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M. tuberculosis H37Rv Rv3252c (alkB)

annotation: PROBABLE TRANSMEMBRANE ALKANE 1-MONOOXYGENASE ALKB (ALKANE 1-HYDROXYLASE) (LAURIC ACID OMEGA-HYDROXYLASE) (OMEGA-HYDROXYLASE) (FATTY ACID OMEGA-HYDROXYLASE) (ALKANE HYDROXYLASE-RUBREDOXIN)
coordinates: 3630738 - 3631988
length: 416

TTQIGSGGPEAPRPPEVEEWRDKKRYLWLMGLIAPTALVVMLPLIWGMNQLGWHAAAQVPLWIGPILLYV
LLPLLDLRFGPDGQNPPDEVTDRLENDKYYRYCTYIYIPFQYLSVVLGAYLFTAANLSWLGFDGALSWAG
KLGVALSVGVLGGVGINTAHEMGHKKDSLERWLSKITLAQTCYGHFYIEHNRGHHVRVSTPEDPASARFG
ETLWEFLPRSVIGGLRSAVHLEAQRLRRLGVSPWNPMTYLRNDVLNAWLMSVVLWGGLIAVFGPALIPFV
IIQAVFGFSLLEAVNYLEHYGLLRQKSANGRYERCAPVHSWNSDHIVTNLFLYHLQRHSDHHANPTRRYQ
TLRSMAGAPNLPSGYASMISLTYFPPLWRKVMDHRVLEHYGGDITRVNLHPRVREKALARYGASA*

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. tuberculosis H37Rv Rv3252c alkB - 100% (416) PROBABLE TRANSMEMBRANE ALKANE 1-MONOOXYGENASE ALKB (ALKANE 1-HYDROXYLASE) (LAURIC ACID OMEGA-HYDROXYLASE) (OMEGA-HYDROXYLASE) (FATTY ACID OMEGA-HYDROXYLASE) (ALKANE HYDROXYLASE-RUBREDOXIN)

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb3280c alkB 0.0 100.00% (416) transmembrane alkane 1-monooxygenase AlkB
M. gilvum PYR-GCK Mflv_4721 - 0.0 80.15% (398) alkane 1-monooxygenase
M. leprae Br4923 - - - - -
M. abscessus ATCC 19977 MAB_3598c - 1e-176 70.52% (407) putative alkane-1-monooxygenase AlkB (fatty acid
M. marinum M MMAR_1291 alkB 0.0 86.02% (415) transmembrane alkane 1-monooxygenase AlkB
M. avium 104 MAV_4215 - 0.0 85.36% (403) alkane-1-monooxygenase
M. smegmatis MC2 155 MSMEG_1839 - 0.0 81.66% (398) alkane 1-monooxygenase
M. thermoresistible (build 8) TH_0470 - 0.0 80.76% (395) PROBABLE TRANSMEMBRANE ALKANE 1-MONOOXYGENASE ALKB (ALKANE
M. ulcerans Agy99 MUL_2749 alkB_1 1e-172 69.06% (404) transmembrane alkane 1-monooxygenase AlkB_1
M. vanbaalenii PYR-1 Mvan_1742 - 0.0 82.54% (401) alkane 1-monooxygenase

CLUSTAL 2.0.9 multiple sequence alignment


Rv3252c|M.tuberculosis_H37Rv        -MTTQIGSGGPEAPRPPEVEEWRDKKRYLWLMGLIAPTALVVMLPLIWGM
Mb3280c|M.bovis_AF2122/97           -MTTQIGSGGPEAPRPPEVEEWRDKKRYLWLMGLIAPTALVVMLPLIWGM
MMAR_1291|M.marinum_M               -MTTQFRSDVPDAPET----EWRDKKRYLWLMGLIAPTALFVVLPIVWGL
MAV_4215|M.avium_104                --MTTVDLQQPSEPAA-----WRDKKRRLWLMGLIAPTALFVMLPLVWAL
Mflv_4721|M.gilvum_PYR-GCK          -MTTHDMLDKPD------ALQWRDKKRYLWLMGLIAPTALFVVLPLVWAL
Mvan_1742|M.vanbaalenii_PYR-1       -------MSKPD------VEQWRDKKRYLWLMGLIAPTALFVMLPLIWAL
MSMEG_1839|M.smegmatis_MC2_155      MVAEVDPSAVAD------VGEWRDKKRYLWLMGLIAPTALFVMLPVVWAL
TH_0470|M.thermoresistible__bu      ---MTTELSNVD------ATVWRDKKRYLWLLGLVAPTALFFMLPVVWAF
MAB_3598c|M.abscessus_ATCC_199      -MTSNLETGPAQP-----AAQWRDRKRYMWLYGMIPPTAIFIATALVYAM
MUL_2749|M.ulcerans_Agy99           -MTSVAQPKSENP-----VQQRRDRKRYLWLVGLVLPTALPASLALAWVF
                                               .          **:** :** *:: ***:    .: : :

Rv3252c|M.tuberculosis_H37Rv        NQLGWHAAAQVPLWIGPILLYVLLPLLDLRFGPDGQNPPDEVTDRLENDK
Mb3280c|M.bovis_AF2122/97           NQLGWHAAAQVPLWIGPILLYVLLPLLDLRFGPDGQNPPDEVTDRLENDK
MMAR_1291|M.marinum_M               NHFGWHLAAQVPLWVGPMLVYILLPLLDLGFGPDGQNPPDEVMERLENDK
MAV_4215|M.avium_104                NRLGWHAAAQVPLWIGPILLYILLPILDLRFGPDGQNPPDEVMERLENDK
Mflv_4721|M.gilvum_PYR-GCK          NALGWHAAAQVPLWIGPILLYVLLPTLDRFFGPDGQNPPDEVMERLENDK
Mvan_1742|M.vanbaalenii_PYR-1       NQFGWHVAAQVPLWIGPILLYILLPALDLKFGPDGQNPPDEVMERLENDK
MSMEG_1839|M.smegmatis_MC2_155      NNAGWHAAAQVPFWIGPILLYVLLPLLDLKFGPDGQNPPDEVMERLENDR
TH_0470|M.thermoresistible__bu      NKLDWHIAAQVPFWIGPILVYVLLPILDLRFGPDGQNPPDEVMERLENDR
MAB_3598c|M.abscessus_ATCC_199      NQLGWQQFSPVLFWIGPLLVYVILPLLDLNFGADGENAPDEVMEALENDK
MUL_2749|M.ulcerans_Agy99           GKLGWTAVTPVLWWIGPFLLYLLLPALDVFFGPDGENPPDEVMERLENDK
                                    .  .*   : *  *:**:*:*::** **  **.**:*.**** : ****:

Rv3252c|M.tuberculosis_H37Rv        YYRYCTYIYIPFQYLSVVLGAYLFTAANLSWLGFDGALSWAGKLGVALSV
Mb3280c|M.bovis_AF2122/97           YYRYCTYIYIPFQYLSVVLGAYLFTAANLSWLGFDGALSWAGKLGVALSV
MMAR_1291|M.marinum_M               YYRYCTYIYIPFQYLSVVLGAYLFTASDLGWLGFDGGLNWLGKIGVALSV
MAV_4215|M.avium_104                YYRYCTYVYIPFQYLSVILGAYLFTATDLSWLGFHGGLGWAGKLGLALSV
Mflv_4721|M.gilvum_PYR-GCK          YYRYCTYLYIPFQYASVIFGAYLFTASDLGWLGFDGALPWPAKIGLALSV
Mvan_1742|M.vanbaalenii_PYR-1       YYRYCTYLYIPFQYASVIMGAYLFTASDLGWLGFEGGLSWPAKIGLALSV
MSMEG_1839|M.smegmatis_MC2_155      YYRYCTYAYIPFQYASVIVGAYLFTASDLGWLGFDGGLGWPAKIGLALSV
TH_0470|M.thermoresistible__bu      YYRYCTYLYIPFQYASFIVGAYLFTATDLGWLGFDGGLGWPAKLGLALSV
MAB_3598c|M.abscessus_ATCC_199      YYRYCTYIFIPFQYASFFLGAYYFTATDLSWIGFDHGISWISKLGIAASI
MUL_2749|M.ulcerans_Agy99           YYRYCTYAFIPLQMVSLVLACYLWSADNLSWLGLGAGLGLISKIGLTMTI
                                    ******* :**:*  *.....* ::* :*.*:*:  .:   .*:*:: ::

Rv3252c|M.tuberculosis_H37Rv        GVLGGVGINTAHEMGHKKDSLERWLSKITLAQTCYGHFYIEHNRGHHVRV
Mb3280c|M.bovis_AF2122/97           GVLGGVGINTAHEMGHKKDSLERWLSKITLAQTCYGHFYIEHNRGHHVRV
MMAR_1291|M.marinum_M               GVLGGVGINTAHEMGHKKDSLERWLSKITLAQTGYGHFYIEHNRGHHVRV
MAV_4215|M.avium_104                GVLGGVGINTAHEMGHKKDSLERWLSKITLAQTCYGHFYIEHNRGHHVRV
Mflv_4721|M.gilvum_PYR-GCK          GLLGGVGINTAHEMGHKKESLERWLAKITLAQTLYGHFYIEHNRGHHVRV
Mvan_1742|M.vanbaalenii_PYR-1       GLLGGVGINTAHEMGHKKDSLERWLAKITLAQTLYGHFYIEHNRGHHVRV
MSMEG_1839|M.smegmatis_MC2_155      GVLGGVGINTAHELGHKKDSLERWLSKITLAQTWYGHFYIEHNRGHHVRV
TH_0470|M.thermoresistible__bu      GVLGGVGINTAHELGHKKDSLERWLSKITLAQTGYGHFYIEHNRGHHVRV
MAB_3598c|M.abscessus_ATCC_199      GVLGGVGINTAHEMGHKKEELERWLSKITLAQTFYGHFYIEHNRGHHVRV
MUL_2749|M.ulcerans_Agy99           GVVGGVGINTAHELGHKRENLEGWLSKITLAQTLYGHFYIEHNRGHHVRV
                                    *::**********:***::.** **:******* ****************

Rv3252c|M.tuberculosis_H37Rv        STPEDPASARFGETLWEFLPRSVIGGLRSAVHLEAQRLRRLGVSPWNPMT
Mb3280c|M.bovis_AF2122/97           STPEDPASARFGETLWEFLPRSVIGGLRSAVHLEAQRLRRLGVSPWNPMT
MMAR_1291|M.marinum_M               STPEDPASARFGETFWEFLPRTVFGSLRSAIGLEAQRLRRQGRSPWNPKT
MAV_4215|M.avium_104                ATPEDPASARFGETFWEFLPRSVFGSLRSALRLEAQRLRRLGKNPWNPLT
Mflv_4721|M.gilvum_PYR-GCK          ATPEDPASARFGETFWEFLPRSVFGSLKSAWELEAKRLERAGKPTWH---
Mvan_1742|M.vanbaalenii_PYR-1       ATPEDPASARFGETFWEFLPRSVFGSLKSAWELEAKRLERAGKSKWH---
MSMEG_1839|M.smegmatis_MC2_155      ATPEDPASARFGETFWEFLPRSVWGSLRSSWELEAKRLERAGKSKWH---
TH_0470|M.thermoresistible__bu      ATPEDPASARFGETFWEFLPRSVFGGLKSGWQLEAQRLRRAGKSPWH---
MAB_3598c|M.abscessus_ATCC_199      ATPEDPASSRFGETFWGFWPRSVWGALRSSWNLEATRMKRLNRFVLH---
MUL_2749|M.ulcerans_Agy99           ATPEDPASARFGESFWMFLPRSMFGSLKSAWELEKSRMQRINKPTLS---
                                    :*******:****::* * **:: *.*:*.  **  *:.* .        

Rv3252c|M.tuberculosis_H37Rv        YLRNDVLNAWLMSVVLWGGLIAVFGPALIPFVIIQAVFGFSLLEAVNYLE
Mb3280c|M.bovis_AF2122/97           YLRNDVLNAWLMSVVLWGGLIAVFGPALIPFVIIQAVFGFSLLEAVNYLE
MMAR_1291|M.marinum_M               YPSNDVLNAWAMSVLLWGVLIAVFGLGLIPFVIIQAVFGFCLLEAVNYLE
MAV_4215|M.avium_104                YPSNDVLNAWAMSIVLWGVLIAVFGPGLIPFVVIQAVFGFSLLEAVNYLE
Mflv_4721|M.gilvum_PYR-GCK          -WSNDVLNAWAMSVVFYGALIAVFGWALVPYILISAIFGFTLLETVNYLE
Mvan_1742|M.vanbaalenii_PYR-1       -WSNDVLNAWAMSVVLYGALIAVFGWALIPYILISAVFGFTLLEAVNYLE
MSMEG_1839|M.smegmatis_MC2_155      -WSNDVLNAWAMSVVFYGVLIAVFGWGLIPYIVISAVFGFTLLETVNYLE
TH_0470|M.thermoresistible__bu      -PSNDVLNAWAMTVVLWGVLIAVFGVGVIPYLLIQAVFGFSLLESVNYLE
MAB_3598c|M.abscessus_ATCC_199      -PSNDVVNAWLMSVVLFGVTIAIFGTAVIPYLIIQAIYGFTFLETVNYLE
MUL_2749|M.ulcerans_Agy99           -MRNDVLNAWIMSVVLFGALTAVFGWQVLPFLIIQGLFGASLLESVNYLE
                                       ***:*** *:::::*   *:**  ::*:::*..::*  :**:*****

Rv3252c|M.tuberculosis_H37Rv        HYGLLR----QKSANGRYERCAPVHSWNSDHIVTNLFLYHLQRHSDHHAN
Mb3280c|M.bovis_AF2122/97           HYGLLR----QKSANGRYERCAPVHSWNSDHIVTNLFLYHLQRHSDHHAN
MMAR_1291|M.marinum_M               HYGLLR----QPTSNGRYERCAPVHSWNSDHIVTNLFLYHLQRHSDHHAN
MAV_4215|M.avium_104                HYGLLRRKIDSPSGKARYERCTPEHSWNSDHVVTNLFLYHLQRHSDHHAN
Mflv_4721|M.gilvum_PYR-GCK          HYGLLR----QKLPSGRYERCAPVHSWNSDHIVTNLFLYHLQRHSDHHAN
Mvan_1742|M.vanbaalenii_PYR-1       HYGLLR----KKLDNGRYERCAPVHSWNSDHIVTNLFLYHLQRHSDHHAN
MSMEG_1839|M.smegmatis_MC2_155      HYGLLR----QKTPSGRYERCSPQHSWNSDHIVTNLFLYHLQRHSDHHAN
TH_0470|M.thermoresistible__bu      HYGLLR----QKTASGRYERCTPEHSWNSDHLVTNLFLYHLQRHSDHHAN
MAB_3598c|M.abscessus_ATCC_199      HYGLLR----QKNGE-RYERCTPKHSWNSDHLVTNIFLYHLQRHSDHHAN
MUL_2749|M.ulcerans_Agy99           HYGLLR----QRTASGRYERCAPVHSWNSDHIVTNIFLYHLQRHSDHHAN
                                    ******    .   . *****:* *******:***:**************

Rv3252c|M.tuberculosis_H37Rv        PTRRYQTLRSMAGAPNLPSGYASMISLTYFPPLWRKVMDHRVLEHYGGDI
Mb3280c|M.bovis_AF2122/97           PTRRYQTLRSMAGAPNLPSGYASMISLTYFPPLWRKVMDHRVLEHYGGDI
MMAR_1291|M.marinum_M               PTRRYQTLRSMDGAPNLPSGYASMISLTYFPPLWRKVMDHRVLEHYGGDI
MAV_4215|M.avium_104                PTRRYQTLRSLDGSPNLPSGYASMISLTYFPPLWRKVMDHRVLAHYGGDI
Mflv_4721|M.gilvum_PYR-GCK          PTRRYQTLRSMEGAPNLPSGYASMIALTYFPPVWRMVMDHRVVDHYDGDL
Mvan_1742|M.vanbaalenii_PYR-1       PTRRYQTLRSMEGAPNLPSGYASMIGLTYFPPLWRRMMDHRVLAHYGGDI
MSMEG_1839|M.smegmatis_MC2_155      PTRRYQTLRSMDGAPNLPSGYASMIALTYFPPLWRKVMDHRVLDHYDGDI
TH_0470|M.thermoresistible__bu      PTRRYQTLRSLDGSPNLPSGYATMIGLTYIPPLWRRVMDHRVLEHYGGDI
MAB_3598c|M.abscessus_ATCC_199      PTRRYQTLRSMDGAPNLPSGYATMLTLAYFPPLWRKVMDHRVLDHYDGDI
MUL_2749|M.ulcerans_Agy99           PLRRYQTLRSMDGAPNLPSGYATLITLTYFPPLWRKLMDHRVIEHYDGDI
                                    * ********: *:********::: *:*:**:** :*****: **.**:

Rv3252c|M.tuberculosis_H37Rv        TRVNLHPRVREKALARYGASA-----------------------
Mb3280c|M.bovis_AF2122/97           TRVNLHPRVREKALARYGASA-----------------------
MMAR_1291|M.marinum_M               TKVNLHPRVRDKMLARYGASHQGIG-------------------
MAV_4215|M.avium_104                TRVNVSPRRRAKLLARYPVVTA----------------------
Mflv_4721|M.gilvum_PYR-GCK          TRINIHPRVRDKVLARYGVRGGVDA-------------------
Mvan_1742|M.vanbaalenii_PYR-1       TQVNIQPRVRDKVLARYGAAADERSREEKKAADERSREEQGGKA
MSMEG_1839|M.smegmatis_MC2_155      TRVNIHPRVRENVLARYGSPE-VRA-------------------
TH_0470|M.thermoresistible__bu      TKVNVHPRVREKVVAKYGGAR-----------------------
MAB_3598c|M.abscessus_ATCC_199      TRVNIQPSKRAKILARYGVTEGAA--------------------
MUL_2749|M.ulcerans_Agy99           TKVNIDPRKRDKILATYGVR------------------------
                                    *::*: *  * : :* *

species	id	gene	e-value	identity (len)	annotation
M. tuberculosis H37Rv	Rv3252c	alkB	-	100% (416)	PROBABLE TRANSMEMBRANE ALKANE 1-MONOOXYGENASE ALKB (ALKANE 1-HYDROXYLASE) (LAURIC ACID OMEGA-HYDROXYLASE) (OMEGA-HYDROXYLASE) (FATTY ACID OMEGA-HYDROXYLASE) (ALKANE HYDROXYLASE-RUBREDOXIN)