For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. bovis AF2122 / 97 Mb0364c (purA)

annotation: adenylosuccinate synthetase
coordinates: 436488 - 437786
length: 432

MPAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVVLPTGENFALHLIPSGVLTPGVTNVIG
NGVVIDPGVLLNELRGLQDRGVDTAKLLISADAHLLMPYHIAIDKVTERYMGSKKIGTTGRGIGPCYQDK
IARIGIRVADVLDPEQLTHKVEAACEFKNQVLVKIYNRKALDPAQVVDALLEQAEGFKHRIADTRLLLNA
ALEAGETVLLEGSQGTLLDVDHGTYPYVTSSNPTAGGAAVGSGIGPTRIGTVLGILKAYTTRVGSGPFPT
ELFDEHGEYLSKTGREFGVTTGRRRRCGWFDAVIARYAARVNGITDYFLTKLDVLSSLESVPVCVGYEID
GRRTRDMPMTQRDLCRAKPVYEELPGWWEDISGAREFDDLPAKARDYVLRLEQLAGAPVSCIGVGPGREQ
TIVRRDVLQDRP
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb0364cpurA-100% (432)adenylosuccinate synthetase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCKMflv_0228-0.088.08% (428) adenylosuccinate synthetase
M. tuberculosis H37RvRv0357cpurA0.0100.00% (432) adenylosuccinate synthetase
M. leprae Br4923MLBr_00280purA0.087.94% (431) adenylosuccinate synthetase
M. abscessus ATCC 19977MAB_4249c-0.086.68% (428) adenylosuccinate synthetase
M. marinum MMMAR_0680purA0.092.34% (431) adenylosuccinate synthetase PurA
M. avium 104MAV_4777purA0.090.05% (432) adenylosuccinate synthetase
M. smegmatis MC2 155MSMEG_0759purA0.087.70% (431) adenylosuccinate synthetase
M. thermoresistible (build 8)TH_0134purA0.086.32% (424) PROBABLE ADENYLOSUCCINATE SYNTHETASE PURA (IMP--ASPARTATE
M. ulcerans Agy99MUL_2834purA0.091.88% (431) adenylosuccinate synthetase
M. vanbaalenii PYR-1Mvan_0677-0.086.54% (431) adenylosuccinate synthetase

CLUSTAL 2.0.9 multiple sequence alignment


Mb0364c|M.bovis_AF2122/97           MPAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVVLPTGEN
Rv0357c|M.tuberculosis_H37Rv        MPAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVVLPTGEN
MMAR_0680|M.marinum_M               MPAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVVLPSGEN
MUL_2834|M.ulcerans_Agy99           MPAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVVLPSGEN
MLBr_00280|M.leprae_Br4923          MPAVVLIGAQWGDEGKGKVTDLLGGRAQWVVRYQGGNNAGHTVVLPTGEN
MAV_4777|M.avium_104                MPAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVVLPTGEN
Mflv_0228|M.gilvum_PYR-GCK          MPAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVVLPTGEN
Mvan_0677|M.vanbaalenii_PYR-1       MPAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVVLPTGEN
MSMEG_0759|M.smegmatis_MC2_155      MPAIVLIGAQWGDEGKGKATDLLGGRVQWVVRYQGGNNAGHTVVLPTGEN
TH_0134|M.thermoresistible__bu      ----VLIGAQWGDEGKGKATDLLGGRVRWVVRYQGGNNAGHTVVLPTGEN
MAB_4249c|M.abscessus_ATCC_199      MPAIVLIGAQWGDEGKGKATDLLGGSVQWVVRYQGGNNAGHTVVLPNGEN
                                        **************.****** .:******************.***

Mb0364c|M.bovis_AF2122/97           FALHLIPSGVLTPGVTNVIGNGVVIDPGVLLNELRGLQDRGVDTAKLLIS
Rv0357c|M.tuberculosis_H37Rv        FALHLIPSGVLTPGVTNVIGNGVVIDPGVLLNELRGLQDRGVDTAKLLIS
MMAR_0680|M.marinum_M               FALHLIPSGVLTPGVTNVIGNGVVIDPGVLLSELKGLEDRGVDTSKLLIS
MUL_2834|M.ulcerans_Agy99           FALHLIPSGVLTPGVTNVIGNGVVIDPGVLLSELKGLEDRGVDTAKLLIS
MLBr_00280|M.leprae_Br4923          FTLHLIPSGVLTPGVTNVIGNGVVVDPGVLLSELQGLEDRGVDTSQLLIS
MAV_4777|M.avium_104                FALHLIPSGVLTPGVTNVIGNGVVVDPGVLLDELKGLEDRGVDTSRLLIS
Mflv_0228|M.gilvum_PYR-GCK          FALHLIPSGILTPGVTNVIGNGVVVDPGVLLTELKGLEDRGVDTDRLLIS
Mvan_0677|M.vanbaalenii_PYR-1       FALHLIPSGILTPGVTNVIGNGVVVDPGVLLAELKGLEERGVDTERLLIS
MSMEG_0759|M.smegmatis_MC2_155      FALHLIPSGILTPGVTNVIGNGVVVDPGVLLTELKGLEDRGVDTSNLLIS
TH_0134|M.thermoresistible__bu      FALHLIPSGILTPGVTNVIGNGVVVDPGVLLTELHGLEERGVDTERLLIS
MAB_4249c|M.abscessus_ATCC_199      FALHLIPSGILTPGVTNVIGNGVVVDPGVLLTELAGLEERGIDTSGLILS
                                    *:*******:**************:****** ** **::**:**  *::*

Mb0364c|M.bovis_AF2122/97           ADAHLLMPYHIAIDKVTERYMGSKKIGTTGRGIGPCYQDKIARIGIRVAD
Rv0357c|M.tuberculosis_H37Rv        ADAHLLMPYHIAIDKVTERYMGSKKIGTTGRGIGPCYQDKIARIGIRVAD
MMAR_0680|M.marinum_M               ADAHLLMPYHVAIDKVTERYMGSKKIGTTGRGIGPCYQDKVARMGIRVAD
MUL_2834|M.ulcerans_Agy99           ADAHLLMPYHVAIDKVTERYMGSKKIGTTGRGIGPCYQDKVARMGIRVAD
MLBr_00280|M.leprae_Br4923          ADAHLLMPYHVAIDKVTERYMGNKKIGTTGRGIGPCYQDKIARMGIRVAD
MAV_4777|M.avium_104                ADAHLLLPYHVAIDKVTERYMGNKKIGTTGRGIGPCYQDKIARIGIRVAD
Mflv_0228|M.gilvum_PYR-GCK          ADAHLLMPYHVAIDKVVERYAGSKKIGTTGRGIGPCYQDKIARQGIRVAD
Mvan_0677|M.vanbaalenii_PYR-1       ADAHLLMPYHVAIDKVVERYAGSKKIGTTGRGIGPCYQDKIARQGIRVAD
MSMEG_0759|M.smegmatis_MC2_155      ADAHLLMPYHVAIDKVVERWAGSKKIGTTGRGIGPCYQDKIARIGIRVAD
TH_0134|M.thermoresistible__bu      ADAHLLMPYHVAIDKVVERWAGKKKIGTTGRGIGPCYQDKIARIGIRVAD
MAB_4249c|M.abscessus_ATCC_199      ADAHLLMPYHVAIDKVTERYLGSKKIGTTGRGIGPCYQDKVARIGIRVAD
                                    ******:***:*****.**: *.*****************:** ******

Mb0364c|M.bovis_AF2122/97           VLDPEQLTHKVEAACEFKNQVLVKIYNRKALDPAQVVDALLEQAEGFKHR
Rv0357c|M.tuberculosis_H37Rv        VLDPEQLTHKVEAACEFKNQVLVKIYNRKALDPAQVVDALLEQAEGFKHR
MMAR_0680|M.marinum_M               VLDTDQLAHKVEAALEFKNQVLVKIYNRKALDPDQVVESLLEQAEGFRHR
MUL_2834|M.ulcerans_Agy99           VLDTDQLAHKVEAALEFKNQVLVKIYNRKALDPDQVVESLLEQAEGFRHR
MLBr_00280|M.leprae_Br4923          VLEPGELTHKIEAALEFKNQVLVKIYNRKALDLAQVVETLLEQAQQFRHR
MAV_4777|M.avium_104                VLDREVLTHKIEAALELKNQILVKIYNRKALDPHQVVECLLEQAEGFRHR
Mflv_0228|M.gilvum_PYR-GCK          VLDPAVLAEKIEGALELKNQVLVKIYNRKALEPAEVVENLLEQAEGFKHR
Mvan_0677|M.vanbaalenii_PYR-1       VLDPALLAEKIEGALELKNQVLVKIYNRKALDPAEVVENLLEQADGFKHR
MSMEG_0759|M.smegmatis_MC2_155      VLDEQVLAEKIEAALEFKNQVLVKIYNRKALEPAEVLENLLEQAEGFKHR
TH_0134|M.thermoresistible__bu      VLDEQVLAEKIEAALEFKNQVLVKIYNRKALDPTEVFENLLEQAAGFKHR
MAB_4249c|M.abscessus_ATCC_199      VLDEESLRQKVHAALEFKNQVLVKIYNRKALDPDQVVDGVLEQAEGFKHR
                                    **:   * .*:..* *:***:**********:  :*.: :****  *:**

Mb0364c|M.bovis_AF2122/97           IADTRLLLNAALEAGETVLLEGSQGTLLDVDHGTYPYVTSSNPTAGGAAV
Rv0357c|M.tuberculosis_H37Rv        IADTRLLLNAALEAGETVLLEGSQGTLLDVDHGTYPYVTSSNPTAGGAAV
MMAR_0680|M.marinum_M               IADARLLLNNALEAGETVLLEGSQGTLLDVDHGTYPYVTSSNPTAGGAAV
MUL_2834|M.ulcerans_Agy99           IADARLLLNNALEAGGTVLLEGSQGTLLDVDHGTYPYVTSSNPTAGGAAV
MLBr_00280|M.leprae_Br4923          ITDTRLLLNDALEAGETVLLEGAQGTLLDVDHGTYPYVTSSNPTAGGAAL
MAV_4777|M.avium_104                IADTRLLLNTALEAGETVLLEGSQGTLLDVDHGTYPYVTSSNPTAGGAAV
Mflv_0228|M.gilvum_PYR-GCK          IADARLLLNEALERDEIVLLEGSQGTLLDVDHGTYPYVTSSNPTAGGASV
Mvan_0677|M.vanbaalenii_PYR-1       IADARLLLNEALERNETVLLEGSQGTLLDVDHGTYPFVTSSNPTAGGASV
MSMEG_0759|M.smegmatis_MC2_155      IADARLLLNQALENDEAVLLEGSQGTLLDVDHGTYPFVTSSNPTAGGAAV
TH_0134|M.thermoresistible__bu      IADTRLLLNNALDNGETVLLEGSQGTLLDVDHGTYPYVTSSNPTAGGAAV
MAB_4249c|M.abscessus_ATCC_199      IADARLQLNQALERGETVLLEGSQGTLLDVDHGTYPFVTSSNPTAGGASV
                                    *:*:** ** **: .  *****:*************:***********::

Mb0364c|M.bovis_AF2122/97           GSGIGPTRIGTVLGILKAYTTRVGSGPFPTELFDEHGEYLSKTGREFGVT
Rv0357c|M.tuberculosis_H37Rv        GSGIGPTRIGTVLGILKAYTTRVGSGPFPTELFDEHGEYLSKTGREFGVT
MMAR_0680|M.marinum_M               GSGIGPTRIRTVLGILKAYTTRVGSGPFPTELFDESGEYLSKTGGEFGVT
MUL_2834|M.ulcerans_Agy99           GSGIGPTRIRTVLGILKAYTTRVGSGPFPTELFYESGEYLSKTGGEFGVT
MLBr_00280|M.leprae_Br4923          GSGIGPTRIHTVLGILKAYTTRVGSGPFPTELFDENGEYLAKTGSEIGVT
MAV_4777|M.avium_104                GSGIGPTRITAVLGILKAYTTRVGSGPFPTELFDENGEYLSKTGGEFGVT
Mflv_0228|M.gilvum_PYR-GCK          GSGIGPTRITTVLGILKAYTTRVGSGPFPTELFDEHGAYLAKTGGEVGVT
Mvan_0677|M.vanbaalenii_PYR-1       GSGIGPTRITTVLGILKAYTTRVGSGPFPTELFDDHGAYLAKTGGEVGVT
MSMEG_0759|M.smegmatis_MC2_155      GSGIGPTRITTVLGILKAYTTRVGSGPFPTELFDEHGAYLAKTGGEVGVT
TH_0134|M.thermoresistible__bu      GSGIGPTRITTVLGILKAYTTRVGSGPFPTELFDDNGAYLAKAGGEVGVT
MAB_4249c|M.abscessus_ATCC_199      GSGIGPTRITTVLGILKAYTTRVGSGPFPTELFDEHGAYLAKTGGEVGVT
                                    ********* :********************** : * **:*:* *.***

Mb0364c|M.bovis_AF2122/97           TGRRRRCGWFDAVIARYAARVNGITDYFLTKLDVLSSLESVPVCVGYEID
Rv0357c|M.tuberculosis_H37Rv        TGRRRRCGWFDAVIARYAARVNGITDYFLTKLDVLSSLESVPVCVGYEID
MMAR_0680|M.marinum_M               TGRRRRCGWFDAVIARYATRVNGITDYFLTKLDVLSSLETVPVCVGYEID
MUL_2834|M.ulcerans_Agy99           TGRRRRCGWFDAVIARYATRVNGITDYFLTKLDVLSSLETVPVCVGYEID
MLBr_00280|M.leprae_Br4923          TGRRRRCGWFDAVIARYATRVNGITDYFLTKLDVLSSLETVPVCVGYQIA
MAV_4777|M.avium_104                TGRRRRCGWFDAVVARYATRVNGITDFFLTKLDVLSSLETVPVCVGYRID
Mflv_0228|M.gilvum_PYR-GCK          TGRARRCGWFDAVIARYATRVNGITDYFLTKLDVLSSLETVPICVGYTVD
Mvan_0677|M.vanbaalenii_PYR-1       TGRARRCGWFDAVIARYATRVNGITDYFLTKLDVLSSLETVPICVGYSVD
MSMEG_0759|M.smegmatis_MC2_155      TGRARRCGWFDAVIARYATRVNGITDYFLTKLDVLSSLETVPVCVGYTVD
TH_0134|M.thermoresistible__bu      TGRARRCGWFDAVIARYATRVNGITDYFLTKLDVLSSLETVPVCVGYRID
MAB_4249c|M.abscessus_ATCC_199      TGRARRCGWFDAVIARYATRVNGITDYFLTKLDVLSSLQTVPICVGYEVD
                                    *** *********:****:*******:***********::**:**** : 

Mb0364c|M.bovis_AF2122/97           GRRTRDMPMTQRDLCRAKPVYEELPGWWEDISGAREFDDLPAKARDYVLR
Rv0357c|M.tuberculosis_H37Rv        GRRTRDMPMTQRDLCRAKPVYEELPGWWEDISGAREFDDLPAKARDYVLR
MMAR_0680|M.marinum_M               GKRTSEMPMTQSDLCRAKPVYEELPGWWEDISAAREFDDLPAKARDYVLR
MUL_2834|M.ulcerans_Agy99           GKRTSEMPMTQSDLCRAKPVYEELPGWWEDISAAREFDDLPAKARDYVLR
MLBr_00280|M.leprae_Br4923          GVRTHDMPITQSDLARAEPIYEELPGWWEDISGAREFEDLPAKARDYVLR
MAV_4777|M.avium_104                GARINEMPMTQSDLHRAEPIYEELPGWWEDISAAREFDDLPAKARDYVLR
Mflv_0228|M.gilvum_PYR-GCK          GKRTDEMPMTQSDIARAEPVYEELPGWWEDISGAREFDDLPAKARDYVLR
Mvan_0677|M.vanbaalenii_PYR-1       GKRTDEMPMTQSDIARAEPIYEELPGWWEDISGCRTFDELPAKARDYVLR
MSMEG_0759|M.smegmatis_MC2_155      GKRVDEMPMTQSDIARAEPVYEELPGWWEDISGAREFEDLPAKARDYVLR
TH_0134|M.thermoresistible__bu      GKRVDEMPMTQSDVARAEPIYEEMPGWWEDISGAREFEDLPAKARDYVLR
MAB_4249c|M.abscessus_ATCC_199      GKRTNEMPMTQSEIYRATPVYEELPGWWEDISGARQFEDLPAKAQDYVLR
                                    * *  :**:** :: ** *:***:********..* *::*****:*****

Mb0364c|M.bovis_AF2122/97           LEQLAGAPVSCIGVGPGREQTIVRRDVLQDRP-
Rv0357c|M.tuberculosis_H37Rv        LEQLAGAPVSCIGVGPGREQTIVRRDVLQDRP-
MMAR_0680|M.marinum_M               LEEIAGAPVSCIGVGPGRDQTIVRRDILQERA-
MUL_2834|M.ulcerans_Agy99           LEEISGAPVSCIGVGPGRDQTIVRRDILQERA-
MLBr_00280|M.leprae_Br4923          LEELAGAQVACIGVGPGRDQTIVRCDVLRSRR-
MAV_4777|M.avium_104                LEELAGAHVSCIGVGPGREQTIVRRDILAARP-
Mflv_0228|M.gilvum_PYR-GCK          LEELAGAHVSCIGVGPGRDQTIVRRDILATS--
Mvan_0677|M.vanbaalenii_PYR-1       LEDLAGAHVSCIGVGPGRDQTIVRRDVLAAR--
MSMEG_0759|M.smegmatis_MC2_155      LEELAGAYVSCIGVGPGRDQTIVRRDVLAAR--
TH_0134|M.thermoresistible__bu      VEELAGARVSCIGVGPGRDQTIVRHDVLAASAR
MAB_4249c|M.abscessus_ATCC_199      LEELAGAPMSCIGVGPGRDQTIVRRDILSRS--
                                    :*:::** ::********:***** *:*