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MAAEPIEVGRISAFVRWVARTPWPVFTLGMLQADIIGALLVLGFLRFGLPPEDRIQLQDLPAYNLAIFLG YLFISFTVASYVTLRMLIPVMRWQRREMLLGDRDPAETEVARMRALKMPFYRSLISATNWLLGSVVFIVA SWPVASKSAPVVAVATALGATATAIIGYLQSERVLRPVAVAALRGGVPENFRAPGVILRQVLSWVLSTGV PVLAILLALIASKLEVLTAPADRLITTILLLSIVALVIGLSSTVLVAMSIADPLRQLRWALGEVQRGNYN AHMQIYDASELGLLQAGFNDMVRDLAERQRLRDLFGRYVGEDVARRALERGTELGGQERDVAVLFVDLVG STHLAATRPAAEVVNLLNEFFRVVVDTVNRHGGFVNKFQGDAALAIFGAPIEHPDASGAALAASRELHDE LIRVLGETDFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEPGHVLASAIAVADALDAE ALCWDVGEIVELRGRTAPTQLARPVNLVSPDDVSQEVASDRR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5395 | - | - | 100% (532) | putative adenylate/guanylate cyclase |
| M. vanbaalenii PYR-1 | Mvan_4309 | - | 1e-89 | 40.33% (491) | putative adenylate/guanylate cyclase |
| M. vanbaalenii PYR-1 | Mvan_4265 | - | 1e-83 | 42.56% (430) | putative adenylate/guanylate cyclase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3669 | - | 0.0 | 78.38% (518) | transmembrane protein |
| M. gilvum PYR-GCK | Mflv_1395 | - | 0.0 | 93.96% (530) | putative adenylate/guanylate cyclase |
| M. tuberculosis H37Rv | Rv3645 | - | 0.0 | 78.38% (518) | transmembrane protein |
| M. leprae Br4923 | MLBr_00201 | - | 0.0 | 76.11% (519) | hypothetical protein MLBr_00201 |
| M. abscessus ATCC 19977 | MAB_0490c | - | 0.0 | 69.03% (507) | putative adenylate cyclase |
| M. marinum M | MMAR_5137 | - | 0.0 | 77.74% (521) | adenylate cyclase |
| M. avium 104 | MAV_0518 | - | 0.0 | 78.78% (523) | adenylate cyclase, family protein 3 |
| M. smegmatis MC2 155 | MSMEG_6154 | - | 0.0 | 87.40% (524) | adenylate cyclase, family protein 3 |
| M. thermoresistible (build 8) | TH_0858 | - | 0.0 | 86.61% (493) | PROBABLE CONSERVED TRANSMEMBRANE PROTEIN |
| M. ulcerans Agy99 | MUL_4221 | - | 0.0 | 77.35% (521) | adenylate cyclase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5395|M.vanbaalenii_PYR-1 --------------------MAAEPI-----EVGRISAFVRWVARTPWPV
Mflv_1395|M.gilvum_PYR-GCK --------------------MAADPT-----ETGRISAFVRWVARTPWPV
MSMEG_6154|M.smegmatis_MC2_155 --------------------MTTEPI-----PIARIGAFARWVARTPWPV
TH_0858|M.thermoresistible__bu -------------------------------------------------V
Mb3669|M.bovis_AF2122/97 MDAEAFVGFRQVPAARYGGLMATTAA-----LPRRIHAFVRWVVRTPWPL
Rv3645|M.tuberculosis_H37Rv MDAEAFVGFRQVPAARYGGLMATTAA-----LPRRIHAFVRWVVRTPWPL
MMAR_5137|M.marinum_M --------------------MATVAT-----LPGRINGFARWVVRTPWPV
MUL_4221|M.ulcerans_Agy99 --------------------MATVAT-----LPGRINGFARWVVRTPWPV
MLBr_00201|M.leprae_Br4923 --------------------MATQAAG----LPGRIGAFVRWGIRTPWPL
MAV_0518|M.avium_104 --------------------MTTAAA-----LPGRISAFARWVVRTPWPL
MAB_0490c|M.abscessus_ATCC_199 --------------------MTGAEGRPDRRPLARAARYSRWVMRTPWPL
:
Mvan_5395|M.vanbaalenii_PYR-1 FTLGMLQADIIGALLVLGFLRFGLPPEDRIQLQDLPAYNLAIFLGYLFIS
Mflv_1395|M.gilvum_PYR-GCK FTLGMLQADIIGALLVLGFLRFGLPPEDRIQLQDLPAYNLAIFLGYLFVS
MSMEG_6154|M.smegmatis_MC2_155 FTLGMLQADIIGALFVLGFLRFGLPPEDRIQLQDLPAFNLAIFLAYLFVS
TH_0858|M.thermoresistible__bu FALGMVQADIIGALFVLGFLRFGLPPGDRLELQDLPAFNLALFLGYLVVS
Mb3669|M.bovis_AF2122/97 FSLSMLQSDIIGALFVLGFLRYGLPPQDNIQLQDLPPVNLLIFVSTVIIL
Rv3645|M.tuberculosis_H37Rv FSLSMLQSDIIGALFVLGFLRYGLPPQDNIQLQDLPPVNLLIFVSTVIIL
MMAR_5137|M.marinum_M FSLSMLQADIIGGLFVLGFLRYGLPPNDRIQLQDLPPLNLAIFLTSVITL
MUL_4221|M.ulcerans_Agy99 FSLSMLQADIIGGLFVLGFLRYGLPPNDRIQLQDLPPLNLAIFLTSVITL
MLBr_00201|M.leprae_Br4923 FSLSMLQSDIIGALFVLGFLRYGLPPQDRVELQDLPIRNLAISTLSVVVA
MAV_0518|M.avium_104 FWLSMMQADIIGALFVLGFLRYALPPEDRIQLQDLPVVNLAVFATSLVVL
MAB_0490c|M.abscessus_ATCC_199 FIMGIAQSNLVGALFVLGFLRFGLPPSDRVELTELGPTRLIILGFSLFIL
* :.: *::::*.*:******:.*** *.::* :* .* : :.
Mvan_5395|M.vanbaalenii_PYR-1 FTVASYVTLRMLIPVMRWQRREMLLGDRDPAETEVARMRALKMPFYRSLI
Mflv_1395|M.gilvum_PYR-GCK FTVASYLTLRMLIPVMRWQRRDMLLGDRDPSDTEVARMRALKMPFYRSLI
MSMEG_6154|M.smegmatis_MC2_155 FTVGAYLALRLLIPVIRWQRRETVLSEGDPGITELARARALKMPFYRTLI
TH_0858|M.thermoresistible__bu FTVGAYVTLRLLLPVIRWQRRDTLLADPDPAATELARARALRMPFYRTLI
Mb3669|M.bovis_AF2122/97 FLAGAVVNLKLLMPVFRWQRRDNLLTEPDPAATELARSRALRMPLYRTLI
Rv3645|M.tuberculosis_H37Rv FLAGAVVNLKLLMPVFRWQRRDNLLTEPDPAATELARSRALRMPLYRTLI
MMAR_5137|M.marinum_M FLAGFALNLKLLVPVFRWQRRDNLVAAADPSATELARSRVLRMPFYRTLI
MUL_4221|M.ulcerans_Agy99 FLAGFALNLKLLVPVFRWQRRDNLVAAADPSATELARSRVLRMPFYRTLI
MLBr_00201|M.leprae_Br4923 FSTGFAVNLKLLMPVFRWQRRDNRLAEADPAATELARSRALRMPFYHTII
MAV_0518|M.avium_104 FLAASVVNLTLLMPVFRWQRRDNLLAESDPAATELARIRALRMPFYRTVT
MAB_0490c|M.abscessus_ATCC_199 FVVGAIVSTYLLLPVLRWQYRS---PDFESEGSEAVRVRALQMPFYRTVI
* .. : :*:**:*** *. :. :* .* *.*:**:*:::
Mvan_5395|M.vanbaalenii_PYR-1 SATNWLLGSVVFIVASWPVASKSAPVVAVATALGATATAIIGYLQSERVL
Mflv_1395|M.gilvum_PYR-GCK SATNWLLGSVVFIVASWPVASKSAPVVAVATGLGATATAIIGYLQSERVL
MSMEG_6154|M.smegmatis_MC2_155 SVTNWCLGSIVFIVASWPVASHSAPVVAVATALGATATAIIGYLQSERVL
TH_0858|M.thermoresistible__bu SGTNWFLGTIVFIVASWPVAGHSAPVIAVATGLGATATAIIGYLQAERVL
Mb3669|M.bovis_AF2122/97 SLAVWATGGGVFILASWSVAKHAAPVVAVATALGATATAIIGYLQSERVL
Rv3645|M.tuberculosis_H37Rv SLAVWATGGGVFILASWSVAKHAAPVVAVATALGATATAIIGYLQSERVL
MMAR_5137|M.marinum_M SVGSWAIGSVIFIVASWSVARYAAPVVAIATALGAIATAIIGYLQSERVL
MUL_4221|M.ulcerans_Agy99 SVGSWAIGSVIFIVASWSVARYAAPVVAIATALGAIATAIIGYLQSERVL
MLBr_00201|M.leprae_Br4923 SLVTWGIGGAVFIIASWSAARHSAPIVALATALGATATAIIGYLQSERVL
MAV_0518|M.avium_104 SMVIWCIGGVVFIIASWSVARFAAPVVAVATGLGAAATAIIGYLQCERVL
MAB_0490c|M.abscessus_ATCC_199 SVATWLVGGAIFVAVTWSSTHSSVLVAAFATVLGATTTSIIGYLQSERVL
* * * :*: .:*. : :. : *.** *** :*:******.****
Mvan_5395|M.vanbaalenii_PYR-1 RPVAVAALRGGVPENFRAPGVILRQVLSWVLSTGVPVLAILLALIASKLE
Mflv_1395|M.gilvum_PYR-GCK RPVAVAALRGGVPENFRAPGVILRQVLTWVLSTGVPVLAIVLALVASKFE
MSMEG_6154|M.smegmatis_MC2_155 RPVAVAALRGGVPENFRAPGVILRQVLTWVLSTGVPLLAIILALVASKFS
TH_0858|M.thermoresistible__bu RPVAVAALRGGVPENFRAPGVVLRQVLTWVLSTGVPVLAIVLALVASKVG
Mb3669|M.bovis_AF2122/97 RPVAVAALRSGVPENVNAPGVILRLMLAWIPSTGVPLLAIVLAVAADKIA
Rv3645|M.tuberculosis_H37Rv RPVAVAALRSGVPENVNAPGVILRLMLAWIPSTGVPLLAIVLAVAADKIA
MMAR_5137|M.marinum_M RPVAVAALRSGVPENLRSPGVILRLMLAWVLSTAVPLLAIVLAVVADKMA
MUL_4221|M.ulcerans_Agy99 RPVAVAALRSGVPENLRSPGVISRLMLAWVLSTAVPLLAIVLAVVADKMA
MLBr_00201|M.leprae_Br4923 RPVAVAALRSGVPENVKTPGVTLRLMLTWVPSTGVPVLAIVLAVVADKIA
MAV_0518|M.avium_104 RPVAVAALRSGVPENVKAPGVILRQILTWMLSTAVPVLAIVLAVVADKTS
MAB_0490c|M.abscessus_ATCC_199 RPVAIQALRRGVPENVTAPGVIVRQILTWALSTGVPILAIVLTVVGQRAG
****: *** *****. :*** * :*:* **.**:***:*:: ..:
Mvan_5395|M.vanbaalenii_PYR-1 VLTAPADRLITTILLLSIVALVIGLSSTVLVAMSIADPLRQLRWALGEVQ
Mflv_1395|M.gilvum_PYR-GCK VLTAPADRLITTILLLAIVALIIGLSSTVLVAMSIADPLRQLRWALGEVQ
MSMEG_6154|M.smegmatis_MC2_155 ILTASADRLNTPILLLAVAALVIGMSSTVLVAMSIADPLRQLRWALGEVQ
TH_0858|M.thermoresistible__bu ILTAPAEQLTTPLLVLAIATLVIGLSGTVLVAMSIADPLRQLRWALGEVQ
Mb3669|M.bovis_AF2122/97 LLHATPEALFNPILMMALAALGIGSVSTLLVAMSIADPLRQLRWALSEVQ
Rv3645|M.tuberculosis_H37Rv LLHATPEALFNPILMMALAALGIGSVSTLLVAMSIADPLRQLRWALSEVQ
MMAR_5137|M.marinum_M ILHATPDKLFNPILLLALAALAIGSASTLLVSMSIADPLRQLRWALSEVQ
MUL_4221|M.ulcerans_Agy99 ILHATPDKLFNPILLLALAALAIGSASTLLVSMSIADPLRQLRWALSEVQ
MLBr_00201|M.leprae_Br4923 LLHAVPEQLFSPILLLALAVLVVGLVSTWLVAMSIADPLRQLRWALSEVQ
MAV_0518|M.avium_104 LLHATPEKLFTPILLLAVAALGIGLVSTLLVAMSIADPLRQLRWALSEVQ
MAB_0490c|M.abscessus_ATCC_199 YLKSNADNLTGSILILAIIALAIGLMGTLLVATSIADPLRQLRWALSEVQ
* : .: * .:*:::: .* :* .* **: *************.***
Mvan_5395|M.vanbaalenii_PYR-1 RGNYNAHMQIYDASELGLLQAGFNDMVRDLAERQRLRDLFGRYVGEDVAR
Mflv_1395|M.gilvum_PYR-GCK RGNYNAHMQIYDASELGLLQAGFNDMVRDLAERQRLRDLFGRYVGEDVAR
MSMEG_6154|M.smegmatis_MC2_155 RGNYNAHMQIYDASELGLLQAGFNDMVRDLAERQRLRDLFGRYVGEDVAR
TH_0858|M.thermoresistible__bu RGNFNAHMQIYDASELGLLQAGFNDMVRDLAERQRLRDLFGRYVGEDVAR
Mb3669|M.bovis_AF2122/97 RGNYNAHMQIYDASELGLLQAGFNDMVRELSERQRLRDLFGRYVGEDVAR
Rv3645|M.tuberculosis_H37Rv RGNYNAHMQIYDASELGLLQAGFNDMVRELSERQRLRDLFGRYVGEDVAR
MMAR_5137|M.marinum_M RGNYNAHMQIYDASELGLLQAGFNDMVRDLSERQRLRDLFGRYVGEDVAR
MUL_4221|M.ulcerans_Agy99 RGNYNAHMQIYDASELGLLQAGFNDMVRDLSERQRLRDLFGRYVGEDVAR
MLBr_00201|M.leprae_Br4923 RGNYNAHMQIYDASELGLLQAGFNDMVRELSERQRLRDLFGRYVGEDVAR
MAV_0518|M.avium_104 RGNYNAHMQIYDASELGLLQAGFNDMVRDLSERQRLRDLFGRYVGEDVAR
MAB_0490c|M.abscessus_ATCC_199 RGNYNAHVPIYDASELGLLQAGFNDMVRDLGERQRLRDLFGRYVGEDVAR
***:***: *******************:*.*******************
Mvan_5395|M.vanbaalenii_PYR-1 RALERGTELGGQERDVAVLFVDLVGSTHLAATRPAAEVVNLLNEFFRVVV
Mflv_1395|M.gilvum_PYR-GCK RALERGTELGGQERDVAVLFVDLVGSTHLAATIPASEVVSLLNEFFRVVV
MSMEG_6154|M.smegmatis_MC2_155 RALERGTELGGQERDVAVLFVDLVGSTHLASTIPAADVVNLLNEFFRVIV
TH_0858|M.thermoresistible__bu RALERGTELGGQERDVAVLFVDLVGSTRLAATTPPADVVNLLNEFFRVVV
Mb3669|M.bovis_AF2122/97 RALERGTELGGQERDVAVLFVDLVGSTQLAATRPPAEVVQLLNEFFRVVV
Rv3645|M.tuberculosis_H37Rv RALERGTELGGQERDVAVLFVDLVGSTQLAATRPPAEVVQLLNEFFRVVV
MMAR_5137|M.marinum_M RAIERGTELGGQERDVAVLFVDLVGSTQLAATRPPVEVVGLLNEFFRVVV
MUL_4221|M.ulcerans_Agy99 RAIERGTELGGQERDVAVLFVDLVGSTQLAATRPPVEVVGLLNEFFRVVV
MLBr_00201|M.leprae_Br4923 RALEHGTELGGQERDVAVLFVDLIGSTQLAETKPPTKVVHLLNEFFRVVV
MAV_0518|M.avium_104 RALERGTELGGQERDVAVLFVDLVGSTQLAATRPPAEVVHLLNEFFRVVV
MAB_0490c|M.abscessus_ATCC_199 RALEYGTELGGQERSVAVLFVDLVGSTQLASTRGPAVVVRVLNEFFRVIV
**:* *********.********:***:** * . ** :*******:*
Mvan_5395|M.vanbaalenii_PYR-1 DTVNRHGGFVNKFQGDAALAIFGAPIEHPDASGAALAASRELHDELIRVL
Mflv_1395|M.gilvum_PYR-GCK DTVNRHGGFVNKFQGDAALAIFGAPIEHPDASGAALAASRELHDELINVL
MSMEG_6154|M.smegmatis_MC2_155 DTVNKHGGFVNKFQGDAALAIFGAPIEHPDASGGALAASRELHDELIKVL
TH_0858|M.thermoresistible__bu DTVNRHGGFVNKFQGDAALAIFGAPIEHPDACGAALAAARELHDELIAVL
Mb3669|M.bovis_AF2122/97 ETVARHGGFVNKFQGDAALAIFGAPIEHPDGAGAALSAARELHDELIPVL
Rv3645|M.tuberculosis_H37Rv ETVARHGGFVNKFQGDAALAIFGAPIEHPDGAGAALSAARELHDELIPVL
MMAR_5137|M.marinum_M DTVARHGGFVNKFQGDAALAIFGAPIEHPDGAGAALRAARELHDELIPVL
MUL_4221|M.ulcerans_Agy99 DTVARHGGFVNKFQGDAALAIFGAPIEHPDGAGAALRAARELHDELIPVL
MLBr_00201|M.leprae_Br4923 DTVGRHGGFVNKFQGDAALAIFGAPIEHPDSAGAALSAARELHDELLPVL
MAV_0518|M.avium_104 ETVGKHGGFVNKFQGDAALAIFGAPIEHPDSPGGALAAARELHDALLPVI
MAB_0490c|M.abscessus_ATCC_199 DTVNKHGGFVNKFQGDAALAIFGAPIDHPDGAAAALAAARELSGELTNVL
:** :*********************:***. ..** *:*** . * *:
Mvan_5395|M.vanbaalenii_PYR-1 G-ETDFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEPG
Mflv_1395|M.gilvum_PYR-GCK G-ETEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEPG
MSMEG_6154|M.smegmatis_MC2_155 GTETEFGIGVSAGRAIAGHIGAKARFEYTVIGDPVNEAARLTELAKLEEG
TH_0858|M.thermoresistible__bu G-ETEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEEG
Mb3669|M.bovis_AF2122/97 G-SAEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEDG
Rv3645|M.tuberculosis_H37Rv G-SAEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEDG
MMAR_5137|M.marinum_M G-SAEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEEG
MUL_4221|M.ulcerans_Agy99 G-SAEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEEG
MLBr_00201|M.leprae_Br4923 G-SAEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEDG
MAV_0518|M.avium_104 G-SAEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEPG
MAB_0490c|M.abscessus_ATCC_199 G-SNDFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKNEPG
* . :*****************:*********************** * *
Mvan_5395|M.vanbaalenii_PYR-1 HVLASAIAVADALDAEALCWDVGEIVELRGRTAPTQLARPVNLVSPDDVS
Mflv_1395|M.gilvum_PYR-GCK HVLASSLAVADALDAEALCWNVGEVVELRGRTAPTQLARPVNLIRPPRVE
MSMEG_6154|M.smegmatis_MC2_155 HVLASAIAVSGALDSEALCWDVGEIVELRGRTVPTQLARPINLARPEDLD
TH_0858|M.thermoresistible__bu HVLASAMAVSGALDAEALCWDVGETVELRGRTVPTQLARPVKLAFSNGPG
Mb3669|M.bovis_AF2122/97 HVLASAIAVSGALDAEALCWDVGEVVELRGRAAPTQLARPMNLAAPEEVS
Rv3645|M.tuberculosis_H37Rv HVLASAIAVSGALDAEALCWDVGEVVELRGRAAPTQLARPMNLAAPEEVS
MMAR_5137|M.marinum_M HVLASAIAISGALDAEALCWDVAEVVELRGRTAPTQLARPLNLAVAQQVS
MUL_4221|M.ulcerans_Agy99 HVLASAFAISGALDAEALCWDVAEVVELRGRTAPTQLARPLNLAVAQKVS
MLBr_00201|M.leprae_Br4923 HVLASAIAVSGALDAEALCWNVGEIVELRGRTAPTQLARPLNLAVPEQIT
MAV_0518|M.avium_104 HVLASAIAVSGALDSEALCWDVGEVVELRGRTAPTQLARPVKLATPEEVA
MAB_0490c|M.abscessus_ATCC_199 NVLASASAVMEARDEEALRWDVGETVELRGRTVSTQVARPRHG-------
:****: *: * * *** *:*.* ******:..**:*** :
Mvan_5395|M.vanbaalenii_PYR-1 QE-VASDRR------------------------------
Mflv_1395|M.gilvum_PYR-GCK EK-VADDVPSTTR--------------------------
MSMEG_6154|M.smegmatis_MC2_155 GS-ANGQSTDGSPAETAFQQEKGLFAVEGVEVVGASVPG
TH_0858|M.thermoresistible__bu PS-NNSDAPGTRTTGSVSRADAETTAPES----------
Mb3669|M.bovis_AF2122/97 -----SEVRG-----------------------------
Rv3645|M.tuberculosis_H37Rv -----SEVRG-----------------------------
MMAR_5137|M.marinum_M -----TKSGS-----------------------------
MUL_4221|M.ulcerans_Agy99 -----TKSGS-----------------------------
MLBr_00201|M.leprae_Br4923 -----SEVTG-----------------------------
MAV_0518|M.avium_104 PQEVSSEVSG-----------------------------
MAB_0490c|M.abscessus_ATCC_199 ---------------------------------------