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M. tuberculosis H37Rv Rv3674c (nth)

annotation: PROBABLE ENDONUCLEASE III NTH (DNA-(APURINIC OR APYRIMIDINIC SITE)LYASE) (AP LYASE) (AP ENDONUCLEASE CLASS I) (ENDODEOXYRIBONUCLEASE (APURINIC OR APYRIMIDINIC)) (DEOXYRIBONUCLEASE (APURINIC OR APYRIMIDINIC))
coordinates: 4115157 - 4115894
length: 245

PGRWSAETRLALVRRARRMNRALAQAFPHVYCELDFTTPLELAVATILSAQSTDKRVNLTTPALFARYRT
ARDYAQADRTELESLIRPTGFYRNKAASLIGLGQALVERFGGEVPATMDKLVTLPGVGRKTANVILGNAF
GIPGITVDTHFGRLVRRWRWTTAEDPVKVEQAVGELIERKEWTLLSHRVIFHGRRVCHARRPACGVCVLA
KDCPSFGLGPTEPLLAAPLVQGPETDHLLALAGL*

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. tuberculosis H37Rv Rv3674c nth - 100% (245) PROBABLE ENDONUCLEASE III NTH (DNA-(APURINIC OR APYRIMIDINIC SITE)LYASE) (AP LYASE) (AP ENDONUCLEASE CLASS I) (ENDODEOXYRIBONUCLEASE (APURINIC OR APYRIMIDINIC)) (DEOXYRIBONUCLEASE (APURINIC OR APYRIMIDINIC))
M. tuberculosis H37Rv Rv3589 mutY 1e-06 27.12% (177) adenine glycosylase MutY

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb3698c nth 1e-141 100.00% (245) endonuclease III
M. gilvum PYR-GCK Mflv_1373 - 1e-122 85.54% (242) endonuclease III
M. leprae Br4923 MLBr_02301 nth 1e-125 88.57% (245) putative endonuclease III
M. abscessus ATCC 19977 MAB_0418 - 1e-116 82.16% (241) endonuclease III protein
M. marinum M MMAR_5162 nth 1e-127 88.57% (245) endonuclease III Nth
M. avium 104 MAV_0455 nth 1e-113 84.05% (232) endonuclease III
M. smegmatis MC2 155 MSMEG_6187 nth 1e-119 85.54% (242) endonuclease III
M. thermoresistible (build 8) TH_2130 nth 1e-102 82.79% (215) PROBABLE ENDONUCLEASE III NTH (DNA-(APURINIC OR APYRIMIDINIC
M. ulcerans Agy99 MUL_4248 nth 1e-122 90.13% (233) endonuclease III Nth
M. vanbaalenii PYR-1 Mvan_5433 - 1e-123 86.78% (242) endonuclease III

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_1373|M.gilvum_PYR-GCK          -----MTVSEPSTGAKSARRSARKWDRETHLGLVRRARRMNRTLTQAFPH
Mvan_5433|M.vanbaalenii_PYR-1       -----MTVK-PARGA-SPRKSGRKWDEETHLGLVRRARRMNRTLAQAFPH
MSMEG_6187|M.smegmatis_MC2_155      -----MSAG-AARAAKPKKSDAKKWDSETHLGLVRRARRMNRTLAKAFPH
TH_2130|M.thermoresistible__bu      --------------------------------------------------
Rv3674c|M.tuberculosis_H37Rv        --------------------MPGRWSAETRLALVRRARRMNRALAQAFPH
Mb3698c|M.bovis_AF2122/97           --------------------MPGRWSAETRLALVRRARRMNRALAQAFPH
MLBr_02301|M.leprae_Br4923          ------------MPLTPGVDVARRWSGETRLGLVRRARRMNRALAQAFPH
MAV_0455|M.avium_104                ---------------------------------MRRARRMNRILAQAFPE
MMAR_5162|M.marinum_M               -----MSGGSKPTANASTPKLPKRWSEETRTALVRRARRMNRKLAQAFPH
MUL_4248|M.ulcerans_Agy99           --------------------------------MVRRARRMNRKLAQAFPH
MAB_0418|M.abscessus_ATCC_1997      MPTTGSAAKPRAKSSVKAPAPVRAWKPETHTGLVRRARRMNRTLAQAFPH
                                                                                      

Mflv_1373|M.gilvum_PYR-GCK          VYCELDFTNPLELTVATILSAQSTDKRVNLTTPALFAKYRTARDYATADR
Mvan_5433|M.vanbaalenii_PYR-1       VYCELDFTDPLELTVATILSAQSTDKRVNLTTPALFKKYRTARDYATADR
MSMEG_6187|M.smegmatis_MC2_155      VYCELDFTNPLELTVATILSAQSTDKRVNLTTPALFKKYRTALDYAQADR
TH_2130|M.thermoresistible__bu      VYCELDFTNPLELTVATILSAQSTDKRVNLTTPALFRKYRTALDYAQADR
Rv3674c|M.tuberculosis_H37Rv        VYCELDFTTPLELAVATILSAQSTDKRVNLTTPALFARYRTARDYAQADR
Mb3698c|M.bovis_AF2122/97           VYCELDFTTPLELAVATILSAQSTDKRVNLTTPALFARYRTARDYAQADR
MLBr_02301|M.leprae_Br4923          VYCELDFTSPLELTVATILSAQSTDKRVNLTTPAVFARYRSALDYMQADR
MAV_0455|M.avium_104                AHCELDFTTPLELTVATILSAQSTDKRVNLTTRALFKRYTCALDYAQADR
MMAR_5162|M.marinum_M               VYCELDFTSPLELAVATILSAQSTDKRVNLTTPDLFVKYQTALDYAQADR
MUL_4248|M.ulcerans_Agy99           VYCELDFTSPLELAVATILSAQSTDKRVNLTTPDLFAKYQTALDYAQADR
MAB_0418|M.abscessus_ATCC_1997      VYCELDFTNPLELAVATILSAQCTDVRVNMVTPALFAKYRTAEDYAGANR
                                    .:****** ****:********.** ***:.*  :* :*  * **  *:*

Mflv_1373|M.gilvum_PYR-GCK          TELEELIRPTGFYRNKATSLIGLGQALEERFDGEVPRTLDELVTLPGIGR
Mvan_5433|M.vanbaalenii_PYR-1       TELEELIRPTGFYRNKANSLIGLGQALEERFDGQVPRTLDELVTLPGVGR
MSMEG_6187|M.smegmatis_MC2_155      TELEELIRPTGFYRNKANSLIKLGQELVERFDGEVPKTLDELVTLPGVGR
TH_2130|M.thermoresistible__bu      AELEELIRPTGFFRTKANSLIRLGQELVERFDGEVPDNLEDLVTLPGVGR
Rv3674c|M.tuberculosis_H37Rv        TELESLIRPTGFYRNKAASLIGLGQALVERFGGEVPATMDKLVTLPGVGR
Mb3698c|M.bovis_AF2122/97           TELESLIRPTGFYRNKAASLIGLGQALVERFGGEVPATMDKLVTLPGVGR
MLBr_02301|M.leprae_Br4923          AELENFIRPTGFFRNKAASLIRLGQALVERFDGEVPSTMVDLFTLPGVGR
MAV_0455|M.avium_104                DELENLIRPTGFFRNKASALIRLGQALVERFDGEVPATMAELVTLPGVGR
MMAR_5162|M.marinum_M               AELENLIRPTGFYRNKANSLIGLGQALVERFDGQVPATMEELVTLPGVGR
MUL_4248|M.ulcerans_Agy99           AELENLIRPTGFYRNKANSLIGLGQALVERFDGQVPATMEELVTLPGVGR
MAB_0418|M.abscessus_ATCC_1997      AELEEMIRTTGFYRNKANSIMGLGTQLVERFGGEIPPRLKDLVTLPGIGR
                                     ***.:**.***:*.** ::: **  * ***.*::*  : .*.****:**

Mflv_1373|M.gilvum_PYR-GCK          KTANVVLGNAFDIPGITVDTHFGRLVRRWRWTAEEDPVKVEHIVGDLIER
Mvan_5433|M.vanbaalenii_PYR-1       KTANVILGNAFDIPGITVDTHFGRLVRRWRWTAEEDPVKVEHIVGELIER
MSMEG_6187|M.smegmatis_MC2_155      KTANVILGNAFDIPGITVDTHFGRLVRRWRWTDHEDPVKVEFAVAELIER
TH_2130|M.thermoresistible__bu      KTANVILGNAFDVPGITVDTHFGRLVRRWRWTDERDPVKVEHAVGKLIER
Rv3674c|M.tuberculosis_H37Rv        KTANVILGNAFGIPGITVDTHFGRLVRRWRWTTAEDPVKVEQAVGELIER
Mb3698c|M.bovis_AF2122/97           KTANVILGNAFGIPGITVDTHFGRLVRRWRWTTAEDPVKVEQAVGELIER
MLBr_02301|M.leprae_Br4923          KTANVILGNAFGIPGITVDTHFGRLVRRWRWTAEEDPVKVEHAVGELIER
MAV_0455|M.avium_104                KTANVILGNAFGVPGITVDTHFARLVHRWRWTAEKDPVKIEHAVGELIER
MMAR_5162|M.marinum_M               KTANVILGNAFDVPGITVDTHFGRLARRWRWTAEEDPVKVEHAVGELIER
MUL_4248|M.ulcerans_Agy99           KTANVILGNAFDVPGITVDTHFGRLARRWRWTAEEDPVKVEHAVGELIER
MAB_0418|M.abscessus_ATCC_1997      KTANVILGNAFDIPGITVDTHFGRLVRRWRWTEEEDPVKVEHLVGELIER
                                    *****:*****.:*********.**.:*****  .****:*  *..****

Mflv_1373|M.gilvum_PYR-GCK          SEWTLLSHRVIFHGRRVCHARKPACGVCVLAKDCPSYGTGPTDPLIAAAL
Mvan_5433|M.vanbaalenii_PYR-1       SEWTLLSHRVIFHGRRVCHARKPACGVCVLAKDCPSYGAGPTDPLIAAPL
MSMEG_6187|M.smegmatis_MC2_155      SEWTLLSHRVIFHGRRVCHARKPACGVCVLAKDCPSYGIGPTDPPTAAAL
TH_2130|M.thermoresistible__bu      REWTLLSHRVIFHGRRVCHARKPACGVCVLADDCPSYGIGETDKLAAAEL
Rv3674c|M.tuberculosis_H37Rv        KEWTLLSHRVIFHGRRVCHARRPACGVCVLAKDCPSFGLGPTEPLLAAPL
Mb3698c|M.bovis_AF2122/97           KEWTLLSHRVIFHGRRVCHARRPACGVCVLAKDCPSFGLGPTEPLLAAPL
MLBr_02301|M.leprae_Br4923          DQWTLLSHRVIFHGRRVCHARKPACGVCVLAKDCPSFGLGPTEPLLAAPL
MAV_0455|M.avium_104                SEWTMLSHRVIFHGRRVCHSRKPACGVCLLARDCPSFGLGPTEPPLAAQL
MMAR_5162|M.marinum_M               KEWTLLSHRVIFHGRRVCHARKPACGVCVLAKDCPSYGLGPTEPLLAAPL
MUL_4248|M.ulcerans_Agy99           KEWTLLSHRVIFHGRRVCHARKPACGVCVLAKDCPSYGLGPTEPLLAAPL
MAB_0418|M.abscessus_ATCC_1997      KEWTLLSHRVIFHGRRVCHARKPACGVCVLAKDCPSYGLGPTDPEVAAPL
                                     :**:**************:*:******:** ****:* * *:   ** *

Mflv_1373|M.gilvum_PYR-GCK          VKGPETEHLLALAGL
Mvan_5433|M.vanbaalenii_PYR-1       VKGPETEHLLALAGL
MSMEG_6187|M.smegmatis_MC2_155      VKGPETEHLLALAGL
TH_2130|M.thermoresistible__bu      VRGPERDHLLALAGL
Rv3674c|M.tuberculosis_H37Rv        VQGPETDHLLALAGL
Mb3698c|M.bovis_AF2122/97           VQGPETDHLLALAGL
MLBr_02301|M.leprae_Br4923          VQGPEAGHLLALAGL
MAV_0455|M.avium_104                VRGPETEHLLALAGL
MMAR_5162|M.marinum_M               VQGPETEHLLAMAGL
MUL_4248|M.ulcerans_Agy99           VQGPETEHLLAMAGL
MAB_0418|M.abscessus_ATCC_1997      VKGPETEHLLALAGL
                                    *:***  ****:***

species	id	gene	e-value	identity (len)	annotation
M. tuberculosis H37Rv	Rv3674c	nth	-	100% (245)	PROBABLE ENDONUCLEASE III NTH (DNA-(APURINIC OR APYRIMIDINIC SITE)LYASE) (AP LYASE) (AP ENDONUCLEASE CLASS I) (ENDODEOXYRIBONUCLEASE (APURINIC OR APYRIMIDINIC)) (DEOXYRIBONUCLEASE (APURINIC OR APYRIMIDINIC))
M. tuberculosis H37Rv	Rv3589	mutY	1e-06	27.12% (177)	adenine glycosylase MutY