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PAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVVLPSGENFALHLIPSGVLTPGVTNVIGN GVVIDPGVLLSELKGLEDRGVDTAKLLISADAHLLMPYHVAIDKVTERYMGSKKIGTTGRGIGPCYQDKV ARMGIRVADVLDTDQLAHKVEAALEFKNQVLVKIYNRKALDPDQVVESLLEQAEGFRHRIADARLLLNNA LEAGGTVLLEGSQGTLLDVDHGTYPYVTSSNPTAGGAAVGSGIGPTRIRTVLGILKAYTTRVGSGPFPTE LFYESGEYLSKTGGEFGVTTGRRRRCGWFDAVIARYATRVNGITDYFLTKLDVLSSLETVPVCVGYEIDG KRTSEMPMTQSDLCRAKPVYEELPGWWEDISAAREFDDLPAKARDYVLRLEEISGAPVSCIGVGPGRDQT IVRRDILQERA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2834 | purA | - | 100% (432) | adenylosuccinate synthetase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0364c | purA | 0.0 | 91.88% (431) | adenylosuccinate synthetase |
| M. gilvum PYR-GCK | Mflv_0228 | - | 0.0 | 89.25% (428) | adenylosuccinate synthetase |
| M. tuberculosis H37Rv | Rv0357c | purA | 0.0 | 91.88% (431) | adenylosuccinate synthetase |
| M. leprae Br4923 | MLBr_00280 | purA | 0.0 | 87.70% (431) | adenylosuccinate synthetase |
| M. abscessus ATCC 19977 | MAB_4249c | - | 0.0 | 87.85% (428) | adenylosuccinate synthetase |
| M. marinum M | MMAR_0680 | purA | 0.0 | 99.07% (432) | adenylosuccinate synthetase PurA |
| M. avium 104 | MAV_4777 | purA | 0.0 | 90.72% (431) | adenylosuccinate synthetase |
| M. smegmatis MC2 155 | MSMEG_0759 | purA | 0.0 | 88.40% (431) | adenylosuccinate synthetase |
| M. thermoresistible (build 8) | TH_0134 | purA | 0.0 | 86.45% (428) | PROBABLE ADENYLOSUCCINATE SYNTHETASE PURA (IMP--ASPARTATE |
| M. vanbaalenii PYR-1 | Mvan_0677 | - | 0.0 | 87.01% (431) | adenylosuccinate synthetase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_2834|M.ulcerans_Agy99 MPAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVVLPSGEN
MMAR_0680|M.marinum_M MPAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVVLPSGEN
Mb0364c|M.bovis_AF2122/97 MPAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVVLPTGEN
Rv0357c|M.tuberculosis_H37Rv MPAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVVLPTGEN
MLBr_00280|M.leprae_Br4923 MPAVVLIGAQWGDEGKGKVTDLLGGRAQWVVRYQGGNNAGHTVVLPTGEN
MAV_4777|M.avium_104 MPAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVVLPTGEN
Mflv_0228|M.gilvum_PYR-GCK MPAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVVLPTGEN
Mvan_0677|M.vanbaalenii_PYR-1 MPAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVVLPTGEN
MSMEG_0759|M.smegmatis_MC2_155 MPAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVVLPTGEN
TH_0134|M.thermoresistible__bu ----VLIGAQWGDEGKGKATDLLGGRVRWVVRYQGGNNAGHTVVLPTGEN
MAB_4249c|M.abscessus_ATCC_199 MPAIVLIGAQWGDEGKGKATDLLGGSVQWVVRYQGGNNAGHTVVLPNGEN
**************.****** .:******************.***
MUL_2834|M.ulcerans_Agy99 FALHLIPSGVLTPGVTNVIGNGVVIDPGVLLSELKGLEDRGVDTAKLLIS
MMAR_0680|M.marinum_M FALHLIPSGVLTPGVTNVIGNGVVIDPGVLLSELKGLEDRGVDTSKLLIS
Mb0364c|M.bovis_AF2122/97 FALHLIPSGVLTPGVTNVIGNGVVIDPGVLLNELRGLQDRGVDTAKLLIS
Rv0357c|M.tuberculosis_H37Rv FALHLIPSGVLTPGVTNVIGNGVVIDPGVLLNELRGLQDRGVDTAKLLIS
MLBr_00280|M.leprae_Br4923 FTLHLIPSGVLTPGVTNVIGNGVVVDPGVLLSELQGLEDRGVDTSQLLIS
MAV_4777|M.avium_104 FALHLIPSGVLTPGVTNVIGNGVVVDPGVLLDELKGLEDRGVDTSRLLIS
Mflv_0228|M.gilvum_PYR-GCK FALHLIPSGILTPGVTNVIGNGVVVDPGVLLTELKGLEDRGVDTDRLLIS
Mvan_0677|M.vanbaalenii_PYR-1 FALHLIPSGILTPGVTNVIGNGVVVDPGVLLAELKGLEERGVDTERLLIS
MSMEG_0759|M.smegmatis_MC2_155 FALHLIPSGILTPGVTNVIGNGVVVDPGVLLTELKGLEDRGVDTSNLLIS
TH_0134|M.thermoresistible__bu FALHLIPSGILTPGVTNVIGNGVVVDPGVLLTELHGLEERGVDTERLLIS
MAB_4249c|M.abscessus_ATCC_199 FALHLIPSGILTPGVTNVIGNGVVVDPGVLLTELAGLEERGIDTSGLILS
*:*******:**************:****** ** **::**:** *::*
MUL_2834|M.ulcerans_Agy99 ADAHLLMPYHVAIDKVTERYMGSKKIGTTGRGIGPCYQDKVARMGIRVAD
MMAR_0680|M.marinum_M ADAHLLMPYHVAIDKVTERYMGSKKIGTTGRGIGPCYQDKVARMGIRVAD
Mb0364c|M.bovis_AF2122/97 ADAHLLMPYHIAIDKVTERYMGSKKIGTTGRGIGPCYQDKIARIGIRVAD
Rv0357c|M.tuberculosis_H37Rv ADAHLLMPYHIAIDKVTERYMGSKKIGTTGRGIGPCYQDKIARIGIRVAD
MLBr_00280|M.leprae_Br4923 ADAHLLMPYHVAIDKVTERYMGNKKIGTTGRGIGPCYQDKIARMGIRVAD
MAV_4777|M.avium_104 ADAHLLLPYHVAIDKVTERYMGNKKIGTTGRGIGPCYQDKIARIGIRVAD
Mflv_0228|M.gilvum_PYR-GCK ADAHLLMPYHVAIDKVVERYAGSKKIGTTGRGIGPCYQDKIARQGIRVAD
Mvan_0677|M.vanbaalenii_PYR-1 ADAHLLMPYHVAIDKVVERYAGSKKIGTTGRGIGPCYQDKIARQGIRVAD
MSMEG_0759|M.smegmatis_MC2_155 ADAHLLMPYHVAIDKVVERWAGSKKIGTTGRGIGPCYQDKIARIGIRVAD
TH_0134|M.thermoresistible__bu ADAHLLMPYHVAIDKVVERWAGKKKIGTTGRGIGPCYQDKIARIGIRVAD
MAB_4249c|M.abscessus_ATCC_199 ADAHLLMPYHVAIDKVTERYLGSKKIGTTGRGIGPCYQDKVARIGIRVAD
******:***:*****.**: *.*****************:** ******
MUL_2834|M.ulcerans_Agy99 VLDTDQLAHKVEAALEFKNQVLVKIYNRKALDPDQVVESLLEQAEGFRHR
MMAR_0680|M.marinum_M VLDTDQLAHKVEAALEFKNQVLVKIYNRKALDPDQVVESLLEQAEGFRHR
Mb0364c|M.bovis_AF2122/97 VLDPEQLTHKVEAACEFKNQVLVKIYNRKALDPAQVVDALLEQAEGFKHR
Rv0357c|M.tuberculosis_H37Rv VLDPEQLTHKVEAACEFKNQVLVKIYNRKALDPAQVVDALLEQAEGFKHR
MLBr_00280|M.leprae_Br4923 VLEPGELTHKIEAALEFKNQVLVKIYNRKALDLAQVVETLLEQAQQFRHR
MAV_4777|M.avium_104 VLDREVLTHKIEAALELKNQILVKIYNRKALDPHQVVECLLEQAEGFRHR
Mflv_0228|M.gilvum_PYR-GCK VLDPAVLAEKIEGALELKNQVLVKIYNRKALEPAEVVENLLEQAEGFKHR
Mvan_0677|M.vanbaalenii_PYR-1 VLDPALLAEKIEGALELKNQVLVKIYNRKALDPAEVVENLLEQADGFKHR
MSMEG_0759|M.smegmatis_MC2_155 VLDEQVLAEKIEAALEFKNQVLVKIYNRKALEPAEVLENLLEQAEGFKHR
TH_0134|M.thermoresistible__bu VLDEQVLAEKIEAALEFKNQVLVKIYNRKALDPTEVFENLLEQAAGFKHR
MAB_4249c|M.abscessus_ATCC_199 VLDEESLRQKVHAALEFKNQVLVKIYNRKALDPDQVVDGVLEQAEGFKHR
**: * .*:..* *:***:**********: :*.: :**** *:**
MUL_2834|M.ulcerans_Agy99 IADARLLLNNALEAGGTVLLEGSQGTLLDVDHGTYPYVTSSNPTAGGAAV
MMAR_0680|M.marinum_M IADARLLLNNALEAGETVLLEGSQGTLLDVDHGTYPYVTSSNPTAGGAAV
Mb0364c|M.bovis_AF2122/97 IADTRLLLNAALEAGETVLLEGSQGTLLDVDHGTYPYVTSSNPTAGGAAV
Rv0357c|M.tuberculosis_H37Rv IADTRLLLNAALEAGETVLLEGSQGTLLDVDHGTYPYVTSSNPTAGGAAV
MLBr_00280|M.leprae_Br4923 ITDTRLLLNDALEAGETVLLEGAQGTLLDVDHGTYPYVTSSNPTAGGAAL
MAV_4777|M.avium_104 IADTRLLLNTALEAGETVLLEGSQGTLLDVDHGTYPYVTSSNPTAGGAAV
Mflv_0228|M.gilvum_PYR-GCK IADARLLLNEALERDEIVLLEGSQGTLLDVDHGTYPYVTSSNPTAGGASV
Mvan_0677|M.vanbaalenii_PYR-1 IADARLLLNEALERNETVLLEGSQGTLLDVDHGTYPFVTSSNPTAGGASV
MSMEG_0759|M.smegmatis_MC2_155 IADARLLLNQALENDEAVLLEGSQGTLLDVDHGTYPFVTSSNPTAGGAAV
TH_0134|M.thermoresistible__bu IADTRLLLNNALDNGETVLLEGSQGTLLDVDHGTYPYVTSSNPTAGGAAV
MAB_4249c|M.abscessus_ATCC_199 IADARLQLNQALERGETVLLEGSQGTLLDVDHGTYPFVTSSNPTAGGASV
*:*:** ** **: . *****:*************:***********::
MUL_2834|M.ulcerans_Agy99 GSGIGPTRIRTVLGILKAYTTRVGSGPFPTELFYESGEYLSKTGGEFGVT
MMAR_0680|M.marinum_M GSGIGPTRIRTVLGILKAYTTRVGSGPFPTELFDESGEYLSKTGGEFGVT
Mb0364c|M.bovis_AF2122/97 GSGIGPTRIGTVLGILKAYTTRVGSGPFPTELFDEHGEYLSKTGREFGVT
Rv0357c|M.tuberculosis_H37Rv GSGIGPTRIGTVLGILKAYTTRVGSGPFPTELFDEHGEYLSKTGREFGVT
MLBr_00280|M.leprae_Br4923 GSGIGPTRIHTVLGILKAYTTRVGSGPFPTELFDENGEYLAKTGSEIGVT
MAV_4777|M.avium_104 GSGIGPTRITAVLGILKAYTTRVGSGPFPTELFDENGEYLSKTGGEFGVT
Mflv_0228|M.gilvum_PYR-GCK GSGIGPTRITTVLGILKAYTTRVGSGPFPTELFDEHGAYLAKTGGEVGVT
Mvan_0677|M.vanbaalenii_PYR-1 GSGIGPTRITTVLGILKAYTTRVGSGPFPTELFDDHGAYLAKTGGEVGVT
MSMEG_0759|M.smegmatis_MC2_155 GSGIGPTRITTVLGILKAYTTRVGSGPFPTELFDEHGAYLAKTGGEVGVT
TH_0134|M.thermoresistible__bu GSGIGPTRITTVLGILKAYTTRVGSGPFPTELFDDNGAYLAKAGGEVGVT
MAB_4249c|M.abscessus_ATCC_199 GSGIGPTRITTVLGILKAYTTRVGSGPFPTELFDEHGAYLAKTGGEVGVT
********* :********************** : * **:*:* *.***
MUL_2834|M.ulcerans_Agy99 TGRRRRCGWFDAVIARYATRVNGITDYFLTKLDVLSSLETVPVCVGYEID
MMAR_0680|M.marinum_M TGRRRRCGWFDAVIARYATRVNGITDYFLTKLDVLSSLETVPVCVGYEID
Mb0364c|M.bovis_AF2122/97 TGRRRRCGWFDAVIARYAARVNGITDYFLTKLDVLSSLESVPVCVGYEID
Rv0357c|M.tuberculosis_H37Rv TGRRRRCGWFDAVIARYAARVNGITDYFLTKLDVLSSLESVPVCVGYEID
MLBr_00280|M.leprae_Br4923 TGRRRRCGWFDAVIARYATRVNGITDYFLTKLDVLSSLETVPVCVGYQIA
MAV_4777|M.avium_104 TGRRRRCGWFDAVVARYATRVNGITDFFLTKLDVLSSLETVPVCVGYRID
Mflv_0228|M.gilvum_PYR-GCK TGRARRCGWFDAVIARYATRVNGITDYFLTKLDVLSSLETVPICVGYTVD
Mvan_0677|M.vanbaalenii_PYR-1 TGRARRCGWFDAVIARYATRVNGITDYFLTKLDVLSSLETVPICVGYSVD
MSMEG_0759|M.smegmatis_MC2_155 TGRARRCGWFDAVIARYATRVNGITDYFLTKLDVLSSLETVPVCVGYTVD
TH_0134|M.thermoresistible__bu TGRARRCGWFDAVIARYATRVNGITDYFLTKLDVLSSLETVPVCVGYRID
MAB_4249c|M.abscessus_ATCC_199 TGRARRCGWFDAVIARYATRVNGITDYFLTKLDVLSSLQTVPICVGYEVD
*** *********:****:*******:***********::**:**** :
MUL_2834|M.ulcerans_Agy99 GKRTSEMPMTQSDLCRAKPVYEELPGWWEDISAAREFDDLPAKARDYVLR
MMAR_0680|M.marinum_M GKRTSEMPMTQSDLCRAKPVYEELPGWWEDISAAREFDDLPAKARDYVLR
Mb0364c|M.bovis_AF2122/97 GRRTRDMPMTQRDLCRAKPVYEELPGWWEDISGAREFDDLPAKARDYVLR
Rv0357c|M.tuberculosis_H37Rv GRRTRDMPMTQRDLCRAKPVYEELPGWWEDISGAREFDDLPAKARDYVLR
MLBr_00280|M.leprae_Br4923 GVRTHDMPITQSDLARAEPIYEELPGWWEDISGAREFEDLPAKARDYVLR
MAV_4777|M.avium_104 GARINEMPMTQSDLHRAEPIYEELPGWWEDISAAREFDDLPAKARDYVLR
Mflv_0228|M.gilvum_PYR-GCK GKRTDEMPMTQSDIARAEPVYEELPGWWEDISGAREFDDLPAKARDYVLR
Mvan_0677|M.vanbaalenii_PYR-1 GKRTDEMPMTQSDIARAEPIYEELPGWWEDISGCRTFDELPAKARDYVLR
MSMEG_0759|M.smegmatis_MC2_155 GKRVDEMPMTQSDIARAEPVYEELPGWWEDISGAREFEDLPAKARDYVLR
TH_0134|M.thermoresistible__bu GKRVDEMPMTQSDVARAEPIYEEMPGWWEDISGAREFEDLPAKARDYVLR
MAB_4249c|M.abscessus_ATCC_199 GKRTNEMPMTQSEIYRATPVYEELPGWWEDISGARQFEDLPAKAQDYVLR
* * :**:** :: ** *:***:********..* *::*****:*****
MUL_2834|M.ulcerans_Agy99 LEEISGAPVSCIGVGPGRDQTIVRRDILQERA-
MMAR_0680|M.marinum_M LEEIAGAPVSCIGVGPGRDQTIVRRDILQERA-
Mb0364c|M.bovis_AF2122/97 LEQLAGAPVSCIGVGPGREQTIVRRDVLQDRP-
Rv0357c|M.tuberculosis_H37Rv LEQLAGAPVSCIGVGPGREQTIVRRDVLQDRP-
MLBr_00280|M.leprae_Br4923 LEELAGAQVACIGVGPGRDQTIVRCDVLRSRR-
MAV_4777|M.avium_104 LEELAGAHVSCIGVGPGREQTIVRRDILAARP-
Mflv_0228|M.gilvum_PYR-GCK LEELAGAHVSCIGVGPGRDQTIVRRDILATS--
Mvan_0677|M.vanbaalenii_PYR-1 LEDLAGAHVSCIGVGPGRDQTIVRRDVLAAR--
MSMEG_0759|M.smegmatis_MC2_155 LEELAGAYVSCIGVGPGRDQTIVRRDVLAAR--
TH_0134|M.thermoresistible__bu VEELAGARVSCIGVGPGRDQTIVRHDVLAASAR
MAB_4249c|M.abscessus_ATCC_199 LEELAGAPMSCIGVGPGRDQTIVRRDILSRS--
:*:::** ::********:***** *:*