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PGNSRRRGAVRKSGTKKGAGVGSGGQRRRGLEGRGPTPPAHLRPHHPAAKRARAQPRRPVKRADETETVL GRNPVLECLRAGVPATALYVALGTEADERLTECVARAADSGIAIVELLRADLDRMTANHLHQGIALQVPP YNYAHPDDLLAAALDQPPALLVALDNLSDPRNLGAIVRSVAAFGGHGVLIPQRRSASVTAVAWRTSAGAA ARIPVARATNLTRTLKGWADRGVRVIGLDAGGGTALDDVDGTDSLVVVVGSEGKGLSRLVRQNCDEVVSI PMAAQAESLNASVAAGVVLAEIARQRRRPREPREQTQNRMI*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3579c | - | - | 100% (322) | POSSIBLE TRNA/RRNA METHYLTRANSFERASE |
| M. tuberculosis H37Rv | Rv1644 | tsnR | 7e-13 | 27.39% (241) | 23S rRNA methyltransferase TsnR |
| M. tuberculosis H37Rv | Rv0881 | - | 7e-10 | 26.98% (215) | rRNA methyltransferase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3610c | - | 1e-178 | 99.37% (316) | putative tRNA/rRNA methyltransferase |
| M. gilvum PYR-GCK | Mflv_1447 | - | 1e-132 | 77.56% (312) | RNA methyltransferase |
| M. leprae Br4923 | MLBr_00324 | - | 1e-130 | 84.12% (277) | putative methyltransferase |
| M. abscessus ATCC 19977 | MAB_0572 | - | 1e-129 | 75.24% (315) | putative tRNA/rRNA methyltransferase |
| M. marinum M | MMAR_5079 | - | 1e-153 | 87.38% (309) | tRNA/rRNA methyltransferase |
| M. avium 104 | MAV_0574 | - | 1e-154 | 88.64% (308) | RNA methyltransferase, TrmH family protein, group 3 |
| M. smegmatis MC2 155 | MSMEG_6073 | - | 1e-131 | 77.00% (313) | RNA methyltransferase, TrmH family protein, group 3 |
| M. thermoresistible (build 8) | TH_1749 | - | 1e-107 | 82.16% (241) | POSSIBLE TRNA/RRNA METHYLTRANSFERASE |
| M. ulcerans Agy99 | MUL_4155 | - | 1e-152 | 87.06% (309) | tRNA/rRNA methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_5337 | - | 1e-133 | 78.53% (312) | RNA methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1447|M.gilvum_PYR-GCK MAGNSQRRGAVRKAGTKKGPQVGSGGVRRRGLEGRGATPPAHERPHHPAG
Mvan_5337|M.vanbaalenii_PYR-1 MAGNSQRRGAVRKAGTKKGPTVGSGGVRRRGLEGKGATPPAHQRPHHPAG
MSMEG_6073|M.smegmatis_MC2_155 MAGNSQRRGAVRKPGTKKGPTVGSGGVRRRGLEGRGATPPAHMRPNHPAA
Rv3579c|M.tuberculosis_H37Rv MPGNSRRRGAVRKSGTKKGAGVGSGGQRRRGLEGRGPTPPAHLRPHHPAA
Mb3610c|M.bovis_AF2122/97 MPGNSRRRGAVRKSGTKKGAGVGSGGQRRRGLEGRGPTPPAHLRPHHPAA
MLBr_00324|M.leprae_Br4923 -------------------------------MEGRGPTPPAYLRPNHPAA
MAV_0574|M.avium_104 MAGNSRRRGAVRKAGTKKGPTVGSGGQRRRGLEGRGPTPPAHLRPNHPAA
MMAR_5079|M.marinum_M MAGNSQRRGAIRKSGTKKGTSVGSGGQRRRGLEGRGPTPPAHMRPNHPAA
MUL_4155|M.ulcerans_Agy99 MAGNSQRRGAIRKSGTKKGTSVGSGGQRRRGLEGRGPTPSAHMRPNHPAA
TH_1749|M.thermoresistible__bu --------------------------------------------------
MAB_0572|M.abscessus_ATCC_1997 MAGNSQRRGAVRKPGTKKGPTVGSGGVRRRGLEGKGATPPAEQRTKHPAA
Mflv_1447|M.gilvum_PYR-GCK KRAAKAARQAQGRH---KKTDDTEIVLGRNPVVECLRAGVPATALYVALG
Mvan_5337|M.vanbaalenii_PYR-1 KRAAKAARQAQGRH---KKTDDTEIVLGRNPVLECLRAGVPATALYVALG
MSMEG_6073|M.smegmatis_MC2_155 KKARAAAKAQQQRAG--RKADETELVLGRNPVLECLRAKVPATALYVALG
Rv3579c|M.tuberculosis_H37Rv KRARAQPRR-PVK-----RADETETVLGRNPVLECLRAGVPATALYVALG
Mb3610c|M.bovis_AF2122/97 KRARAQPRR-PVK-----RADETETVLGRNPVLECLRAGVPATALYVALG
MLBr_00324|M.leprae_Br4923 KRNQSSPHR-PVK-----RTDETETVLGRNPVLECLRAGVPATALYVALG
MAV_0574|M.avium_104 KRAQSPPRR-PAK-----RTEETETVLGRNPVLECLRAGVPATALYVALG
MMAR_5079|M.marinum_M KRAKAQQRR-PARG----RTDETETVLGRNPVLECLRAGVPSTALYVALG
MUL_4155|M.ulcerans_Agy99 KRAKAQQRR-PARG----RTDETETVLGRNPVLECLRAGVPSTALYVALG
TH_1749|M.thermoresistible__bu -------------------------VLGRNPVVECLRAEVPATALYVALG
MAB_0572|M.abscessus_ATCC_1997 KRAAVQRKIADAKQRRLKQGDEAEMVLGRNPVLECLRTGVPATALYVAVG
*******:****: **:******:*
Mflv_1447|M.gilvum_PYR-GCK TDADERLTESVQMAADRGISILEVQRHDLDRMAANGLHQGIALQVPPYAY
Mvan_5337|M.vanbaalenii_PYR-1 ADSDERLTESVQIAADKGIAILEVPRHDLDRIAANGMHQGIALQVPPYNY
MSMEG_6073|M.smegmatis_MC2_155 TDADERVTESVQIAADRGISILEVPRTDLDRMSNHGLHQGLGLQVPPYAY
Rv3579c|M.tuberculosis_H37Rv TEADERLTECVARAADSGIAIVELLRADLDRMTANHLHQGIALQVPPYNY
Mb3610c|M.bovis_AF2122/97 TEADERLTECVARAADSGIAIVELLRADLDRMTANHLHQGIALQVPPYNY
MLBr_00324|M.leprae_Br4923 TEVDKRLTESVMRAADVGVAILEVPRTYLDRITNNHLHQGIALQVPPYHY
MAV_0574|M.avium_104 TEADERLTESVSRAADSGISILEVPRADLDRMTGNHLHQGIALQVPPYIY
MMAR_5079|M.marinum_M VEADERLTESVSRAADSGIPILEVPRTDLDRMTANHLHQGIALQVPPYNY
MUL_4155|M.ulcerans_Agy99 VEADERLTESVSRAADSGIPILEVPRTDLDRMTANHLHQGIALQVPPYNY
TH_1749|M.thermoresistible__bu TEADERLTEAVRLAADAGISILEVPRHDLDRISANGLHQGIALQVPPYQY
MAB_0572|M.abscessus_ATCC_1997 ADNDERLTESVALAADAGIAILEVPRPDLDRMSTNGLHQGLALQIPPYKY
.: *:*:**.* *** *:.*:*: * ***:: : :***:.**:*** *
Mflv_1447|M.gilvum_PYR-GCK AHPDDLLRDAKSDAAPALLVALDNISDPRNLGAIVRSVAAFGGHGVVLPQ
Mvan_5337|M.vanbaalenii_PYR-1 AHPDDLLAEAKSDAMPALLVALDNISDPRNLGAIVRSVAAFGGHGVLIPQ
MSMEG_6073|M.smegmatis_MC2_155 AHPDDLLATARADAAPALLVALDNISDPRNLGAIVRSVAAFAGHGVVIPQ
Rv3579c|M.tuberculosis_H37Rv AHPDDLLA-AALDQPPALLVALDNLSDPRNLGAIVRSVAAFGGHGVLIPQ
Mb3610c|M.bovis_AF2122/97 AHPDDLLA-AALDQPPALLVALDNLSDPRNLGAIMRSVAAFGGHGVLIPQ
MLBr_00324|M.leprae_Br4923 VHSDDLLA-AATDSPPALLVALDNISDPRNLGAIVRSVAAFSGHGILIPQ
MAV_0574|M.avium_104 AHPDDLLE-AAAGSPPALLVALDNISDPRNLGAIVRSVAAFGGHGVLIPQ
MMAR_5079|M.marinum_M AHPDDLLA-AALDTPPALLVALDNISDPRNLGAIVRSVAAFGGHGVLIPQ
MUL_4155|M.ulcerans_Agy99 AHPDDLLA-AALDTPPALLVALDNISDPRNLGAIVRSVAAFGGHGVLIPQ
TH_1749|M.thermoresistible__bu AHPDDLLERATTDTEPALLVALDNISDPRNLGAIVRSVAAFAGHGVVIPQ
MAB_0572|M.abscessus_ATCC_1997 AHPDDLLARARAEAQPALLVALDNISDPRNLGAIVRSVAAFGGHGVVIPQ
.*.**** * *********:*********:******.***:::**
Mflv_1447|M.gilvum_PYR-GCK RRSASVTAVAWRTSAGAAARTPVARATNLNRTLKQYADAGLQVVGLDAGG
Mvan_5337|M.vanbaalenii_PYR-1 RRSASVTAVAWRTSAGAAARTPVARATNLTRALKQWADAGLQVVGLDADG
MSMEG_6073|M.smegmatis_MC2_155 RRSASVTAVAWRTSAGAAARVPVARATNLNRTLKSFADAGLQIVGLDAGG
Rv3579c|M.tuberculosis_H37Rv RRSASVTAVAWRTSAGAAARIPVARATNLTRTLKGWADRGVRVIGLDAGG
Mb3610c|M.bovis_AF2122/97 RRSASVTAVAWRTSAGAAARIPVARATNLTRTLKGWADRGVRVIGLDAGG
MLBr_00324|M.leprae_Br4923 RRSASVTAVAWRTSAGAAARIPVARATNLTRALKVWADQGLRVIGLDHDG
MAV_0574|M.avium_104 RRSASVTAVAWRTSAGAAARIPVARATNLTRTLQDWADRGLRVIGLDAGG
MMAR_5079|M.marinum_M RRSASVTAVAWRTSAGAAARMPVARATNLTRALKDWADRGVRVVGLDAGG
MUL_4155|M.ulcerans_Agy99 RRSASVTAVAWRTSAGAAARMPVARATNLTRALKDWADRGVRVVGLDAGG
TH_1749|M.thermoresistible__bu RRSASVTAVAWRTSAGAAARVPVARATNLNRTLKNWADAGLMIVGLDAGG
MAB_0572|M.abscessus_ATCC_1997 RRSASVTAVAWRTSAGAAARLPVARATNLTRTLKDWQDKGITIVGLDAGG
******************** ********.*:*: : * *: ::*** .*
Mflv_1447|M.gilvum_PYR-GCK DTTIDEIDGLTPTIVVVGSEGKGLSRLVRENCDRIVSIPMAGPTESLNAS
Mvan_5337|M.vanbaalenii_PYR-1 DTTVDQIDGAGPIVVVVGSEGKGLSRLVRENCDAVVSIPMAGPTESLNAS
MSMEG_6073|M.smegmatis_MC2_155 DTTLDELDATGPTVVVVGSEGKGLSRLVREHCDAIVSIPMAGPTESLNAS
Rv3579c|M.tuberculosis_H37Rv GTALDDVDGTDSLVVVVGSEGKGLSRLVRQNCDEVVSIPMAAQAESLNAS
Mb3610c|M.bovis_AF2122/97 GTALDDVDGTDSLVVVVGSEGKGLSRLVRQNCDEVVSIPMAAQAESLNAS
MLBr_00324|M.leprae_Br4923 DTALDDLDGTDPLAVVVGSEGKGLSRLVRHSCDEVVSIPMAGQVESLNAS
MAV_0574|M.avium_104 DTTLDDLDGSDPLVVVVGSEGKGLSRLVRQNCDEVVSIPMAGSAESLNAS
MMAR_5079|M.marinum_M DTAIDDLDGSDPIVVVVGSEGKGLSRLVRQTCDEVVSVPMAGPTESLNAS
MUL_4155|M.ulcerans_Agy99 DTAIDDLDGSDPIVVVVGSEGKGLSRLVRQTCDEVVSVPMAGPTESLNAS
TH_1749|M.thermoresistible__bu DTTLDELDGTTPLVVVVGSEGKGLSRLVRENCDLVVSIPMAGPAESLNAS
MAB_0572|M.abscessus_ATCC_1997 DTELDNLDGVGDIAVVVGSEGKGLSQLVRKTCDAVVSIPMAGPVESLNAS
.* :*::*. ***********:***. ** :**:***. .******
Mflv_1447|M.gilvum_PYR-GCK VAAGVVLAEIARQRRLS---------------------------------
Mvan_5337|M.vanbaalenii_PYR-1 VAAGVVLAEIARQRRSA---------------------------------
MSMEG_6073|M.smegmatis_MC2_155 VAAGVVLAEIARQRRS----------------------------------
Rv3579c|M.tuberculosis_H37Rv VAAGVVLAEIARQRRRPREPREQ-------TQNRMI--------------
Mb3610c|M.bovis_AF2122/97 VAAGVVLAAIARQRRRPREPREQDAESHDLSSNHAILRLLAPLRLDPQNL
MLBr_00324|M.leprae_Br4923 VAVGVVLAEIARQRRL----------------------------------
MAV_0574|M.avium_104 VAAGVVLAEISRQRRG----------------------------------
MMAR_5079|M.marinum_M VAAGVVLAEIARQRRT----------------------------------
MUL_4155|M.ulcerans_Agy99 VAAGVVLAEIARQRRT----------------------------------
TH_1749|M.thermoresistible__bu VAAGVVLADIARQRRR----------------------------------
MAB_0572|M.abscessus_ATCC_1997 VAAGVVLAEIARQRR-----------------------------------
**.***** *:****
Mflv_1447|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5337|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6073|M.smegmatis_MC2_155 --------------------------------------------------
Rv3579c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3610c|M.bovis_AF2122/97 GAGPQREHRHRQGRRHGAQSQSGVLADAGVDVVPAQHAPPQQVRQRTGIG
MLBr_00324|M.leprae_Br4923 --------------------------------------------------
MAV_0574|M.avium_104 --------------------------------------------------
MMAR_5079|M.marinum_M --------------------------------------------------
MUL_4155|M.ulcerans_Agy99 --------------------------------------------------
TH_1749|M.thermoresistible__bu --------------------------------------------------
MAB_0572|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_1447|M.gilvum_PYR-GCK ---------
Mvan_5337|M.vanbaalenii_PYR-1 ---------
MSMEG_6073|M.smegmatis_MC2_155 ---------
Rv3579c|M.tuberculosis_H37Rv ---------
Mb3610c|M.bovis_AF2122/97 QVGSDVDPE
MLBr_00324|M.leprae_Br4923 ---------
MAV_0574|M.avium_104 ---------
MMAR_5079|M.marinum_M ---------
MUL_4155|M.ulcerans_Agy99 ---------
TH_1749|M.thermoresistible__bu ---------
MAB_0572|M.abscessus_ATCC_1997 ---------