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M. thermoresistible (build 8) TH_0470 ()

annotation: PROBABLE TRANSMEMBRANE ALKANE 1-MONOOXYGENASE ALKB (ALKANE 1-HYDROXYLASE) (LAURIC ACID OMEGA-HYDROXYLASE) (OMEGA-HYDROXYLASE) (FATTY ACID OMEGA-HYDROXYLASE) (ALKANE HYDROXYLASE-RUBREDOXIN)
coordinates: 1006354 - 1007568
length: 405

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_0470-100% (405)PROBABLE TRANSMEMBRANE ALKANE 1-MONOOXYGENASE ALKB (ALKANE 1-HYDROXYLASE) (LAURIC ACID OMEGA-HYDROXYLASE) (OMEGA-HYDROXYLASE) (FATTY ACID OMEGA-HYDROXYLASE) (ALKANE HYDROXYLASE-RUBREDOXIN)
M. thermoresistible (build 8)TH_4585-e-11550.39% (387) PUTATIVE alkane 1-monooxygenase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3280calkB0.080.76% (395) transmembrane alkane 1-monooxygenase AlkB
M. gilvum PYR-GCKMflv_4721-0.081.11% (397) alkane 1-monooxygenase
M. tuberculosis H37RvRv3252calkB0.080.76% (395) transmembrane alkane 1-monooxygenase AlkB
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_3598c-0.072.70% (392) putative alkane-1-monooxygenase AlkB (fatty acid
M. marinum MMMAR_1291alkB0.080.00% (405) transmembrane alkane 1-monooxygenase AlkB
M. avium 104MAV_4215-0.082.75% (400) alkane-1-monooxygenase
M. smegmatis MC2 155MSMEG_1839-0.086.01% (393) alkane 1-monooxygenase
M. ulcerans Agy99MUL_2749alkB_11e-17471.13% (388) transmembrane alkane 1-monooxygenase AlkB_1
M. vanbaalenii PYR-1Mvan_1742-0.082.46% (399) alkane 1-monooxygenase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_4721|M.gilvum_PYR-GCK          -MTTHDMLDKPD------ALQWRDKKRYLWLMGLIAPTALFVVLPLVWAL
Mvan_1742|M.vanbaalenii_PYR-1       -------MSKPD------VEQWRDKKRYLWLMGLIAPTALFVMLPLIWAL
MSMEG_1839|M.smegmatis_MC2_155      MVAEVDPSAVAD------VGEWRDKKRYLWLMGLIAPTALFVMLPVVWAL
TH_0470|M.thermoresistible__bu      ---MTTELSNVD------ATVWRDKKRYLWLLGLVAPTALFFMLPVVWAF
Mb3280c|M.bovis_AF2122/97           -MTTQIGSGGPEAPRPPEVEEWRDKKRYLWLMGLIAPTALVVMLPLIWGM
Rv3252c|M.tuberculosis_H37Rv        -MTTQIGSGGPEAPRPPEVEEWRDKKRYLWLMGLIAPTALVVMLPLIWGM
MMAR_1291|M.marinum_M               -MTTQFRSDVPDAPET----EWRDKKRYLWLMGLIAPTALFVVLPIVWGL
MAV_4215|M.avium_104                --MTTVDLQQPSEPAA-----WRDKKRRLWLMGLIAPTALFVMLPLVWAL
MAB_3598c|M.abscessus_ATCC_199      -MTSNLETGPAQP-----AAQWRDRKRYMWLYGMIPPTAIFIATALVYAM
MUL_2749|M.ulcerans_Agy99           -MTSVAQPKSENP-----VQQRRDRKRYLWLVGLVLPTALPASLALAWVF
                                               .          **:** :** *:: ***:    .: : :

Mflv_4721|M.gilvum_PYR-GCK          NALGWHAAAQVPLWIGPILLYVLLPTLDRFFGPDGQNPPDEVMERLENDK
Mvan_1742|M.vanbaalenii_PYR-1       NQFGWHVAAQVPLWIGPILLYILLPALDLKFGPDGQNPPDEVMERLENDK
MSMEG_1839|M.smegmatis_MC2_155      NNAGWHAAAQVPFWIGPILLYVLLPLLDLKFGPDGQNPPDEVMERLENDR
TH_0470|M.thermoresistible__bu      NKLDWHIAAQVPFWIGPILVYVLLPILDLRFGPDGQNPPDEVMERLENDR
Mb3280c|M.bovis_AF2122/97           NQLGWHAAAQVPLWIGPILLYVLLPLLDLRFGPDGQNPPDEVTDRLENDK
Rv3252c|M.tuberculosis_H37Rv        NQLGWHAAAQVPLWIGPILLYVLLPLLDLRFGPDGQNPPDEVTDRLENDK
MMAR_1291|M.marinum_M               NHFGWHLAAQVPLWVGPMLVYILLPLLDLGFGPDGQNPPDEVMERLENDK
MAV_4215|M.avium_104                NRLGWHAAAQVPLWIGPILLYILLPILDLRFGPDGQNPPDEVMERLENDK
MAB_3598c|M.abscessus_ATCC_199      NQLGWQQFSPVLFWIGPLLVYVILPLLDLNFGADGENAPDEVMEALENDK
MUL_2749|M.ulcerans_Agy99           GKLGWTAVTPVLWWIGPFLLYLLLPALDVFFGPDGENPPDEVMERLENDK
                                    .  .*   : *  *:**:*:*::** **  **.**:*.**** : ****:

Mflv_4721|M.gilvum_PYR-GCK          YYRYCTYLYIPFQYASVIFGAYLFTASDLGWLGFDGALPWPAKIGLALSV
Mvan_1742|M.vanbaalenii_PYR-1       YYRYCTYLYIPFQYASVIMGAYLFTASDLGWLGFEGGLSWPAKIGLALSV
MSMEG_1839|M.smegmatis_MC2_155      YYRYCTYAYIPFQYASVIVGAYLFTASDLGWLGFDGGLGWPAKIGLALSV
TH_0470|M.thermoresistible__bu      YYRYCTYLYIPFQYASFIVGAYLFTATDLGWLGFDGGLGWPAKLGLALSV
Mb3280c|M.bovis_AF2122/97           YYRYCTYIYIPFQYLSVVLGAYLFTAANLSWLGFDGALSWAGKLGVALSV
Rv3252c|M.tuberculosis_H37Rv        YYRYCTYIYIPFQYLSVVLGAYLFTAANLSWLGFDGALSWAGKLGVALSV
MMAR_1291|M.marinum_M               YYRYCTYIYIPFQYLSVVLGAYLFTASDLGWLGFDGGLNWLGKIGVALSV
MAV_4215|M.avium_104                YYRYCTYVYIPFQYLSVILGAYLFTATDLSWLGFHGGLGWAGKLGLALSV
MAB_3598c|M.abscessus_ATCC_199      YYRYCTYIFIPFQYASFFLGAYYFTATDLSWIGFDHGISWISKLGIAASI
MUL_2749|M.ulcerans_Agy99           YYRYCTYAFIPLQMVSLVLACYLWSADNLSWLGLGAGLGLISKIGLTMTI
                                    ******* :**:*  *.....* ::* :*.*:*:  .:   .*:*:: ::

Mflv_4721|M.gilvum_PYR-GCK          GLLGGVGINTAHEMGHKKESLERWLAKITLAQTLYGHFYIEHNRGHHVRV
Mvan_1742|M.vanbaalenii_PYR-1       GLLGGVGINTAHEMGHKKDSLERWLAKITLAQTLYGHFYIEHNRGHHVRV
MSMEG_1839|M.smegmatis_MC2_155      GVLGGVGINTAHELGHKKDSLERWLSKITLAQTWYGHFYIEHNRGHHVRV
TH_0470|M.thermoresistible__bu      GVLGGVGINTAHELGHKKDSLERWLSKITLAQTGYGHFYIEHNRGHHVRV
Mb3280c|M.bovis_AF2122/97           GVLGGVGINTAHEMGHKKDSLERWLSKITLAQTCYGHFYIEHNRGHHVRV
Rv3252c|M.tuberculosis_H37Rv        GVLGGVGINTAHEMGHKKDSLERWLSKITLAQTCYGHFYIEHNRGHHVRV
MMAR_1291|M.marinum_M               GVLGGVGINTAHEMGHKKDSLERWLSKITLAQTGYGHFYIEHNRGHHVRV
MAV_4215|M.avium_104                GVLGGVGINTAHEMGHKKDSLERWLSKITLAQTCYGHFYIEHNRGHHVRV
MAB_3598c|M.abscessus_ATCC_199      GVLGGVGINTAHEMGHKKEELERWLSKITLAQTFYGHFYIEHNRGHHVRV
MUL_2749|M.ulcerans_Agy99           GVVGGVGINTAHELGHKRENLEGWLSKITLAQTLYGHFYIEHNRGHHVRV
                                    *::**********:***::.** **:******* ****************

Mflv_4721|M.gilvum_PYR-GCK          ATPEDPASARFGETFWEFLPRSVFGSLKSAWELEAKRLERAGKPTWH---
Mvan_1742|M.vanbaalenii_PYR-1       ATPEDPASARFGETFWEFLPRSVFGSLKSAWELEAKRLERAGKSKWH---
MSMEG_1839|M.smegmatis_MC2_155      ATPEDPASARFGETFWEFLPRSVWGSLRSSWELEAKRLERAGKSKWH---
TH_0470|M.thermoresistible__bu      ATPEDPASARFGETFWEFLPRSVFGGLKSGWQLEAQRLRRAGKSPWH---
Mb3280c|M.bovis_AF2122/97           STPEDPASARFGETLWEFLPRSVIGGLRSAVHLEAQRLRRLGVSPWNPMT
Rv3252c|M.tuberculosis_H37Rv        STPEDPASARFGETLWEFLPRSVIGGLRSAVHLEAQRLRRLGVSPWNPMT
MMAR_1291|M.marinum_M               STPEDPASARFGETFWEFLPRTVFGSLRSAIGLEAQRLRRQGRSPWNPKT
MAV_4215|M.avium_104                ATPEDPASARFGETFWEFLPRSVFGSLRSALRLEAQRLRRLGKNPWNPLT
MAB_3598c|M.abscessus_ATCC_199      ATPEDPASSRFGETFWGFWPRSVWGALRSSWNLEATRMKRLNRFVLH---
MUL_2749|M.ulcerans_Agy99           ATPEDPASARFGESFWMFLPRSMFGSLKSAWELEKSRMQRINKPTLS---
                                    :*******:****::* * **:: *.*:*.  **  *:.* .        

Mflv_4721|M.gilvum_PYR-GCK          -WSNDVLNAWAMSVVFYGALIAVFGWALVPYILISAIFGFTLLETVNYLE
Mvan_1742|M.vanbaalenii_PYR-1       -WSNDVLNAWAMSVVLYGALIAVFGWALIPYILISAVFGFTLLEAVNYLE
MSMEG_1839|M.smegmatis_MC2_155      -WSNDVLNAWAMSVVFYGVLIAVFGWGLIPYIVISAVFGFTLLETVNYLE
TH_0470|M.thermoresistible__bu      -PSNDVLNAWAMTVVLWGVLIAVFGVGVIPYLLIQAVFGFSLLESVNYLE
Mb3280c|M.bovis_AF2122/97           YLRNDVLNAWLMSVVLWGGLIAVFGPALIPFVIIQAVFGFSLLEAVNYLE
Rv3252c|M.tuberculosis_H37Rv        YLRNDVLNAWLMSVVLWGGLIAVFGPALIPFVIIQAVFGFSLLEAVNYLE
MMAR_1291|M.marinum_M               YPSNDVLNAWAMSVLLWGVLIAVFGLGLIPFVIIQAVFGFCLLEAVNYLE
MAV_4215|M.avium_104                YPSNDVLNAWAMSIVLWGVLIAVFGPGLIPFVVIQAVFGFSLLEAVNYLE
MAB_3598c|M.abscessus_ATCC_199      -PSNDVVNAWLMSVVLFGVTIAIFGTAVIPYLIIQAIYGFTFLETVNYLE
MUL_2749|M.ulcerans_Agy99           -MRNDVLNAWIMSVVLFGALTAVFGWQVLPFLIIQGLFGASLLESVNYLE
                                       ***:*** *:::::*   *:**  ::*:::*..::*  :**:*****

Mflv_4721|M.gilvum_PYR-GCK          HYGLLR----QKLPSGRYERCAPVHSWNSDHIVTNLFLYHLQRHSDHHAN
Mvan_1742|M.vanbaalenii_PYR-1       HYGLLR----KKLDNGRYERCAPVHSWNSDHIVTNLFLYHLQRHSDHHAN
MSMEG_1839|M.smegmatis_MC2_155      HYGLLR----QKTPSGRYERCSPQHSWNSDHIVTNLFLYHLQRHSDHHAN
TH_0470|M.thermoresistible__bu      HYGLLR----QKTASGRYERCTPEHSWNSDHLVTNLFLYHLQRHSDHHAN
Mb3280c|M.bovis_AF2122/97           HYGLLR----QKSANGRYERCAPVHSWNSDHIVTNLFLYHLQRHSDHHAN
Rv3252c|M.tuberculosis_H37Rv        HYGLLR----QKSANGRYERCAPVHSWNSDHIVTNLFLYHLQRHSDHHAN
MMAR_1291|M.marinum_M               HYGLLR----QPTSNGRYERCAPVHSWNSDHIVTNLFLYHLQRHSDHHAN
MAV_4215|M.avium_104                HYGLLRRKIDSPSGKARYERCTPEHSWNSDHVVTNLFLYHLQRHSDHHAN
MAB_3598c|M.abscessus_ATCC_199      HYGLLR----QKNGE-RYERCTPKHSWNSDHLVTNIFLYHLQRHSDHHAN
MUL_2749|M.ulcerans_Agy99           HYGLLR----QRTASGRYERCAPVHSWNSDHIVTNIFLYHLQRHSDHHAN
                                    ******    .   . *****:* *******:***:**************

Mflv_4721|M.gilvum_PYR-GCK          PTRRYQTLRSMEGAPNLPSGYASMIALTYFPPVWRMVMDHRVVDHYDGDL
Mvan_1742|M.vanbaalenii_PYR-1       PTRRYQTLRSMEGAPNLPSGYASMIGLTYFPPLWRRMMDHRVLAHYGGDI
MSMEG_1839|M.smegmatis_MC2_155      PTRRYQTLRSMDGAPNLPSGYASMIALTYFPPLWRKVMDHRVLDHYDGDI
TH_0470|M.thermoresistible__bu      PTRRYQTLRSLDGSPNLPSGYATMIGLTYIPPLWRRVMDHRVLEHYGGDI
Mb3280c|M.bovis_AF2122/97           PTRRYQTLRSMAGAPNLPSGYASMISLTYFPPLWRKVMDHRVLEHYGGDI
Rv3252c|M.tuberculosis_H37Rv        PTRRYQTLRSMAGAPNLPSGYASMISLTYFPPLWRKVMDHRVLEHYGGDI
MMAR_1291|M.marinum_M               PTRRYQTLRSMDGAPNLPSGYASMISLTYFPPLWRKVMDHRVLEHYGGDI
MAV_4215|M.avium_104                PTRRYQTLRSLDGSPNLPSGYASMISLTYFPPLWRKVMDHRVLAHYGGDI
MAB_3598c|M.abscessus_ATCC_199      PTRRYQTLRSMDGAPNLPSGYATMLTLAYFPPLWRKVMDHRVLDHYDGDI
MUL_2749|M.ulcerans_Agy99           PLRRYQTLRSMDGAPNLPSGYATLITLTYFPPLWRKLMDHRVIEHYDGDI
                                    * ********: *:********::: *:*:**:** :*****: **.**:

Mflv_4721|M.gilvum_PYR-GCK          TRINIHPRVRDKVLARYGVRGGVDA-------------------
Mvan_1742|M.vanbaalenii_PYR-1       TQVNIQPRVRDKVLARYGAAADERSREEKKAADERSREEQGGKA
MSMEG_1839|M.smegmatis_MC2_155      TRVNIHPRVRENVLARYGSPE-VRA-------------------
TH_0470|M.thermoresistible__bu      TKVNVHPRVREKVVAKYGGAR-----------------------
Mb3280c|M.bovis_AF2122/97           TRVNLHPRVREKALARYGASA-----------------------
Rv3252c|M.tuberculosis_H37Rv        TRVNLHPRVREKALARYGASA-----------------------
MMAR_1291|M.marinum_M               TKVNLHPRVRDKMLARYGASHQGIG-------------------
MAV_4215|M.avium_104                TRVNVSPRRRAKLLARYPVVTA----------------------
MAB_3598c|M.abscessus_ATCC_199      TRVNIQPSKRAKILARYGVTEGAA--------------------
MUL_2749|M.ulcerans_Agy99           TKVNIDPRKRDKILATYGVR------------------------
                                    *::*: *  * : :* *