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SSVVLSVGSNLGDRLANLRSVVDGLGDTLVGASRVYETDPWGGVAQEPFLNVVLIADDPARDGHAWLHQA QEYERAAGRQRLQRWGPRTLDVDLVACYQAGPAGRTEVRCNDSILTLPHPLAHQRAFVMVPWLDVDPAAE LTGPEGPRPVAALLAGLPPADRASVRLTSLTVAA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4188 | folK | - | 100% (175) | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase FolK |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3636c | folK | 3e-59 | 66.27% (169) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridi ne |
| M. gilvum PYR-GCK | Mflv_1420 | - | 4e-50 | 57.80% (173) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine |
| M. tuberculosis H37Rv | Rv3606c | folK | 3e-59 | 66.27% (169) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridi ne |
| M. leprae Br4923 | MLBr_00226 | folK | 3e-52 | 61.14% (175) | putative 2-amino-4-hydroxy-6-hydroxymethyldihydropterine |
| M. abscessus ATCC 19977 | MAB_0537 | - | 1e-41 | 53.94% (165) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine |
| M. marinum M | MMAR_5109 | folK | 2e-98 | 98.86% (175) | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine |
| M. avium 104 | MAV_0546 | folK | 7e-59 | 65.90% (173) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine |
| M. smegmatis MC2 155 | MSMEG_6101 | folK | 7e-51 | 57.80% (173) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine |
| M. thermoresistible (build 8) | TH_0987 | folK | 3e-54 | 62.35% (170) | 2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDI NE |
| M. vanbaalenii PYR-1 | Mvan_5368 | - | 7e-51 | 57.80% (173) | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine |
CLUSTAL 2.0.9 multiple sequence alignment
MAB_0537|M.abscessus_ATCC_1997 -MRAVLSIGSNVGDRLAHLQSVVDALGSDVVGVSPVYQTAPWGHVPQPDF
TH_0987|M.thermoresistible__bu ---VVLSIGSNLGDRLAHLQSVVDALGAAVSAVSPVYETEAWGGVEQGRF
Mflv_1420|M.gilvum_PYR-GCK MTSVVLSIGSNLGDRLAHLQSVLDALGPAVTGVSPVYETDAWGGVEQGPF
Mvan_5368|M.vanbaalenii_PYR-1 MTSVVLSIGSNLGDRMAHLQSVLDGLAGSALAVSPVYETDAWGGVEQGPF
MUL_4188|M.ulcerans_Agy99 MSSVVLSVGSNLGDRLANLRSVVDGLGDTLVGASRVYETDPWGGVAQEPF
MMAR_5109|M.marinum_M MSSVVLSVGSNLGDRLANLRSVVDGLGDTLVGASRVYETDPWGGVAQEPF
Mb3636c|M.bovis_AF2122/97 MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQF
Rv3606c|M.tuberculosis_H37Rv MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQF
MAV_0546|M.avium_104 MTRVVLSIGSNLGDRLARLQSVVDGLGGAVRAISPVYETQPWGRVDQAPF
MLBr_00226|M.leprae_Br4923 MTRVVLSIGSNLGDRLAWLQSAVDGLGDAVVAVSPVYDTVPWGAVEQRSF
MSMEG_6101|M.smegmatis_MC2_155 MTSTVLSIGSNLGDRLTRLQSVLDGLGPAVRAVSAVYETAAWGFEEQGPF
.***:***:***:: *:*. *.*. . * :*:: .** * *
MAB_0537|M.abscessus_ATCC_1997 FNAIVVAD--GREPLEWLAVAHRLEQSAQRLRDERWGPRTLDVDVISCRR
TH_0987|M.thermoresistible__bu LNATLIAETPALDCHGWLDTAQQLERAADRVRERRWGPRTLDVDLITCHD
Mflv_1420|M.gilvum_PYR-GCK LNAIVLAEDPALDAHGWLRRAHELEDACGRTREQHWGPRTLDVDLVSCRD
Mvan_5368|M.vanbaalenii_PYR-1 LNAVVLAEDRELDGYGWLRRAHELEDAAGRVRDQRWGPRTLDVDLVQCHG
MUL_4188|M.ulcerans_Agy99 LNVVLIADDPARDGHAWLHQAQEYERAAGRQRLQRWGPRTLDVDLVACYQ
MMAR_5109|M.marinum_M LNVVLIADDPARDGHAWLHQAQEFERAAGRQRLQRWGPRTLDVDLVACYQ
Mb3636c|M.bovis_AF2122/97 LNAVLIADDPTCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQ
Rv3606c|M.tuberculosis_H37Rv LNAVLIADDPTCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQ
MAV_0546|M.avium_104 LNAVLIADDPACDGQGWLRRAQEFERAAGRVRGERWGPRTLDVDLIACYG
MLBr_00226|M.leprae_Br4923 LNAVVIADGPAYDTKAWLCRAQELERNAGRVRGQRWGARTLDVDLISCYQ
MSMEG_6101|M.smegmatis_MC2_155 LNAVLLADDPDLDGHGWLRRAQELEAAAGRVRGQRWGPRTLDVDLITCHD
:*. ::*: : ** *:. * . * * .:**.*.****:: *
MAB_0537|M.abscessus_ATCC_1997 -----HDAGEVLSDDPDLTLPHPRAHLRAFVLVPWLALEPGAVLTVDGVV
TH_0987|M.thermoresistible__bu -----GDR-EVRMDDERLILPHPYAHQRAFVLVPWLAIDPGAVLTVAGTP
Mflv_1420|M.gilvum_PYR-GCK -----GDA-EIVMDDPDLTLPHPYAHVRAFVLVPWSAVDASAASAVS---
Mvan_5368|M.vanbaalenii_PYR-1 -----PDG-EVVVHDDVLTLPHPYAHARAFVLVPWLQVEPTATLTVDGRT
MUL_4188|M.ulcerans_Agy99 -AGP-AGRTEVRCNDSILTLPHPLAHQRAFVMVPWLDVDPAAELTGPEGP
MMAR_5109|M.marinum_M -AGP-AGRTEVRCNDSILTLPHPLAHQRAFVMVPWLDVDPAAELTAPEGP
Mb3636c|M.bovis_AF2122/97 -TSATEALVEVTARENHLTLPHPLAHLRAFVLIPWIAVDPTAQLTVAGCP
Rv3606c|M.tuberculosis_H37Rv -TSATEALVEVTARENHLTLPHPLAHLRAFVLIPWIAVDPTAQLTVAGCP
MAV_0546|M.avium_104 -DGE------VISRENNLTLPHPLAHLRAFVLIPWLAVDPDARLTVADGP
MLBr_00226|M.leprae_Br4923 TSGATTGAVEVITCESNLTLPHPRAHLRAFVLVPWLAVDSDAELTVAGRA
MSMEG_6101|M.smegmatis_MC2_155 ------GADEIISRDEGLTLPHPLAHLRAFVLIPWLDVDPDATLTVAGES
: : * **** ** ****::** ::. * :
MAB_0537|M.abscessus_ATCC_1997 RPVADLLSGLDAAEREGVRRMDAALTG-PVT----------
TH_0987|M.thermoresistible__bu RPVAGLLAGLDPAERAGVHRTDLTLRIDPRRGA--------
Mflv_1420|M.gilvum_PYR-GCK ----AHLAALDPAERAGVRLTDLVLRPRSAG----------
Mvan_5368|M.vanbaalenii_PYR-1 DPLTAHLAAVDAAERAGVRTTDFVLRIADGA----------
MUL_4188|M.ulcerans_Agy99 RPVAALLAGLPPADRASVRLT--SLTVAA------------
MMAR_5109|M.marinum_M RPVAALLAGLPPADRASVRLT--SLTVAA------------
Mb3636c|M.bovis_AF2122/97 RPVTRLLAELEPADRDSVRLFRPSFDLNSRHPVSRAPES--
Rv3606c|M.tuberculosis_H37Rv RPVTRLLAELEPADRDSVRLFRPSFDLNSRHPVSRAPES--
MAV_0546|M.avium_104 QPVARLLAQLDQADRDGVRPTGLTLTPPAGSSADSGAGS--
MLBr_00226|M.leprae_Br4923 QRVDRLLAEMEPTEREGVRLTNLTLKLKRSSPARPVSPKSD
MSMEG_6101|M.smegmatis_MC2_155 RPVQRLLSEIDQSERDGVTRTDLVLDIRTETAAG-------
*: : ::* .* :