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M. bovis AF2122 / 97 Mb3808 (-)

annotation: transmembrane protein alanine and leucine rich
coordinates: 4161280 - 4163280
length: 666

VGLWFGTLIALILLIAPGAMVARIAQLRWPVAIAVGPALTYGVVALAIIPYGALGIPWNGWTALAALAVT
CAVATGLQLLLARFRDLDAEALAVSRWPAVTVAAGVLLGALLIGWAAYRGIPHWQSIPSTWDAVWHANTV
RFILDTGQASSTHMGELRNVETHAPLYYPSVFHGLVAVFCQLTGAAPTTGYTLSSLAASVWLFPVSAAVL
TWRAVRSHPGALWSASCASAEWRAAGAAGTAAALSASFTAVPYVEFDTAAMPNLAAYGIAVPTMVLITST
LRHRDRIPVAVLALVGVFSLHITGGIVVALLVSAWWLFEALRHPVRSRLADLLTLAGVAAMAGLVMLPQF
LSVRQQEDIIAGHAFPTYLSKKRGLFDAVFQHSRHLNDFPVQYALIVLAAIGGLILLVKKIWWPLAVWLL
LIVMNVDAGTPLGGPIGGVAGALGEFFYHDPRRIAAATTLLLMLMAGVALFATVMLLVAAAKRLTDRFRP
QPVSVWASATATLLIGATLVSAWHYFPRHRFLFGDKYDSVMIDQKDLDAMAYLASLPGARDTLIGNANTD
GTAWMYAVAGLHPLWTHYDYPLQQGPGYHRFIFWAYGRNGESDPRVLEAIQVLRIRYILTSTPTVRGFAV
PDGLVSLETSRSWAKIYDNGEARIYEWRGTAAATHS
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3808--100% (666)transmembrane protein alanine and leucine rich

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. gilvum PYR-GCK-----
M. tuberculosis H37RvRv3779-0.0100.00% (666) transmembrane protein alanine and leucine rich
M. leprae Br4923MLBr_00116-0.066.52% (666) hypothetical protein MLBr_00116
M. abscessus ATCC 19977MAB_0205c-0.050.83% (663) hypothetical protein MAB_0205c
M. marinum MMMAR_5334-0.081.38% (666) transmembrane protein
M. avium 104-----
M. smegmatis MC2 155-----
M. thermoresistible (build 8)-----
M. ulcerans Agy99MUL_0094-0.081.08% (666) transmembrane protein
M. vanbaalenii PYR-1Mvan_5631-7e-0726.20% (355) cell wall arabinan synthesis protein

CLUSTAL 2.0.9 multiple sequence alignment


Mb3808|M.bovis_AF2122/97            --------MGLWFGTLIALILLIAPGAMVAR----------------IAQ
Rv3779|M.tuberculosis_H37Rv         --------MGLWFGTLIALILLIAPGAMVAR----------------IAQ
MMAR_5334|M.marinum_M               --------MTLWFGTLIALILLIAPGTLIAR----------------IAQ
MUL_0094|M.ulcerans_Agy99           --------MTLWFGTLIALILLIAPGTLIAR----------------IAQ
MLBr_00116|M.leprae_Br4923          --------MGLCCGTLIALFLLIVPETIVAR----------------FAA
MAB_0205c|M.abscessus_ATCC_199      --------MSFAFGVAAALLLLFIPGWLIGR----------------ALG
Mvan_5631|M.vanbaalenii_PYR-1       MPAPSARLVAVIAGLLGMLLCGLAPLLPVKQSTATITWPQSVNAEGFVSD
                                            : .  *    *:  : *   : :                   

Mb3808|M.bovis_AF2122/97            LRWPVAIAVGPALTYGVVALAIIPYGALG------IPWNGWTALAALAVT
Rv3779|M.tuberculosis_H37Rv         LRWPVAIAVGPALTYGVVALAIIPYGALG------IPWNGWTALAALAVT
MMAR_5334|M.marinum_M               LSWPIAIAVGPPLTYGVIALAIVPYGALG------IPWNGWTALLALAVV
MUL_0094|M.ulcerans_Agy99           LSWPIAIAVGPPLTYGVIALAIVPYGALG------IPWNGWTALVALAVV
MLBr_00116|M.leprae_Br4923          LTWPIAIAVSPALTYGVIALVIIPFGAVG------IPWNSWTALAALVAV
MAB_0205c|M.abscessus_ATCC_199      LPTHSAAVTAPALTYGLVGLCIVAFGSIG------IPWNSLSAGFALVGA
Mvan_5631|M.vanbaalenii_PYR-1       ITAPLVSGAPHALDVTIPCPAVATLPGDDGVVFSTIPADGIDAGRNGLFV
                                    :    .  .  .*   :    : .  . .      ** :.  *      .

Mb3808|M.bovis_AF2122/97            CAVATGLQLLLARFRDLDAEALAVSRWPAVTVAAGVLLGALLIGWAAYRG
Rv3779|M.tuberculosis_H37Rv         CAVATGLQLLLARFRDLDAEALAVSRWPAVTVAAGVLLGALLIGWAAYRG
MMAR_5334|M.marinum_M               AAAVTGFQLLLGRFRDKEAEARGVSRGPALTVAAGVALGTLFIAWAAYRG
MUL_0094|M.ulcerans_Agy99           TAAVTGFQLLLGRFRDKEAEARGVSRGPALTVAAGVALGTLFIAWAAYRG
MLBr_00116|M.leprae_Br4923          SMLMIAFRLLLVRYRDTAAETRGISGWPAVTVAVGVLLGALLIGWAAYRG
MAB_0205c|M.abscessus_ATCC_199      VIIARLLWRWLRPKRQ-AEQTPSQNRAALVAVTFGVALGMALIFYAFLRG
Mvan_5631|M.vanbaalenii_PYR-1       RANADVVYVAFRDTVAAVAPREAVDSGACSELRIWAGVGAVGADFVGIPG
                                          .   :           . .  .   :   . :*     :.   *

Mb3808|M.bovis_AF2122/97            IP----------------HWQSIPSTWDAVWHANTVRFILD---------
Rv3779|M.tuberculosis_H37Rv         IP----------------HWQSIPSTWDAVWHANTVRFILD---------
MMAR_5334|M.marinum_M               IP----------------HWQSIPSTWDAVWHANTVRFILD---------
MUL_0094|M.ulcerans_Agy99           IP----------------HWQSIPSSWDAVWHANTVRFILD---------
MLBr_00116|M.leprae_Br4923          LL----------------HWQSIPSTWDAVWHANTVRFILD---------
MAB_0205c|M.abscessus_ATCC_199      LT----------------HWQSIPSTWDSMWHGNTIRYILD---------
Mvan_5631|M.vanbaalenii_PYR-1       AAGTLEPEKRPQVAGVFTDLEAGPDSGLRARIDVDTRFITTPTTVKLAVM
                                                      . :: *.:          *:*           

Mb3808|M.bovis_AF2122/97            --------------------TGQASSTHMGELRNVETHAPLYYPSVF---
Rv3779|M.tuberculosis_H37Rv         --------------------TGQASSTHMGELRNVETHAPLYYPSVF---
MMAR_5334|M.marinum_M               --------------------TGQASPTHMGELRNVETHALLYYPSVF---
MUL_0094|M.ulcerans_Agy99           --------------------TGQASPTHMGELRNVETHALLYYPSVF---
MLBr_00116|M.leprae_Br4923          --------------------TGQASPTHMGELRNVETHSVLYYPSVL---
MAB_0205c|M.abscessus_ATCC_199      --------------------TGQASSTRMGDLRNVETHATLYYPSAF---
Mvan_5631|M.vanbaalenii_PYR-1       VLGVLCVIAAIVALAVLDRASGRRMPRELRRRRRTGLWTWLTDAAVVGSL
                                                        :*:  . .:   *..   : *  .:..   

Mb3808|M.bovis_AF2122/97            ------------HGLVAVFCQLTGAAPTTG--------------------
Rv3779|M.tuberculosis_H37Rv         ------------HGLVAVFCQLTGAAPTTG--------------------
MMAR_5334|M.marinum_M               ------------HGLTAVFCQLTGAAPTTG--------------------
MUL_0094|M.ulcerans_Agy99           ------------HGLTTVFCQLTGAAPTTG--------------------
MLBr_00116|M.leprae_Br4923          ------------HALAGVYCQLTGAAPTTG--------------------
MAB_0205c|M.abscessus_ATCC_199      ------------HGLAAVLCQLTGAAPTTS--------------------
Mvan_5631|M.vanbaalenii_PYR-1       LIWHLVGALSSDDGYNTTIARVSGEAGYITNYYRYFGASEAPFDWYQSVL
                                                ..   . .:::* *                        

Mb3808|M.bovis_AF2122/97            --YTLSSLAASVWLFPVSAAVLTWRAVRSHPGALWSASCASAEWRAAGAA
Rv3779|M.tuberculosis_H37Rv         --YTLSSLAASVWLFPVSAAVLTWRAVRSHPGALWSASCASAEWRAAGAA
MMAR_5334|M.marinum_M               --YTLNSLAAAIWLFPVSAATLTWRAMRGH----------LTEWRTAGSA
MUL_0094|M.ulcerans_Agy99           --YTLNSLAAAIWLFPVSAATLTWRAMRGH----------LTEWRTAGSA
MLBr_00116|M.leprae_Br4923          --YTVSSLAVAVWLFPVSAATLTWHLLRPV----------TTQKRAAGAS
MAB_0205c|M.abscessus_ATCC_199      --YTLYAVAGS-LLFPLGSAALAWQMLRGR----------TTRTFQAGAA
Mvan_5631|M.vanbaalenii_PYR-1       AQLASISTASVWLRLPATAAAIGTWLIVSR-------CVLPRLGRRVADN
                                       :  : *     :*  :*.:    :                   ..  

Mb3808|M.bovis_AF2122/97            GTAAALSASFTAVPYVEFDTAAMPNLAAYGIAVPTMVLITSTLRHRDRIP
Rv3779|M.tuberculosis_H37Rv         GTAAALSASFTAVPYVEFDTAAMPNLAAYGIAVPTMVLITSTLRHRDRIP
MMAR_5334|M.marinum_M               ATAAALSASFTALPYVEFGTAAMPNLASYGVAVPAMVLITSTPRHRDRIP
MUL_0094|M.ulcerans_Agy99           ATAAALSASFTALPYVEFGTAAMPNLASYGVAVPAMVLITSTPRHRDRIP
MLBr_00116|M.leprae_Br4923          ATAAALSAAFTSVPYVEFGVAAMPNLAAYGVAVPTMVLITSTLRHRDRIP
MAB_0205c|M.abscessus_ATCC_199      ATAAALSASFSALPYVEFHVSAIPNLMSFALVGPALLAITSVVADRSRIP
Mvan_5631|M.vanbaalenii_PYR-1       RVAVLTGGAVFLAAWLPFNNGLRPEPLIAFGVVAAWILTERALATRRLWP
                                     .*.  ..:.   .:: *  .  *:      . .: :    .   *   *

Mb3808|M.bovis_AF2122/97            VAVLALVGVFSLHITGGIVVALLVSAWWLFEALRHPVRSRLADLLTLAG-
Rv3779|M.tuberculosis_H37Rv         VAVLALVGVFSLHITGGIVVALLVSAWWLFEALRHPVRSRLADLLTLAG-
MMAR_5334|M.marinum_M               IAVLALVGVLSVHIAGGMVVVLLVAAWWLFEALWHPVRGRLADLATLAG-
MUL_0094|M.ulcerans_Agy99           IAVLALVGVLSVHIAGGMVVVLLVAAWWLFGALWHPVRGRLADLATLAG-
MLBr_00116|M.leprae_Br4923          VAILALVGTFSVHLTGGIVVSLFLLGWWLMNALLHPVRSRAADARTLAA-
MAB_0205c|M.abscessus_ATCC_199      AAILAFTGVASVHTSGAIVVVVFVAAWWVLAPLSRYPGTKSKDKHRLGSG
Mvan_5631|M.vanbaalenii_PYR-1       YAVAIVVAVFSVTLAPQGLVALAPLLVGARGVTRIVAARRPVDGLAAQLA
                                     *:  .... *:  :   :* :                 :  *       

Mb3808|M.bovis_AF2122/97            -----VAAMAGLVML-PQFLSVRQQE--DIIAGHAFPTYLSKKRGLFDAV
Rv3779|M.tuberculosis_H37Rv         -----VAAMAGLVML-PQFLSVRQQE--DIIAGHAFPTYLSKKRGLFDAV
MMAR_5334|M.marinum_M               -----VAAISGLIML-PQFISVEQQE--DIIAGHSFLTYLSKKRGVFDAV
MUL_0094|M.ulcerans_Agy99           -----VAAISGLIML-PQFISVEQQE--DIIAGHSFLTYLSKKRGVFDAV
MLBr_00116|M.leprae_Br4923          -----VVMPTALILA-PQFIAVLNQA--DIIAGHSFPSFKSVKQGVIDAL
MAB_0205c|M.abscessus_ATCC_199      FTPLAVAGVGSLVLLYPQLRTLMQLS--EIIAGHQFTTPWGKKRALLDAL
Mvan_5631|M.vanbaalenii_PYR-1       PLAAAASLLFVVVFRDQTLATVAESVRIKYVVGPTIPWYQEFLRYYFLTV
                                         .     :::    : :: :    . :.*  :       :  : ::

Mb3808|M.bovis_AF2122/97            FQHSRHLNDFPVQYALIVLAAIGGLILLVKKIWWP--------------L
Rv3779|M.tuberculosis_H37Rv         FQHSRHLNDFPVQYALIVLAAIGGLILLVKKIWWP--------------L
MMAR_5334|M.marinum_M               FQHSRHLNDFPVQYALIALAAIGGFILLIKKIWWP--------------L
MUL_0094|M.ulcerans_Agy99           FQHSRHLNDFPVQYALIALAAIGGFILLIKKIWWP--------------L
MLBr_00116|M.leprae_Br4923          LLHTRHLNDFPIQYGLVVLAAIGMAILLYQKIWWP--------------S
MAB_0205c|M.abscessus_ATCC_199      TQHTRHLADYPVQSALLGLALIGAVVLIVKRVYWP--------------V
Mvan_5631|M.vanbaalenii_PYR-1       EESVDGSLTRRFSVLILLLCLFGVLMVLLRRGSLPGAVNGPVWRLAGTTA
                                               ..  :: *. :*  ::: ::   *               

Mb3808|M.bovis_AF2122/97            AVWLLLIVMNVDAGTPLGGPIGGVAGA-------LGEFFYHDPRRIAAAT
Rv3779|M.tuberculosis_H37Rv         AVWLLLIVMNVDAGTPLGGPIGGVAGA-------LGEFFYHDPRRIAAAT
MMAR_5334|M.marinum_M               AVWVLLVVMNVNAGTPLGGPIDAMAGA-------LGEFFYNDPRRIAAAT
MUL_0094|M.ulcerans_Agy99           AVWLLLVVMNVNAGTPLGGPIDAMAGS-------LGEFFYNDPRRIAAAT
MLBr_00116|M.leprae_Br4923          IAWLVLTVATVYSAAPFRGPIGSAIES-------FSQFFYNDPRRLSAVV
MAB_0205c|M.abscessus_ATCC_199      AVWLLLVIAIVHSSKPFGGFVGHAVAL-------FSDAFYSDPRRLSAIV
Mvan_5631|M.vanbaalenii_PYR-1       IGLLLLTLTPTKWAVQFGVFAGLAGALGAITAFAFARVGLHSRRNLALYV
                                       ::* :  .  .  :    .            :.     . *.::  .

Mb3808|M.bovis_AF2122/97            TLLLMLMAG-----------------------------------------
Rv3779|M.tuberculosis_H37Rv         TLLLMLMAG-----------------------------------------
MMAR_5334|M.marinum_M               TLLLMLMAG-----------------------------------------
MUL_0094|M.ulcerans_Agy99           TLLLMLMAG-----------------------------------------
MLBr_00116|M.leprae_Br4923          TMLLTPMAG-----------------------------------------
MAB_0205c|M.abscessus_ATCC_199      CLLLAPAAG-----------------------------------------
Mvan_5631|M.vanbaalenii_PYR-1       TALLFVLAWATSGINGWFYVGNYGVPWFDKQPVIVGYPVTTIFLVLAIAC
                                      **   *                                          

Mb3808|M.bovis_AF2122/97            ------------------------------VALFATVMLLVAAAKRLTDR
Rv3779|M.tuberculosis_H37Rv         ------------------------------VALFATVMLLVAAAKRLTDR
MMAR_5334|M.marinum_M               ------------------------------VALFWIVTLVVTAAQGLTDR
MUL_0094|M.ulcerans_Agy99           ------------------------------VALFWIVTLVVAAARGLTDR
MLBr_00116|M.leprae_Br4923          ------------------------------IALFAGVLLLVVGARRVTAR
MAB_0205c|M.abscessus_ATCC_199      ------------------------------IGLFALAAAALATLR--RAR
Mvan_5631|M.vanbaalenii_PYR-1       GLLAGWLHFRMDYAGHTEVADTGRNRALASTPLLVVAVIMVVLELGSMLK
                                                                    *:  .   :.       :

Mb3808|M.bovis_AF2122/97            FRPQPVSVWASATATLLIGATLVSAWHYFPRHRFLFGDKYDSVMIDQK--
Rv3779|M.tuberculosis_H37Rv         FRPQPVSVWASATATLLIGATLVSAWHYFPRHRFLFGDKYDSVMIDQK--
MMAR_5334|M.marinum_M               FRPLPQPFWVSVTVALLLGVCLVSTWHYFPRHRFLFGDKYDSVMIDQK--
MUL_0094|M.ulcerans_Agy99           FRPLPQPFWVSVTVALLLGVCLVSTWHYFPRHRFLFGDKYDSVMIDQK--
MLBr_00116|M.leprae_Br4923          FTALPRPVWTTATVVLLVAATVLTAWHYLFRHLVLFGDKYDSVMVNQK--
MAB_0205c|M.abscessus_ATCC_199      KTRADSRWTLVAAAIVLAAICGFSARHYFLPHKYLVGAKYDQVMVGPK--
Mvan_5631|M.vanbaalenii_PYR-1       ATAGRYPVYTTGAANISALRSGLSDASCSMADAVLVEADTNAGMLTPVPG
                                                :. :      .:       .  *.  . :  *:     

Mb3808|M.bovis_AF2122/97            ------------------------DLDAMAYLASLPGARDT-------LI
Rv3779|M.tuberculosis_H37Rv         ------------------------DLDAMAYLASLPGARDT-------LI
MMAR_5334|M.marinum_M               ------------------------DLDAMAYLATLPGARDT-------MI
MUL_0094|M.ulcerans_Agy99           ------------------------DLDAMAYLATLPGARDT-------MI
MLBr_00116|M.leprae_Br4923          ------------------------DLDAMSYLATLPGAHNT-------II
MAB_0205c|M.abscessus_ATCC_199      ------------------------KLDAFAYLATLPGAKTT-------TI
Mvan_5631|M.vanbaalenii_PYR-1       QRFGEYGPLGGEDPVGFTPNGVSDTLEPAEPVAANPGTVNSDGPVDKPNI
                                                             *:.   :*: **:  :        *

Mb3808|M.bovis_AF2122/97            GNANTDGTA-----------------------------------------
Rv3779|M.tuberculosis_H37Rv         GNANTDGTA-----------------------------------------
MMAR_5334|M.marinum_M               GNANTDGTA-----------------------------------------
MUL_0094|M.ulcerans_Agy99           GDANTDGTA-----------------------------------------
MLBr_00116|M.leprae_Br4923          GNSNTDGSS-----------------------------------------
MAB_0205c|M.abscessus_ATCC_199      GDGNVDGSG-----------------------------------------
Mvan_5631|M.vanbaalenii_PYR-1       GVGYAAGTGGGYGPEGVNGSRVFLPFGLDPATTPVMGSFDENTLAAKATS
                                    * . . *:.                                         

Mb3808|M.bovis_AF2122/97            -----------------------WMYAVAG--------------------
Rv3779|M.tuberculosis_H37Rv         -----------------------WMYAVAG--------------------
MMAR_5334|M.marinum_M               -----------------------WMYAVAG--------------------
MUL_0094|M.ulcerans_Agy99           -----------------------WMYAVAG--------------------
MLBr_00116|M.leprae_Br4923          -----------------------WMYAVAD--------------------
MAB_0205c|M.abscessus_ATCC_199      -----------------------WMYAVAG--------------------
Mvan_5631|M.vanbaalenii_PYR-1       AWYQLPPRTPDRPLVSVAAAGAIWYYNEDGSFNYGQSLKLQWGVHRPDGS
                                                           * *   .                    

Mb3808|M.bovis_AF2122/97            -------------LHPLWTHYDYPLQQGP---------------------
Rv3779|M.tuberculosis_H37Rv         -------------LHPLWTHYDYPLQQGP---------------------
MMAR_5334|M.marinum_M               -------------LHPLWTHYDYPVQQGP---------------------
MUL_0094|M.ulcerans_Agy99           -------------LHPLWTHYDYPVQQGP---------------------
MLBr_00116|M.leprae_Br4923          -------------LHPLWTHYDFPQQTGP---------------------
MAB_0205c|M.abscessus_ATCC_199      -------------LHPLWTHYDFPQQQGP---------------------
Mvan_5631|M.vanbaalenii_PYR-1       YQELGEVQPIDIFVQKAWRNLRFPLEWAPPEANVARIVADDPNLSEDQWF
                                                 ::  * :  :* : .*                     

Mb3808|M.bovis_AF2122/97            --------------------------------------------------
Rv3779|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_5334|M.marinum_M               --------------------------------------------------
MUL_0094|M.ulcerans_Agy99           --------------------------------------------------
MLBr_00116|M.leprae_Br4923          --------------------------------------------------
MAB_0205c|M.abscessus_ATCC_199      --------------------------------------------------
Mvan_5631|M.vanbaalenii_PYR-1       AFTPPRVPVLQTAQDFLGRQTPVLMDIATAANFPCQRPFTEHLGIAELPE
                                                                                      

Mb3808|M.bovis_AF2122/97            -----GYHRFIF----WAYGRNGESDPRVLEAIQVLRIRYILTSTPTVRG
Rv3779|M.tuberculosis_H37Rv         -----GYHRFIF----WAYGRNGESDPRVLEAIQVLRIRYILTSTPTVRG
MMAR_5334|M.marinum_M               -----GYHRFIV----WAYAGRGDSDPRVVESIKVLNIRYILTSSPTVRG
MUL_0094|M.ulcerans_Agy99           -----GYHRFIF----WAYAGRGDSDPRVVESIKVLNIRYILTSSPTVRG
MLBr_00116|M.leprae_Br4923          -----GYFRYAF----WAYARTG--NPWVVEAVRVFNIRYILTTSPTVQG
MAB_0205c|M.abscessus_ATCC_199      -----GYHRYIF----WAYADDADTDRRVTEAVHALNIRYVMTSTPVVQG
Mvan_5631|M.vanbaalenii_PYR-1       YRIMPNFKQIVVSSNQWQAAQDGGPFLFIQALLRTESIPTYLSGDWYRDW
                                         .: :  .    *  .  .     :   ::.  *   ::       

Mb3808|M.bovis_AF2122/97            FAVPDGLVSLETSRSWAKIYDNGEARIYEWRGTAAATHS---
Rv3779|M.tuberculosis_H37Rv         FAVPDGLVSLETSRSWAKIYDNGEARIYEWRGTAAATHS---
MMAR_5334|M.marinum_M               FAVPDGLVSLENSPSWKKIYDNGGARIYEWSGKTAQTHSK--
MUL_0094|M.ulcerans_Agy99           FAVPDGLVSLENSPSWKKIYDNGGARIYEWSGKTAQTHSK--
MLBr_00116|M.leprae_Br4923          FAIPDGLVSLEESKSWTKIYDNGAARIFEWSGNATATRA---
MAB_0205c|M.abscessus_ATCC_199      FKVPDGLRSLDISRSWRKLYDNGAAQIYEWVGDRKPDAEGDK
Mvan_5631|M.vanbaalenii_PYR-1       GSLERYLRVVPKDEAPDAVIEEGSTRVFGWSRGGPIRALP--
                                      :   *  :  . :   : ::* :::: *