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M. leprae Br4923 MLBr_00226 (folK)

annotation: putative 2-amino-4-hydroxy-6-hydroxymethyldihydropterine pyrophosphokinase
coordinates: 297956 - 298531
length: 191

MTRVVLSIGSNLGDRLAWLQSAVDGLGDAVVAVSPVYDTVPWGAVEQRSFLNAVVIADGPAYDTKAWLCR
AQELERNAGRVRGQRWGARTLDVDLISCYQTSGATTGAVEVITCESNLTLPHPRAHLRAFVLVPWLAVDS
DAELTVAGRAQRVDRLLAEMEPTEREGVRLTNLTLKLKRSSPARPVSPKSD

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. leprae Br4923 MLBr_00226 folK - 100% (191) putative 2-amino-4-hydroxy-6-hydroxymethyldihydropterine pyrophosphokinase

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb3636c folK 1e-62 64.84% (182) 2-amino-4-hydroxy-6-hydroxymethyldihydropteridi ne
M. gilvum PYR-GCK Mflv_1420 - 1e-49 57.95% (176) 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine
M. tuberculosis H37Rv Rv3606c folK 1e-62 64.84% (182) 2-amino-4-hydroxy-6-hydroxymethyldihydropteridi ne
M. abscessus ATCC 19977 MAB_0537 - 2e-46 56.65% (173) 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine
M. marinum M MMAR_5109 folK 4e-52 61.14% (175) 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine
M. avium 104 MAV_0546 folK 2e-62 67.76% (183) 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine
M. smegmatis MC2 155 MSMEG_6101 folK 2e-56 61.20% (183) 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine
M. thermoresistible (build 8) TH_0987 folK 2e-51 61.49% (174) 2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDI NE
M. ulcerans Agy99 MUL_4188 folK 8e-52 61.14% (175) 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine
M. vanbaalenii PYR-1 Mvan_5368 - 7e-49 56.50% (177) 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine

CLUSTAL 2.0.9 multiple sequence alignment


MAB_0537|M.abscessus_ATCC_1997      -MRAVLSIGSNVGDRLAHLQSVVDALGSDVVGVSPVYQTAPWGHVPQPDF
TH_0987|M.thermoresistible__bu      ---VVLSIGSNLGDRLAHLQSVVDALGAAVSAVSPVYETEAWGGVEQGRF
Mflv_1420|M.gilvum_PYR-GCK          MTSVVLSIGSNLGDRLAHLQSVLDALGPAVTGVSPVYETDAWGGVEQGPF
Mvan_5368|M.vanbaalenii_PYR-1       MTSVVLSIGSNLGDRMAHLQSVLDGLAGSALAVSPVYETDAWGGVEQGPF
Mb3636c|M.bovis_AF2122/97           MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQF
Rv3606c|M.tuberculosis_H37Rv        MTRVVLSVGSNLGDRLARLRSVADGLGDALIAASPIYEADPWGGVEQGQF
MMAR_5109|M.marinum_M               MSSVVLSVGSNLGDRLANLRSVVDGLGDTLVGASRVYETDPWGGVAQEPF
MUL_4188|M.ulcerans_Agy99           MSSVVLSVGSNLGDRLANLRSVVDGLGDTLVGASRVYETDPWGGVAQEPF
MAV_0546|M.avium_104                MTRVVLSIGSNLGDRLARLQSVVDGLGGAVRAISPVYETQPWGRVDQAPF
MLBr_00226|M.leprae_Br4923          MTRVVLSIGSNLGDRLAWLQSAVDGLGDAVVAVSPVYDTVPWGAVEQRSF
MSMEG_6101|M.smegmatis_MC2_155      MTSTVLSIGSNLGDRLTRLQSVLDGLGPAVRAVSAVYETAAWGFEEQGPF
                                       .***:***:***:: *:*. *.*.    . * :*:: .**   *  *

MAB_0537|M.abscessus_ATCC_1997      FNAIVVAD--GREPLEWLAVAHRLEQSAQRLRDERWGPRTLDVDVISCRR
TH_0987|M.thermoresistible__bu      LNATLIAETPALDCHGWLDTAQQLERAADRVRERRWGPRTLDVDLITCHD
Mflv_1420|M.gilvum_PYR-GCK          LNAIVLAEDPALDAHGWLRRAHELEDACGRTREQHWGPRTLDVDLVSCRD
Mvan_5368|M.vanbaalenii_PYR-1       LNAVVLAEDRELDGYGWLRRAHELEDAAGRVRDQRWGPRTLDVDLVQCHG
Mb3636c|M.bovis_AF2122/97           LNAVLIADDPTCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQ
Rv3606c|M.tuberculosis_H37Rv        LNAVLIADDPTCEPREWLRRAQEFERAAGRVRGQRWGPRNLDVDLIACYQ
MMAR_5109|M.marinum_M               LNVVLIADDPARDGHAWLHQAQEFERAAGRQRLQRWGPRTLDVDLVACYQ
MUL_4188|M.ulcerans_Agy99           LNVVLIADDPARDGHAWLHQAQEYERAAGRQRLQRWGPRTLDVDLVACYQ
MAV_0546|M.avium_104                LNAVLIADDPACDGQGWLRRAQEFERAAGRVRGERWGPRTLDVDLIACYG
MLBr_00226|M.leprae_Br4923          LNAVVIADGPAYDTKAWLCRAQELERNAGRVRGQRWGARTLDVDLISCYQ
MSMEG_6101|M.smegmatis_MC2_155      LNAVLLADDPDLDGHGWLRRAQELEAAAGRVRGQRWGPRTLDVDLITCHD
                                    :*. ::*:    :   **  *:. *  . * * .:**.*.****:: *  

MAB_0537|M.abscessus_ATCC_1997      -----HDAGEVLSDDPDLTLPHPRAHLRAFVLVPWLALEPGAVLTVDGVV
TH_0987|M.thermoresistible__bu      -----GDR-EVRMDDERLILPHPYAHQRAFVLVPWLAIDPGAVLTVAGTP
Mflv_1420|M.gilvum_PYR-GCK          -----GDA-EIVMDDPDLTLPHPYAHVRAFVLVPWSAVDASAASAVS---
Mvan_5368|M.vanbaalenii_PYR-1       -----PDG-EVVVHDDVLTLPHPYAHARAFVLVPWLQVEPTATLTVDGRT
Mb3636c|M.bovis_AF2122/97           -TSATEALVEVTARENHLTLPHPLAHLRAFVLIPWIAVDPTAQLTVAGCP
Rv3606c|M.tuberculosis_H37Rv        -TSATEALVEVTARENHLTLPHPLAHLRAFVLIPWIAVDPTAQLTVAGCP
MMAR_5109|M.marinum_M               -AGP-AGRTEVRCNDSILTLPHPLAHQRAFVMVPWLDVDPAAELTAPEGP
MUL_4188|M.ulcerans_Agy99           -AGP-AGRTEVRCNDSILTLPHPLAHQRAFVMVPWLDVDPAAELTGPEGP
MAV_0546|M.avium_104                -DGE------VISRENNLTLPHPLAHLRAFVLIPWLAVDPDARLTVADGP
MLBr_00226|M.leprae_Br4923          TSGATTGAVEVITCESNLTLPHPRAHLRAFVLVPWLAVDSDAELTVAGRA
MSMEG_6101|M.smegmatis_MC2_155      ------GADEIISRDEGLTLPHPLAHLRAFVLIPWLDVDPDATLTVAGES
                                              :   :  * **** ** ****::**  ::. *  :     

MAB_0537|M.abscessus_ATCC_1997      RPVADLLSGLDAAEREGVRRMDAALTG-PVT----------
TH_0987|M.thermoresistible__bu      RPVAGLLAGLDPAERAGVHRTDLTLRIDPRRGA--------
Mflv_1420|M.gilvum_PYR-GCK          ----AHLAALDPAERAGVRLTDLVLRPRSAG----------
Mvan_5368|M.vanbaalenii_PYR-1       DPLTAHLAAVDAAERAGVRTTDFVLRIADGA----------
Mb3636c|M.bovis_AF2122/97           RPVTRLLAELEPADRDSVRLFRPSFDLNSRHPVSRAPES--
Rv3606c|M.tuberculosis_H37Rv        RPVTRLLAELEPADRDSVRLFRPSFDLNSRHPVSRAPES--
MMAR_5109|M.marinum_M               RPVAALLAGLPPADRASVRLT--SLTVAA------------
MUL_4188|M.ulcerans_Agy99           RPVAALLAGLPPADRASVRLT--SLTVAA------------
MAV_0546|M.avium_104                QPVARLLAQLDQADRDGVRPTGLTLTPPAGSSADSGAGS--
MLBr_00226|M.leprae_Br4923          QRVDRLLAEMEPTEREGVRLTNLTLKLKRSSPARPVSPKSD
MSMEG_6101|M.smegmatis_MC2_155      RPVQRLLSEIDQSERDGVTRTDLVLDIRTETAAG-------
                                          *: :  ::* .*      :

species	id	gene	e-value	identity (len)	annotation
M. leprae Br4923	MLBr_00226	folK	-	100% (191)	putative 2-amino-4-hydroxy-6-hydroxymethyldihydropterine pyrophosphokinase