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VGLWFGTLIALILLIAPGAMVARIAQLRWPVAIAVGPALTYGVVALAIIPYGALGIPWNGWTALAALAVT CAVATGLQLLLARFRDLDAEALAVSRWPAVTVAAGVLLGALLIGWAAYRGIPHWQSIPSTWDAVWHANTV RFILDTGQASSTHMGELRNVETHAPLYYPSVFHGLVAVFCQLTGAAPTTGYTLSSLAASVWLFPVSAAVL TWRAVRSHPGALWSASCASAEWRAAGAAGTAAALSASFTAVPYVEFDTAAMPNLAAYGIAVPTMVLITST LRHRDRIPVAVLALVGVFSLHITGGIVVALLVSAWWLFEALRHPVRSRLADLLTLAGVAAMAGLVMLPQF LSVRQQEDIIAGHAFPTYLSKKRGLFDAVFQHSRHLNDFPVQYALIVLAAIGGLILLVKKIWWPLAVWLL LIVMNVDAGTPLGGPIGGVAGALGEFFYHDPRRIAAATTLLLMLMAGVALFATVMLLVAAAKRLTDRFRP QPVSVWASATATLLIGATLVSAWHYFPRHRFLFGDKYDSVMIDQKDLDAMAYLASLPGARDTLIGNANTD GTAWMYAVAGLHPLWTHYDYPLQQGPGYHRFIFWAYGRNGESDPRVLEAIQVLRIRYILTSTPTVRGFAV PDGLVSLETSRSWAKIYDNGEARIYEWRGTAAATHS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3779 | - | - | 100% (666) | PROBABLE CONSERVED TRANSMEMBRANE PROTEIN ALANINE AND LEUCINE RICH |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3808 | - | 0.0 | 100.00% (666) | transmembrane protein alanine and leucine rich |
| M. gilvum PYR-GCK | - | - | - | - | - |
| M. leprae Br4923 | MLBr_00116 | - | 0.0 | 66.52% (666) | hypothetical protein MLBr_00116 |
| M. abscessus ATCC 19977 | MAB_0205c | - | 0.0 | 50.83% (663) | hypothetical protein MAB_0205c |
| M. marinum M | MMAR_5334 | - | 0.0 | 81.38% (666) | transmembrane protein |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | - | - | - | - | - |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_0094 | - | 0.0 | 81.08% (666) | transmembrane protein |
| M. vanbaalenii PYR-1 | Mvan_5631 | - | 7e-07 | 26.20% (355) | cell wall arabinan synthesis protein |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3779|M.tuberculosis_H37Rv --------MGLWFGTLIALILLIAPGAMVAR----------------IAQ
Mb3808|M.bovis_AF2122/97 --------MGLWFGTLIALILLIAPGAMVAR----------------IAQ
MMAR_5334|M.marinum_M --------MTLWFGTLIALILLIAPGTLIAR----------------IAQ
MUL_0094|M.ulcerans_Agy99 --------MTLWFGTLIALILLIAPGTLIAR----------------IAQ
MLBr_00116|M.leprae_Br4923 --------MGLCCGTLIALFLLIVPETIVAR----------------FAA
MAB_0205c|M.abscessus_ATCC_199 --------MSFAFGVAAALLLLFIPGWLIGR----------------ALG
Mvan_5631|M.vanbaalenii_PYR-1 MPAPSARLVAVIAGLLGMLLCGLAPLLPVKQSTATITWPQSVNAEGFVSD
: . * *: : * : :
Rv3779|M.tuberculosis_H37Rv LRWPVAIAVGPALTYGVVALAIIPYGALG------IPWNGWTALAALAVT
Mb3808|M.bovis_AF2122/97 LRWPVAIAVGPALTYGVVALAIIPYGALG------IPWNGWTALAALAVT
MMAR_5334|M.marinum_M LSWPIAIAVGPPLTYGVIALAIVPYGALG------IPWNGWTALLALAVV
MUL_0094|M.ulcerans_Agy99 LSWPIAIAVGPPLTYGVIALAIVPYGALG------IPWNGWTALVALAVV
MLBr_00116|M.leprae_Br4923 LTWPIAIAVSPALTYGVIALVIIPFGAVG------IPWNSWTALAALVAV
MAB_0205c|M.abscessus_ATCC_199 LPTHSAAVTAPALTYGLVGLCIVAFGSIG------IPWNSLSAGFALVGA
Mvan_5631|M.vanbaalenii_PYR-1 ITAPLVSGAPHALDVTIPCPAVATLPGDDGVVFSTIPADGIDAGRNGLFV
: . . .* : : . . . ** :. * .
Rv3779|M.tuberculosis_H37Rv CAVATGLQLLLARFRDLDAEALAVSRWPAVTVAAGVLLGALLIGWAAYRG
Mb3808|M.bovis_AF2122/97 CAVATGLQLLLARFRDLDAEALAVSRWPAVTVAAGVLLGALLIGWAAYRG
MMAR_5334|M.marinum_M AAAVTGFQLLLGRFRDKEAEARGVSRGPALTVAAGVALGTLFIAWAAYRG
MUL_0094|M.ulcerans_Agy99 TAAVTGFQLLLGRFRDKEAEARGVSRGPALTVAAGVALGTLFIAWAAYRG
MLBr_00116|M.leprae_Br4923 SMLMIAFRLLLVRYRDTAAETRGISGWPAVTVAVGVLLGALLIGWAAYRG
MAB_0205c|M.abscessus_ATCC_199 VIIARLLWRWLRPKRQ-AEQTPSQNRAALVAVTFGVALGMALIFYAFLRG
Mvan_5631|M.vanbaalenii_PYR-1 RANADVVYVAFRDTVAAVAPREAVDSGACSELRIWAGVGAVGADFVGIPG
. : . . . : . :* :. *
Rv3779|M.tuberculosis_H37Rv IP----------------HWQSIPSTWDAVWHANTVRFILD---------
Mb3808|M.bovis_AF2122/97 IP----------------HWQSIPSTWDAVWHANTVRFILD---------
MMAR_5334|M.marinum_M IP----------------HWQSIPSTWDAVWHANTVRFILD---------
MUL_0094|M.ulcerans_Agy99 IP----------------HWQSIPSSWDAVWHANTVRFILD---------
MLBr_00116|M.leprae_Br4923 LL----------------HWQSIPSTWDAVWHANTVRFILD---------
MAB_0205c|M.abscessus_ATCC_199 LT----------------HWQSIPSTWDSMWHGNTIRYILD---------
Mvan_5631|M.vanbaalenii_PYR-1 AAGTLEPEKRPQVAGVFTDLEAGPDSGLRARIDVDTRFITTPTTVKLAVM
. :: *.: *:*
Rv3779|M.tuberculosis_H37Rv --------------------TGQASSTHMGELRNVETHAPLYYPSVF---
Mb3808|M.bovis_AF2122/97 --------------------TGQASSTHMGELRNVETHAPLYYPSVF---
MMAR_5334|M.marinum_M --------------------TGQASPTHMGELRNVETHALLYYPSVF---
MUL_0094|M.ulcerans_Agy99 --------------------TGQASPTHMGELRNVETHALLYYPSVF---
MLBr_00116|M.leprae_Br4923 --------------------TGQASPTHMGELRNVETHSVLYYPSVL---
MAB_0205c|M.abscessus_ATCC_199 --------------------TGQASSTRMGDLRNVETHATLYYPSAF---
Mvan_5631|M.vanbaalenii_PYR-1 VLGVLCVIAAIVALAVLDRASGRRMPRELRRRRRTGLWTWLTDAAVVGSL
:*: . .: *.. : * .:..
Rv3779|M.tuberculosis_H37Rv ------------HGLVAVFCQLTGAAPTTG--------------------
Mb3808|M.bovis_AF2122/97 ------------HGLVAVFCQLTGAAPTTG--------------------
MMAR_5334|M.marinum_M ------------HGLTAVFCQLTGAAPTTG--------------------
MUL_0094|M.ulcerans_Agy99 ------------HGLTTVFCQLTGAAPTTG--------------------
MLBr_00116|M.leprae_Br4923 ------------HALAGVYCQLTGAAPTTG--------------------
MAB_0205c|M.abscessus_ATCC_199 ------------HGLAAVLCQLTGAAPTTS--------------------
Mvan_5631|M.vanbaalenii_PYR-1 LIWHLVGALSSDDGYNTTIARVSGEAGYITNYYRYFGASEAPFDWYQSVL
.. . .:::* *
Rv3779|M.tuberculosis_H37Rv --YTLSSLAASVWLFPVSAAVLTWRAVRSHPGALWSASCASAEWRAAGAA
Mb3808|M.bovis_AF2122/97 --YTLSSLAASVWLFPVSAAVLTWRAVRSHPGALWSASCASAEWRAAGAA
MMAR_5334|M.marinum_M --YTLNSLAAAIWLFPVSAATLTWRAMRGH----------LTEWRTAGSA
MUL_0094|M.ulcerans_Agy99 --YTLNSLAAAIWLFPVSAATLTWRAMRGH----------LTEWRTAGSA
MLBr_00116|M.leprae_Br4923 --YTVSSLAVAVWLFPVSAATLTWHLLRPV----------TTQKRAAGAS
MAB_0205c|M.abscessus_ATCC_199 --YTLYAVAGS-LLFPLGSAALAWQMLRGR----------TTRTFQAGAA
Mvan_5631|M.vanbaalenii_PYR-1 AQLASISTASVWLRLPATAAAIGTWLIVSR-------CVLPRLGRRVADN
: : * :* :*.: : ..
Rv3779|M.tuberculosis_H37Rv GTAAALSASFTAVPYVEFDTAAMPNLAAYGIAVPTMVLITSTLRHRDRIP
Mb3808|M.bovis_AF2122/97 GTAAALSASFTAVPYVEFDTAAMPNLAAYGIAVPTMVLITSTLRHRDRIP
MMAR_5334|M.marinum_M ATAAALSASFTALPYVEFGTAAMPNLASYGVAVPAMVLITSTPRHRDRIP
MUL_0094|M.ulcerans_Agy99 ATAAALSASFTALPYVEFGTAAMPNLASYGVAVPAMVLITSTPRHRDRIP
MLBr_00116|M.leprae_Br4923 ATAAALSAAFTSVPYVEFGVAAMPNLAAYGVAVPTMVLITSTLRHRDRIP
MAB_0205c|M.abscessus_ATCC_199 ATAAALSASFSALPYVEFHVSAIPNLMSFALVGPALLAITSVVADRSRIP
Mvan_5631|M.vanbaalenii_PYR-1 RVAVLTGGAVFLAAWLPFNNGLRPEPLIAFGVVAAWILTERALATRRLWP
.*. ..:. .:: * . *: . .: : . * *
Rv3779|M.tuberculosis_H37Rv VAVLALVGVFSLHITGGIVVALLVSAWWLFEALRHPVRSRLADLLTLAG-
Mb3808|M.bovis_AF2122/97 VAVLALVGVFSLHITGGIVVALLVSAWWLFEALRHPVRSRLADLLTLAG-
MMAR_5334|M.marinum_M IAVLALVGVLSVHIAGGMVVVLLVAAWWLFEALWHPVRGRLADLATLAG-
MUL_0094|M.ulcerans_Agy99 IAVLALVGVLSVHIAGGMVVVLLVAAWWLFGALWHPVRGRLADLATLAG-
MLBr_00116|M.leprae_Br4923 VAILALVGTFSVHLTGGIVVSLFLLGWWLMNALLHPVRSRAADARTLAA-
MAB_0205c|M.abscessus_ATCC_199 AAILAFTGVASVHTSGAIVVVVFVAAWWVLAPLSRYPGTKSKDKHRLGSG
Mvan_5631|M.vanbaalenii_PYR-1 YAVAIVVAVFSVTLAPQGLVALAPLLVGARGVTRIVAARRPVDGLAAQLA
*: .... *: : :* : : *
Rv3779|M.tuberculosis_H37Rv -----VAAMAGLVML-PQFLSVRQQE--DIIAGHAFPTYLSKKRGLFDAV
Mb3808|M.bovis_AF2122/97 -----VAAMAGLVML-PQFLSVRQQE--DIIAGHAFPTYLSKKRGLFDAV
MMAR_5334|M.marinum_M -----VAAISGLIML-PQFISVEQQE--DIIAGHSFLTYLSKKRGVFDAV
MUL_0094|M.ulcerans_Agy99 -----VAAISGLIML-PQFISVEQQE--DIIAGHSFLTYLSKKRGVFDAV
MLBr_00116|M.leprae_Br4923 -----VVMPTALILA-PQFIAVLNQA--DIIAGHSFPSFKSVKQGVIDAL
MAB_0205c|M.abscessus_ATCC_199 FTPLAVAGVGSLVLLYPQLRTLMQLS--EIIAGHQFTTPWGKKRALLDAL
Mvan_5631|M.vanbaalenii_PYR-1 PLAAAASLLFVVVFRDQTLATVAESVRIKYVVGPTIPWYQEFLRYYFLTV
. ::: : :: : . :.* : : : ::
Rv3779|M.tuberculosis_H37Rv FQHSRHLNDFPVQYALIVLAAIGGLILLVKKIWWP--------------L
Mb3808|M.bovis_AF2122/97 FQHSRHLNDFPVQYALIVLAAIGGLILLVKKIWWP--------------L
MMAR_5334|M.marinum_M FQHSRHLNDFPVQYALIALAAIGGFILLIKKIWWP--------------L
MUL_0094|M.ulcerans_Agy99 FQHSRHLNDFPVQYALIALAAIGGFILLIKKIWWP--------------L
MLBr_00116|M.leprae_Br4923 LLHTRHLNDFPIQYGLVVLAAIGMAILLYQKIWWP--------------S
MAB_0205c|M.abscessus_ATCC_199 TQHTRHLADYPVQSALLGLALIGAVVLIVKRVYWP--------------V
Mvan_5631|M.vanbaalenii_PYR-1 EESVDGSLTRRFSVLILLLCLFGVLMVLLRRGSLPGAVNGPVWRLAGTTA
.. :: *. :* ::: :: *
Rv3779|M.tuberculosis_H37Rv AVWLLLIVMNVDAGTPLGGPIGGVAGA-------LGEFFYHDPRRIAAAT
Mb3808|M.bovis_AF2122/97 AVWLLLIVMNVDAGTPLGGPIGGVAGA-------LGEFFYHDPRRIAAAT
MMAR_5334|M.marinum_M AVWVLLVVMNVNAGTPLGGPIDAMAGA-------LGEFFYNDPRRIAAAT
MUL_0094|M.ulcerans_Agy99 AVWLLLVVMNVNAGTPLGGPIDAMAGS-------LGEFFYNDPRRIAAAT
MLBr_00116|M.leprae_Br4923 IAWLVLTVATVYSAAPFRGPIGSAIES-------FSQFFYNDPRRLSAVV
MAB_0205c|M.abscessus_ATCC_199 AVWLLLVIAIVHSSKPFGGFVGHAVAL-------FSDAFYSDPRRLSAIV
Mvan_5631|M.vanbaalenii_PYR-1 IGLLLLTLTPTKWAVQFGVFAGLAGALGAITAFAFARVGLHSRRNLALYV
::* : . . : . :. . *.:: .
Rv3779|M.tuberculosis_H37Rv TLLLMLMAG-----------------------------------------
Mb3808|M.bovis_AF2122/97 TLLLMLMAG-----------------------------------------
MMAR_5334|M.marinum_M TLLLMLMAG-----------------------------------------
MUL_0094|M.ulcerans_Agy99 TLLLMLMAG-----------------------------------------
MLBr_00116|M.leprae_Br4923 TMLLTPMAG-----------------------------------------
MAB_0205c|M.abscessus_ATCC_199 CLLLAPAAG-----------------------------------------
Mvan_5631|M.vanbaalenii_PYR-1 TALLFVLAWATSGINGWFYVGNYGVPWFDKQPVIVGYPVTTIFLVLAIAC
** *
Rv3779|M.tuberculosis_H37Rv ------------------------------VALFATVMLLVAAAKRLTDR
Mb3808|M.bovis_AF2122/97 ------------------------------VALFATVMLLVAAAKRLTDR
MMAR_5334|M.marinum_M ------------------------------VALFWIVTLVVTAAQGLTDR
MUL_0094|M.ulcerans_Agy99 ------------------------------VALFWIVTLVVAAARGLTDR
MLBr_00116|M.leprae_Br4923 ------------------------------IALFAGVLLLVVGARRVTAR
MAB_0205c|M.abscessus_ATCC_199 ------------------------------IGLFALAAAALATLR--RAR
Mvan_5631|M.vanbaalenii_PYR-1 GLLAGWLHFRMDYAGHTEVADTGRNRALASTPLLVVAVIMVVLELGSMLK
*: . :. :
Rv3779|M.tuberculosis_H37Rv FRPQPVSVWASATATLLIGATLVSAWHYFPRHRFLFGDKYDSVMIDQK--
Mb3808|M.bovis_AF2122/97 FRPQPVSVWASATATLLIGATLVSAWHYFPRHRFLFGDKYDSVMIDQK--
MMAR_5334|M.marinum_M FRPLPQPFWVSVTVALLLGVCLVSTWHYFPRHRFLFGDKYDSVMIDQK--
MUL_0094|M.ulcerans_Agy99 FRPLPQPFWVSVTVALLLGVCLVSTWHYFPRHRFLFGDKYDSVMIDQK--
MLBr_00116|M.leprae_Br4923 FTALPRPVWTTATVVLLVAATVLTAWHYLFRHLVLFGDKYDSVMVNQK--
MAB_0205c|M.abscessus_ATCC_199 KTRADSRWTLVAAAIVLAAICGFSARHYFLPHKYLVGAKYDQVMVGPK--
Mvan_5631|M.vanbaalenii_PYR-1 ATAGRYPVYTTGAANISALRSGLSDASCSMADAVLVEADTNAGMLTPVPG
:. : .: . *. . : *:
Rv3779|M.tuberculosis_H37Rv ------------------------DLDAMAYLASLPGARDT-------LI
Mb3808|M.bovis_AF2122/97 ------------------------DLDAMAYLASLPGARDT-------LI
MMAR_5334|M.marinum_M ------------------------DLDAMAYLATLPGARDT-------MI
MUL_0094|M.ulcerans_Agy99 ------------------------DLDAMAYLATLPGARDT-------MI
MLBr_00116|M.leprae_Br4923 ------------------------DLDAMSYLATLPGAHNT-------II
MAB_0205c|M.abscessus_ATCC_199 ------------------------KLDAFAYLATLPGAKTT-------TI
Mvan_5631|M.vanbaalenii_PYR-1 QRFGEYGPLGGEDPVGFTPNGVSDTLEPAEPVAANPGTVNSDGPVDKPNI
*:. :*: **: : *
Rv3779|M.tuberculosis_H37Rv GNANTDGTA-----------------------------------------
Mb3808|M.bovis_AF2122/97 GNANTDGTA-----------------------------------------
MMAR_5334|M.marinum_M GNANTDGTA-----------------------------------------
MUL_0094|M.ulcerans_Agy99 GDANTDGTA-----------------------------------------
MLBr_00116|M.leprae_Br4923 GNSNTDGSS-----------------------------------------
MAB_0205c|M.abscessus_ATCC_199 GDGNVDGSG-----------------------------------------
Mvan_5631|M.vanbaalenii_PYR-1 GVGYAAGTGGGYGPEGVNGSRVFLPFGLDPATTPVMGSFDENTLAAKATS
* . . *:.
Rv3779|M.tuberculosis_H37Rv -----------------------WMYAVAG--------------------
Mb3808|M.bovis_AF2122/97 -----------------------WMYAVAG--------------------
MMAR_5334|M.marinum_M -----------------------WMYAVAG--------------------
MUL_0094|M.ulcerans_Agy99 -----------------------WMYAVAG--------------------
MLBr_00116|M.leprae_Br4923 -----------------------WMYAVAD--------------------
MAB_0205c|M.abscessus_ATCC_199 -----------------------WMYAVAG--------------------
Mvan_5631|M.vanbaalenii_PYR-1 AWYQLPPRTPDRPLVSVAAAGAIWYYNEDGSFNYGQSLKLQWGVHRPDGS
* * .
Rv3779|M.tuberculosis_H37Rv -------------LHPLWTHYDYPLQQGP---------------------
Mb3808|M.bovis_AF2122/97 -------------LHPLWTHYDYPLQQGP---------------------
MMAR_5334|M.marinum_M -------------LHPLWTHYDYPVQQGP---------------------
MUL_0094|M.ulcerans_Agy99 -------------LHPLWTHYDYPVQQGP---------------------
MLBr_00116|M.leprae_Br4923 -------------LHPLWTHYDFPQQTGP---------------------
MAB_0205c|M.abscessus_ATCC_199 -------------LHPLWTHYDFPQQQGP---------------------
Mvan_5631|M.vanbaalenii_PYR-1 YQELGEVQPIDIFVQKAWRNLRFPLEWAPPEANVARIVADDPNLSEDQWF
:: * : :* : .*
Rv3779|M.tuberculosis_H37Rv --------------------------------------------------
Mb3808|M.bovis_AF2122/97 --------------------------------------------------
MMAR_5334|M.marinum_M --------------------------------------------------
MUL_0094|M.ulcerans_Agy99 --------------------------------------------------
MLBr_00116|M.leprae_Br4923 --------------------------------------------------
MAB_0205c|M.abscessus_ATCC_199 --------------------------------------------------
Mvan_5631|M.vanbaalenii_PYR-1 AFTPPRVPVLQTAQDFLGRQTPVLMDIATAANFPCQRPFTEHLGIAELPE
Rv3779|M.tuberculosis_H37Rv -----GYHRFIF----WAYGRNGESDPRVLEAIQVLRIRYILTSTPTVRG
Mb3808|M.bovis_AF2122/97 -----GYHRFIF----WAYGRNGESDPRVLEAIQVLRIRYILTSTPTVRG
MMAR_5334|M.marinum_M -----GYHRFIV----WAYAGRGDSDPRVVESIKVLNIRYILTSSPTVRG
MUL_0094|M.ulcerans_Agy99 -----GYHRFIF----WAYAGRGDSDPRVVESIKVLNIRYILTSSPTVRG
MLBr_00116|M.leprae_Br4923 -----GYFRYAF----WAYARTG--NPWVVEAVRVFNIRYILTTSPTVQG
MAB_0205c|M.abscessus_ATCC_199 -----GYHRYIF----WAYADDADTDRRVTEAVHALNIRYVMTSTPVVQG
Mvan_5631|M.vanbaalenii_PYR-1 YRIMPNFKQIVVSSNQWQAAQDGGPFLFIQALLRTESIPTYLSGDWYRDW
.: : . * . . : ::. * ::
Rv3779|M.tuberculosis_H37Rv FAVPDGLVSLETSRSWAKIYDNGEARIYEWRGTAAATHS---
Mb3808|M.bovis_AF2122/97 FAVPDGLVSLETSRSWAKIYDNGEARIYEWRGTAAATHS---
MMAR_5334|M.marinum_M FAVPDGLVSLENSPSWKKIYDNGGARIYEWSGKTAQTHSK--
MUL_0094|M.ulcerans_Agy99 FAVPDGLVSLENSPSWKKIYDNGGARIYEWSGKTAQTHSK--
MLBr_00116|M.leprae_Br4923 FAIPDGLVSLEESKSWTKIYDNGAARIFEWSGNATATRA---
MAB_0205c|M.abscessus_ATCC_199 FKVPDGLRSLDISRSWRKLYDNGAAQIYEWVGDRKPDAEGDK
Mvan_5631|M.vanbaalenii_PYR-1 GSLERYLRVVPKDEAPDAVIEEGSTRVFGWSRGGPIRALP--
: * : . : : ::* :::: *