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M. tuberculosis H37Rv Rv3606c (folK)

annotation: 2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDI NE PYROPHOSPHOKINASE FOLK (7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE) (HPPK) (6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE) (PPPK) (2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE DIPHOSPHOKINASE) (7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-DIPHOSPHOKINASE) (6-HYDROXYMETHYL-7,8-DIHYDROPTERIN DIPHOSPHOKINASE)
coordinates: 4048181 - 4048747
length: 188

TRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQFLNAVLIADDPTCEPREWLRRA
QEFERAAGRVRGQRWGPRNLDVDLIACYQTSATEALVEVTARENHLTLPHPLAHLRAFVLIPWIAVDPTA
QLTVAGCPRPVTRLLAELEPADRDSVRLFRPSFDLNSRHPVSRAPES*

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. tuberculosis H37Rv Rv3606c folK - 100% (188) 2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDI NE PYROPHOSPHOKINASE FOLK (7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE) (HPPK) (6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE) (PPPK) (2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE DIPHOSPHOKINASE) (7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-DIPHOSPHOKINASE) (6-HYDROXYMETHYL-7,8-DIHYDROPTERIN DIPHOSPHOKINASE)

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb3636c folK 1e-107 100.00% (188) 2-amino-4-hydroxy-6-hydroxymethyldihydropteridi ne
M. gilvum PYR-GCK Mflv_1420 - 9e-48 55.62% (169) 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine
M. leprae Br4923 MLBr_00226 folK 6e-63 64.84% (182) putative 2-amino-4-hydroxy-6-hydroxymethyldihydropterine
M. abscessus ATCC 19977 MAB_0537 - 3e-45 53.01% (166) 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine
M. marinum M MMAR_5109 folK 9e-60 66.86% (169) 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine
M. avium 104 MAV_0546 folK 1e-67 73.81% (168) 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine
M. smegmatis MC2 155 MSMEG_6101 folK 1e-56 64.67% (167) 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine
M. thermoresistible (build 8) TH_0987 folK 3e-52 60.98% (164) 2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDI NE
M. ulcerans Agy99 MUL_4188 folK 3e-59 66.27% (169) 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine
M. vanbaalenii PYR-1 Mvan_5368 - 6e-51 57.74% (168) 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine

CLUSTAL 2.0.9 multiple sequence alignment


MAB_0537|M.abscessus_ATCC_1997      -MRAVLSIGSNVGDRLAHLQSVVDALGSDVVGVSPVYQTAPWGHVPQPDF
TH_0987|M.thermoresistible__bu      ---VVLSIGSNLGDRLAHLQSVVDALGAAVSAVSPVYETEAWGGVEQGRF
Mflv_1420|M.gilvum_PYR-GCK          MTSVVLSIGSNLGDRLAHLQSVLDALGPAVTGVSPVYETDAWGGVEQGPF
Mvan_5368|M.vanbaalenii_PYR-1       MTSVVLSIGSNLGDRMAHLQSVLDGLAGSALAVSPVYETDAWGGVEQGPF
Rv3606c|M.tuberculosis_H37Rv        MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQF
Mb3636c|M.bovis_AF2122/97           MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQF
MMAR_5109|M.marinum_M               MSSVVLSVGSNLGDRLANLRSVVDGLGDTLVGASRVYETDPWGGVAQEPF
MUL_4188|M.ulcerans_Agy99           MSSVVLSVGSNLGDRLANLRSVVDGLGDTLVGASRVYETDPWGGVAQEPF
MAV_0546|M.avium_104                MTRVVLSIGSNLGDRLARLQSVVDGLGGAVRAISPVYETQPWGRVDQAPF
MLBr_00226|M.leprae_Br4923          MTRVVLSIGSNLGDRLAWLQSAVDGLGDAVVAVSPVYDTVPWGAVEQRSF
MSMEG_6101|M.smegmatis_MC2_155      MTSTVLSIGSNLGDRLTRLQSVLDGLGPAVRAVSAVYETAAWGFEEQGPF
                                       .***:***:***:: *:*. *.*.    . * :*:: .**   *  *

MAB_0537|M.abscessus_ATCC_1997      FNAIVVAD--GREPLEWLAVAHRLEQSAQRLRDERWGPRTLDVDVISCRR
TH_0987|M.thermoresistible__bu      LNATLIAETPALDCHGWLDTAQQLERAADRVRERRWGPRTLDVDLITCHD
Mflv_1420|M.gilvum_PYR-GCK          LNAIVLAEDPALDAHGWLRRAHELEDACGRTREQHWGPRTLDVDLVSCRD
Mvan_5368|M.vanbaalenii_PYR-1       LNAVVLAEDRELDGYGWLRRAHELEDAAGRVRDQRWGPRTLDVDLVQCHG
Rv3606c|M.tuberculosis_H37Rv        LNAVLIADDPTCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQ
Mb3636c|M.bovis_AF2122/97           LNAVLIADDPTCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQ
MMAR_5109|M.marinum_M               LNVVLIADDPARDGHAWLHQAQEFERAAGRQRLQRWGPRTLDVDLVACYQ
MUL_4188|M.ulcerans_Agy99           LNVVLIADDPARDGHAWLHQAQEYERAAGRQRLQRWGPRTLDVDLVACYQ
MAV_0546|M.avium_104                LNAVLIADDPACDGQGWLRRAQEFERAAGRVRGERWGPRTLDVDLIACYG
MLBr_00226|M.leprae_Br4923          LNAVVIADGPAYDTKAWLCRAQELERNAGRVRGQRWGARTLDVDLISCYQ
MSMEG_6101|M.smegmatis_MC2_155      LNAVLLADDPDLDGHGWLRRAQELEAAAGRVRGQRWGPRTLDVDLITCHD
                                    :*. ::*:    :   **  *:. *  . * * .:**.*.****:: *  

MAB_0537|M.abscessus_ATCC_1997      -----HDAGEVLSDDPDLTLPHPRAHLRAFVLVPWLALEPGAVLTVDGVV
TH_0987|M.thermoresistible__bu      -----GDR-EVRMDDERLILPHPYAHQRAFVLVPWLAIDPGAVLTVAGTP
Mflv_1420|M.gilvum_PYR-GCK          -----GDA-EIVMDDPDLTLPHPYAHVRAFVLVPWSAVDASAASAVS---
Mvan_5368|M.vanbaalenii_PYR-1       -----PDG-EVVVHDDVLTLPHPYAHARAFVLVPWLQVEPTATLTVDGRT
Rv3606c|M.tuberculosis_H37Rv        -TSATEALVEVTARENHLTLPHPLAHLRAFVLIPWIAVDPTAQLTVAGCP
Mb3636c|M.bovis_AF2122/97           -TSATEALVEVTARENHLTLPHPLAHLRAFVLIPWIAVDPTAQLTVAGCP
MMAR_5109|M.marinum_M               -AGP-AGRTEVRCNDSILTLPHPLAHQRAFVMVPWLDVDPAAELTAPEGP
MUL_4188|M.ulcerans_Agy99           -AGP-AGRTEVRCNDSILTLPHPLAHQRAFVMVPWLDVDPAAELTGPEGP
MAV_0546|M.avium_104                -DGE------VISRENNLTLPHPLAHLRAFVLIPWLAVDPDARLTVADGP
MLBr_00226|M.leprae_Br4923          TSGATTGAVEVITCESNLTLPHPRAHLRAFVLVPWLAVDSDAELTVAGRA
MSMEG_6101|M.smegmatis_MC2_155      ------GADEIISRDEGLTLPHPLAHLRAFVLIPWLDVDPDATLTVAGES
                                              :   :  * **** ** ****::**  ::. *  :     

MAB_0537|M.abscessus_ATCC_1997      RPVADLLSGLDAAEREGVRRMDAALTG-PVT----------
TH_0987|M.thermoresistible__bu      RPVAGLLAGLDPAERAGVHRTDLTLRIDPRRGA--------
Mflv_1420|M.gilvum_PYR-GCK          ----AHLAALDPAERAGVRLTDLVLRPRSAG----------
Mvan_5368|M.vanbaalenii_PYR-1       DPLTAHLAAVDAAERAGVRTTDFVLRIADGA----------
Rv3606c|M.tuberculosis_H37Rv        RPVTRLLAELEPADRDSVRLFRPSFDLNSRHPVSRAPES--
Mb3636c|M.bovis_AF2122/97           RPVTRLLAELEPADRDSVRLFRPSFDLNSRHPVSRAPES--
MMAR_5109|M.marinum_M               RPVAALLAGLPPADRASVRLT--SLTVAA------------
MUL_4188|M.ulcerans_Agy99           RPVAALLAGLPPADRASVRLT--SLTVAA------------
MAV_0546|M.avium_104                QPVARLLAQLDQADRDGVRPTGLTLTPPAGSSADSGAGS--
MLBr_00226|M.leprae_Br4923          QRVDRLLAEMEPTEREGVRLTNLTLKLKRSSPARPVSPKSD
MSMEG_6101|M.smegmatis_MC2_155      RPVQRLLSEIDQSERDGVTRTDLVLDIRTETAAG-------
                                          *: :  ::* .*      :

species	id	gene	e-value	identity (len)	annotation
M. tuberculosis H37Rv	Rv3606c	folK	-	100% (188)	2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDI NE PYROPHOSPHOKINASE FOLK (7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE) (HPPK) (6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE) (PPPK) (2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE DIPHOSPHOKINASE) (7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-DIPHOSPHOKINASE) (6-HYDROXYMETHYL-7,8-DIHYDROPTERIN DIPHOSPHOKINASE)