 RLWTDAGKGELIVGYVSDNEHDEAKFIADEIDALVGGGE---ITYDDVAV
..* * : . : : * .::* .: . **
Rv3201c|M.tuberculosis_H37Rv LVRRNADAAAIADTLRARGIPAEVVGLAGLLSIPEVAEVVAMLRLVADPT
Mb3226c|M.bovis_AF2122/97 LVRRNADAAAIADTLRARGIPAEVVGLAGLLSIPEVAEVVAMLRLVADPT
MMAR_1359|M.marinum_M LVRRNADAAPIADALVARGIPVEVVGLAGLLSIPEVADLVAMLRLVGDPT
MUL_2520|M.ulcerans_Agy99 LVRRNADAAPIADALVARGIPVEVVGLAGLLSIPEVADLVAMLRLVGDPT
MAV_4147|M.avium_104 LVRRNADAAPIADALRARGIPVEVVGLAGLLSVPEVAELVAMLRLVADPT
Mflv_4665|M.gilvum_PYR-GCK LVRRNADAAPMADALSRRGVPVEVVGLAGLLAVPEVADVVAMLRVAVDPT
Mvan_1802|M.vanbaalenii_PYR-1 LVRRNADAAPMADALTRRGVAVEVVGLAGLLAVPEVADVVAMLRLAADPT
MSMEG_1943|M.smegmatis_MC2_155 LVRRNADAAPMAEALTARGVPVEVVGVAGLLAVPEVADLVAMLRLIADPT
TH_1441|M.thermoresistible__bu LVRRNADAAPMAQALTARGVPVEVVGLAGLLAVPEVADVVAMLRLAADPT
MAB_3515c|M.abscessus_ATCC_199 LVRRNSDAAPMAEALAAQGVPAEVVGLTGLLGLPEVADTVAMLRLVADPT
MLBr_00153|M.leprae_Br4923 LYRANNLSRSLEEVFIPTGIPYKVVGGFCFYESKEIRDLIAYLRVLDNPG
* * * : .: :.: *:. :*** : *: : :* **: :*
Rv3201c|M.tuberculosis_H37Rv AGAAAMRVLTGPRWRLGARDLAALWRRALTLSG-----ESPSTASPESIA
Mb3226c|M.bovis_AF2122/97 AGAAAMRVLTGPRWRLGARDLAALWRRALTLSG-----ESPSTASPESIA
MMAR_1359|M.marinum_M AGAAAMRVLTGPRWRLGGSDVAALWRRAVALVGGP---QVGASASPGAVA
MUL_2520|M.ulcerans_Agy99 AGAAAMRVLTGPRWRLGGSDVAALWRRAVALVGGP---QVGASVSPGAVA
MAV_4147|M.avium_104 AGAAAMRVLTGPRWRLGARDLAALWQRARALGGAG---TAGGPATAEAIA
Mflv_4665|M.gilvum_PYR-GCK AGAAAVRVLTGPRWRLGARDLTALWRRAVTLVDTGP-SASDAVSATAEIV
Mvan_1802|M.vanbaalenii_PYR-1 AGAAAVRVLTGPRWRLGARDVAALWRRAVALVEPG--ASSDGESATAGIV
MSMEG_1943|M.smegmatis_MC2_155 AGSAVMRILTGPRWRFGARDIAALWRRAVELDDRP-----KGELGTADIV
TH_1441|M.thermoresistible__bu AGSAAVRILTGPRWRLGARDLTALWRRAVELGTVEPPGARPDTDGVEQIL
MAB_3515c|M.abscessus_ATCC_199 AGPAALRVLTGPRWRLGAHDLVVLWRRATGFGRGG----------APAVG
MLBr_00153|M.leprae_Br4923 DAVSMRRILNTPRRGIGDR-------------------------AEACVS
. : *:*. ** :* :
Rv3201c|M.tuberculosis_H37Rv MAASA---DADNPCLADAISDPGSAEGYSVAGYGRIGALAGELSALRGRL
Mb3226c|M.bovis_AF2122/97 MAASA---DADNPCLADAISDPGSAEGYSVAGYGRIGALAGELSALRGRL
MMAR_1359|M.marinum_M AAAGP---DTDTACLADAICDPGPADWYSSAGYERIGALAAELNALRGHL
MUL_2520|M.ulcerans_Agy99 AAAGP---DTDTACLADAICDPGPADWYSSAGYERIGALAAELNALRGHL
MAV_4147|M.avium_104 SAADPRNVEADAVCLADAIADPGPAEGYSAAGYARIAALAAELSALRAHL
Mflv_4665|M.gilvum_PYR-GCK AKLEP---DADDACLADAVCDPGPAAAYSPTGYARIVALGRELTALRAHL
Mvan_1802|M.vanbaalenii_PYR-1 AQLGP---DADAACLADAICDPGPATAYSEAGHARIVALGRELTGLRAHL
MSMEG_1943|M.smegmatis_MC2_155 AQAAP---DADTACVADAICDPGDAERYSPAGYERIVALGRELTMLRAHL
TH_1441|M.thermoresistible__bu AGIGP---DADEPCLADAICDPGDAAAYSEEGYRRITALAQELTALRAHL
MAB_3515c|M.abscessus_ATCC_199 PDVGE---EADIPCLADAISDPGTPDEYSPEGWKRLTALRRELSALRARL
MLBr_00153|M.leprae_Br4923 VYAEN---TGTSFADALQAVAEGKVPMLNTRSVKAIAGFVALLDDLRCRV
. * * . . : .: * ** ::
Rv3201c|M.tuberculosis_H37Rv GHSLPDLVAEVRRVLGVDCEVRASAPVSGGWAGPEHLDAFADVVAGYAER
Mb3226c|M.bovis_AF2122/97 GHSLPDLVAEVRRVLGVDCEVRASAPVSGGWAGPEHLDAFADVVAGYAER
MMAR_1359|M.marinum_M GHWLPDLVAEVRRVLGLDCDVRAAATASGAWAGAEHLDAFADVVADYAER
MUL_2520|M.ulcerans_Agy99 GHWLPDLVAEVRRVLGLDCDVRAAATASGAWAGAEHLDAFADVVADYAER
MAV_4147|M.avium_104 DHPLGDLVAEVRRVMDLDCEVRAAAAAG--WAGTEHLDAFADVVAGYAER
Mflv_4665|M.gilvum_PYR-GCK SSPLPDLVAEIRRTLGIDAEVRAAQPISAGWSGTEHLDRFGDVVAEFASR
Mvan_1802|M.vanbaalenii_PYR-1 QSPLPDLLAEVRRVLGIDTEVRAAQPVSAGWSGTEHLDAFGDVVADFAAR
MSMEG_1943|M.smegmatis_MC2_155 GHPLPELVAEVRRVLGLDAEARAARPVAAGWAGTENLDRFSDLVSDFAGH
TH_1441|M.thermoresistible__bu HHPLPDLIAEIRRILGVDAEARAGQPVAAGWAGTENLDAFADVVAEFAVR
MAB_3515c|M.abscessus_ATCC_199 GMPLTDLIAEVQRVLALDVELVAGRRGE----GLDQLRAFTDVAAGFAES
MLBr_00153|M.leprae_Br4923 DDDLGELVESVLERSGYLRELESS-TDPQELARLDNLNELVSFAHEFSTE
* :*: .: . : :. ::* : ... ::
Rv3201c|M.tuberculosis_H37Rv -----ASARSSEASVAGLLAYLDVAEVVENGLPPAELTVACDRVQVLTVH
Mb3226c|M.bovis_AF2122/97 -----ASARSSEASVAGLLAYLDVAEVVENGLPPAELTVACDRVQVLTVH
MMAR_1359|M.marinum_M AAISAGSALSTKASVDGLLAYLDVAAEVENGLPPAQLTVARDRVQVLTVH
MUL_2520|M.ulcerans_Agy99 TAISAGSALSTKASVDGLLAYLDVAAEVENGLPPAQLTVARDGVQVLTVH
MAV_4147|M.avium_104 ADTG-GTDASASASVAGLLAFLDVAESVENGLPAAPLAVARDRVQVLTVH
Mflv_4665|M.gilvum_PYR-GCK ----------GTPTASGLLAYLDTAEQVENGLAPAEVTVSSDRVQILTVH
Mvan_1802|M.vanbaalenii_PYR-1 ----------GGATVSALLGYLDIAEQVENGLAPAEVTVSADRVQILTVH
MSMEG_1943|M.smegmatis_MC2_155 ----------AGASVSALLAYLDAAVEVENGLAPAELTVSHDRVQILTVH
TH_1441|M.thermoresistible__bu ----------PNATVPALLGYLSAAMEVENGLAPADVTVATDRVQILTVH
MAB_3515c|M.abscessus_ATCC_199 -----ADQSDPVGVVSAFLQYLDAAWEIEKGLAPVEVAASPGRVQILTVH
MLBr_00153|M.leprae_Br4923 -----------QANAAALAKSLHTPEDED---------------------
. .: * . :
Rv3201c|M.tuberculosis_H37Rv AAKGLEWQVVAVAHLSRGVFPSTVSRSSWLTDPAELPPLLRGDRASAG-A
Mb3226c|M.bovis_AF2122/97 AAKGLEWQVVAVAHLSRGVFPSTVSRSSWLTDPAELPPLLRGDRASAG-A
MMAR_1359|M.marinum_M AAKGLEWQVVAVAHLSAGVFPSTASRSSWLTDPGELPPLLRGDRASVG-A
MUL_2520|M.ulcerans_Agy99 AAKGLEWQVVAVAHLSAGVFPSTASRSSWLTDPGELPPLLRGDRASVG-A
MAV_4147|M.avium_104 SAKGLEWQLVAVAHLSGGVFPSTTAKTTWLTDAAELPPLLRGDRARPG-A
Mflv_4665|M.gilvum_PYR-GCK AAKGLEWQIVAVPHLVGRVFPSTASPRTWLTDAADLPPLLRGDCATVS-A
Mvan_1802|M.vanbaalenii_PYR-1 AAKGLEWQIVAVPHLSGRVFPSTASPRTWLTDAADLPPLLRGDCATVS-E
MSMEG_1943|M.smegmatis_MC2_155 AAKGLEWQVVAVPHLSARVFPSTTQARTWLTDASDLPPLLRGDRATES-E
TH_1441|M.thermoresistible__bu AAKGLEWEVVAVPHLSRRVFPSTASPRTWLTDAGELPPLLRGDRATTS-E
MAB_3515c|M.abscessus_ATCC_199 SAKGLEWDVVAVPHLSAGVFPSGVAAPTWLTSATELPPLVRGDRASQGDQ
MLBr_00153|M.leprae_Br4923 -------------VPDTGALAAFLEKVSLMSDTDQIPENNSGVVTLMT-L
.:.: : ::.. ::* * :
Rv3201c|M.tuberculosis_H37Rv HGIPVLDTSAVADRKQLSDKISEHRRLLDRRRVDEERRLLYVAVTRAEDT
Mb3226c|M.bovis_AF2122/97 HGIPVLDTSAVADRKQLSDKISEHRRLLDRRRVDEERRLLYVAVTRAEDT
MMAR_1359|M.marinum_M LGIPVLDTSAVTNRKQLSDTISAHREQLDQRRVDEERRLLYVGVTRAEDT
MUL_2520|M.ulcerans_Agy99 LGIPVLDTSAVTNRKQLSDTISAHREQLDQRRVDEERRLLYVGVTRAEDT
MAV_4147|M.avium_104 LGIPVLDTSDVTNRKQLSDKISEHRRQLEQRRVDEERRLLYVAVTRAEDT
Mflv_4665|M.gilvum_PYR-GCK HGVPVLDTSDVSDRKGLSDKIAAHKSSLDQRRTDEERRLLYVAITRAEHT
Mvan_1802|M.vanbaalenii_PYR-1 HGVPVLDTSDVSDRKGLSDKIYDHKRSLEQRRTDEERRLLYVAITRAEHT
MSMEG_1943|M.smegmatis_MC2_155 IGVPVLDTSDIYDRKILSDKISDHKKSLDQRRVDEERRLLYVAITRAEDT
TH_1441|M.thermoresistible__bu HGVPVLDTADVNDRKALSDKIAEHKNRLAQRRTDEERRLLYVAVTRAEDT
MAB_3515c|M.abscessus_ATCC_199 FGVPQLDTEGITNRKQLADAIARHKDSLATRRIDEERRLLYVAVTRCAEQ
MLBr_00153|M.leprae_Br4923 HAAKGLEFPVVFVTGWEDGMLPHMRTLGDPTELSEERRLAYVGITRARQR
. *: : . : : . .***** **.:**. .
Rv3201c|M.tuberculosis_H37Rv LLVSGHHWGPTGTKPRGPSEFLCELKDIIDRSAAAGDPCGVVEQWASAPA
Mb3226c|M.bovis_AF2122/97 LLVSGHHWGPTGTKPRGPSEFLCELKDIIDRSAAAGDPCGVVEQWASAPA
MMAR_1359|M.marinum_M VLVSGHHWGATGLKPRGPSDFLCELKDIIERSAAAGDPCGTVDQWDPAPV
MUL_2520|M.ulcerans_Agy99 VLVSGHHWGATGLKPRGPSDFLCELKDIIERSAAAGDPCGTVDQWDRAPV
MAV_4147|M.avium_104 LLVSGHHWAATGIKPRGPSDFLCEIKDVIDASAAAGDPCGTVEQWAPAPA
Mflv_4665|M.gilvum_PYR-GCK LLVSGHHWGATESKPRGPSTFLTEIKDVIDASIEEGRPCGSIAVWADAPA
Mvan_1802|M.vanbaalenii_PYR-1 LLVSGHHWGATESKPRGPSTFLCELKDVIDASVQSGSPCGAVDVWADAPA
MSMEG_1943|M.smegmatis_MC2_155 LLLSGHHWGATESKPRGPSEFLCELKTILEEATAAGTPCGEIEHWAPDPA
TH_1441|M.thermoresistible__bu LLVSGHHWGATESKPRGPSEFLLEIKDVIDRSAEAGDPCGTIDLWAPEPP
MAB_3515c|M.abscessus_ATCC_199 LFVSGHHWGQTGLKPKGPSDFLVELRDVIESAAAEGVPCGTVERWAPEPP
MLBr_00153|M.leprae_Br4923 LYLS---------------------------------RAITRSSWGQPIL
: :* . *
Rv3201c|M.tuberculosis_H37Rv GDERNPLCDNAIEAVWPADPLAARRGDVERGAALVAAAMSADLPGSTTDI
Mb3226c|M.bovis_AF2122/97 GDERNPLCDNAIEAVWPADPLAARRGDVERGAALVAAAMSADLPGSTTDI
MMAR_1359|M.marinum_M AGERNPLLDDVVEAVWPTDPLATRRGDVERGARLVAEAISADA-GVEAPA
MUL_2520|M.ulcerans_Agy99 AGERNPLLDDVVEAVWPTDPLATRRGDVERGARLVAEAISADA-GVEAPA
MAV_4147|M.avium_104 DGERNPLRDNAVEAVWPADPLASRRGEVERGAALVRQAMAAEP-------
Mflv_4665|M.gilvum_PYR-GCK DGETNPIRDRVVEAVWPVDPVAGRRGPVDRGAHLVAEALSGECPEV----
Mvan_1802|M.vanbaalenii_PYR-1 DGEPNPLRDRVVEAVWPEDPLAGRRAHTDHGARLVTTAMSTAGGAG----
MSMEG_1943|M.smegmatis_MC2_155 PGETNPLRDQVVEALWP--PVASADDHVHRGAQLVAAAMAGEVSA-----
TH_1441|M.thermoresistible__bu DGTPNPLRDKAFEVLWPAPPXXXPAGPPPPVSPRITTPSAGGA-------
MAB_3515c|M.abscessus_ATCC_199 AGERNPMLDQTVEAQWPADPLAGRRDDIEAGARLVRAALADGAALTME--
MLBr_00153|M.leprae_Br4923 NPESRFLR------EIPPELIDWRR-------------------------
. : *
Rv3201c|M.tuberculosis_H37Rv DHPPRPGDAPWSTDVDALLAERAHAARGAPARGLPNHLSVSSLVELVGDP
Mb3226c|M.bovis_AF2122/97 DHPPRPGDAPWSTDVDALLAERAHAARGAPARGLPNHLSVSSLVELVGDP
MMAR_1359|M.marinum_M GGAAVADIEGWTADVDALLAERARAVG-PPTRALPNQLSVSGLVELARDP
MUL_2520|M.ulcerans_Agy99 GGAAVADIEGWTADVDALLAERARAVG-PPTRALPNQLSVSGLVELARDP
MAV_4147|M.avium_104 -GDPGADVEGWAADVDALLVERARVTG-PPPQVLPGQLSVSSLVGLARDP
Mflv_4665|M.gilvum_PYR-GCK ---GSDDDHGWVADVDALLAERDLAAQ-RAVPSLPAQLSVSAMVELGRDP
Mvan_1802|M.vanbaalenii_PYR-1 ---PQPDVHGWTADVDALLAERELAAQ-RPVPPLPLQLSVSAMVELGRDP
MSMEG_1943|M.smegmatis_MC2_155 ----EADQEGWAADVDALLAERERPPQ-QEDTELPGQLSVSTLVELSRDP
TH_1441|M.thermoresistible__bu ----QPNRRRLIAGVAGVAA-----------VAVLGGLAFWLLSPSGTDQ
MAB_3515c|M.abscessus_ATCC_199 ---DDDDTDGWEADVDALLREREQGHR-RPEMTLPQHLSVTSLVELRQDP
MLBr_00153|M.leprae_Br4923 ----------------------------------------SILTDSYSTP
:
Rv3201c|M.tuberculosis_H37Rv VGARQRLMCRLPKRPDPHAWLGDAFHAWVQQFYGAELLFDLGDLPGAADR
Mb3226c|M.bovis_AF2122/97 VGARQRLMCRLPKRPDPHAWLGDAFHAWVQQFYGAELLFDLGDLPGAADR
MMAR_1359|M.marinum_M VGARQRLVHRLPTRPDPHAQLGNAFHTWVQQFYGAELLFDLGDLPGAADS
MUL_2520|M.ulcerans_Agy99 VGARQRLVHRLPTRPDPHAQLGNIFHTWVQQFYGAELLFDLGDLPGAADS
MAV_4147|M.avium_104 ARAAQRLRHRLPSRPEPHALLGNAFHAWVQKFYGAECLFELGDLPGAADS
Mflv_4665|M.gilvum_PYR-GCK EAVAHRLQRRLPRRPDSHALLGTAFHEWVQRYFQAEKLFDLDDLPGAVDA
Mvan_1802|M.vanbaalenii_PYR-1 EAVAQRLQRRLPRRPDAQALLGTAFHEWVQRYFQAEKLFDLDDLPGAVDA
MSMEG_1943|M.smegmatis_MC2_155 KAALTRLRRRLPQRPDPHALLGTTFHEWVQRYFHAERLFDLDDLPGAVDS
TH_1441|M.thermoresistible__bu ADGARADDTAETTSPPRDTAAENRLLTMLPPGYSAGACGPVPAPEGALAQ
MAB_3515c|M.abscessus_ATCC_199 QALARRLARPRPTRPDLDARRGTAFHSWVQRHYGSVRLIDFEDLPGDGYG
MLBr_00153|M.leprae_Br4923 ASGASRFGRVRPSSIRSG--------------------------------
.
Rv3201c|M.tuberculosis_H37Rv E--VGDPEELAALQRAFTASSWAARTPAAVEVPFEMPIGDTVVRGRIDAV
Mb3226c|M.bovis_AF2122/97 E--VGDPEELAALQRAFTASSWAARTPAAVEVPFEMPIGDTVVRGRIDAV
MMAR_1359|M.marinum_M D--VGQVEDLAPLQEAFAGSPWAARTPIAVEVPFEMPVGDTVVRGRIDAV
MUL_2520|M.ulcerans_Agy99 D--VGQVEDLAPLQEAFAGSPWAARTPIAVEVPFEMPVGDTVVRGRIDAV
MAV_4147|M.avium_104 D--VGDTAELAELQAAFLESPWAARTPVAVEVPFEMPIGDTLVRGRIDAV
Mflv_4665|M.gilvum_PYR-GCK D--RQDRGELDELQTAFAVSPWAARTPIDVEVPFDMMLAGRIVRGRIDAI
Mvan_1802|M.vanbaalenii_PYR-1 D--RQDRGELEELQAAFALSPWAARTPIDVEVPFDMMIAGRVVRGRIDAV
MSMEG_1943|M.smegmatis_MC2_155 DSGRAVEESLAELQDAFVKSPWAARTPVEVEVPFDMVLGETVVRGRIDAV
TH_1441|M.thermoresistible__bu VVCRENTDPGGPPTATYT----LARDEAAMQRAFDEIIAASATVN--CPN
MAB_3515c|M.abscessus_ATCC_199 S--FEDAEDLAALQSAFLESEWADRTPVEVEVPFEISVAGIVVRGRIDAV
MLBr_00153|M.leprae_Br4923 ----------------------ASKRALLVLAPGDRVTHDKYGLGRVEEV
: : . : .
Rv3201c|M.tuberculosis_H37Rv FV--DPDGGATVVDWKTGKPPHGPAAMRQAAVQLAVYRLAWAALRGCPTS
Mb3226c|M.bovis_AF2122/97 FV--DPDGGATVVDWKTGKPPHGPAAMRQAAVQLAVYRLAWAALRGCPTS
MMAR_1359|M.marinum_M FE--DPDGGATVVDWKTGEPPRGPEAMRQAAVQLAVYRMAWAALRGCPES
MUL_2520|M.ulcerans_Agy99 FE--DPDGGATVVDWKTGEPPRGPEAMRQAAVQLAVYRMAWAALRGCPES
MAV_4147|M.avium_104 FA--ESDGGATVVDWKTGAPPDSPEAMRQAAVQLAVYRLAWAALAKVPES
Mflv_4665|M.gilvum_PYR-GCK FA--DGDGSFTVVDWKTGEMPTDPEVLAHNALQLAVYRLAWARLHGCPTS
Mvan_1802|M.vanbaalenii_PYR-1 FA--DGDG-VMVVDWKTGEPPATEEELQHNAVQLAVYRLAWARLHDCPVS
MSMEG_1943|M.smegmatis_MC2_155 FA--EPDGTTMVLDWKTGDPPETPEAKEHAAVQLAVYRLAWAAMRGCPPE
TH_1441|M.thermoresistible__bu FI--QSPG-----PWRRNATPDRISGTLFCGIQQNEPLVAWTDDANLVVS
MAB_3515c|M.abscessus_ATCC_199 FGPDSAEDTWTVVDWKTGHEPAG-DEMKAAALQLAVYRRAWASLREIDPA
MLBr_00153|M.leprae_Br4923 SG--VGESAISLIDFGSS-----------GRIKLMHNHAPVTKL------
. : . :: . :
Rv3201c|M.tuberculosis_H37Rv SVRTAFYYVRSGITVVPDELPAPGELAMLLTDCAGRRSDT-----
Mb3226c|M.bovis_AF2122/97 SVRTAFYYVRSGITVVPDELPAPGELAMLLTDCAGRRSDT-----
MMAR_1359|M.marinum_M SVRTAFHYVRTGVTVIPDELPDGMALAELLADSDPPCSC------
MUL_2520|M.ulcerans_Agy99 SVRTAFHYVRTGVTVIPDELPDGMALAELLADSDPPCSC------
MAV_4147|M.avium_104 SVRTAFHYVRARTTVVPEALPTSDQLAGLLAPTAPV---------
Mflv_4665|M.gilvum_PYR-GCK AVRAAFHYVRSGRTVMPDALPEEDDLIALLADRDDEDAA------
Mvan_1802|M.vanbaalenii_PYR-1 SVRAAFHYVRSGRTVVPDGLPDADDLAALLADPPAA---------
MSMEG_1943|M.smegmatis_MC2_155 SVRAAFHYVRSGQTVIPETLPGAEELVKLLAAAPTETAEEADRIT
TH_1441|M.thermoresistible__bu AVHSG---------------PQGPTLDELYAWWTTHS--------
MAB_3515c|M.abscessus_ATCC_199 RVRAVFHYVRSGRTVAPTELPDLPHAEELAELTRD----------
MLBr_00153|M.leprae_Br4923 ---------------------------------------------