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ASPLNRPGLRAAAASAALTLVALSANVPAAQAIPPPSVDPAMVPADARPGPDQPMRRSNSCSTPITVRNP DVAQLAPGFNLVNISKAWQYSTGNGVPVAVIDTGVSPNPRLPVVPGGDYIMGEDGLSDCDAHGTVVSSII AAAPLGILPMPRAMPATAAFPPPAGPPPVTAAPAPPVEVPPPMPPPPPVTITQTVAPPPPPPEDAGAMAP SNGPPDPQTEDEPAVPPPPPGAPDGVVGVAPHATIISIRQSSRAFEPVNPSSAGPNSDEKVKAGTLDSVA RAVVHAANMGAKVINISVTACLPAAAPGDQRVLGAALWYAATVKDAVIVAAAGNDGEAGCGNNPMYDPLD PSDPRDWHQVTVVSSPSWFSDYVLSVGAVDAYGAALDKSMSGPWVGVAAPGTHIMGLSPQGGGPVNAYPP SRPGEKNMPFWGTSFSAAYVSGVAALVRAKFPELTAYQVINRIVQSAHNPPAGVDNKLGYGLVDPVAALT FNIPSGDRMAPGAQSRVITPAAPPPPPDHRARNIAIGFVGAVATGVLAMAIGARLRRAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3886c | mycP2 | - | 100% (550) | PROBABLE ALANINE AND PROLINE RICH MEMBRANE-ANCHORED MYCOSIN MYCP2 (SERINE PROTEASE) (SUBTILISIN-LIKE PROTEASE) (SUBTILASE-LIKE) (MYCOSIN-2) |
| M. tuberculosis H37Rv | Rv1796 | mycP5 | e-129 | 47.08% (582) | proline rich membrane-anchored mycosin MYCP5 (serine |
| M. tuberculosis H37Rv | Rv3883c | mycP1 | 4e-71 | 41.53% (443) | membrane-anchored mycosin MYCP1 (serine protease) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3916c | - | 0.0 | 100.00% (550) | secreted alanine and proline rich protease |
| M. gilvum PYR-GCK | Mflv_0755 | - | 2e-71 | 47.50% (320) | peptidase S8 and S53, subtilisin, kexin, sedolisin |
| M. leprae Br4923 | MLBr_01538 | - | 1e-119 | 42.86% (574) | putative protease |
| M. abscessus ATCC 19977 | MAB_2225c | - | 2e-66 | 44.89% (323) | peptidase |
| M. marinum M | MMAR_2678 | mycP5 | 1e-126 | 43.63% (589) | proline rich membrane-anchored mycosin MycP5 |
| M. avium 104 | MAV_0158 | - | 0.0 | 88.14% (548) | subtilase family protein |
| M. smegmatis MC2 155 | MSMEG_0083 | - | 2e-72 | 46.07% (356) | membrane-anchored mycosin mycp1 |
| M. thermoresistible (build 8) | TH_3348 | - | 2e-74 | 48.90% (319) | PUTATIVE peptidase S8 and S53, subtilisin, kexin, sedolisin |
| M. ulcerans Agy99 | MUL_3079 | mycP5 | 1e-125 | 43.71% (588) | proline rich membrane-anchored mycosin MycP5 |
| M. vanbaalenii PYR-1 | Mvan_0092 | - | 6e-72 | 40.22% (455) | peptidase S8 and S53, subtilisin, kexin, sedolisin |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3886c|M.tuberculosis_H37Rv -----MASPLNRPGLRAAAASAALTLVA-LSANVPAAQAIPPPSVDPAMV
Mb3916c|M.bovis_AF2122/97 -----MASPLNRPGLRAAAASAALTLVA-LSANVPAAQAIPPPSVDPAMV
MAV_0158|M.avium_104 -----MDSPLRR-----AAALAGMTLVA-LSANVPAAQAITPPSVDPGMV
Mflv_0755|M.gilvum_PYR-GCK -------------MRRIGALIAALLLV---LVTAPPAGAVEQPVIDPAAI
Mvan_0092|M.vanbaalenii_PYR-1 -------------MRRIGALIAALFLV---LLTAPPASAIEPPIVDPAAI
TH_3348|M.thermoresistible__bu ----------------LGVLITALLLA---VVTAPPAGAIEPPVIDPAAV
MSMEG_0083|M.smegmatis_MC2_155 -------------MQRVAVMVLAVLLA---LFSAPPAWAIDPPVIDAGAV
MMAR_2678|M.marinum_M MQRFGTVSGRLRPGRGSTATIAALLLASGALAGLPPAYAINPPTIDLGAL
MUL_3079|M.ulcerans_Agy99 MQRFGTVSGRLRPGRGSTATIAALLLASGALAGLPPAYAINPPTIDLGAL
MLBr_01538|M.leprae_Br4923 ------------------MFVALALLTSGAFAGLPPAYAISPPKIDPGAV
MAB_2225c|M.abscessus_ATCC_199 --MTHFIRDAPRARRALGGVVAATLLALS-PVAAPVAGAVIQPEADPAAL
*. * * *: * * . :
Rv3886c|M.tuberculosis_H37Rv PADARPGPDQPMRRSNSCSTPITVRNPDVAQLAPGFNLVNISKAWQYSTG
Mb3916c|M.bovis_AF2122/97 PADARPGPDQPMRRSNSCSTPITVRNPDVAQLAPGFNLVNISKAWQYSTG
MAV_0158|M.avium_104 PPDGPPRPDQPMRRANSCSAPITVRNPDVAQLAPGFNLLNIAKAWQYSTG
Mflv_0755|M.gilvum_PYR-GCK PPD-ETGPDQPMEQRRVCAAPTVFPNANFADRPWASDYLRLADAQQFATG
Mvan_0092|M.vanbaalenii_PYR-1 PPD-ETGPDQPMEQRRICAAPTVFPNSNFADRPWASDYLRLTEAQKFATG
TH_3348|M.thermoresistible__bu PPD-ETGPDNPMEQRRVCAAPTVYPDSNFADRPWASDYLRLTEAHKFATG
MSMEG_0083|M.smegmatis_MC2_155 PPD-ETGPDQPTEQRKICATPTVMPNSNFADRPWANDYLRIQEAQKFATG
MMAR_2678|M.marinum_M PPDGTPGPPAPMKQNSYCTEVGVLPGTDFKLQPKYMEMLNINEAWQFGRG
MUL_3079|M.ulcerans_Agy99 PPDGTPGPPAPMKQNSYCTEVGVLPGTDFKLQPKYMEMLNINEAWQFGRG
MLBr_01538|M.leprae_Br4923 PPDGPPGPATPMKQYSYCTEVGVLPETDFRLLPKYMDMLNMFDAWEFGRG
MAB_2225c|M.abscessus_ATCC_199 PKDSSPSATAGMQS-SACSTTVLLPGTGTSGKPS----PEFEEAWRFSRG
* * . . . *: .. . .: .* .:. *
Rv3886c|M.tuberculosis_H37Rv NGVPVAVIDTGVSPNPRLP-VVPGGDYIMGE-DGLSDCDAHGTVVSSIIA
Mb3916c|M.bovis_AF2122/97 NGVPVAVIDTGVSPNPRLP-VVPGGDYIMGE-DGLSDCDAHGTVVSSIIA
MAV_0158|M.avium_104 NGVPVAVIDTGVSPNPRLP-VVPGGDYIMGE-DGLSDCDAHGTIVSSIIG
Mflv_0755|M.gilvum_PYR-GCK AGVTVAVIDTGVNGSPRVP-AEPGGDFVDAAGDGMSDCDAHGTLTAAVIA
Mvan_0092|M.vanbaalenii_PYR-1 AGVTVAVIDTGVNGSPRVP-AEPGGDFVDQAGNGMSDCDAHGTLTAAVIA
TH_3348|M.thermoresistible__bu AGITVAVIDTGVNGSPRVP-AEPGGDFVDAAGNGMSDCDAHGTLTASVIA
MSMEG_0083|M.smegmatis_MC2_155 AGVTVAVIDTGVNGSPRVP-AEPGGDFVDAAGNGMSDCDAHGTMTAAIIG
MMAR_2678|M.marinum_M AGVKVAVIDTGVTPHPRFPHLIPGGDYVMGG-DGLQDCDAHGTIVASMIG
MUL_3079|M.ulcerans_Agy99 AGVKVAVIDTGVTPHPRFPHLIPGGDYVMGG-DGLQDCDAHGTIVASMIG
MLBr_01538|M.leprae_Br4923 GGQKIAVIDTGVTPHPRLPHLIAGGDYVMAGGDGLSDCDAHGTIVASMIG
MAB_2225c|M.abscessus_ATCC_199 EGQSVAIIDTGVKPSARLH-VEPGGDYVQST-DGLTDCDGHGTMVAGIIG
* :*:*****. .*. .***:: :*: ***.***:.:.:*.
Rv3886c|M.tuberculosis_H37Rv AAPLGILPMPRAMPATAAFPPPAG--PPPVTAAPAPPVEVPP---PMPPP
Mb3916c|M.bovis_AF2122/97 AAPLGILPMPRAMPATAAFPPPAG--PPPVTAAPAPPVEVPP---PMPPP
MAV_0158|M.avium_104 AAPQGILPMPRPMPATPAFPPPAG--PPPAVGAPPPPVEVPPPVAPPPPP
Mflv_0755|M.gilvum_PYR-GCK GR------------------------PAP---------------------
Mvan_0092|M.vanbaalenii_PYR-1 GR------------------------PAP---------------------
TH_3348|M.thermoresistible__bu GR------------------------GAP---------------------
MSMEG_0083|M.smegmatis_MC2_155 GR------------------------PSP---------------------
MMAR_2678|M.marinum_M AAPANGALPPPAVPRRPVTIPTTEKPPPPQTVTLSPVPPQTVTVIPGPPP
MUL_3079|M.ulcerans_Agy99 AAPANGALPPPAVPRRPVTIPTTEKPPPPQTVTLSPVPPQTVTVIPGPPP
MLBr_01538|M.leprae_Br4923 AAPATGA-PVPAAPRKPVPIPTTEKSPPPQTVTLSPLP-QTVTVIPVPPP
MAB_2225c|M.abscessus_ATCC_199 AQ------------------------PGP---------------------
. *
Rv3886c|M.tuberculosis_H37Rv PPVTITQTVAPPPPPP----EDAGAMAPSNGPPDPQTEDEPAVPPPPPG-
Mb3916c|M.bovis_AF2122/97 PPVTITQTVAPPPPPP----EDAGAMAPSNGPPDPQTEDEPAVPPPPPG-
MAV_0158|M.avium_104 PPVTITQVLPPPPPPPPPPPEGGGATAASNGPPDPQTEDEPAVPPLPPG-
Mflv_0755|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0092|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_3348|M.thermoresistible__bu --------------------------------------------------
MSMEG_0083|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_2678|M.marinum_M EEGAPQGEPGPGPVPPPAPGQPPASN-HGGGTVTIPSYSGGARVTGVDHA
MUL_3079|M.ulcerans_Agy99 EEGAPQGESGPGPVPPPAPGQPPASN-HGGGTVTIPSYSGGARVTGVDHA
MLBr_01538|M.leprae_Br4923 PE---EGLSPPGVPPPLQSGQHASSGRWDGSTVTISNYLGGRQVIAIDNP
MAB_2225c|M.abscessus_ATCC_199 --------------------------------------------------
Rv3886c|M.tuberculosis_H37Rv ---------------------APDGVVGVAPHATIISIRQSSRAFEPVNP
Mb3916c|M.bovis_AF2122/97 ---------------------APDGVVGVAPHATIISIRQSSRAFEPVNP
MAV_0158|M.avium_104 ---------------------APDGVVGVAPHATIISIRQSSRAFEPVNP
Mflv_0755|M.gilvum_PYR-GCK ----------------------TDAFIGVAPDARILSLRQTSDSFSPVGA
Mvan_0092|M.vanbaalenii_PYR-1 ----------------------HDAFIGVAPNARILSLRQTSDSFLPVGA
TH_3348|M.thermoresistible__bu ----------------------TDGFIGVAPDARILSLRHTSAAFQPVGA
MSMEG_0083|M.smegmatis_MC2_155 ----------------------TDGFVGMAPDVRLLSLRQTSVAFQPKGA
MMAR_2678|M.marinum_M GGPRPLDPPPP----------APDAFSGIAPEVELISIRQSSQAFGLKDP
MUL_3079|M.ulcerans_Agy99 GGPRPLDPPP-----------APDAFSGIAPEVELISIRQSSQAFGLKDP
MLBr_01538|M.leprae_Br4923 ANSSPRAPVPNQPSSPLAPTSRPDAYAGIASDVDILSIRQSSQAFGFKDL
MAB_2225c|M.abscessus_ATCC_199 -----------------------DGFSGIAPAAKLISIRQESSKFSPR--
*. *:*. . ::*:*: * *
Rv3886c|M.tuberculosis_H37Rv SSAGPNSDEKVKAGTLDSVARAVVHAANMGAKVINISVTACLPAAAPGDQ
Mb3916c|M.bovis_AF2122/97 SSAGPNSDEKVKAGTLDSVARAVVHAANMGAKVINISVTACLPAAAPGDQ
MAV_0158|M.avium_104 PPGDPNSDEKVKAGTLNSVARAVVHAANMGAKVINISVTACLPAAAPADQ
Mflv_0755|M.gilvum_PYR-GCK RNDPNDPNATQTAGSLRSLARAIVHAANLGAQVINISEAACYKVTRRIDE
Mvan_0092|M.vanbaalenii_PYR-1 RTDPNDPNSTQTAGSLRSLARAIVHAANMGAQVINISEAACYKITRPINE
TH_3348|M.thermoresistible__bu RTDPNNPNTTQTAGSLRSLARAIVHAANLGAQVINISEAACYKVTRPIDE
MSMEG_0083|M.smegmatis_MC2_155 RQDPNDPNTTQTAGSIRSLARSVVHAANLGAQVINISEAACYKVTRRIDE
MMAR_2678|M.marinum_M YTGDEDPQTQQKIDDVETMARAIVHAANMGASVINISDVTCMSARNVIDQ
MUL_3079|M.ulcerans_Agy99 YTGDEDPQTQQKIDDVETMARAIVHAANMGASVINISDVTCMSARNVIDQ
MLBr_01538|M.leprae_Br4923 YTGDADPQTSQTIHYIQTMARAIVHAANMGATVINISEVTCMSARNVIDQ
MAB_2225c|M.abscessus_ATCC_199 LTAGGDPSTNAATQYVNTLARSIVHAANLGARVINISSAECVPAAKPIDQ
:.. : ::**::*****:** ***** . * ::
Rv3886c|M.tuberculosis_H37Rv RVLGAALWYAATVKDAVIVAAAGND--GEAGCGNNPMYDPLDPSDPRDWH
Mb3916c|M.bovis_AF2122/97 RVLGAALWYAATVKDAVIVAAAGND--GEAGCGNNPMYDPLDPSDPRDWH
MAV_0158|M.avium_104 RALGAALWYAATVKDAVVVAAAGND--GEAGCNNNPMFDPLDPSDPRDWH
Mflv_0755|M.gilvum_PYR-GCK AVVGAAINYAVNVKGTVIVAAAGN---TGENCAQNPPPDPAVPADPRGWQ
Mvan_0092|M.vanbaalenii_PYR-1 AVVGAAINYAVNVKGAVIVVAAGN---TGENCTQNPPPDPAVPADPRGWQ
TH_3348|M.thermoresistible__bu TGVGAAVNYAVHVKNAVVIAAAGN---TGQDCTQNPPPDPAVPSDPRGWQ
MSMEG_0083|M.smegmatis_MC2_155 TSLGAAINYAVNVKGAVIVVAAGN---TGQDCSQNPPPDPSVPSDPRGWR
MMAR_2678|M.marinum_M NALGAAVHYAAVDKNVVIVAAAGDG--SKKDCKQNPIFDPLQPDDPRDWN
MUL_3079|M.ulcerans_Agy99 NALGAAVHYAAVDKNVVIVAAAGDG--SKKDCKQNPIFDPLQPDDPRDWN
MLBr_01538|M.leprae_Br4923 RALGAAVRYAAVDKNVVIVAAAGDS--SKKNCKQNPLFDPLQPNDPRGWN
MAB_2225c|M.abscessus_ATCC_199 AALGAALRYAVAEKDAVVVAAAGNTSGGSANCQQNPLTGSG--ADPRNWS
:***: **. *..*::.***: .* :** .. ***.*
Rv3886c|M.tuberculosis_H37Rv QVTVVSSPSWFSDYVLSVGAVDAYGAA-LDKSMSGPWVGVAAPGTHIMGL
Mb3916c|M.bovis_AF2122/97 QVTVVSSPSWFSDYVLSVGAVDAYGAA-LDKSMSGPWVGVAAPGTHIMGL
MAV_0158|M.avium_104 QVKVVSAPSWFSDYVLSVGAVDASGAA-LDKSMSGPWVGVAAPGTHIMGL
Mflv_0755|M.gilvum_PYR-GCK QVQTIVSPAWYSPLVLTVGSIAPNGQP-SGFSVQGPWVGAAAPGENLVAL
Mvan_0092|M.vanbaalenii_PYR-1 EVQTIVSPAWYSPLVLTVGSIAPNGQP-SGFSMQGPWVGAAAPGENLIAL
TH_3348|M.thermoresistible__bu QVQTIVSPAWYSPLVLTVGGIGPTGQP-SNFSMSGPWVGAAAPAENITAL
MSMEG_0083|M.smegmatis_MC2_155 EVQTIVSPAWYDPLVLTVGSIGQNGQP-SNFSMSGPWVGAAAPGENLTSL
MMAR_2678|M.marinum_M AVTTVVTPSWFSDYVLTVGAVDTNGQPMTKMSIAGPWVSIAAPGTDVIGL
MUL_3079|M.ulcerans_Agy99 AVTTVVTPSWFSDYVLTVGAVDTNGQPMTKMSIAGPWVSIAAPGTDVIGL
MLBr_01538|M.leprae_Br4923 GVNTVVTPSWFSEYVLTVGAVDSHGQPLTQTSIAGPWVSIAAPGTDIIGL
MAB_2225c|M.abscessus_ATCC_199 GVESVSVPSWWQPYVLSVGSVGIDGSP-SKFTMAGPWVGIAANGENVTSL
* : *:*:. **:**.: * . :: ****. ** . .: .*
Rv3886c|M.tuberculosis_H37Rv SP-QGGGPVNAYPPSRPGEKNMPFWGTSFSAAYVSGVAALVRAKFPELTA
Mb3916c|M.bovis_AF2122/97 SP-QGGGPVNAYPPSRPGEKNMPFWGTSFSAAYVSGVAALVRAKFPELTA
MAV_0158|M.avium_104 SP-QGGGPVNAYPPSRPGEKNMPFWGTSFSAAYVSGVAALVRAKFPELSA
Mflv_0755|M.gilvum_PYR-GCK G--YDGNPVNALQ--GEDG-PIPISGTSFSAAFVSGVAALIKQRFPELTP
Mvan_0092|M.vanbaalenii_PYR-1 G--YDGNPVNALQ--GEDG-PIPISGTSFSAAYVSGLAALLRQRFPELTP
TH_3348|M.thermoresistible__bu G--YGGEPVNALQ--GQDG-LVPVAGTSFAAAYVSGLAALIRQRYPDLTP
MSMEG_0083|M.smegmatis_MC2_155 G--YDGQPVNATP--GEDG-PVPLNGTSFSAAYVSGLAALVKQRFPDLTP
MMAR_2678|M.marinum_M SP-RDDGLINAID--GPDNSLLVPAGTSFATAIVSGVVALVRAKYPELSA
MUL_3079|M.ulcerans_Agy99 SP-RDDGLINAID--GPDNSLLVPAGTSFATAIVSGVVALVRAKYPELSA
MLBr_01538|M.leprae_Br4923 SP-RDDSLINAID--GPDNTLLVPTGTSFSAAIVSGVAALVRGRYPQLTA
MAB_2225c|M.abscessus_ATCC_199 SNDAEGGLANGMI--GQNGKPVPLFGTSYATAYVAGVAALVRSRYPELTA
. . *. . : ***:::* *:*:.**:: ::*:*:.
Rv3886c|M.tuberculosis_H37Rv YQVINRIVQSAHNPPAGVDNKLGYGLVDPVAALTFNIPSGDRMAPGAQSR
Mb3916c|M.bovis_AF2122/97 YQVINRIVQSAHNPPAGVDNKLGYGLVDPVAALTFNIPSGDRMAPGAQSR
MAV_0158|M.avium_104 HQVINRIVQSAHNPPAGVDNKVGYGLVDPVAALTFNIPPGDRMAPGSQSR
Mflv_0755|M.gilvum_PYR-GCK GQIINRITATARHPGGGVNNVVGAGVIDPVAALTWDVPAGPADIPYQIKE
Mvan_0092|M.vanbaalenii_PYR-1 AQIINRITATARHPGGGVNNVVGAGVIDPVAALTWDVPPGPADIPYNIKE
TH_3348|M.thermoresistible__bu AQVINRITATARHPGGGVDNYVGAGVIDPVAALTWDVPEGPETAPYRAKE
MSMEG_0083|M.smegmatis_MC2_155 AQIINRITATARHPGGGVDNYVGAGVIDPVAALTWEIPDGPEKAPFRVKE
MMAR_2678|M.marinum_M YQIRNRLIHTARPPARGVDNQVGYGVVDPVAALTWDVPEGPVKPPKQLSA
MUL_3079|M.ulcerans_Agy99 YQIRNRLIHTARPPARGVDNQVGYGVVDPVAALTWDVPEGPVKPPKQLSA
MLBr_01538|M.leprae_Br4923 YQVINRLIHTARSPARGVDNQVGYGIVDPLAALTWDVPEGPAKPPPQLSS
MAB_2225c|M.abscessus_ATCC_199 PQVISRLQRTARDAGRSPSNLVGAGTVDPVAALTWEVPADGNASSGPGAR
*: .*: :*: . . .* :* * :**:****:::* . .
Rv3886c|M.tuberculosis_H37Rv VITPAAPPPPPDHRARNIAIG-FVGAVATGVLAMAIGARLRRAR---
Mb3916c|M.bovis_AF2122/97 VITPAAPPPPPDHRARNIAIG-FVGAVATGVLAMAIGARLRRAR---
MAV_0158|M.avium_104 IITPAPPPPPPDHRARNIAIG-FLGTVAAGVLVLAIAARLRRAR---
Mflv_0755|M.gilvum_PYR-GCK IPPPVHIPPPDRSPITGVVVVTIVVAALLGIGAMARRALRRR-----
Mvan_0092|M.vanbaalenii_PYR-1 IPPPVYVPPPDRSPITGVVLVGVGLAALLGIAALGRRALRRR-----
TH_3348|M.thermoresistible__bu IPEPEFIPPPDRGPITWVVVSSAAVALALGIGALTRRALRRR-----
MSMEG_0083|M.smegmatis_MC2_155 VPPPVYIPPPDRGPITAVVIAGATLAFALGIGALARRALRRKQ----
MMAR_2678|M.marinum_M PLELPKPPAERNMVPVWVAAGGLTGALLIGGAVFGTATLMRRSRKRR
MUL_3079|M.ulcerans_Agy99 PLELPKPPAERNMVPVWVAAGGLTGALLIGGAVSGTATLMRRSRKRR
MLBr_01538|M.leprae_Br4923 PLNLPKLPAHRDMVPVWVAAGGLTTAVLIGAAAFGTAMLVRRTQK--
MAB_2225c|M.abscessus_ATCC_199 AVVPPPPPTPENPLPRRLAFLGAGVCLIAVVVVAALSARRRQESTE-
*. :. . *: