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M. thermoresistible (build 8) TH_1435 (cobU)

aa seq not available

Operon Prediction Model: Genebank

Paralogs

species	id	gene	e-value	identity (len)	annotation
M. thermoresistible (build 8)	TH_1435	cobU	-	100% (177)	Cobinamide kinase / cobinamide phosphate guanyltransferase
M. thermoresistible (build 8)	TH_0974	cobU	4e-39	50.57% (176)	PROBABLE BIFUNCTIONAL COBALAMIN BIOSYNTHESIS PROTEIN COBU:

Closest Orthologs (e-value cutoff: 1e-4)

species	id	gene	e-value	identity (len)	annotation
M. bovis AF2122 / 97	Mb0260c	cobU	1e-33	48.57% (175)	putative bifunctional cobalamin biosynthesis protein cobU:
M. gilvum PYR-GCK	Mflv_0355	-	1e-35	49.16% (179)	cobalbumin biosynthesis enzyme
M. tuberculosis H37Rv	Rv0254c	cobU	1e-33	48.57% (175)	bifunctional cobinamide kinase/cobinamide phosphate
M. leprae Br4923	-	-	-	-	-
M. abscessus ATCC 19977	MAB_1954c	-	6e-55	61.05% (172)	putative cobinamide kinase/cobinamide phosphate
M. marinum M	MMAR_3251	cobU	9e-59	62.09% (182)	bifunctional cobalamin biosynthesis protein CobU
M. avium 104	MAV_2284	cobU	8e-64	66.48% (176)	cobinamide kinase / cobinamide phosphate guanyltransferase
M. smegmatis MC2 155	MSMEG_4274	cobU	1e-65	67.61% (176)	cobinamide kinase / cobinamide phosphate guanyltransferase
M. ulcerans Agy99	MUL_3564	cobU	2e-59	62.64% (182)	bifunctional cobalamin biosynthesis protein CobU
M. vanbaalenii PYR-1	Mvan_0379	-	4e-37	49.15% (177)	cobalbumin biosynthesis enzyme

CLUSTAL 2.0.9 multiple sequence alignment


TH_1435|M.thermoresistible__bu      -VRILVLGGIRSGKSQWAETALADAVGD---APARYLATGRVPDA-DTD-
MSMEG_4274|M.smegmatis_MC2_155      ---MLVLGGIRSGKSQWAESVAQQLAGEGDRAPVRYVATGPVPEG-DAD-
MMAR_3251|M.marinum_M               -MRTLVLGGIRSGKSRWAEETIADSLTPE--QPVRYLASGPATDS-DSAA
MUL_3564|M.ulcerans_Agy99           -MRTLVLGGIRSGKSRWAEETIADSLTPE--QPVRYLASGPATDS-DSAA
MAV_2284|M.avium_104                -MRTLVLGGIRSGKSQWAEEAVADGLPAG--RRVRYLAPGPPGVH-DAA-
MAB_1954c|M.abscessus_ATCC_199      MATTLVLGGIRSGKSRFAESLLP---AEG---PARYLATGSPDTG-DPA-
Mb0260c|M.bovis_AF2122/97           -MRILVTGGVRSGKSTHAEALLGDA------ADVVYVAPGRPAAGSDPD-
Rv0254c|M.tuberculosis_H37Rv        -MRILVTGGVRSGKSTHAEALLGDA------ADVVYVAPGRPAAGSDPD-
Mflv_0355|M.gilvum_PYR-GCK          -MRILVTGGVRSGKSRHAEELLAGA------GHVTYVAPGRAADGTDPD-
Mvan_0379|M.vanbaalenii_PYR-1       -MMILVTGGVRSGKSRHAEALLSDA------RQVTYLAPGRPADGSDPD-
                                        ** **:*****  **              . *:*.*      *.  

TH_1435|M.thermoresistible__bu      ---WAARVSAHRRRRPAHWSTCETTDVATQLRTYPDLPTMIDDVGGWLTA
MSMEG_4274|M.smegmatis_MC2_155      ---WATRVEAHQVRRPAHWQTVETTDLTATLTAAPHVATLVDDIGGWLTA
MMAR_3251|M.marinum_M               SQDWDQRVARHRDRRPGHWSTVETDDITTQLRQVPDTPTLVDDLGTWLTS
MUL_3564|M.ulcerans_Agy99           SQDWDQRVARHRDRRPGHWSTVETDDIATQLRQVPDTPTLVDDLGTWLTS
MAV_2284|M.avium_104                ---WAHRVAEHRDRRPAHWSTIETDDIATELRRCPQVPTLVDDLGGWLTG
MAB_1954c|M.abscessus_ATCC_199      ---WTERIAAHRSRRPSQWTTAETTDIATELRTRAPLPTLVDDLGGWLTA
Mb0260c|M.bovis_AF2122/97           ---WDARVALHRARRPPTWLTVETADVATALSEARS-PVLVDCLGTWLTA
Rv0254c|M.tuberculosis_H37Rv        ---WDARVALHRARRPPTWLTVETADVATALSEARS-PVLVDCLGTWLTA
Mflv_0355|M.gilvum_PYR-GCK          ---WDARVSRHRARRPAHWRTVETADVAVAVRDAQG-TVLVDCLGTWLTA
Mvan_0379|M.vanbaalenii_PYR-1       ---WDARVAGHRTRRPAHWQTVETADVAAAVRDADG-AVLVDCLGTWLTA
                                       *  *:  *: ***  * * ** *::. :      ..::* :* ***.

TH_1435|M.thermoresistible__bu      TMDRHDAWSGGS------VTADTDELVAAVADFRSTLLVVSPEVGLSVVP
MSMEG_4274|M.smegmatis_MC2_155      TMDRRDAWAGHP------VTGDVTALVDAVAAFRAPLVMVSPEVGLTVVP
MMAR_3251|M.marinum_M               AMDSHRAWEGGSP--PAALQDTIDDMLAAVGEFGSTLVLVSPEVGLTVVP
MUL_3564|M.ulcerans_Agy99           AMDSHRAWEGGSP--PAALQDTIDDMLAAVGEFGSTLVLVSPEVGLTVVP
MAV_2284|M.avium_104                MLDRHDGWQGGS------VTAPVDDLLAAVAEFAAALVLVSPEVGLTVVP
MAB_1954c|M.abscessus_ATCC_199      AMDAHGAWDVGAG----AVSADIGALVEAVADYPVDLVIVSPEVGLTVVP
Mb0260c|M.bovis_AF2122/97           IMDGEALWSAATADVYAVLEARLDGLCAALTG-LPTAIVVTNEVGLGVVP
Rv0254c|M.tuberculosis_H37Rv        IMDGEALWSAATADVYAVLEARLDGLCAALTG-LPTAIVVTNEVGLGVVP
Mflv_0355|M.gilvum_PYR-GCK          VLDDNGLWDKGSREATDEVEIRVTALCDALAG-AAGAVVVTNEVGLGVVP
Mvan_0379|M.vanbaalenii_PYR-1       VLDRNNLWDKGSREVHDAVDARLTALCAALTARREAVVVVTNEVGLGVVP
                                     :* .  *   .      :      :  *:       ::*: **** ***

TH_1435|M.thermoresistible__bu      TTAVGRRFADALGTLNQRLARVCDRVVLVVAGQPVTVKEPV-
MSMEG_4274|M.smegmatis_MC2_155      ATAAGRRFADELGTVNQRLAAVCDRVVLVVAGQPVTVKEPT-
MMAR_3251|M.marinum_M               ATASGRRFADELGTLNQRMAALCDRVVLVVAGQAVPIKPSRA
MUL_3564|M.ulcerans_Agy99           ATASGRRFADELGTLNQRMAALCDRVVLVVAGQAVPIKPSRA
MAV_2284|M.avium_104                ATASARRFADELGSLNQRLARLCDRVVLVVAGQPVPIKTPGV
MAB_1954c|M.abscessus_ATCC_199      ATAAGRLFADALGALNQAVAARADRVLLVVAGQPLTIKGGRS
Mb0260c|M.bovis_AF2122/97           SHSSGVLFRDLLGTINRRVAAVCDEVHLVIAGRVLKL-----
Rv0254c|M.tuberculosis_H37Rv        SHSSGVLFRDLLGTINRRVAAVCDEVHLVIAGRVLKL-----
Mflv_0355|M.gilvum_PYR-GCK          SHRSGVLFRDLLGTVNQRVAQVCDEVHLVIAGRVLTL-----
Mvan_0379|M.vanbaalenii_PYR-1       SHRSGVLFRDLLGTANQRVAAVCDEVHLVIAGRVLKI-----
                                    :   .  * * **: *: :*  .*.* **:**: : :