For questions or suggestions e-mail us at: ioerger@cs.tamu.edu
MQQAVSGITGALGGAVGGVMGPLTQLPQQAMQAGQGAMQPLMSALQQTYGAEGLDVADGARLVDSIEGEP GLGGEPGAGDVGAGGGGGGTTPTGYLGPPPVPTSSPPTTPAGAPAKSVTPDPVSGTPRASGPAGMTGMPM VPPGALGAGAEGANKDKPVEKRVTGCAEWSTGQGPLNSTAECSGEICRRQAGGHQVDATDPCCAERRQG*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3897c | - | - | 100% (210) | hypothetical protein Rv3897c |
| M. tuberculosis H37Rv | Rv2083 | - | 1e-65 | 73.05% (167) | hypothetical protein Rv2083 |
| M. tuberculosis H37Rv | Rv3514 | PE_PGRS57 | 3e-09 | 29.90% (194) | PE-PGRS family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3927c | - | 3e-94 | 98.81% (168) | hypothetical protein Mb3927c |
| M. gilvum PYR-GCK | Mflv_2790 | - | 8e-09 | 33.11% (151) | hypothetical protein Mflv_2790 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_3067 | - | 7e-65 | 70.66% (167) | hypothetical protein MMAR_3067 |
| M. avium 104 | MAV_5287 | - | 1e-59 | 69.88% (166) | hypothetical protein MAV_5287 |
| M. smegmatis MC2 155 | MSMEG_2961 | secD | 1e-06 | 29.66% (145) | preprotein translocase subunit SecD |
| M. thermoresistible (build 8) | TH_3113 | - | 2e-06 | 27.70% (148) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_2312 | - | 1e-64 | 70.66% (167) | hypothetical protein MUL_2312 |
| M. vanbaalenii PYR-1 | Mvan_3258 | - | 9e-09 | 26.92% (182) | hypothetical protein Mvan_3258 |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2790|M.gilvum_PYR-GCK -------MRVQLMPAVGGSAGSYGRLIVTPDMEPPDAGHWDDQEQTYRAG
Mvan_3258|M.vanbaalenii_PYR-1 ------------MPAVGGSAGSYGRLIVTPDMEPPDAGHWDAQEQTYRVG
Rv3897c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3927c|M.bovis_AF2122/97 -----------MTGDQNPAPGPAPGVPIKVTPEILLQVLTTPPASGPAPF
MMAR_3067|M.marinum_M -------------------------MTINSVPESYGHATGMPAPIPLAPG
MUL_2312|M.ulcerans_Agy99 -------------------------MTINSVPESYGHATGMPAPIPLAPG
MAV_5287|M.avium_104 -------------------MGGPGGIIKNDLPTTTAIVGGPPASIP-RPF
TH_3113|M.thermoresistible__bu MALPPEVHSTLLRTGPGPGALSAAADAWRMLSDEYRAAAVELAAVVSQTC
MSMEG_2961|M.smegmatis_MC2_155 ----------MASSSAPVHPARYLTLFLVLLVGVYLLVFLTGDKKPEPKL
Mflv_2790|M.gilvum_PYR-GCK ATSWDGIHQQIVTDSA----------RFREAADSQGFDEVHRVNAVLAEE
Mvan_3258|M.vanbaalenii_PYR-1 ATTWDGIHQKIVTDNA----------EFRDAADSQGFDEAHRAGAVLAEE
Rv3897c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3927c|M.bovis_AF2122/97 PAVPVDLPAPADIANG----------ALFAAGNS---GVPGDVESSGLED
MMAR_3067|M.marinum_M PVHPGG-TSPVDAAMA----------GFGMATNA---DLGPVNGEIAADD
MUL_2312|M.ulcerans_Agy99 PVHPGG-TSPVDAAMA----------GFGMATNA---DLGPVNGEIAADD
MAV_5287|M.avium_104 PVPPGG-TSPADAGQG----------MVGGAGNA---NVPKDAADAAAAD
TH_3113|M.thermoresistible__bu ATAWEGVGADAYAAAHGPYLFWLTDTAAAAAAAGAQLEAAAAAHASALAA
MSMEG_2961|M.smegmatis_MC2_155 GIDLQGGTRVTLTART-------------PDGSAPTRDALNQAQQIISAR
Mflv_2790|M.gilvum_PYR-GCK AKTIAEWHAKVADKCGDIATVLRETRSGQEQVVREADAKIASAKLPGEVE
Mvan_3258|M.vanbaalenii_PYR-1 AKTIAEWHDKCANKCADIATVLRDTRAGQEQLVREADAKIASAKLPGEAE
Rv3897c|M.tuberculosis_H37Rv ---------------------------------------MMQQAVSGITG
Mb3927c|M.bovis_AF2122/97 LDRRAHAADAVQKFSANEADAAQQFQGVGAQAEAQGATQMMQQAVSGITG
MMAR_3067|M.marinum_M ADRRAHAADAAAKFPANEADAAQQFQGVGADGMAQ----MIPQMASGIGG
MUL_2312|M.ulcerans_Agy99 ADRRAHAADAAAKFPANEADAAQQFQGVGADGMAQ----MIPQMASGIGG
MAV_5287|M.avium_104 ADRKARAADAAAKFPANEANGSQEMQ-------------MLQQMLSSVTG
TH_3113|M.thermoresistible__bu MPTMAELTANRTTHAALVATNFFGVNTIPIAVNEADYARMWIQAATTMAT
MSMEG_2961|M.smegmatis_MC2_155 VDGLGVSGSEVVIDGDNLVITVPGNDGNEARNLGQTARLYIRPVIHAMAA
Mflv_2790|M.gilvum_PYR-GCK TLVTQYHGIARYRTEAGVTAAMASHTSFKRSTENTRALDLLTRWGDALAA
Mvan_3258|M.vanbaalenii_PYR-1 ALVTQYHGIARYQTEAGVTAAMASHTAFKASTENTRALDLLTKWGDAPTA
Rv3897c|M.tuberculosis_H37Rv ALGGAVGGVMGPLTQLPQQAMQAGQGAMQPLMSALQQTYGAEGLDVADGA
Mb3927c|M.bovis_AF2122/97 ALGGAVGGVMGPLTQLPQQAMQAGQGAMQPLMSALQQTYGAEGLDVADGA
MMAR_3067|M.marinum_M ALSGALGGVLGPLTQIPQQALQAGQGALQPLMGALQQSAGVEGLEAADGA
MUL_2312|M.ulcerans_Agy99 ALSGALGGVLGPLTQIPQQALQAGQGALQPLMGALQQSAGVEGLEAADGA
MAV_5287|M.avium_104 ALGGAMGGVMGPLTQLPQQAMQAGQSALQPLMSAVQGAHGAA--SLADNA
TH_3113|M.thermoresistible__bu YEAVASAAVSATPRTVAPPPILG-AGTGESATAAITGAHVTAELRAAESR
MSMEG_2961|M.smegmatis_MC2_155 QPPTEDGQPPAGAPGAPGAPGGAPGAPGLPGLPGLSGLPGMPGAPGAPGA
. . . *
Mflv_2790|M.gilvum_PYR-GCK PPVQPLDSPSPGIAQGDNNPKKAPPQEEDSSKSTPLQEGSDQSPPAMSPT
Mvan_3258|M.vanbaalenii_PYR-1 PPVQPVDHTSPGIEQDENPYSDTEKREAGADAPKPVDD---------APT
Rv3897c|M.tuberculosis_H37Rv RLVDSIEGE-PGLGGE----------------------------------
Mb3927c|M.bovis_AF2122/97 RLVDSIEGE-PGLGGE----------------------------------
MMAR_3067|M.marinum_M RLVDSLESE-PGLGGGG---------------------------------
MUL_2312|M.ulcerans_Agy99 RLVDSLESE-PGLGGGG---------------------------------
MAV_5287|M.avium_104 HLVDSVGGAGSGLGGG----------------------------------
TH_3113|M.thermoresistible__bu TLLDEINELIDRLFAPLFPPG-----------------------------
MSMEG_2961|M.smegmatis_MC2_155 PQEAPPGMPVPGEAPGGEAP------------------------------
Mflv_2790|M.gilvum_PYR-GCK DSAGTSTTQP----GIKSVTSDEGIKVATGPL-QPTPGVASPGAGASPLG
Mvan_3258|M.vanbaalenii_PYR-1 DPAGTSTTQPGVSPGSKSAAGDESIKAATGPVTQPTPGVTSS-PAASALG
Rv3897c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3927c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3067|M.marinum_M --------------------------------------------------
MUL_2312|M.ulcerans_Agy99 --------------------------------------------------
MAV_5287|M.avium_104 --------------------------------------------------
TH_3113|M.thermoresistible__bu --------------------------------------------------
MSMEG_2961|M.smegmatis_MC2_155 --------------------------------------------------
Mflv_2790|M.gilvum_PYR-GCK GGGMSSMGGMVGGGMGSGG-APKLPGGLGSGGLPGMGSNPLGSGVDQMPS
Mvan_3258|M.vanbaalenii_PYR-1 GAGMPSMGGIGGGGMGSGGGIPKMPGGLGSGGMPGMGSNPLSGGVGQMPG
Rv3897c|M.tuberculosis_H37Rv -------PGAGDVGAGGGGGGTTPTGYLG---------------------
Mb3927c|M.bovis_AF2122/97 -------PGAGDVGAGGGGGGTTPTGYLG---------------------
MMAR_3067|M.marinum_M -------AGELGTGGGGGGGGTIPTGYLG---------------------
MUL_2312|M.ulcerans_Agy99 -------AGELGTGGGGGGGGTISTGYLG---------------------
MAV_5287|M.avium_104 -------AGAGGGGAGLGGGGTVPTSSLG---------------------
TH_3113|M.thermoresistible__bu ------FADALPDGLLGTLLAPLLPGATGDGPPMATIMSFLLMG------
MSMEG_2961|M.smegmatis_MC2_155 ------APPAGEQPAPQPRPYPLEPAPTPGEPTPAP--------------
. ..
Mflv_2790|M.gilvum_PYR-GCK AGSGLPSAGGVPGDGSGAGSPAVAFSQGMSTGGAIGGGMPAAPAPAPASP
Mvan_3258|M.vanbaalenii_PYR-1 AASGLPNPGAVPGAGS-ASPLSSAFNQGMATTAGMGGGIPSAPPPAPASP
Rv3897c|M.tuberculosis_H37Rv ------------------------------------------PPPVPTSS
Mb3927c|M.bovis_AF2122/97 ------------------------------------------PPPVPTSS
MMAR_3067|M.marinum_M ------------------------------------------PPPVPTSS
MUL_2312|M.ulcerans_Agy99 ------------------------------------------PPPVPTSS
MAV_5287|M.avium_104 ------------------------------------------PPPVPTSS
TH_3113|M.thermoresistible__bu -----------------LSNPAYLFPVLVYLLFTGVVHTTVAVSGMLAQL
MSMEG_2961|M.smegmatis_MC2_155 -----------------------------------------APEPAPGEN
.
Mflv_2790|M.gilvum_PYR-GCK SPALSAG------AQAAPVPATAGGGVPPAAAQSGLVAPAAP----PTGA
Mvan_3258|M.vanbaalenii_PYR-1 SPALSAGGG----HAAPPVSAAPGGGVSPAGAQAGMVSPATPAAAAPTGA
Rv3897c|M.tuberculosis_H37Rv PPTTPAGAP----AKSVTPDPVSG--TPRASGPAGMTG------------
Mb3927c|M.bovis_AF2122/97 PPTTPAGAP----AKSVTPDPVSG--TPRASGPAGMTG------------
MMAR_3067|M.marinum_M PPTTPAGAP----TKPASMMSTGG--TPSSSTPMGATG------------
MUL_2312|M.ulcerans_Agy99 PPTTPAGAP----TKPASMMSTSG--TPSSSTPMGATG------------
MAV_5287|M.avium_104 PPTTPAGA------KAAMMPPTGG--MPAMPGQTGMTG------------
TH_3113|M.thermoresistible__bu VPLMPALLP----VAVAALGGLAG-VWAGLSGLAGLAG------------
MSMEG_2961|M.smegmatis_MC2_155 PPAAPAPGADGDKADLAQRIATAKQWRQSTDPTMQILG------------
* .* .
Mflv_2790|M.gilvum_PYR-GCK GMGTGGGAPMMLPPGSMGPPAGPVPPPAATVPAGALGAGSNAPSAAPPAA
Mvan_3258|M.vanbaalenii_PYR-1 GIG-GGGAPMMLPPGSMGPPAG-APPPAPTVPAGTVGSTNAPAAPAPSAA
Rv3897c|M.tuberculosis_H37Rv --------MPMVPPGALG--------------AGAEGANKDKPVEKRVTG
Mb3927c|M.bovis_AF2122/97 --------MPMVPPGALG--------------AGAEGANKDKPVEKRVT-
MMAR_3067|M.marinum_M --------MPMMPPGAMG--------------AGGTGGSKEKPAEKRVT-
MUL_2312|M.ulcerans_Agy99 --------MPMMPPGAMG--------------AGGTGGSKEKPAEKRVT-
MAV_5287|M.avium_104 --------MPMMPPGAMG--------------AGGEGGNKDKPVEKRVT-
TH_3113|M.thermoresistible__bu --------LTAVPAADGG-------ASAAPVPAGGPSLPSGSSAPPAPTG
MSMEG_2961|M.smegmatis_MC2_155 ---------LQVQANLCG-------------EDDILAGNDDPNLPLITCS
: . * . . .
Mflv_2790|M.gilvum_PYR-GCK AAGAGPTLIPASVVAAGQTAAARERRESADAAAAKELVWKLQHASYMAGN
Mvan_3258|M.vanbaalenii_PYR-1 SAAAGPTLIPASVVAAGQTAAARERRESADAAAAKELVWKLQHAAYVALN
Rv3897c|M.tuberculosis_H37Rv CAEWSTGQGPLNSTAECSGEIC------RRQAGGHQ--VDATDP------
Mb3927c|M.bovis_AF2122/97 APAVPNGQ-PVKGRLTVPPSVP------VKSADDKP--VVTKSTRRILVV
MMAR_3067|M.marinum_M APGVPNGQ-PVKGRLTVPPSVP------VKSVDGKPPVVT-RSTRRILLP
MUL_2312|M.ulcerans_Agy99 APGVPNGQ-SVKGRLTVPPSVP------VKSVDGKPPVVT-RSTRPILLP
MAV_5287|M.avium_104 APGVPNGQ-PVKGRLTIPPSAPG-----SKPGEAKPTVVTNRPNRRIVIM
TH_3113|M.thermoresistible__bu SAAPTTGTAPGGAGSPPPAGHS-----VPPAPHSAPPVGTSGPPYLIAAQ
MSMEG_2961|M.smegmatis_MC2_155 TDGSTVYLLNKSIMSGEEIKNATSGLDQQQGQYVVDVEFKSGGAQTWADF
Mflv_2790|M.gilvum_PYR-GCK YLTGWAVGVFRSPSGTETVITSNDGASYIPAGVFVPRSVRVLATDLVIHD
Mvan_3258|M.vanbaalenii_PYR-1 PAAGWAVGVFRSPSGTETVITSNDGSSYIPAGVFVPRSVRVLATDPLVDD
Rv3897c|M.tuberculosis_H37Rv CCA-------ERRQG-----------------------------------
Mb3927c|M.bovis_AF2122/97 PND-------DKVKE-----------------------------------
MMAR_3067|M.marinum_M DRNEIGRNISDEKTDGSE--------------------------------
MUL_2312|M.ulcerans_Agy99 DRNEIGRNISDEKTDGNE--------------------------------
MAV_5287|M.avium_104 PSD-------DEPKE-----------------------------------
TH_3113|M.thermoresistible__bu PAPGVARRSAGARRAASIVEPAGSAAAAAAARESAPIRRRRGQKDGLHGH
MSMEG_2961|M.smegmatis_MC2_155 TAANVGTQTAFTLDSKVVSAPEIREAIPGGNTQITGQFTADSAKELANVL
Mflv_2790|M.gilvum_PYR-GCK SFRQLWFGWSDPARVLVEYAQQRAEWGWRLVAAASTLPTPALRDAGVEHP
Mvan_3258|M.vanbaalenii_PYR-1 SFRQRWFGWGDPARVLVEYAQLRAQWGWKLVAAATTAGVSVLRDAGVEHP
Rv3897c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3927c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3067|M.marinum_M --------------------------------------------------
MUL_2312|M.ulcerans_Agy99 --------------------------------------------------
MAV_5287|M.avium_104 --------------------------------------------------
TH_3113|M.thermoresistible__bu RHEHQQPASMSAATAPSAAGIRVLGGAGRISRTRGSVPHAEITPGDPTEP
MSMEG_2961|M.smegmatis_MC2_155 KYGSLPLSFESSEAETVSATLGLSSLRAGLIAGAIGLAAVLLYSLLYYRV
Mflv_2790|M.gilvum_PYR-GCK PACTRETNPLLQPGVQVPAPVLDDMHVHRLAVLWPEVYPRLLRVMDADPI
Mvan_3258|M.vanbaalenii_PYR-1 PSCSGDTNPLLQQGVDVPAPVLDDMHIHRLAVLWPEVYPRLLRIMDADPL
Rv3897c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3927c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3067|M.marinum_M --------------------------------------------------
MUL_2312|M.ulcerans_Agy99 --------------------------------------------------
MAV_5287|M.avium_104 --------------------------------------------------
TH_3113|M.thermoresistible__bu SSPTDRAHRPAEPN------------------------------------
MSMEG_2961|M.smegmatis_MC2_155 LGLLVALSLVAAGAVVYAILVLLGRYIG--------------YTLDLAGI
Mflv_2790|M.gilvum_PYR-GCK CQDRIVSGVSAALMVAATTQAQAVE--IPDALRHIWVARGGDREPSTQQW
Mvan_3258|M.vanbaalenii_PYR-1 CQDRIVSAVTAAMINAATTQAQVIDGGIDEALRLVWAVRGSDREPTVQQW
Rv3897c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3927c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3067|M.marinum_M --------------------------------------------------
MUL_2312|M.ulcerans_Agy99 --------------------------------------------------
MAV_5287|M.avium_104 --------------------------------------------------
TH_3113|M.thermoresistible__bu --------------------------------------------------
MSMEG_2961|M.smegmatis_MC2_155 AGLIIGIGTTADSFVVFFERIKDEIREGRSFRSAVPRGWVRARKTIVSGN
Mflv_2790|M.gilvum_PYR-GCK AKYNEEAQTFNGTTAMSRPAFLT--GGAGHPRDSSEELANYRGHWLVART
Mvan_3258|M.vanbaalenii_PYR-1 ADYDKAAKALNVMTAMRRPAFATNTGAVADPSDTTEFLADYRAHWLVART
Rv3897c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3927c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3067|M.marinum_M --------------------------------------------------
MUL_2312|M.ulcerans_Agy99 --------------------------------------------------
MAV_5287|M.avium_104 --------------------------------------------------
TH_3113|M.thermoresistible__bu --------------------------------------------------
MSMEG_2961|M.smegmatis_MC2_155 AVTFLAAAVLYVLAIGQVKGFAFTLGLTTILDLVVVFLVTWPLVYLASKS
Mflv_2790|M.gilvum_PYR-GCK IEHIGGWANRPLPLPDMCYAAAATGDPDLHDKIVKALVSVEDDLAVGS--
Mvan_3258|M.vanbaalenii_PYR-1 AEHIGGWSRRPLPLPDMCYAAAATGDPDLRDMIVKALVSVEEDLQYEAPR
Rv3897c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3927c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_3067|M.marinum_M --------------------------------------------------
MUL_2312|M.ulcerans_Agy99 --------------------------------------------------
MAV_5287|M.avium_104 --------------------------------------------------
TH_3113|M.thermoresistible__bu --------------------------------------------------
MSMEG_2961|M.smegmatis_MC2_155 PTMAKPKLNGLGAVQQIARERREVSHATAGRG------------------