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NPRYSPDEIASALGIFPPTDEQAAVIAAPPGPLVVIAGAGAGKTETMAARVVWLVANGYAEPGQVLGLTF TRKAAGQLLRRVRSRLARLAGTTVGVAVGEAAGAPTVSTYHAFAGSLLRDHGLLLPIEPDTRLLSETELW QLAFEVVNGYRGELCTQKTPAAVTATVLRLWGQLAEHLVDTRQLRDTHIELERLVHALPAGPNQRDSGPN QWLLRMLVTQTERAELVPLLDALHERMRAAKVMDFGMQMAAAARLAATCPQVGGELRSRYRVVLLDEYQD TGHSQRIALSALFGGGVDDGLALTAVGDPIQSIYGWRGASATNLPRFSTDFALSDGAPAPVLELRTSWRN PPRALHLANAISAEPRRRSVAVHALRSRPDAPAGTVRCALLADVQAERDWIADQLQGHYQRAAADGVSPP TAAVLVRRNADAAPIADALVARGIPVEVVGLAGLLSIPEVADLVAMLRLVGDPTAGAAAMRVLTGPRWRL GGSDVAALWRRAVALVGGPQVGASVSPGAVAAAAGPDTDTACLADAICDPGPADWYSSAGYERIGALAAE LNALRGHLGHWLPDLVAEVRRVLGLDCDVRAAATASGAWAGAEHLDAFADVVADYAERTAISAGSALSTK ASVDGLLAYLDVAAEVENGLPPAQLTVARDGVQVLTVHAAKGLEWQVVAVAHLSAGVFPSTASRSSWLTD PGELPPLLRGDRASVGALGIPVLDTSAVTNRKQLSDTISAHREQLDQRRVDEERRLLYVGVTRAEDTVLV SGHHWGATGLKPRGPSDFLCELKDIIERSAAAGDPCGTVDQWDRAPVAGERNPLLDDVVEAVWPTDPLAT RRGDVERGARLVAEAISADAGVEAPAGGAAVADIEGWTADVDALLAERARAVGPPTRALPNQLSVSGLVE LARDPVGARQRLVHRLPTRPDPHAQLGNIFHTWVQQFYGAELLFDLGDLPGAADSDVGQVEDLAPLQEAF AGSPWAARTPIAVEVPFEMPVGDTVVRGRIDAVFEDPDGGATVVDWKTGEPPRGPEAMRQAAVQLAVYRM AWAALRGCPESSVRTAFHYVRTGVTVIPDELPDGMALAELLADSDPPCSC*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2520 | - | - | 100% (1101) | ATP-dependent DNA helicase |
| M. ulcerans Agy99 | MUL_4723 | uvrD1 | 1e-43 | 25.13% (788) | ATP-dependent DNA helicase II UvrD1 |
| M. ulcerans Agy99 | MUL_2512 | uvrD2 | 2e-30 | 29.35% (460) | ATP-dependent DNA helicase II UvrD2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3226c | - | 0.0 | 78.98% (1094) | ATP-dependent DNA helicase |
| M. gilvum PYR-GCK | Mflv_4665 | - | 0.0 | 67.42% (1099) | UvrD/REP helicase |
| M. tuberculosis H37Rv | Rv3201c | - | 0.0 | 78.98% (1094) | ATP-dependent DNA helicase |
| M. leprae Br4923 | MLBr_00153 | uvrD | 3e-40 | 24.91% (807) | putative ATP-dependent DNA helicase |
| M. abscessus ATCC 19977 | MAB_3515c | - | 0.0 | 59.96% (1104) | ATP-dependent DNA helicase |
| M. marinum M | MMAR_1359 | - | 0.0 | 99.18% (1101) | ATP-dependent DNA helicase |
| M. avium 104 | MAV_4147 | - | 0.0 | 77.01% (1105) | superfamily protein I DNA and RNA helicases |
| M. smegmatis MC2 155 | MSMEG_1943 | - | 0.0 | 69.78% (1092) | ATP-dependent DNA helicase |
| M. thermoresistible (build 8) | TH_1441 | - | 0.0 | 70.81% (853) | PROBABLE ATP-DEPENDENT DNA HELICASE |
| M. vanbaalenii PYR-1 | Mvan_1802 | - | 0.0 | 68.30% (1104) | UvrD/REP helicase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_2520|M.ulcerans_Agy99 -------------MNPRYSPDEIASALGIFPPTDEQAAVIAAPPGPLVVI
MMAR_1359|M.marinum_M -------------MNPRYSPDEIASALGIFPPTDEQAAVIAAPPGPLVVI
Mb3226c|M.bovis_AF2122/97 --------MTQTAAPARYSPAELACALGLFPPTAEQAAVIAAPPGPLVVI
Rv3201c|M.tuberculosis_H37Rv --------MTQTAAPARYSPAELACALGLFPPTAEQAAVIAAPPGPLVVI
MAV_4147|M.avium_104 -------------MSDRYSPRELACALGLFPPTEEQAAVIAAPPGPLVVI
Mflv_4665|M.gilvum_PYR-GCK ------------MSTPLYSPAELSRALGLFEPTEEQAAVIAAPPGPLVVI
Mvan_1802|M.vanbaalenii_PYR-1 ------------MTTPRYSPAELSRALGLFEPTDEQAAVIAAEPGPLVVI
MSMEG_1943|M.smegmatis_MC2_155 -------------MQARYSPVELSAALGLFPPTDEQAAVIAAPPGPLVVI
TH_1441|M.thermoresistible__bu LSGAGRAGRIGAAVTARHSPADLAEALGLFPPTEEQAAVIAAPPGPLVVI
MAB_3515c|M.abscessus_ATCC_199 --------------MNAYSPAELSRVLGLFEPTDEQAAVIGAPPGPMVVI
MLBr_00153|M.leprae_Br4923 ---------MSVHTTDAKPDSEVDRLLDGLNPQQRQAVVHEGSP--LLIV
. :: *. : * .**.* . * ::::
MUL_2520|M.ulcerans_Agy99 AGAGAGKTETMAARVVWLVANGYAEPGQVLGLTFTRKAAGQLLRRVRSRL
MMAR_1359|M.marinum_M AGAGAGKTETMAARVVWLVANGYAEPGQVLGLTFTRKAAGQLLRRVRSRL
Mb3226c|M.bovis_AF2122/97 AGAGAGKTETMAARVVWLVANGYAEPGQVLGLTFTRKAAGQLLRRVRSRL
Rv3201c|M.tuberculosis_H37Rv AGAGAGKTETMAARVVWLVANGYAEPGQVLGLTFTRKAAGQLLRRVRSRL
MAV_4147|M.avium_104 AGAGAGKTETMAARVVWLIANGYAHPGQVLGLTFTRKAAGQLLRRVRSRL
Mflv_4665|M.gilvum_PYR-GCK AGAGAGKTETMAARVVWLVANGYATPGEVLGLTFTRKAAGQLLRRVRSRL
Mvan_1802|M.vanbaalenii_PYR-1 AGAGAGKTETMAARVVWLVANGYARPGEVLGLTFTRKAAGQLLRRVRARL
MSMEG_1943|M.smegmatis_MC2_155 AGAGAGKTETMAARVVWLVANGFATPSQVLGLTFTRKAAGQLLRRVRTRL
TH_1441|M.thermoresistible__bu AGAGAGKTETMAARVVWLVANGYARPDQVLGLTFTRKAAGQLLRRVRSRL
MAB_3515c|M.abscessus_ATCC_199 AGAGAGKTETMAARVVWLVANGYATPGQVLGLTFTRKAAAQLLRRVRSRL
MLBr_00153|M.leprae_Br4923 AGAGSGKTTVLARRIAYLIAARSVGVSQILAITFTNKAAAEMRERVARLV
****:*** .:* *:.:*:* . .::*.:***.***.:: .** :
MUL_2520|M.ulcerans_Agy99 ARLAGTTVGVAV-----GEAAGAPTVSTYHAFAGSLLRDHGLLLPIEPDT
MMAR_1359|M.marinum_M ARLAGTTVGVAV-----GEAAGAPTVSTYHAFAGSLLRDHGLLLPIEPDT
Mb3226c|M.bovis_AF2122/97 ARLAGIGLGCG------DPAACAPVVSTYHAFAGSLLRDYGLLLPLEPDT
Rv3201c|M.tuberculosis_H37Rv ARLAGIGLGCG------DPAACAPVVSTYHAFAGSLLRDYGLLLPLEPDT
MAV_4147|M.avium_104 ARLAGVGLGAASPNHGAVDPEAAPVVSTYHAFAGSLLRDYGLLLPVEPDT
Mflv_4665|M.gilvum_PYR-GCK ARLAGAGLTIPAA--GADLADDPVTIGTYHAFAGTLLREFGLMLPVEPDT
Mvan_1802|M.vanbaalenii_PYR-1 ARLAGAGLMIPTG--GADFADDPVTISTYHAFAGNLLREFGLLLPVEPDT
MSMEG_1943|M.smegmatis_MC2_155 ARLAGAGLAP-----GSGASDESATVSTYHAFAGTLLREHGLLLPVEPDT
TH_1441|M.thermoresistible__bu ARLAGTGLVPANS--APDWTTESVTVSTYHAFAGTLLREHGLLLPVEPDT
MAB_3515c|M.abscessus_ATCC_199 ARLAGSGILAP-----VAADEPDPVIATYHAYAGTLLREHGLLLPMEPNA
MLBr_00153|M.leprae_Br4923 GDHTGP----------------SMWVSTFHSTCVRILRNQASLIGGLNSN
. :* :.*:*: . :**: . :: .
MUL_2520|M.ulcerans_Agy99 RLLSETELWQLAFEVVNGYRGELCTQKTPAAVTATVLRLWGQLAEHLVDT
MMAR_1359|M.marinum_M RLLSETELWQLAFEVVNGYRGELCTQKTPAAVTATVLRLWGQLAEHLVDT
Mb3226c|M.bovis_AF2122/97 RLLSETELWQLAFDVVSGYDGVLCTDKSPAAVTSIVVRLWGQLGEHLVDT
Rv3201c|M.tuberculosis_H37Rv RLLSETELWQLAFDVVSGYDGVLCTDKSPAAVTSIVVRLWGQLGEHLVDT
MAV_4147|M.avium_104 RLLSETELWQLAFDVVNRYRGPLRTDKTPAAVTSMVLRLWGQLAEHLVDT
Mflv_4665|M.gilvum_PYR-GCK RLLGETELWQLAFRVVCEHPAALDTDKSPASITAMVLRLAGQLSEHLVDT
Mvan_1802|M.vanbaalenii_PYR-1 RLLGETELWQLAFRVVCAHPAALDTEKSPASITDMVLRLAGQLSEHLVDT
MSMEG_1943|M.smegmatis_MC2_155 RLLSETELWQLAYDVVCAHPGHLDTEKTPAAVTAMVLRLSGALAEHLVDT
TH_1441|M.thermoresistible__bu RLIGETELWQLAYRVVCEHPGPLDTDKTPAAITAMVLRLAGQLAEHLVDT
MAB_3515c|M.abscessus_ATCC_199 RLLTETQLWQLAFRLVCDFDGDLDTEKTPGAVTAQVLALAGQLSEHLVNT
MLBr_00153|M.leprae_Br4923 FSIYDVDDSRSLLQMIGQDMGLDIKRYSPRLMANAISNLKNELIDAESAV
: :.: : :: . . :* :: : * . * : .
MUL_2520|M.ulcerans_Agy99 RQLRDTHIELERLVHALPAGPNQRDSGPNQWLLRMLVTQTERAELVPLLD
MMAR_1359|M.marinum_M RQLRDTHIELERLVHALPAGPNQRDSGPNQWLLRMLATQTERAELVPLLD
Mb3226c|M.bovis_AF2122/97 RALRDTHVELERLVHALPAGRYQRDRGPSQWLLRMLATQTQRAELVPLLD
Rv3201c|M.tuberculosis_H37Rv RALRDTHVELERLVHALPAGRYQRDRGPSQWLLRMLATQTQRAELVPLLD
MAV_4147|M.avium_104 SQLRETHLELERLVHALPAGPYQRDRGPSQWLRRLSGTQSERAELVPLLE
Mflv_4665|M.gilvum_PYR-GCK EQLRDTHVELDRLVHTLPAGRYQRDRGPSQWLLRMLATQTERTMLVPLID
Mvan_1802|M.vanbaalenii_PYR-1 AALRDTHVELERLVLNLPAGRYQRDRGPSQWLLRMLATQTERTMLVPLVD
MSMEG_1943|M.smegmatis_MC2_155 DQLRDTHVELERLVHTLPAGPYQRDRGPSQWLLRMLATQTERTELVPLID
TH_1441|M.thermoresistible__bu DQLRDTHVELERLVHTLPAGPYQRDRGPSQWLLNMLATQTERAALVPLID
MAB_3515c|M.abscessus_ATCC_199 TDLLSSHDELERLILTLPPGPRQREGGPSAWLLRLIETQRERTQLMAIVE
MLBr_00153|M.leprae_Br4923 ANLSSDTDDLARTVATVYG-------------------------------
* . :* * : :
MUL_2520|M.ulcerans_Agy99 ALHERMRAAKVMDFGMQMAAAARLAATCPQVGGELRSRYRVVLLDEYQDT
MMAR_1359|M.marinum_M ALHERMRAAKVMDFGMQMAAAARLAATCPQVGEELRSRYRVVLLDEYQDT
Mb3226c|M.bovis_AF2122/97 ALGERMHAGKVMDFAMQMASAARLAATSPQVGQDLRRRYRVVLLDEYQDT
Rv3201c|M.tuberculosis_H37Rv ALGERMHAGKVMDFAMQMASAARLAATSPQVGQDLRRRYRVVLLDEYQDT
MAV_4147|M.avium_104 ALDERMRAVKVMDFGMQMASAARLAAAFPQVGADLRGRYRVVLLDEYQDT
Mflv_4665|M.gilvum_PYR-GCK ALHRRMREERVMDFGMQMASAARLASTHPAVGEQLRQRYRVVLLDEYQDT
Mvan_1802|M.vanbaalenii_PYR-1 ALHRRMREERVMDFGMQMASAARLAAQFPQVGAQLRQRYRVVLLDEYQDT
MSMEG_1943|M.smegmatis_MC2_155 ALHQRMRAEKVMDFGMQMAAAARLAARFPQVGEQLRQRFRVVLLDEYQDT
TH_1441|M.thermoresistible__bu AVHRRMRAEKVMDFGMQMAAAARLASEHPQVGAALRQRFRVVLLDEYQDT
MAB_3515c|M.abscessus_ATCC_199 QLIALMRTRGVLDFGAQMALSARLAADHPIVGQTQRERYRVVLLDEYQDT
MLBr_00153|M.leprae_Br4923 EYQRRLRTANALDFDDLIGETVGILQAFPQIAEHYRRRFRHVLVDEYQDT
:: .:** :. :. : * :. * *:* **:******
MUL_2520|M.ulcerans_Agy99 GHSQRIALSALFGGGVDDG------LALTAVGDPIQSIYGWRGASATNLP
MMAR_1359|M.marinum_M GHSQRVALSALFGGGVDDG------LALTAVGDPIQSIYGWRGASATNLP
Mb3226c|M.bovis_AF2122/97 GHAQRVVLSSLFGGGVDDG------LALTAVGDPIQSIYGWRGASATNLP
Rv3201c|M.tuberculosis_H37Rv GHAQRVVLSSLFGGGVDDG------LALTAVGDPIQSIYGWRGASATNLP
MAV_4147|M.avium_104 GHAQRIALSALFGGGVDDG------LALTAVGDPIQSIYGWRGASATNLP
Mflv_4665|M.gilvum_PYR-GCK GHAQRVALSSLFGGGADDG------LALTAVGDPIQSIYGWRGASATNLP
Mvan_1802|M.vanbaalenii_PYR-1 GHAQRVALSSLFGGGADDG------LALTAVGDPIQSIYGWRGASATNLP
MSMEG_1943|M.smegmatis_MC2_155 GHAQRIALSSLFGGGADDG------LALTAVGDPIQSIYGWRGASATNLP
TH_1441|M.thermoresistible__bu GHAQRIALSALFGGGVDDD------LALTAVGDPIQSIYGWRGASATNLP
MAB_3515c|M.abscessus_ATCC_199 GHAQRILLSSLFGRGVDPD------LALTAVGDPIQSIYGWRGASATNLP
MLBr_00153|M.leprae_Br4923 NHAQYVLVRELVGHGARNSPDDMPPGELCVVGDADQSIYAFRGSTISNIE
.*:* : : *.* *. . * .***. ****.:**:: :*:
MUL_2520|M.ulcerans_Agy99 RFSTDFALSDGAPAPVLELRTSWRNPPRALHLANAISAEPRRRSVAVHAL
MMAR_1359|M.marinum_M RFSTDFALSDGAPAPVLELRTSWRNPPRALHLANAISAEARRRSVAVHAL
Mb3226c|M.bovis_AF2122/97 RFTTDFPLSDGTPAPVLELLTSWRNPPQALRVANGISAEARRRSVAVRAL
Rv3201c|M.tuberculosis_H37Rv RFTTDFPLSDGTPAPVLELLTSWRNPPQALRVANGISAEARRRSVAVRAL
MAV_4147|M.avium_104 RFTTDFPRSDGTPAPVLELRTSWRNPPRTLRVANAISAEARRRSVAVHAL
Mflv_4665|M.gilvum_PYR-GCK RFTTDFPLSDGTPAPTLELRTSWRNPPEVLHLANAASVDARRRSVEVRSL
Mvan_1802|M.vanbaalenii_PYR-1 RFTTDFPLSDGTPAPTLELRTSWRNPPEVLHLANEVSVDARRRSVAVRAL
MSMEG_1943|M.smegmatis_MC2_155 RFTTDFPYSDGTPAPTLELRTSWRNPPSTLHVANAVSEEARRRSVAVRAL
TH_1441|M.thermoresistible__bu RFATDFPHSDGSPAPTLELRTSWRNPPRTLHLANAISAEARRRSVAVRAL
MAB_3515c|M.abscessus_ATCC_199 RFTTDFPLPDGSPAPTRELRTSWRNPPEALHLANSVSEEARRRSVAVRPL
MLBr_00153|M.leprae_Br4923 DFERDYP-----DTTTILLEQNYRSTQNILSAANSVIARNFGR----RDK
* *:. :.. * .:*.. * ** * :
MUL_2520|M.ulcerans_Agy99 RSRPDAPAGTVRCALLADVQA-ERDWIADQLQGHYQRAAADGVSPPTAAV
MMAR_1359|M.marinum_M RSRPDAPAGTVRCALLADVQA-ERDWIADQLQGHYQRAAADGVSPPTAAV
Mb3226c|M.bovis_AF2122/97 RPRPDAPPGAVRCALLPDVQA-EREWIADHLRMRYQRAEADGVKPPTAAV
Rv3201c|M.tuberculosis_H37Rv RPRPDAPPGAVRCALLPDVQA-EREWIADHLRMRYQRAEADGVKPPTAAV
MAV_4147|M.avium_104 CPRPDAPPGTVRCALLPDMVA-EREWIADHIDAHYRRARADGVSPPTAAV
Mflv_4665|M.gilvum_PYR-GCK QPRPNAEPGSVRAALLSDVEA-ERDWVADQVAHRWHGGLAASGTAPTAAV
Mvan_1802|M.vanbaalenii_PYR-1 QPRPGAEPGSVRCALLSDVER-ERDWVADQIARRWHAGIEADGAAPTAAV
MSMEG_1943|M.smegmatis_MC2_155 RPRPDAEPGTIRCALLNNVAA-ERDWVADHLARAYHGAIGRGEAAPTAAV
TH_1441|M.thermoresistible__bu RPRPDAEPGTIRCALLDDVQS-EREWVAEQLAALYRHARDAGDTPPTAAV
MAB_3515c|M.abscessus_ATCC_199 LPRPDAASGRIACALLGDIAA-EREWVATQLAAVYEQAHREGNRPPSSAV
MLBr_00153|M.leprae_Br4923 RLWTDAGKGELIVGYVSDNEHDEAKFIADEIDALVGGGE---ITYDDVAV
..* * : . : : * .::* .: . **
MUL_2520|M.ulcerans_Agy99 LVRRNADAAPIADALVARGIPVEVVGLAGLLSIPEVADLVAMLRLVGDPT
MMAR_1359|M.marinum_M LVRRNADAAPIADALVARGIPVEVVGLAGLLSIPEVADLVAMLRLVGDPT
Mb3226c|M.bovis_AF2122/97 LVRRNADAAAIADTLRARGIPAEVVGLAGLLSIPEVAEVVAMLRLVADPT
Rv3201c|M.tuberculosis_H37Rv LVRRNADAAAIADTLRARGIPAEVVGLAGLLSIPEVAEVVAMLRLVADPT
MAV_4147|M.avium_104 LVRRNADAAPIADALRARGIPVEVVGLAGLLSVPEVAELVAMLRLVADPT
Mflv_4665|M.gilvum_PYR-GCK LVRRNADAAPMADALSRRGVPVEVVGLAGLLAVPEVADVVAMLRVAVDPT
Mvan_1802|M.vanbaalenii_PYR-1 LVRRNADAAPMADALTRRGVAVEVVGLAGLLAVPEVADVVAMLRLAADPT
MSMEG_1943|M.smegmatis_MC2_155 LVRRNADAAPMAEALTARGVPVEVVGVAGLLAVPEVADLVAMLRLIADPT
TH_1441|M.thermoresistible__bu LVRRNADAAPMAQALTARGVPVEVVGLAGLLAVPEVADVVAMLRLAADPT
MAB_3515c|M.abscessus_ATCC_199 LVRRNSDAAPMAEALAAQGVPAEVVGLTGLLGLPEVADTVAMLRLVADPT
MLBr_00153|M.leprae_Br4923 LYRANNLSRSLEEVFIPTGIPYKVVGGFCFYESKEIRDLIAYLRVLDNPG
* * * : .: :.: *:. :*** : *: : :* **: :*
MUL_2520|M.ulcerans_Agy99 AGAAAMRVLTGPRWRLGGSDVAALWRRAVALVGGP---QVGASVSPGAVA
MMAR_1359|M.marinum_M AGAAAMRVLTGPRWRLGGSDVAALWRRAVALVGGP---QVGASASPGAVA
Mb3226c|M.bovis_AF2122/97 AGAAAMRVLTGPRWRLGARDLAALWRRALTLSG-----ESPSTASPESIA
Rv3201c|M.tuberculosis_H37Rv AGAAAMRVLTGPRWRLGARDLAALWRRALTLSG-----ESPSTASPESIA
MAV_4147|M.avium_104 AGAAAMRVLTGPRWRLGARDLAALWQRARALGGAG---TAGGPATAEAIA
Mflv_4665|M.gilvum_PYR-GCK AGAAAVRVLTGPRWRLGARDLTALWRRAVTLVDTGP-SASDAVSATAEIV
Mvan_1802|M.vanbaalenii_PYR-1 AGAAAVRVLTGPRWRLGARDVAALWRRAVALVEPG--ASSDGESATAGIV
MSMEG_1943|M.smegmatis_MC2_155 AGSAVMRILTGPRWRFGARDIAALWRRAVELDDRP-----KGELGTADIV
TH_1441|M.thermoresistible__bu AGSAAVRILTGPRWRLGARDLTALWRRAVELGTVEPPGARPDTDGVEQIL
MAB_3515c|M.abscessus_ATCC_199 AGPAALRVLTGPRWRLGAHDLVVLWRRATGFGRGG----------APAVG
MLBr_00153|M.leprae_Br4923 DAVSMRRILNTPRRGIGDR-------------------------AEACVS
. : *:*. ** :* :
MUL_2520|M.ulcerans_Agy99 AAAGP---DTDTACLADAICDPGPADWYSSAGYERIGALAAELNALRGHL
MMAR_1359|M.marinum_M AAAGP---DTDTACLADAICDPGPADWYSSAGYERIGALAAELNALRGHL
Mb3226c|M.bovis_AF2122/97 MAASA---DADNPCLADAISDPGSAEGYSVAGYGRIGALAGELSALRGRL
Rv3201c|M.tuberculosis_H37Rv MAASA---DADNPCLADAISDPGSAEGYSVAGYGRIGALAGELSALRGRL
MAV_4147|M.avium_104 SAADPRNVEADAVCLADAIADPGPAEGYSAAGYARIAALAAELSALRAHL
Mflv_4665|M.gilvum_PYR-GCK AKLEP---DADDACLADAVCDPGPAAAYSPTGYARIVALGRELTALRAHL
Mvan_1802|M.vanbaalenii_PYR-1 AQLGP---DADAACLADAICDPGPATAYSEAGHARIVALGRELTGLRAHL
MSMEG_1943|M.smegmatis_MC2_155 AQAAP---DADTACVADAICDPGDAERYSPAGYERIVALGRELTMLRAHL
TH_1441|M.thermoresistible__bu AGIGP---DADEPCLADAICDPGDAAAYSEEGYRRITALAQELTALRAHL
MAB_3515c|M.abscessus_ATCC_199 PDVGE---EADIPCLADAISDPGTPDEYSPEGWKRLTALRRELSALRARL
MLBr_00153|M.leprae_Br4923 VYAEN---TGTSFADALQAVAEGKVPMLNTRSVKAIAGFVALLDDLRCRV
. * * . . : .: * ** ::
MUL_2520|M.ulcerans_Agy99 GHWLPDLVAEVRRVLGLDCDVRAAATASGAWAGAEHLDAFADVVADYAER
MMAR_1359|M.marinum_M GHWLPDLVAEVRRVLGLDCDVRAAATASGAWAGAEHLDAFADVVADYAER
Mb3226c|M.bovis_AF2122/97 GHSLPDLVAEVRRVLGVDCEVRASAPVSGGWAGPEHLDAFADVVAGYAER
Rv3201c|M.tuberculosis_H37Rv GHSLPDLVAEVRRVLGVDCEVRASAPVSGGWAGPEHLDAFADVVAGYAER
MAV_4147|M.avium_104 DHPLGDLVAEVRRVMDLDCEVRAAAAAG--WAGTEHLDAFADVVAGYAER
Mflv_4665|M.gilvum_PYR-GCK SSPLPDLVAEIRRTLGIDAEVRAAQPISAGWSGTEHLDRFGDVVAEFASR
Mvan_1802|M.vanbaalenii_PYR-1 QSPLPDLLAEVRRVLGIDTEVRAAQPVSAGWSGTEHLDAFGDVVADFAAR
MSMEG_1943|M.smegmatis_MC2_155 GHPLPELVAEVRRVLGLDAEARAARPVAAGWAGTENLDRFSDLVSDFAGH
TH_1441|M.thermoresistible__bu HHPLPDLIAEIRRILGVDAEARAGQPVAAGWAGTENLDAFADVVAEFAVR
MAB_3515c|M.abscessus_ATCC_199 GMPLTDLIAEVQRVLALDVELVAGRRGE----GLDQLRAFTDVAAGFAES
MLBr_00153|M.leprae_Br4923 DDDLGELVESVLERSGYLRELESS-TDPQELARLDNLNELVSFAHEFSTE
* :*: .: . : :. ::* : ... ::
MUL_2520|M.ulcerans_Agy99 TAISAGSALSTKASVDGLLAYLDVAAEVENGLPPAQLTVARDGVQVLTVH
MMAR_1359|M.marinum_M AAISAGSALSTKASVDGLLAYLDVAAEVENGLPPAQLTVARDRVQVLTVH
Mb3226c|M.bovis_AF2122/97 -----ASARSSEASVAGLLAYLDVAEVVENGLPPAELTVACDRVQVLTVH
Rv3201c|M.tuberculosis_H37Rv -----ASARSSEASVAGLLAYLDVAEVVENGLPPAELTVACDRVQVLTVH
MAV_4147|M.avium_104 ADTG-GTDASASASVAGLLAFLDVAESVENGLPAAPLAVARDRVQVLTVH
Mflv_4665|M.gilvum_PYR-GCK ----------GTPTASGLLAYLDTAEQVENGLAPAEVTVSSDRVQILTVH
Mvan_1802|M.vanbaalenii_PYR-1 ----------GGATVSALLGYLDIAEQVENGLAPAEVTVSADRVQILTVH
MSMEG_1943|M.smegmatis_MC2_155 ----------AGASVSALLAYLDAAVEVENGLAPAELTVSHDRVQILTVH
TH_1441|M.thermoresistible__bu ----------PNATVPALLGYLSAAMEVENGLAPADVTVATDRVQILTVH
MAB_3515c|M.abscessus_ATCC_199 -----ADQSDPVGVVSAFLQYLDAAWEIEKGLAPVEVAASPGRVQILTVH
MLBr_00153|M.leprae_Br4923 -----------QANAAALAKSLHTPEDED---------------------
. .: * . :
MUL_2520|M.ulcerans_Agy99 AAKGLEWQVVAVAHLSAGVFPSTASRSSWLTDPGELPPLLRGDRASVG-A
MMAR_1359|M.marinum_M AAKGLEWQVVAVAHLSAGVFPSTASRSSWLTDPGELPPLLRGDRASVG-A
Mb3226c|M.bovis_AF2122/97 AAKGLEWQVVAVAHLSRGVFPSTVSRSSWLTDPAELPPLLRGDRASAG-A
Rv3201c|M.tuberculosis_H37Rv AAKGLEWQVVAVAHLSRGVFPSTVSRSSWLTDPAELPPLLRGDRASAG-A
MAV_4147|M.avium_104 SAKGLEWQLVAVAHLSGGVFPSTTAKTTWLTDAAELPPLLRGDRARPG-A
Mflv_4665|M.gilvum_PYR-GCK AAKGLEWQIVAVPHLVGRVFPSTASPRTWLTDAADLPPLLRGDCATVS-A
Mvan_1802|M.vanbaalenii_PYR-1 AAKGLEWQIVAVPHLSGRVFPSTASPRTWLTDAADLPPLLRGDCATVS-E
MSMEG_1943|M.smegmatis_MC2_155 AAKGLEWQVVAVPHLSARVFPSTTQARTWLTDASDLPPLLRGDRATES-E
TH_1441|M.thermoresistible__bu AAKGLEWEVVAVPHLSRRVFPSTASPRTWLTDAGELPPLLRGDRATTS-E
MAB_3515c|M.abscessus_ATCC_199 SAKGLEWDVVAVPHLSAGVFPSGVAAPTWLTSATELPPLVRGDRASQGDQ
MLBr_00153|M.leprae_Br4923 -------------VPDTGALAAFLEKVSLMSDTDQIPENNSGVVTLMT-L
.:.: : ::.. ::* * :
MUL_2520|M.ulcerans_Agy99 LGIPVLDTSAVTNRKQLSDTISAHREQLDQRRVDEERRLLYVGVTRAEDT
MMAR_1359|M.marinum_M LGIPVLDTSAVTNRKQLSDTISAHREQLDQRRVDEERRLLYVGVTRAEDT
Mb3226c|M.bovis_AF2122/97 HGIPVLDTSAVADRKQLSDKISEHRRLLDRRRVDEERRLLYVAVTRAEDT
Rv3201c|M.tuberculosis_H37Rv HGIPVLDTSAVADRKQLSDKISEHRRLLDRRRVDEERRLLYVAVTRAEDT
MAV_4147|M.avium_104 LGIPVLDTSDVTNRKQLSDKISEHRRQLEQRRVDEERRLLYVAVTRAEDT
Mflv_4665|M.gilvum_PYR-GCK HGVPVLDTSDVSDRKGLSDKIAAHKSSLDQRRTDEERRLLYVAITRAEHT
Mvan_1802|M.vanbaalenii_PYR-1 HGVPVLDTSDVSDRKGLSDKIYDHKRSLEQRRTDEERRLLYVAITRAEHT
MSMEG_1943|M.smegmatis_MC2_155 IGVPVLDTSDIYDRKILSDKISDHKKSLDQRRVDEERRLLYVAITRAEDT
TH_1441|M.thermoresistible__bu HGVPVLDTADVNDRKALSDKIAEHKNRLAQRRTDEERRLLYVAVTRAEDT
MAB_3515c|M.abscessus_ATCC_199 FGVPQLDTEGITNRKQLADAIARHKDSLATRRIDEERRLLYVAVTRCAEQ
MLBr_00153|M.leprae_Br4923 HAAKGLEFPVVFVTGWEDGMLPHMRTLGDPTELSEERRLAYVGITRARQR
. *: : . : : . .***** **.:**. .
MUL_2520|M.ulcerans_Agy99 VLVSGHHWGATGLKPRGPSDFLCELKDIIERSAAAGDPCGTVDQWDRAPV
MMAR_1359|M.marinum_M VLVSGHHWGATGLKPRGPSDFLCELKDIIERSAAAGDPCGTVDQWDPAPV
Mb3226c|M.bovis_AF2122/97 LLVSGHHWGPTGTKPRGPSEFLCELKDIIDRSAAAGDPCGVVEQWASAPA
Rv3201c|M.tuberculosis_H37Rv LLVSGHHWGPTGTKPRGPSEFLCELKDIIDRSAAAGDPCGVVEQWASAPA
MAV_4147|M.avium_104 LLVSGHHWAATGIKPRGPSDFLCEIKDVIDASAAAGDPCGTVEQWAPAPA
Mflv_4665|M.gilvum_PYR-GCK LLVSGHHWGATESKPRGPSTFLTEIKDVIDASIEEGRPCGSIAVWADAPA
Mvan_1802|M.vanbaalenii_PYR-1 LLVSGHHWGATESKPRGPSTFLCELKDVIDASVQSGSPCGAVDVWADAPA
MSMEG_1943|M.smegmatis_MC2_155 LLLSGHHWGATESKPRGPSEFLCELKTILEEATAAGTPCGEIEHWAPDPA
TH_1441|M.thermoresistible__bu LLVSGHHWGATESKPRGPSEFLLEIKDVIDRSAEAGDPCGTIDLWAPEPP
MAB_3515c|M.abscessus_ATCC_199 LFVSGHHWGQTGLKPKGPSDFLVELRDVIESAAAEGVPCGTVERWAPEPP
MLBr_00153|M.leprae_Br4923 LYLS---------------------------------RAITRSSWGQPIL
: :* . *
MUL_2520|M.ulcerans_Agy99 AGERNPLLDDVVEAVWPTDPLATRRGDVERGARLVAEAISADA-GVEAPA
MMAR_1359|M.marinum_M AGERNPLLDDVVEAVWPTDPLATRRGDVERGARLVAEAISADA-GVEAPA
Mb3226c|M.bovis_AF2122/97 GDERNPLCDNAIEAVWPADPLAARRGDVERGAALVAAAMSADLPGSTTDI
Rv3201c|M.tuberculosis_H37Rv GDERNPLCDNAIEAVWPADPLAARRGDVERGAALVAAAMSADLPGSTTDI
MAV_4147|M.avium_104 DGERNPLRDNAVEAVWPADPLASRRGEVERGAALVRQAMAAEP-------
Mflv_4665|M.gilvum_PYR-GCK DGETNPIRDRVVEAVWPVDPVAGRRGPVDRGAHLVAEALSGECPEV----
Mvan_1802|M.vanbaalenii_PYR-1 DGEPNPLRDRVVEAVWPEDPLAGRRAHTDHGARLVTTAMSTAGGAG----
MSMEG_1943|M.smegmatis_MC2_155 PGETNPLRDQVVEALWP--PVASADDHVHRGAQLVAAAMAGEVSA-----
TH_1441|M.thermoresistible__bu DGTPNPLRDKAFEVLWPAPPXXXPAGPPPPVSPRITTPSAGGA-------
MAB_3515c|M.abscessus_ATCC_199 AGERNPMLDQTVEAQWPADPLAGRRDDIEAGARLVRAALADGAALTME--
MLBr_00153|M.leprae_Br4923 NPESRFLR------EIPPELIDWRR-------------------------
. : *
MUL_2520|M.ulcerans_Agy99 GGAAVADIEGWTADVDALLAERARAVG-PPTRALPNQLSVSGLVELARDP
MMAR_1359|M.marinum_M GGAAVADIEGWTADVDALLAERARAVG-PPTRALPNQLSVSGLVELARDP
Mb3226c|M.bovis_AF2122/97 DHPPRPGDAPWSTDVDALLAERAHAARGAPARGLPNHLSVSSLVELVGDP
Rv3201c|M.tuberculosis_H37Rv DHPPRPGDAPWSTDVDALLAERAHAARGAPARGLPNHLSVSSLVELVGDP
MAV_4147|M.avium_104 -GDPGADVEGWAADVDALLVERARVTG-PPPQVLPGQLSVSSLVGLARDP
Mflv_4665|M.gilvum_PYR-GCK ---GSDDDHGWVADVDALLAERDLAAQ-RAVPSLPAQLSVSAMVELGRDP
Mvan_1802|M.vanbaalenii_PYR-1 ---PQPDVHGWTADVDALLAERELAAQ-RPVPPLPLQLSVSAMVELGRDP
MSMEG_1943|M.smegmatis_MC2_155 ----EADQEGWAADVDALLAERERPPQ-QEDTELPGQLSVSTLVELSRDP
TH_1441|M.thermoresistible__bu ----QPNRRRLIAGVAGVAA-----------VAVLGGLAFWLLSPSGTDQ
MAB_3515c|M.abscessus_ATCC_199 ---DDDDTDGWEADVDALLREREQGHR-RPEMTLPQHLSVTSLVELRQDP
MLBr_00153|M.leprae_Br4923 ----------------------------------------SILTDSYSTP
:
MUL_2520|M.ulcerans_Agy99 VGARQRLVHRLPTRPDPHAQLGNIFHTWVQQFYGAELLFDLGDLPGAADS
MMAR_1359|M.marinum_M VGARQRLVHRLPTRPDPHAQLGNAFHTWVQQFYGAELLFDLGDLPGAADS
Mb3226c|M.bovis_AF2122/97 VGARQRLMCRLPKRPDPHAWLGDAFHAWVQQFYGAELLFDLGDLPGAADR
Rv3201c|M.tuberculosis_H37Rv VGARQRLMCRLPKRPDPHAWLGDAFHAWVQQFYGAELLFDLGDLPGAADR
MAV_4147|M.avium_104 ARAAQRLRHRLPSRPEPHALLGNAFHAWVQKFYGAECLFELGDLPGAADS
Mflv_4665|M.gilvum_PYR-GCK EAVAHRLQRRLPRRPDSHALLGTAFHEWVQRYFQAEKLFDLDDLPGAVDA
Mvan_1802|M.vanbaalenii_PYR-1 EAVAQRLQRRLPRRPDAQALLGTAFHEWVQRYFQAEKLFDLDDLPGAVDA
MSMEG_1943|M.smegmatis_MC2_155 KAALTRLRRRLPQRPDPHALLGTTFHEWVQRYFHAERLFDLDDLPGAVDS
TH_1441|M.thermoresistible__bu ADGARADDTAETTSPPRDTAAENRLLTMLPPGYSAGACGPVPAPEGALAQ
MAB_3515c|M.abscessus_ATCC_199 QALARRLARPRPTRPDLDARRGTAFHSWVQRHYGSVRLIDFEDLPGDGYG
MLBr_00153|M.leprae_Br4923 ASGASRFGRVRPSSIRSG--------------------------------
.
MUL_2520|M.ulcerans_Agy99 D--VGQVEDLAPLQEAFAGSPWAARTPIAVEVPFEMPVGDTVVRGRIDAV
MMAR_1359|M.marinum_M D--VGQVEDLAPLQEAFAGSPWAARTPIAVEVPFEMPVGDTVVRGRIDAV
Mb3226c|M.bovis_AF2122/97 E--VGDPEELAALQRAFTASSWAARTPAAVEVPFEMPIGDTVVRGRIDAV
Rv3201c|M.tuberculosis_H37Rv E--VGDPEELAALQRAFTASSWAARTPAAVEVPFEMPIGDTVVRGRIDAV
MAV_4147|M.avium_104 D--VGDTAELAELQAAFLESPWAARTPVAVEVPFEMPIGDTLVRGRIDAV
Mflv_4665|M.gilvum_PYR-GCK D--RQDRGELDELQTAFAVSPWAARTPIDVEVPFDMMLAGRIVRGRIDAI
Mvan_1802|M.vanbaalenii_PYR-1 D--RQDRGELEELQAAFALSPWAARTPIDVEVPFDMMIAGRVVRGRIDAV
MSMEG_1943|M.smegmatis_MC2_155 DSGRAVEESLAELQDAFVKSPWAARTPVEVEVPFDMVLGETVVRGRIDAV
TH_1441|M.thermoresistible__bu VVCRENTDPGGPPTATYT----LARDEAAMQRAFDEIIAASATVN--CPN
MAB_3515c|M.abscessus_ATCC_199 S--FEDAEDLAALQSAFLESEWADRTPVEVEVPFEISVAGIVVRGRIDAV
MLBr_00153|M.leprae_Br4923 ----------------------ASKRALLVLAPGDRVTHDKYGLGRVEEV
: : . : .
MUL_2520|M.ulcerans_Agy99 FE--DPDGGATVVDWKTGEPPRGPEAMRQAAVQLAVYRMAWAALRGCPES
MMAR_1359|M.marinum_M FE--DPDGGATVVDWKTGEPPRGPEAMRQAAVQLAVYRMAWAALRGCPES
Mb3226c|M.bovis_AF2122/97 FV--DPDGGATVVDWKTGKPPHGPAAMRQAAVQLAVYRLAWAALRGCPTS
Rv3201c|M.tuberculosis_H37Rv FV--DPDGGATVVDWKTGKPPHGPAAMRQAAVQLAVYRLAWAALRGCPTS
MAV_4147|M.avium_104 FA--ESDGGATVVDWKTGAPPDSPEAMRQAAVQLAVYRLAWAALAKVPES
Mflv_4665|M.gilvum_PYR-GCK FA--DGDGSFTVVDWKTGEMPTDPEVLAHNALQLAVYRLAWARLHGCPTS
Mvan_1802|M.vanbaalenii_PYR-1 FA--DGDG-VMVVDWKTGEPPATEEELQHNAVQLAVYRLAWARLHDCPVS
MSMEG_1943|M.smegmatis_MC2_155 FA--EPDGTTMVLDWKTGDPPETPEAKEHAAVQLAVYRLAWAAMRGCPPE
TH_1441|M.thermoresistible__bu FI--QSPG-----PWRRNATPDRISGTLFCGIQQNEPLVAWTDDANLVVS
MAB_3515c|M.abscessus_ATCC_199 FGPDSAEDTWTVVDWKTGHEPAG-DEMKAAALQLAVYRRAWASLREIDPA
MLBr_00153|M.leprae_Br4923 SG--VGESAISLIDFGSS-----------GRIKLMHNHAPVTKL------
. : . :: . :
MUL_2520|M.ulcerans_Agy99 SVRTAFHYVRTGVTVIPDELPDGMALAELLADSDPPCSC------
MMAR_1359|M.marinum_M SVRTAFHYVRTGVTVIPDELPDGMALAELLADSDPPCSC------
Mb3226c|M.bovis_AF2122/97 SVRTAFYYVRSGITVVPDELPAPGELAMLLTDCAGRRSDT-----
Rv3201c|M.tuberculosis_H37Rv SVRTAFYYVRSGITVVPDELPAPGELAMLLTDCAGRRSDT-----
MAV_4147|M.avium_104 SVRTAFHYVRARTTVVPEALPTSDQLAGLLAPTAPV---------
Mflv_4665|M.gilvum_PYR-GCK AVRAAFHYVRSGRTVMPDALPEEDDLIALLADRDDEDAA------
Mvan_1802|M.vanbaalenii_PYR-1 SVRAAFHYVRSGRTVVPDGLPDADDLAALLADPPAA---------
MSMEG_1943|M.smegmatis_MC2_155 SVRAAFHYVRSGQTVIPETLPGAEELVKLLAAAPTETAEEADRIT
TH_1441|M.thermoresistible__bu AVHSG---------------PQGPTLDELYAWWTTHS--------
MAB_3515c|M.abscessus_ATCC_199 RVRAVFHYVRSGRTVAPTELPDLPHAEELAELTRD----------
MLBr_00153|M.leprae_Br4923 ---------------------------------------------