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RILVTGGVRSGKSRHAEELLAGAGHVTYVAPGRAADGTDPDWDARVSRHRARRPAHWRTVETADVAVAVR DAQGTVLVDCLGTWLTAVLDDNGLWDKGSREATDEVEIRVTALCDALAGAAGAVVVTNEVGLGVVPSHRS GVLFRDLLGTVNQRVAQVCDEVHLVIAGRVLTL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_0355 | - | - | 100% (174) | cobalbumin biosynthesis enzyme |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0260c | cobU | 2e-65 | 69.54% (174) | putative bifunctional cobalamin biosynthesis protein cobU: |
| M. tuberculosis H37Rv | Rv0254c | cobU | 2e-65 | 69.54% (174) | bifunctional cobinamide kinase/cobinamide phosphate |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1954c | - | 7e-35 | 46.51% (172) | putative cobinamide kinase/cobinamide phosphate |
| M. marinum M | MMAR_3251 | cobU | 4e-35 | 45.65% (184) | bifunctional cobalamin biosynthesis protein CobU |
| M. avium 104 | MAV_2284 | cobU | 2e-31 | 48.00% (175) | cobinamide kinase / cobinamide phosphate guanyltransferase |
| M. smegmatis MC2 155 | MSMEG_4274 | cobU | 8e-34 | 48.89% (180) | cobinamide kinase / cobinamide phosphate guanyltransferase |
| M. thermoresistible (build 8) | TH_0974 | cobU | 1e-41 | 53.76% (173) | PROBABLE BIFUNCTIONAL COBALAMIN BIOSYNTHESIS PROTEIN COBU: |
| M. ulcerans Agy99 | MUL_3564 | cobU | 1e-35 | 46.20% (184) | bifunctional cobalamin biosynthesis protein CobU |
| M. vanbaalenii PYR-1 | Mvan_0379 | - | 4e-75 | 80.35% (173) | cobalbumin biosynthesis enzyme |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_3251|M.marinum_M --------------------------------------------------
MUL_3564|M.ulcerans_Agy99 --------------------------------------------------
MAV_2284|M.avium_104 --------------------------------------------------
MSMEG_4274|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1954c|M.abscessus_ATCC_199 --------------------------------------------------
TH_0974|M.thermoresistible__bu VTGGDPGGGMEVVLLGTGSADGWPNPFCGCRSCRWASAVGEIRGQTAALV
Mflv_0355|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0379|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0260c|M.bovis_AF2122/97 --------------------------------------------------
Rv0254c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3251|M.marinum_M --------------------------------------------------
MUL_3564|M.ulcerans_Agy99 --------------------------------------------------
MAV_2284|M.avium_104 --------------------------------------------------
MSMEG_4274|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1954c|M.abscessus_ATCC_199 --------------------------------------------------
TH_0974|M.thermoresistible__bu DGAVLIDCGPETPRGALRYGRTLAGVRHILCTHADFDHLDPAALLMRHWA
Mflv_0355|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0379|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0260c|M.bovis_AF2122/97 --------------------------------------------------
Rv0254c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3251|M.marinum_M --------------------------------------------------
MUL_3564|M.ulcerans_Agy99 --------------------------------------------------
MAV_2284|M.avium_104 --------------------------------------------------
MSMEG_4274|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1954c|M.abscessus_ATCC_199 --------------------------------------------------
TH_0974|M.thermoresistible__bu GRTEPLQVHGPAAVVSRCRDWVGPDDPVVFHDVAPGDELILSDTGHTVRV
Mflv_0355|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0379|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0260c|M.bovis_AF2122/97 --------------------------------------------------
Rv0254c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3251|M.marinum_M --------------------------------------------------
MUL_3564|M.ulcerans_Agy99 --------------------------------------------------
MAV_2284|M.avium_104 --------------------------------------------------
MSMEG_4274|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1954c|M.abscessus_ATCC_199 --------------------------------------------------
TH_0974|M.thermoresistible__bu LAAAHTDALGGAAVLYDIARAGTRMLWATDTGPLPDPTHAAIAGARYDAV
Mflv_0355|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0379|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0260c|M.bovis_AF2122/97 --------------------------------------------------
Rv0254c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3251|M.marinum_M --------------------------------------------------
MUL_3564|M.ulcerans_Agy99 --------------------------------------------------
MAV_2284|M.avium_104 --------------------------------------------------
MSMEG_4274|M.smegmatis_MC2_155 --------------------------------------------------
MAB_1954c|M.abscessus_ATCC_199 --------------------------------------------------
TH_0974|M.thermoresistible__bu FLDQTFGPHTDHGTDHHDLPAFAATVARMRGSGAVHRDTEIIAVHLSHHN
Mflv_0355|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0379|M.vanbaalenii_PYR-1 --------------------------------------------------
Mb0260c|M.bovis_AF2122/97 --------------------------------------------------
Rv0254c|M.tuberculosis_H37Rv --------------------------------------------------
MMAR_3251|M.marinum_M -----------------------------------MRTLVLGGIRSGKSR
MUL_3564|M.ulcerans_Agy99 -----------------------------------MRTLVLGGIRSGKSR
MAV_2284|M.avium_104 -----------------------------------MRTLVLGGIRSGKSQ
MSMEG_4274|M.smegmatis_MC2_155 -------------------------------------MLVLGGIRSGKSQ
MAB_1954c|M.abscessus_ATCC_199 ----------------------------------MATTLVLGGIRSGKSR
TH_0974|M.thermoresistible__bu PPGDELAQALAASGARPGRDGEVVRLGGSTRPVGATRTLVLGGVRSGKSV
Mflv_0355|M.gilvum_PYR-GCK -----------------------------------MRILVTGGVRSGKSR
Mvan_0379|M.vanbaalenii_PYR-1 -----------------------------------MMILVTGGVRSGKSR
Mb0260c|M.bovis_AF2122/97 -----------------------------------MRILVTGGVRSGKST
Rv0254c|M.tuberculosis_H37Rv -----------------------------------MRILVTGGVRSGKST
** **:*****
MMAR_3251|M.marinum_M WAEETIADSLTPE---QPVRYLASG-PATDSDSAASQDWDQRVARHRDRR
MUL_3564|M.ulcerans_Agy99 WAEETIADSLTPE---QPVRYLASG-PATDSDSAASQDWDQRVARHRDRR
MAV_2284|M.avium_104 WAEEAVADGLPAG---RRVRYLAPG-PPGVHDAA----WAHRVAEHRDRR
MSMEG_4274|M.smegmatis_MC2_155 WAES-VAQQLAGEGDRAPVRYVATG-PVPEGDAD----WATRVEAHQVRR
MAB_1954c|M.abscessus_ATCC_199 FAES----LLPAEG---PARYLATG-SPDTGDPA----WTERIAAHRSRR
TH_0974|M.thermoresistible__bu YAES----LLAGQ---PRVTYVATG-SSDPDDTE----WAERVRRHRARR
Mflv_0355|M.gilvum_PYR-GCK HAEE----LLAGAG---HVTYVAPGRAADGTDPD----WDARVSRHRARR
Mvan_0379|M.vanbaalenii_PYR-1 HAEA----LLSDAR---QVTYLAPGRPADGSDPD----WDARVAGHRTRR
Mb0260c|M.bovis_AF2122/97 HAEA----LLGDAA---DVVYVAPGRPAAGSDPD----WDARVALHRARR
Rv0254c|M.tuberculosis_H37Rv HAEA----LLGDAA---DVVYVAPGRPAAGSDPD----WDARVALHRARR
** * . *:*.* . *. * *: *: **
MMAR_3251|M.marinum_M PGHWSTVETDDITTQLRQVPDTPTLVDDLGTWLTSAMDSHRAWEGGSPPA
MUL_3564|M.ulcerans_Agy99 PGHWSTVETDDIATQLRQVPDTPTLVDDLGTWLTSAMDSHRAWEGGSPPA
MAV_2284|M.avium_104 PAHWSTIETDDIATELRRCPQVPTLVDDLGGWLTGMLDRHDGWQGGS---
MSMEG_4274|M.smegmatis_MC2_155 PAHWQTVETTDLTATLTAAPHVATLVDDIGGWLTATMDRRDAWAGHP---
MAB_1954c|M.abscessus_ATCC_199 PSQWTTAETTDIATELRTRAPLPTLVDDLGGWLTAAMDAHGAWDVGAG--
TH_0974|M.thermoresistible__bu PATWRTVETTEAAAELR-AATTPVLVDCLGTWLTGRIDRHRGWDRGELDA
Mflv_0355|M.gilvum_PYR-GCK PAHWRTVETADVAVAVR-DAQGTVLVDCLGTWLTAVLDDNGLWDKGSREA
Mvan_0379|M.vanbaalenii_PYR-1 PAHWQTVETADVAAAVR-DADGAVLVDCLGTWLTAVLDRNNLWDKGSREV
Mb0260c|M.bovis_AF2122/97 PPTWLTVETADVATALS-EARSPVLVDCLGTWLTAIMDGEALWSAATADV
Rv0254c|M.tuberculosis_H37Rv PPTWLTVETADVATALS-EARSPVLVDCLGTWLTAIMDGEALWSAATADV
* * * ** : :. : . ..*** :* ***. :* . *
MMAR_3251|M.marinum_M A---LQDTIDDMLAAVGEFGSTLVLVSPEVGLTVVPATASGRRFADELGT
MUL_3564|M.ulcerans_Agy99 A---LQDTIDDMLAAVGEFGSTLVLVSPEVGLTVVPATASGRRFADELGT
MAV_2284|M.avium_104 ----VTAPVDDLLAAVAEFAAALVLVSPEVGLTVVPATASARRFADELGS
MSMEG_4274|M.smegmatis_MC2_155 ----VTGDVTALVDAVAAFRAPLVMVSPEVGLTVVPATAAGRRFADELGT
MAB_1954c|M.abscessus_ATCC_199 A---VSADIGALVEAVADYPVDLVIVSPEVGLTVVPATAAGRLFADALGA
TH_0974|M.thermoresistible__bu VHSDIDDDIDDLVAAWRRCAVPAVAVSNEVGSGVVPDTAAGRLFRDLLGV
Mflv_0355|M.gilvum_PYR-GCK T-DEVEIRVTALCDALAG-AAGAVVVTNEVGLGVVPSHRSGVLFRDLLGT
Mvan_0379|M.vanbaalenii_PYR-1 H-DAVDARLTALCAALTARREAVVVVTNEVGLGVVPSHRSGVLFRDLLGT
Mb0260c|M.bovis_AF2122/97 Y-AVLEARLDGLCAALTG-LPTAIVVTNEVGLGVVPSHSSGVLFRDLLGT
Rv0254c|M.tuberculosis_H37Rv Y-AVLEARLDGLCAALTG-LPTAIVVTNEVGLGVVPSHSSGVLFRDLLGT
: : : * : *: *** *** :. * * **
MMAR_3251|M.marinum_M LNQRMAALCDRVVLVVAGQAVPIKPSRA---
MUL_3564|M.ulcerans_Agy99 LNQRMAALCDRVVLVVAGQAVPIKPSRA---
MAV_2284|M.avium_104 LNQRLARLCDRVVLVVAGQPVPIKTPGV---
MSMEG_4274|M.smegmatis_MC2_155 VNQRLAAVCDRVVLVVAGQPVTVKEPT----
MAB_1954c|M.abscessus_ATCC_199 LNQAVAARADRVLLVVAGQPLTIKGGRS---
TH_0974|M.thermoresistible__bu LNMRIAAVSDRVVLMVAGVPVPLPRADLSSP
Mflv_0355|M.gilvum_PYR-GCK VNQRVAQVCDEVHLVIAGRVLTL--------
Mvan_0379|M.vanbaalenii_PYR-1 ANQRVAAVCDEVHLVIAGRVLKI--------
Mb0260c|M.bovis_AF2122/97 INRRVAAVCDEVHLVIAGRVLKL--------
Rv0254c|M.tuberculosis_H37Rv INRRVAAVCDEVHLVIAGRVLKL--------
* :* .*.* *::** : :