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M. thermoresistible (build 8) TH_0134 (purA)

annotation: PROBABLE ADENYLOSUCCINATE SYNTHETASE PURA (IMP--ASPARTATE LIGASE) (ADSS) (AMPSASE)
coordinates: 288182 - 289471
length: 430

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_0134purA-100% (430)PROBABLE ADENYLOSUCCINATE SYNTHETASE PURA (IMP--ASPARTATE LIGASE) (ADSS) (AMPSASE)

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0364cpurA0.086.32% (424) adenylosuccinate synthetase
M. gilvum PYR-GCKMflv_0228-0.091.10% (427) adenylosuccinate synthetase
M. tuberculosis H37RvRv0357cpurA0.086.32% (424) adenylosuccinate synthetase
M. leprae Br4923MLBr_00280purA0.087.03% (424) adenylosuccinate synthetase
M. abscessus ATCC 19977MAB_4249c-0.086.42% (427) adenylosuccinate synthetase
M. marinum MMMAR_0680purA0.087.15% (428) adenylosuccinate synthetase PurA
M. avium 104MAV_4777purA0.088.73% (426) adenylosuccinate synthetase
M. smegmatis MC2 155MSMEG_0759purA0.093.66% (426) adenylosuccinate synthetase
M. ulcerans Agy99MUL_2834purA0.086.45% (428) adenylosuccinate synthetase
M. vanbaalenii PYR-1Mvan_0677-0.091.31% (426) adenylosuccinate synthetase

CLUSTAL 2.0.9 multiple sequence alignment


MLBr_00280|M.leprae_Br4923          MPAVVLIGAQWGDEGKGKVTDLLGGRAQWVVRYQGGNNAGHTVVLPTGEN
MAV_4777|M.avium_104                MPAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVVLPTGEN
Mb0364c|M.bovis_AF2122/97           MPAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVVLPTGEN
Rv0357c|M.tuberculosis_H37Rv        MPAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVVLPTGEN
MMAR_0680|M.marinum_M               MPAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVVLPSGEN
MUL_2834|M.ulcerans_Agy99           MPAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVVLPSGEN
TH_0134|M.thermoresistible__bu      ----VLIGAQWGDEGKGKATDLLGGRVRWVVRYQGGNNAGHTVVLPTGEN
MSMEG_0759|M.smegmatis_MC2_155      MPAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVVLPTGEN
Mflv_0228|M.gilvum_PYR-GCK          MPAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVVLPTGEN
Mvan_0677|M.vanbaalenii_PYR-1       MPAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVVLPTGEN
MAB_4249c|M.abscessus_ATCC_199      MPAIVLIGAQWGDEGKGKATDLLGGSVQWVVRYQGGNNAGHTVVLPNGEN
                                        **************.****** .:******************.***

MLBr_00280|M.leprae_Br4923          FTLHLIPSGVLTPGVTNVIGNGVVVDPGVLLSELQGLEDRGVDTSQLLIS
MAV_4777|M.avium_104                FALHLIPSGVLTPGVTNVIGNGVVVDPGVLLDELKGLEDRGVDTSRLLIS
Mb0364c|M.bovis_AF2122/97           FALHLIPSGVLTPGVTNVIGNGVVIDPGVLLNELRGLQDRGVDTAKLLIS
Rv0357c|M.tuberculosis_H37Rv        FALHLIPSGVLTPGVTNVIGNGVVIDPGVLLNELRGLQDRGVDTAKLLIS
MMAR_0680|M.marinum_M               FALHLIPSGVLTPGVTNVIGNGVVIDPGVLLSELKGLEDRGVDTSKLLIS
MUL_2834|M.ulcerans_Agy99           FALHLIPSGVLTPGVTNVIGNGVVIDPGVLLSELKGLEDRGVDTAKLLIS
TH_0134|M.thermoresistible__bu      FALHLIPSGILTPGVTNVIGNGVVVDPGVLLTELHGLEERGVDTERLLIS
MSMEG_0759|M.smegmatis_MC2_155      FALHLIPSGILTPGVTNVIGNGVVVDPGVLLTELKGLEDRGVDTSNLLIS
Mflv_0228|M.gilvum_PYR-GCK          FALHLIPSGILTPGVTNVIGNGVVVDPGVLLTELKGLEDRGVDTDRLLIS
Mvan_0677|M.vanbaalenii_PYR-1       FALHLIPSGILTPGVTNVIGNGVVVDPGVLLAELKGLEERGVDTERLLIS
MAB_4249c|M.abscessus_ATCC_199      FALHLIPSGILTPGVTNVIGNGVVVDPGVLLTELAGLEERGIDTSGLILS
                                    *:*******:**************:****** ** **::**:**  *::*

MLBr_00280|M.leprae_Br4923          ADAHLLMPYHVAIDKVTERYMGNKKIGTTGRGIGPCYQDKIARMGIRVAD
MAV_4777|M.avium_104                ADAHLLLPYHVAIDKVTERYMGNKKIGTTGRGIGPCYQDKIARIGIRVAD
Mb0364c|M.bovis_AF2122/97           ADAHLLMPYHIAIDKVTERYMGSKKIGTTGRGIGPCYQDKIARIGIRVAD
Rv0357c|M.tuberculosis_H37Rv        ADAHLLMPYHIAIDKVTERYMGSKKIGTTGRGIGPCYQDKIARIGIRVAD
MMAR_0680|M.marinum_M               ADAHLLMPYHVAIDKVTERYMGSKKIGTTGRGIGPCYQDKVARMGIRVAD
MUL_2834|M.ulcerans_Agy99           ADAHLLMPYHVAIDKVTERYMGSKKIGTTGRGIGPCYQDKVARMGIRVAD
TH_0134|M.thermoresistible__bu      ADAHLLMPYHVAIDKVVERWAGKKKIGTTGRGIGPCYQDKIARIGIRVAD
MSMEG_0759|M.smegmatis_MC2_155      ADAHLLMPYHVAIDKVVERWAGSKKIGTTGRGIGPCYQDKIARIGIRVAD
Mflv_0228|M.gilvum_PYR-GCK          ADAHLLMPYHVAIDKVVERYAGSKKIGTTGRGIGPCYQDKIARQGIRVAD
Mvan_0677|M.vanbaalenii_PYR-1       ADAHLLMPYHVAIDKVVERYAGSKKIGTTGRGIGPCYQDKIARQGIRVAD
MAB_4249c|M.abscessus_ATCC_199      ADAHLLMPYHVAIDKVTERYLGSKKIGTTGRGIGPCYQDKVARIGIRVAD
                                    ******:***:*****.**: *.*****************:** ******

MLBr_00280|M.leprae_Br4923          VLEPGELTHKIEAALEFKNQVLVKIYNRKALDLAQVVETLLEQAQQFRHR
MAV_4777|M.avium_104                VLDREVLTHKIEAALELKNQILVKIYNRKALDPHQVVECLLEQAEGFRHR
Mb0364c|M.bovis_AF2122/97           VLDPEQLTHKVEAACEFKNQVLVKIYNRKALDPAQVVDALLEQAEGFKHR
Rv0357c|M.tuberculosis_H37Rv        VLDPEQLTHKVEAACEFKNQVLVKIYNRKALDPAQVVDALLEQAEGFKHR
MMAR_0680|M.marinum_M               VLDTDQLAHKVEAALEFKNQVLVKIYNRKALDPDQVVESLLEQAEGFRHR
MUL_2834|M.ulcerans_Agy99           VLDTDQLAHKVEAALEFKNQVLVKIYNRKALDPDQVVESLLEQAEGFRHR
TH_0134|M.thermoresistible__bu      VLDEQVLAEKIEAALEFKNQVLVKIYNRKALDPTEVFENLLEQAAGFKHR
MSMEG_0759|M.smegmatis_MC2_155      VLDEQVLAEKIEAALEFKNQVLVKIYNRKALEPAEVLENLLEQAEGFKHR
Mflv_0228|M.gilvum_PYR-GCK          VLDPAVLAEKIEGALELKNQVLVKIYNRKALEPAEVVENLLEQAEGFKHR
Mvan_0677|M.vanbaalenii_PYR-1       VLDPALLAEKIEGALELKNQVLVKIYNRKALDPAEVVENLLEQADGFKHR
MAB_4249c|M.abscessus_ATCC_199      VLDEESLRQKVHAALEFKNQVLVKIYNRKALDPDQVVDGVLEQAEGFKHR
                                    **:   * .*:..* *:***:**********:  :*.: :****  *:**

MLBr_00280|M.leprae_Br4923          ITDTRLLLNDALEAGETVLLEGAQGTLLDVDHGTYPYVTSSNPTAGGAAL
MAV_4777|M.avium_104                IADTRLLLNTALEAGETVLLEGSQGTLLDVDHGTYPYVTSSNPTAGGAAV
Mb0364c|M.bovis_AF2122/97           IADTRLLLNAALEAGETVLLEGSQGTLLDVDHGTYPYVTSSNPTAGGAAV
Rv0357c|M.tuberculosis_H37Rv        IADTRLLLNAALEAGETVLLEGSQGTLLDVDHGTYPYVTSSNPTAGGAAV
MMAR_0680|M.marinum_M               IADARLLLNNALEAGETVLLEGSQGTLLDVDHGTYPYVTSSNPTAGGAAV
MUL_2834|M.ulcerans_Agy99           IADARLLLNNALEAGGTVLLEGSQGTLLDVDHGTYPYVTSSNPTAGGAAV
TH_0134|M.thermoresistible__bu      IADTRLLLNNALDNGETVLLEGSQGTLLDVDHGTYPYVTSSNPTAGGAAV
MSMEG_0759|M.smegmatis_MC2_155      IADARLLLNQALENDEAVLLEGSQGTLLDVDHGTYPFVTSSNPTAGGAAV
Mflv_0228|M.gilvum_PYR-GCK          IADARLLLNEALERDEIVLLEGSQGTLLDVDHGTYPYVTSSNPTAGGASV
Mvan_0677|M.vanbaalenii_PYR-1       IADARLLLNEALERNETVLLEGSQGTLLDVDHGTYPFVTSSNPTAGGASV
MAB_4249c|M.abscessus_ATCC_199      IADARLQLNQALERGETVLLEGSQGTLLDVDHGTYPFVTSSNPTAGGASV
                                    *:*:** ** **: .  *****:*************:***********::

MLBr_00280|M.leprae_Br4923          GSGIGPTRIHTVLGILKAYTTRVGSGPFPTELFDENGEYLAKTGSEIGVT
MAV_4777|M.avium_104                GSGIGPTRITAVLGILKAYTTRVGSGPFPTELFDENGEYLSKTGGEFGVT
Mb0364c|M.bovis_AF2122/97           GSGIGPTRIGTVLGILKAYTTRVGSGPFPTELFDEHGEYLSKTGREFGVT
Rv0357c|M.tuberculosis_H37Rv        GSGIGPTRIGTVLGILKAYTTRVGSGPFPTELFDEHGEYLSKTGREFGVT
MMAR_0680|M.marinum_M               GSGIGPTRIRTVLGILKAYTTRVGSGPFPTELFDESGEYLSKTGGEFGVT
MUL_2834|M.ulcerans_Agy99           GSGIGPTRIRTVLGILKAYTTRVGSGPFPTELFYESGEYLSKTGGEFGVT
TH_0134|M.thermoresistible__bu      GSGIGPTRITTVLGILKAYTTRVGSGPFPTELFDDNGAYLAKAGGEVGVT
MSMEG_0759|M.smegmatis_MC2_155      GSGIGPTRITTVLGILKAYTTRVGSGPFPTELFDEHGAYLAKTGGEVGVT
Mflv_0228|M.gilvum_PYR-GCK          GSGIGPTRITTVLGILKAYTTRVGSGPFPTELFDEHGAYLAKTGGEVGVT
Mvan_0677|M.vanbaalenii_PYR-1       GSGIGPTRITTVLGILKAYTTRVGSGPFPTELFDDHGAYLAKTGGEVGVT
MAB_4249c|M.abscessus_ATCC_199      GSGIGPTRITTVLGILKAYTTRVGSGPFPTELFDEHGAYLAKTGGEVGVT
                                    ********* :********************** : * **:*:* *.***

MLBr_00280|M.leprae_Br4923          TGRRRRCGWFDAVIARYATRVNGITDYFLTKLDVLSSLETVPVCVGYQIA
MAV_4777|M.avium_104                TGRRRRCGWFDAVVARYATRVNGITDFFLTKLDVLSSLETVPVCVGYRID
Mb0364c|M.bovis_AF2122/97           TGRRRRCGWFDAVIARYAARVNGITDYFLTKLDVLSSLESVPVCVGYEID
Rv0357c|M.tuberculosis_H37Rv        TGRRRRCGWFDAVIARYAARVNGITDYFLTKLDVLSSLESVPVCVGYEID
MMAR_0680|M.marinum_M               TGRRRRCGWFDAVIARYATRVNGITDYFLTKLDVLSSLETVPVCVGYEID
MUL_2834|M.ulcerans_Agy99           TGRRRRCGWFDAVIARYATRVNGITDYFLTKLDVLSSLETVPVCVGYEID
TH_0134|M.thermoresistible__bu      TGRARRCGWFDAVIARYATRVNGITDYFLTKLDVLSSLETVPVCVGYRID
MSMEG_0759|M.smegmatis_MC2_155      TGRARRCGWFDAVIARYATRVNGITDYFLTKLDVLSSLETVPVCVGYTVD
Mflv_0228|M.gilvum_PYR-GCK          TGRARRCGWFDAVIARYATRVNGITDYFLTKLDVLSSLETVPICVGYTVD
Mvan_0677|M.vanbaalenii_PYR-1       TGRARRCGWFDAVIARYATRVNGITDYFLTKLDVLSSLETVPICVGYSVD
MAB_4249c|M.abscessus_ATCC_199      TGRARRCGWFDAVIARYATRVNGITDYFLTKLDVLSSLQTVPICVGYEVD
                                    *** *********:****:*******:***********::**:**** : 

MLBr_00280|M.leprae_Br4923          GVRTHDMPITQSDLARAEPIYEELPGWWEDISGAREFEDLPAKARDYVLR
MAV_4777|M.avium_104                GARINEMPMTQSDLHRAEPIYEELPGWWEDISAAREFDDLPAKARDYVLR
Mb0364c|M.bovis_AF2122/97           GRRTRDMPMTQRDLCRAKPVYEELPGWWEDISGAREFDDLPAKARDYVLR
Rv0357c|M.tuberculosis_H37Rv        GRRTRDMPMTQRDLCRAKPVYEELPGWWEDISGAREFDDLPAKARDYVLR
MMAR_0680|M.marinum_M               GKRTSEMPMTQSDLCRAKPVYEELPGWWEDISAAREFDDLPAKARDYVLR
MUL_2834|M.ulcerans_Agy99           GKRTSEMPMTQSDLCRAKPVYEELPGWWEDISAAREFDDLPAKARDYVLR
TH_0134|M.thermoresistible__bu      GKRVDEMPMTQSDVARAEPIYEEMPGWWEDISGAREFEDLPAKARDYVLR
MSMEG_0759|M.smegmatis_MC2_155      GKRVDEMPMTQSDIARAEPVYEELPGWWEDISGAREFEDLPAKARDYVLR
Mflv_0228|M.gilvum_PYR-GCK          GKRTDEMPMTQSDIARAEPVYEELPGWWEDISGAREFDDLPAKARDYVLR
Mvan_0677|M.vanbaalenii_PYR-1       GKRTDEMPMTQSDIARAEPIYEELPGWWEDISGCRTFDELPAKARDYVLR
MAB_4249c|M.abscessus_ATCC_199      GKRTNEMPMTQSEIYRATPVYEELPGWWEDISGARQFEDLPAKAQDYVLR
                                    * *  :**:** :: ** *:***:********..* *::*****:*****

MLBr_00280|M.leprae_Br4923          LEELAGAQVACIGVGPGRDQTIVRCDVLRSRR-
MAV_4777|M.avium_104                LEELAGAHVSCIGVGPGREQTIVRRDILAARP-
Mb0364c|M.bovis_AF2122/97           LEQLAGAPVSCIGVGPGREQTIVRRDVLQDRP-
Rv0357c|M.tuberculosis_H37Rv        LEQLAGAPVSCIGVGPGREQTIVRRDVLQDRP-
MMAR_0680|M.marinum_M               LEEIAGAPVSCIGVGPGRDQTIVRRDILQERA-
MUL_2834|M.ulcerans_Agy99           LEEISGAPVSCIGVGPGRDQTIVRRDILQERA-
TH_0134|M.thermoresistible__bu      VEELAGARVSCIGVGPGRDQTIVRHDVLAASAR
MSMEG_0759|M.smegmatis_MC2_155      LEELAGAYVSCIGVGPGRDQTIVRRDVLAAR--
Mflv_0228|M.gilvum_PYR-GCK          LEELAGAHVSCIGVGPGRDQTIVRRDILATS--
Mvan_0677|M.vanbaalenii_PYR-1       LEDLAGAHVSCIGVGPGRDQTIVRRDVLAAR--
MAB_4249c|M.abscessus_ATCC_199      LEELAGAPMSCIGVGPGRDQTIVRRDILSRS--
                                    :*:::** ::********:***** *:*