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M. marinum M MMAR_5137 (-)

annotation: adenylate cyclase
coordinates: 6217734 - 6219323
length: 529

VATVATLPGRINGFARWVVRTPWPVFSLSMLQADIIGGLFVLGFLRYGLPPNDRIQLQDLPPLNLAIFLT
SVITLFLAGFALNLKLLVPVFRWQRRDNLVAAADPSATELARSRVLRMPFYRTLISVGSWAIGSVIFIVA
SWSVARYAAPVVAIATALGAIATAIIGYLQSERVLRPVAVAALRSGVPENLRSPGVILRLMLAWVLSTAV
PLLAIVLAVVADKMAILHATPDKLFNPILLLALAALAIGSASTLLVSMSIADPLRQLRWALSEVQRGNYN
AHMQIYDASELGLLQAGFNDMVRDLSERQRLRDLFGRYVGEDVARRAIERGTELGGQERDVAVLFVDLVG
STQLAATRPPVEVVGLLNEFFRVVVDTVARHGGFVNKFQGDAALAIFGAPIEHPDGAGAALRAARELHDE
LIPVLGSAEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEEGHVLASAIAISGALDAE
ALCWDVAEVVELRGRTAPTQLARPLNLAVAQQVSTKSGS
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. marinum MMMAR_5137--100% (529)adenylate cyclase
M. marinum MMMAR_4370-2e-9142.89% (457) hypothetical protein MMAR_4370
M. marinum MMMAR_3640-3e-8739.92% (491) adenylate cyclase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3669-0.085.93% (526) transmembrane protein
M. gilvum PYR-GCKMflv_1395-0.077.76% (526) putative adenylate/guanylate cyclase
M. tuberculosis H37RvRv3645-0.085.93% (526) transmembrane protein
M. leprae Br4923MLBr_00201-0.082.54% (527) hypothetical protein MLBr_00201
M. abscessus ATCC 19977MAB_0490c-0.068.66% (501) putative adenylate cyclase
M. avium 104MAV_0518-0.082.99% (529) adenylate cyclase, family protein 3
M. smegmatis MC2 155MSMEG_6154-0.080.20% (510) adenylate cyclase, family protein 3
M. thermoresistible (build 8)TH_0858-0.079.15% (494) PROBABLE CONSERVED TRANSMEMBRANE PROTEIN
M. ulcerans Agy99MUL_4221-0.099.43% (529) adenylate cyclase
M. vanbaalenii PYR-1Mvan_5395-0.077.74% (521) putative adenylate/guanylate cyclase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_1395|M.gilvum_PYR-GCK          --------------------MAADPT-----ETGRISAFVRWVARTPWPV
Mvan_5395|M.vanbaalenii_PYR-1       --------------------MAAEPI-----EVGRISAFVRWVARTPWPV
MSMEG_6154|M.smegmatis_MC2_155      --------------------MTTEPI-----PIARIGAFARWVARTPWPV
TH_0858|M.thermoresistible__bu      -------------------------------------------------V
MMAR_5137|M.marinum_M               --------------------MATVAT-----LPGRINGFARWVVRTPWPV
MUL_4221|M.ulcerans_Agy99           --------------------MATVAT-----LPGRINGFARWVVRTPWPV
Mb3669|M.bovis_AF2122/97            MDAEAFVGFRQVPAARYGGLMATTAA-----LPRRIHAFVRWVVRTPWPL
Rv3645|M.tuberculosis_H37Rv         MDAEAFVGFRQVPAARYGGLMATTAA-----LPRRIHAFVRWVVRTPWPL
MLBr_00201|M.leprae_Br4923          --------------------MATQAAG----LPGRIGAFVRWGIRTPWPL
MAV_0518|M.avium_104                --------------------MTTAAA-----LPGRISAFARWVVRTPWPL
MAB_0490c|M.abscessus_ATCC_199      --------------------MTGAEGRPDRRPLARAARYSRWVMRTPWPL
                                                                                     :

Mflv_1395|M.gilvum_PYR-GCK          FTLGMLQADIIGALLVLGFLRFGLPPEDRIQLQDLPAYNLAIFLGYLFVS
Mvan_5395|M.vanbaalenii_PYR-1       FTLGMLQADIIGALLVLGFLRFGLPPEDRIQLQDLPAYNLAIFLGYLFIS
MSMEG_6154|M.smegmatis_MC2_155      FTLGMLQADIIGALFVLGFLRFGLPPEDRIQLQDLPAFNLAIFLAYLFVS
TH_0858|M.thermoresistible__bu      FALGMVQADIIGALFVLGFLRFGLPPGDRLELQDLPAFNLALFLGYLVVS
MMAR_5137|M.marinum_M               FSLSMLQADIIGGLFVLGFLRYGLPPNDRIQLQDLPPLNLAIFLTSVITL
MUL_4221|M.ulcerans_Agy99           FSLSMLQADIIGGLFVLGFLRYGLPPNDRIQLQDLPPLNLAIFLTSVITL
Mb3669|M.bovis_AF2122/97            FSLSMLQSDIIGALFVLGFLRYGLPPQDNIQLQDLPPVNLLIFVSTVIIL
Rv3645|M.tuberculosis_H37Rv         FSLSMLQSDIIGALFVLGFLRYGLPPQDNIQLQDLPPVNLLIFVSTVIIL
MLBr_00201|M.leprae_Br4923          FSLSMLQSDIIGALFVLGFLRYGLPPQDRVELQDLPIRNLAISTLSVVVA
MAV_0518|M.avium_104                FWLSMMQADIIGALFVLGFLRYALPPEDRIQLQDLPVVNLAVFATSLVVL
MAB_0490c|M.abscessus_ATCC_199      FIMGIAQSNLVGALFVLGFLRFGLPPSDRVELTELGPTRLIILGFSLFIL
                                    * :.: *::::*.*:******:.*** *.::* :*   .* :    :.  

Mflv_1395|M.gilvum_PYR-GCK          FTVASYLTLRMLIPVMRWQRRDMLLGDRDPSDTEVARMRALKMPFYRSLI
Mvan_5395|M.vanbaalenii_PYR-1       FTVASYVTLRMLIPVMRWQRREMLLGDRDPAETEVARMRALKMPFYRSLI
MSMEG_6154|M.smegmatis_MC2_155      FTVGAYLALRLLIPVIRWQRRETVLSEGDPGITELARARALKMPFYRTLI
TH_0858|M.thermoresistible__bu      FTVGAYVTLRLLLPVIRWQRRDTLLADPDPAATELARARALRMPFYRTLI
MMAR_5137|M.marinum_M               FLAGFALNLKLLVPVFRWQRRDNLVAAADPSATELARSRVLRMPFYRTLI
MUL_4221|M.ulcerans_Agy99           FLAGFALNLKLLVPVFRWQRRDNLVAAADPSATELARSRVLRMPFYRTLI
Mb3669|M.bovis_AF2122/97            FLAGAVVNLKLLMPVFRWQRRDNLLTEPDPAATELARSRALRMPLYRTLI
Rv3645|M.tuberculosis_H37Rv         FLAGAVVNLKLLMPVFRWQRRDNLLTEPDPAATELARSRALRMPLYRTLI
MLBr_00201|M.leprae_Br4923          FSTGFAVNLKLLMPVFRWQRRDNRLAEADPAATELARSRALRMPFYHTII
MAV_0518|M.avium_104                FLAASVVNLTLLMPVFRWQRRDNLLAESDPAATELARIRALRMPFYRTVT
MAB_0490c|M.abscessus_ATCC_199      FVVGAIVSTYLLLPVLRWQYRS---PDFESEGSEAVRVRALQMPFYRTVI
                                    * ..  :   :*:**:*** *.      :.  :* .* *.*:**:*::: 

Mflv_1395|M.gilvum_PYR-GCK          SATNWLLGSVVFIVASWPVASKSAPVVAVATGLGATATAIIGYLQSERVL
Mvan_5395|M.vanbaalenii_PYR-1       SATNWLLGSVVFIVASWPVASKSAPVVAVATALGATATAIIGYLQSERVL
MSMEG_6154|M.smegmatis_MC2_155      SVTNWCLGSIVFIVASWPVASHSAPVVAVATALGATATAIIGYLQSERVL
TH_0858|M.thermoresistible__bu      SGTNWFLGTIVFIVASWPVAGHSAPVIAVATGLGATATAIIGYLQAERVL
MMAR_5137|M.marinum_M               SVGSWAIGSVIFIVASWSVARYAAPVVAIATALGAIATAIIGYLQSERVL
MUL_4221|M.ulcerans_Agy99           SVGSWAIGSVIFIVASWSVARYAAPVVAIATALGAIATAIIGYLQSERVL
Mb3669|M.bovis_AF2122/97            SLAVWATGGGVFILASWSVAKHAAPVVAVATALGATATAIIGYLQSERVL
Rv3645|M.tuberculosis_H37Rv         SLAVWATGGGVFILASWSVAKHAAPVVAVATALGATATAIIGYLQSERVL
MLBr_00201|M.leprae_Br4923          SLVTWGIGGAVFIIASWSAARHSAPIVALATALGATATAIIGYLQSERVL
MAV_0518|M.avium_104                SMVIWCIGGVVFIIASWSVARFAAPVVAVATGLGAAATAIIGYLQCERVL
MAB_0490c|M.abscessus_ATCC_199      SVATWLVGGAIFVAVTWSSTHSSVLVAAFATVLGATTTSIIGYLQSERVL
                                    *   *  *  :*: .:*. :  :. : *.** *** :*:******.****

Mflv_1395|M.gilvum_PYR-GCK          RPVAVAALRGGVPENFRAPGVILRQVLTWVLSTGVPVLAIVLALVASKFE
Mvan_5395|M.vanbaalenii_PYR-1       RPVAVAALRGGVPENFRAPGVILRQVLSWVLSTGVPVLAILLALIASKLE
MSMEG_6154|M.smegmatis_MC2_155      RPVAVAALRGGVPENFRAPGVILRQVLTWVLSTGVPLLAIILALVASKFS
TH_0858|M.thermoresistible__bu      RPVAVAALRGGVPENFRAPGVVLRQVLTWVLSTGVPVLAIVLALVASKVG
MMAR_5137|M.marinum_M               RPVAVAALRSGVPENLRSPGVILRLMLAWVLSTAVPLLAIVLAVVADKMA
MUL_4221|M.ulcerans_Agy99           RPVAVAALRSGVPENLRSPGVISRLMLAWVLSTAVPLLAIVLAVVADKMA
Mb3669|M.bovis_AF2122/97            RPVAVAALRSGVPENVNAPGVILRLMLAWIPSTGVPLLAIVLAVAADKIA
Rv3645|M.tuberculosis_H37Rv         RPVAVAALRSGVPENVNAPGVILRLMLAWIPSTGVPLLAIVLAVAADKIA
MLBr_00201|M.leprae_Br4923          RPVAVAALRSGVPENVKTPGVTLRLMLTWVPSTGVPVLAIVLAVVADKIA
MAV_0518|M.avium_104                RPVAVAALRSGVPENVKAPGVILRQILTWMLSTAVPVLAIVLAVVADKTS
MAB_0490c|M.abscessus_ATCC_199      RPVAIQALRRGVPENVTAPGVIVRQILTWALSTGVPILAIVLTVVGQRAG
                                    ****: *** *****. :***  * :*:*  **.**:***:*:: ..:  

Mflv_1395|M.gilvum_PYR-GCK          VLTAPADRLITTILLLAIVALIIGLSSTVLVAMSIADPLRQLRWALGEVQ
Mvan_5395|M.vanbaalenii_PYR-1       VLTAPADRLITTILLLSIVALVIGLSSTVLVAMSIADPLRQLRWALGEVQ
MSMEG_6154|M.smegmatis_MC2_155      ILTASADRLNTPILLLAVAALVIGMSSTVLVAMSIADPLRQLRWALGEVQ
TH_0858|M.thermoresistible__bu      ILTAPAEQLTTPLLVLAIATLVIGLSGTVLVAMSIADPLRQLRWALGEVQ
MMAR_5137|M.marinum_M               ILHATPDKLFNPILLLALAALAIGSASTLLVSMSIADPLRQLRWALSEVQ
MUL_4221|M.ulcerans_Agy99           ILHATPDKLFNPILLLALAALAIGSASTLLVSMSIADPLRQLRWALSEVQ
Mb3669|M.bovis_AF2122/97            LLHATPEALFNPILMMALAALGIGSVSTLLVAMSIADPLRQLRWALSEVQ
Rv3645|M.tuberculosis_H37Rv         LLHATPEALFNPILMMALAALGIGSVSTLLVAMSIADPLRQLRWALSEVQ
MLBr_00201|M.leprae_Br4923          LLHAVPEQLFSPILLLALAVLVVGLVSTWLVAMSIADPLRQLRWALSEVQ
MAV_0518|M.avium_104                LLHATPEKLFTPILLLAVAALGIGLVSTLLVAMSIADPLRQLRWALSEVQ
MAB_0490c|M.abscessus_ATCC_199      YLKSNADNLTGSILILAIIALAIGLMGTLLVATSIADPLRQLRWALSEVQ
                                     * : .: *  .:*:::: .* :*  .* **: *************.***

Mflv_1395|M.gilvum_PYR-GCK          RGNYNAHMQIYDASELGLLQAGFNDMVRDLAERQRLRDLFGRYVGEDVAR
Mvan_5395|M.vanbaalenii_PYR-1       RGNYNAHMQIYDASELGLLQAGFNDMVRDLAERQRLRDLFGRYVGEDVAR
MSMEG_6154|M.smegmatis_MC2_155      RGNYNAHMQIYDASELGLLQAGFNDMVRDLAERQRLRDLFGRYVGEDVAR
TH_0858|M.thermoresistible__bu      RGNFNAHMQIYDASELGLLQAGFNDMVRDLAERQRLRDLFGRYVGEDVAR
MMAR_5137|M.marinum_M               RGNYNAHMQIYDASELGLLQAGFNDMVRDLSERQRLRDLFGRYVGEDVAR
MUL_4221|M.ulcerans_Agy99           RGNYNAHMQIYDASELGLLQAGFNDMVRDLSERQRLRDLFGRYVGEDVAR
Mb3669|M.bovis_AF2122/97            RGNYNAHMQIYDASELGLLQAGFNDMVRELSERQRLRDLFGRYVGEDVAR
Rv3645|M.tuberculosis_H37Rv         RGNYNAHMQIYDASELGLLQAGFNDMVRELSERQRLRDLFGRYVGEDVAR
MLBr_00201|M.leprae_Br4923          RGNYNAHMQIYDASELGLLQAGFNDMVRELSERQRLRDLFGRYVGEDVAR
MAV_0518|M.avium_104                RGNYNAHMQIYDASELGLLQAGFNDMVRDLSERQRLRDLFGRYVGEDVAR
MAB_0490c|M.abscessus_ATCC_199      RGNYNAHVPIYDASELGLLQAGFNDMVRDLGERQRLRDLFGRYVGEDVAR
                                    ***:***: *******************:*.*******************

Mflv_1395|M.gilvum_PYR-GCK          RALERGTELGGQERDVAVLFVDLVGSTHLAATIPASEVVSLLNEFFRVVV
Mvan_5395|M.vanbaalenii_PYR-1       RALERGTELGGQERDVAVLFVDLVGSTHLAATRPAAEVVNLLNEFFRVVV
MSMEG_6154|M.smegmatis_MC2_155      RALERGTELGGQERDVAVLFVDLVGSTHLASTIPAADVVNLLNEFFRVIV
TH_0858|M.thermoresistible__bu      RALERGTELGGQERDVAVLFVDLVGSTRLAATTPPADVVNLLNEFFRVVV
MMAR_5137|M.marinum_M               RAIERGTELGGQERDVAVLFVDLVGSTQLAATRPPVEVVGLLNEFFRVVV
MUL_4221|M.ulcerans_Agy99           RAIERGTELGGQERDVAVLFVDLVGSTQLAATRPPVEVVGLLNEFFRVVV
Mb3669|M.bovis_AF2122/97            RALERGTELGGQERDVAVLFVDLVGSTQLAATRPPAEVVQLLNEFFRVVV
Rv3645|M.tuberculosis_H37Rv         RALERGTELGGQERDVAVLFVDLVGSTQLAATRPPAEVVQLLNEFFRVVV
MLBr_00201|M.leprae_Br4923          RALEHGTELGGQERDVAVLFVDLIGSTQLAETKPPTKVVHLLNEFFRVVV
MAV_0518|M.avium_104                RALERGTELGGQERDVAVLFVDLVGSTQLAATRPPAEVVHLLNEFFRVVV
MAB_0490c|M.abscessus_ATCC_199      RALEYGTELGGQERSVAVLFVDLVGSTQLASTRGPAVVVRVLNEFFRVIV
                                    **:* *********.********:***:** *  .  ** :*******:*

Mflv_1395|M.gilvum_PYR-GCK          DTVNRHGGFVNKFQGDAALAIFGAPIEHPDASGAALAASRELHDELINVL
Mvan_5395|M.vanbaalenii_PYR-1       DTVNRHGGFVNKFQGDAALAIFGAPIEHPDASGAALAASRELHDELIRVL
MSMEG_6154|M.smegmatis_MC2_155      DTVNKHGGFVNKFQGDAALAIFGAPIEHPDASGGALAASRELHDELIKVL
TH_0858|M.thermoresistible__bu      DTVNRHGGFVNKFQGDAALAIFGAPIEHPDACGAALAAARELHDELIAVL
MMAR_5137|M.marinum_M               DTVARHGGFVNKFQGDAALAIFGAPIEHPDGAGAALRAARELHDELIPVL
MUL_4221|M.ulcerans_Agy99           DTVARHGGFVNKFQGDAALAIFGAPIEHPDGAGAALRAARELHDELIPVL
Mb3669|M.bovis_AF2122/97            ETVARHGGFVNKFQGDAALAIFGAPIEHPDGAGAALSAARELHDELIPVL
Rv3645|M.tuberculosis_H37Rv         ETVARHGGFVNKFQGDAALAIFGAPIEHPDGAGAALSAARELHDELIPVL
MLBr_00201|M.leprae_Br4923          DTVGRHGGFVNKFQGDAALAIFGAPIEHPDSAGAALSAARELHDELLPVL
MAV_0518|M.avium_104                ETVGKHGGFVNKFQGDAALAIFGAPIEHPDSPGGALAAARELHDALLPVI
MAB_0490c|M.abscessus_ATCC_199      DTVNKHGGFVNKFQGDAALAIFGAPIDHPDGAAAALAAARELSGELTNVL
                                    :** :*********************:***. ..** *:*** . *  *:

Mflv_1395|M.gilvum_PYR-GCK          G-ETEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEPG
Mvan_5395|M.vanbaalenii_PYR-1       G-ETDFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEPG
MSMEG_6154|M.smegmatis_MC2_155      GTETEFGIGVSAGRAIAGHIGAKARFEYTVIGDPVNEAARLTELAKLEEG
TH_0858|M.thermoresistible__bu      G-ETEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEEG
MMAR_5137|M.marinum_M               G-SAEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEEG
MUL_4221|M.ulcerans_Agy99           G-SAEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEEG
Mb3669|M.bovis_AF2122/97            G-SAEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEDG
Rv3645|M.tuberculosis_H37Rv         G-SAEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEDG
MLBr_00201|M.leprae_Br4923          G-SAEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEDG
MAV_0518|M.avium_104                G-SAEFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKLEPG
MAB_0490c|M.abscessus_ATCC_199      G-SNDFGIGVSAGRAIAGHIGAQARFEYTVIGDPVNEAARLTELAKNEPG
                                    * . :*****************:*********************** * *

Mflv_1395|M.gilvum_PYR-GCK          HVLASSLAVADALDAEALCWNVGEVVELRGRTAPTQLARPVNLIRPPRVE
Mvan_5395|M.vanbaalenii_PYR-1       HVLASAIAVADALDAEALCWDVGEIVELRGRTAPTQLARPVNLVSPDDVS
MSMEG_6154|M.smegmatis_MC2_155      HVLASAIAVSGALDSEALCWDVGEIVELRGRTVPTQLARPINLARPEDLD
TH_0858|M.thermoresistible__bu      HVLASAMAVSGALDAEALCWDVGETVELRGRTVPTQLARPVKLAFSNGPG
MMAR_5137|M.marinum_M               HVLASAIAISGALDAEALCWDVAEVVELRGRTAPTQLARPLNLAVAQQVS
MUL_4221|M.ulcerans_Agy99           HVLASAFAISGALDAEALCWDVAEVVELRGRTAPTQLARPLNLAVAQKVS
Mb3669|M.bovis_AF2122/97            HVLASAIAVSGALDAEALCWDVGEVVELRGRAAPTQLARPMNLAAPEEVS
Rv3645|M.tuberculosis_H37Rv         HVLASAIAVSGALDAEALCWDVGEVVELRGRAAPTQLARPMNLAAPEEVS
MLBr_00201|M.leprae_Br4923          HVLASAIAVSGALDAEALCWNVGEIVELRGRTAPTQLARPLNLAVPEQIT
MAV_0518|M.avium_104                HVLASAIAVSGALDSEALCWDVGEVVELRGRTAPTQLARPVKLATPEEVA
MAB_0490c|M.abscessus_ATCC_199      NVLASASAVMEARDEEALRWDVGETVELRGRTVSTQVARPRHG-------
                                    :****: *:  * * *** *:*.* ******:..**:*** :        

Mflv_1395|M.gilvum_PYR-GCK          EK-VADDVPSTTR--------------------------
Mvan_5395|M.vanbaalenii_PYR-1       QE-VASDRR------------------------------
MSMEG_6154|M.smegmatis_MC2_155      GS-ANGQSTDGSPAETAFQQEKGLFAVEGVEVVGASVPG
TH_0858|M.thermoresistible__bu      PS-NNSDAPGTRTTGSVSRADAETTAPES----------
MMAR_5137|M.marinum_M               -----TKSGS-----------------------------
MUL_4221|M.ulcerans_Agy99           -----TKSGS-----------------------------
Mb3669|M.bovis_AF2122/97            -----SEVRG-----------------------------
Rv3645|M.tuberculosis_H37Rv         -----SEVRG-----------------------------
MLBr_00201|M.leprae_Br4923          -----SEVTG-----------------------------
MAV_0518|M.avium_104                PQEVSSEVSG-----------------------------
MAB_0490c|M.abscessus_ATCC_199      ---------------------------------------