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AGNSQRRGAVRKAGTKKGPTVGSGGVRRRGLEGKGATPPAHQRPHHPAGKRAAKAARQAQGRHKKTDDTE IVLGRNPVLECLRAGVPATALYVALGADSDERLTESVQIAADKGIAILEVPRHDLDRIAANGMHQGIALQ VPPYNYAHPDDLLAEAKSDAMPALLVALDNISDPRNLGAIVRSVAAFGGHGVLIPQRRSASVTAVAWRTS AGAAARTPVARATNLTRALKQWADAGLQVVGLDADGDTTVDQIDGAGPIVVVVGSEGKGLSRLVRENCDA VVSIPMAGPTESLNASVAAGVVLAEIARQRRSA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_5337 | - | - | 100% (314) | RNA methyltransferase |
| M. vanbaalenii PYR-1 | Mvan_3325 | - | 4e-15 | 27.21% (272) | tRNA/rRNA methyltransferase (SpoU) |
| M. vanbaalenii PYR-1 | Mvan_5036 | - | 7e-12 | 29.80% (151) | tRNA/rRNA methyltransferase (SpoU) |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3610c | - | 1e-132 | 77.88% (312) | putative tRNA/rRNA methyltransferase |
| M. gilvum PYR-GCK | Mflv_1447 | - | 1e-161 | 90.38% (312) | RNA methyltransferase |
| M. tuberculosis H37Rv | Rv3579c | - | 1e-133 | 78.53% (312) | tRNA/rRNA methyltransferase |
| M. leprae Br4923 | MLBr_00324 | - | 1e-117 | 76.87% (281) | putative methyltransferase |
| M. abscessus ATCC 19977 | MAB_0572 | - | 1e-143 | 81.27% (315) | putative tRNA/rRNA methyltransferase |
| M. marinum M | MMAR_5079 | - | 1e-141 | 82.17% (314) | tRNA/rRNA methyltransferase |
| M. avium 104 | MAV_0574 | - | 1e-139 | 80.77% (312) | RNA methyltransferase, TrmH family protein, group 3 |
| M. smegmatis MC2 155 | MSMEG_6073 | - | 1e-146 | 82.80% (314) | RNA methyltransferase, TrmH family protein, group 3 |
| M. thermoresistible (build 8) | TH_1749 | - | 1e-114 | 84.58% (240) | POSSIBLE TRNA/RRNA METHYLTRANSFERASE |
| M. ulcerans Agy99 | MUL_4155 | - | 1e-141 | 81.85% (314) | tRNA/rRNA methyltransferase |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_5337|M.vanbaalenii_PYR-1 MAGNSQRRGAVRKAGTKKGPTVGSGGVRRRGLEGKGATPPAHQRPHHPAG
Mflv_1447|M.gilvum_PYR-GCK MAGNSQRRGAVRKAGTKKGPQVGSGGVRRRGLEGRGATPPAHERPHHPAG
MSMEG_6073|M.smegmatis_MC2_155 MAGNSQRRGAVRKPGTKKGPTVGSGGVRRRGLEGRGATPPAHMRPNHPAA
Mb3610c|M.bovis_AF2122/97 MPGNSRRRGAVRKSGTKKGAGVGSGGQRRRGLEGRGPTPPAHLRPHHPAA
Rv3579c|M.tuberculosis_H37Rv MPGNSRRRGAVRKSGTKKGAGVGSGGQRRRGLEGRGPTPPAHLRPHHPAA
MLBr_00324|M.leprae_Br4923 -------------------------------MEGRGPTPPAYLRPNHPAA
MAV_0574|M.avium_104 MAGNSRRRGAVRKAGTKKGPTVGSGGQRRRGLEGRGPTPPAHLRPNHPAA
MMAR_5079|M.marinum_M MAGNSQRRGAIRKSGTKKGTSVGSGGQRRRGLEGRGPTPPAHMRPNHPAA
MUL_4155|M.ulcerans_Agy99 MAGNSQRRGAIRKSGTKKGTSVGSGGQRRRGLEGRGPTPSAHMRPNHPAA
TH_1749|M.thermoresistible__bu --------------------------------------------------
MAB_0572|M.abscessus_ATCC_1997 MAGNSQRRGAVRKPGTKKGPTVGSGGVRRRGLEGKGATPPAEQRTKHPAA
Mvan_5337|M.vanbaalenii_PYR-1 KRAAKAARQAQGRH---KKTDDTEIVLGRNPVLECLRAGVPATALYVALG
Mflv_1447|M.gilvum_PYR-GCK KRAAKAARQAQGRH---KKTDDTEIVLGRNPVVECLRAGVPATALYVALG
MSMEG_6073|M.smegmatis_MC2_155 KKARAAAKAQQQRAG--RKADETELVLGRNPVLECLRAKVPATALYVALG
Mb3610c|M.bovis_AF2122/97 KRARAQPRR-PVK-----RADETETVLGRNPVLECLRAGVPATALYVALG
Rv3579c|M.tuberculosis_H37Rv KRARAQPRR-PVK-----RADETETVLGRNPVLECLRAGVPATALYVALG
MLBr_00324|M.leprae_Br4923 KRNQSSPHR-PVK-----RTDETETVLGRNPVLECLRAGVPATALYVALG
MAV_0574|M.avium_104 KRAQSPPRR-PAK-----RTEETETVLGRNPVLECLRAGVPATALYVALG
MMAR_5079|M.marinum_M KRAKAQQRR-PARG----RTDETETVLGRNPVLECLRAGVPSTALYVALG
MUL_4155|M.ulcerans_Agy99 KRAKAQQRR-PARG----RTDETETVLGRNPVLECLRAGVPSTALYVALG
TH_1749|M.thermoresistible__bu -------------------------VLGRNPVVECLRAEVPATALYVALG
MAB_0572|M.abscessus_ATCC_1997 KRAAVQRKIADAKQRRLKQGDEAEMVLGRNPVLECLRTGVPATALYVAVG
*******:****: **:******:*
Mvan_5337|M.vanbaalenii_PYR-1 ADSDERLTESVQIAADKGIAILEVPRHDLDRIAANGMHQGIALQVPPYNY
Mflv_1447|M.gilvum_PYR-GCK TDADERLTESVQMAADRGISILEVQRHDLDRMAANGLHQGIALQVPPYAY
MSMEG_6073|M.smegmatis_MC2_155 TDADERVTESVQIAADRGISILEVPRTDLDRMSNHGLHQGLGLQVPPYAY
Mb3610c|M.bovis_AF2122/97 TEADERLTECVARAADSGIAIVELLRADLDRMTANHLHQGIALQVPPYNY
Rv3579c|M.tuberculosis_H37Rv TEADERLTECVARAADSGIAIVELLRADLDRMTANHLHQGIALQVPPYNY
MLBr_00324|M.leprae_Br4923 TEVDKRLTESVMRAADVGVAILEVPRTYLDRITNNHLHQGIALQVPPYHY
MAV_0574|M.avium_104 TEADERLTESVSRAADSGISILEVPRADLDRMTGNHLHQGIALQVPPYIY
MMAR_5079|M.marinum_M VEADERLTESVSRAADSGIPILEVPRTDLDRMTANHLHQGIALQVPPYNY
MUL_4155|M.ulcerans_Agy99 VEADERLTESVSRAADSGIPILEVPRTDLDRMTANHLHQGIALQVPPYNY
TH_1749|M.thermoresistible__bu TEADERLTEAVRLAADAGISILEVPRHDLDRISANGLHQGIALQVPPYQY
MAB_0572|M.abscessus_ATCC_1997 ADNDERLTESVALAADAGIAILEVPRPDLDRMSTNGLHQGLALQIPPYKY
.: *:*:**.* *** *:.*:*: * ***:: : :***:.**:*** *
Mvan_5337|M.vanbaalenii_PYR-1 AHPDDLLAEAKSDAMPALLVALDNISDPRNLGAIVRSVAAFGGHGVLIPQ
Mflv_1447|M.gilvum_PYR-GCK AHPDDLLRDAKSDAAPALLVALDNISDPRNLGAIVRSVAAFGGHGVVLPQ
MSMEG_6073|M.smegmatis_MC2_155 AHPDDLLATARADAAPALLVALDNISDPRNLGAIVRSVAAFAGHGVVIPQ
Mb3610c|M.bovis_AF2122/97 AHPDDLLA-AALDQPPALLVALDNLSDPRNLGAIMRSVAAFGGHGVLIPQ
Rv3579c|M.tuberculosis_H37Rv AHPDDLLA-AALDQPPALLVALDNLSDPRNLGAIVRSVAAFGGHGVLIPQ
MLBr_00324|M.leprae_Br4923 VHSDDLLA-AATDSPPALLVALDNISDPRNLGAIVRSVAAFSGHGILIPQ
MAV_0574|M.avium_104 AHPDDLLE-AAAGSPPALLVALDNISDPRNLGAIVRSVAAFGGHGVLIPQ
MMAR_5079|M.marinum_M AHPDDLLA-AALDTPPALLVALDNISDPRNLGAIVRSVAAFGGHGVLIPQ
MUL_4155|M.ulcerans_Agy99 AHPDDLLA-AALDTPPALLVALDNISDPRNLGAIVRSVAAFGGHGVLIPQ
TH_1749|M.thermoresistible__bu AHPDDLLERATTDTEPALLVALDNISDPRNLGAIVRSVAAFAGHGVVIPQ
MAB_0572|M.abscessus_ATCC_1997 AHPDDLLARARAEAQPALLVALDNISDPRNLGAIVRSVAAFGGHGVVIPQ
.*.**** * *********:*********:******.***:::**
Mvan_5337|M.vanbaalenii_PYR-1 RRSASVTAVAWRTSAGAAARTPVARATNLTRALKQWADAGLQVVGLDADG
Mflv_1447|M.gilvum_PYR-GCK RRSASVTAVAWRTSAGAAARTPVARATNLNRTLKQYADAGLQVVGLDAGG
MSMEG_6073|M.smegmatis_MC2_155 RRSASVTAVAWRTSAGAAARVPVARATNLNRTLKSFADAGLQIVGLDAGG
Mb3610c|M.bovis_AF2122/97 RRSASVTAVAWRTSAGAAARIPVARATNLTRTLKGWADRGVRVIGLDAGG
Rv3579c|M.tuberculosis_H37Rv RRSASVTAVAWRTSAGAAARIPVARATNLTRTLKGWADRGVRVIGLDAGG
MLBr_00324|M.leprae_Br4923 RRSASVTAVAWRTSAGAAARIPVARATNLTRALKVWADQGLRVIGLDHDG
MAV_0574|M.avium_104 RRSASVTAVAWRTSAGAAARIPVARATNLTRTLQDWADRGLRVIGLDAGG
MMAR_5079|M.marinum_M RRSASVTAVAWRTSAGAAARMPVARATNLTRALKDWADRGVRVVGLDAGG
MUL_4155|M.ulcerans_Agy99 RRSASVTAVAWRTSAGAAARMPVARATNLTRALKDWADRGVRVVGLDAGG
TH_1749|M.thermoresistible__bu RRSASVTAVAWRTSAGAAARVPVARATNLNRTLKNWADAGLMIVGLDAGG
MAB_0572|M.abscessus_ATCC_1997 RRSASVTAVAWRTSAGAAARLPVARATNLTRTLKDWQDKGITIVGLDAGG
******************** ********.*:*: : * *: ::*** .*
Mvan_5337|M.vanbaalenii_PYR-1 DTTVDQIDGAGPIVVVVGSEGKGLSRLVRENCDAVVSIPMAGPTESLNAS
Mflv_1447|M.gilvum_PYR-GCK DTTIDEIDGLTPTIVVVGSEGKGLSRLVRENCDRIVSIPMAGPTESLNAS
MSMEG_6073|M.smegmatis_MC2_155 DTTLDELDATGPTVVVVGSEGKGLSRLVREHCDAIVSIPMAGPTESLNAS
Mb3610c|M.bovis_AF2122/97 GTALDDVDGTDSLVVVVGSEGKGLSRLVRQNCDEVVSIPMAAQAESLNAS
Rv3579c|M.tuberculosis_H37Rv GTALDDVDGTDSLVVVVGSEGKGLSRLVRQNCDEVVSIPMAAQAESLNAS
MLBr_00324|M.leprae_Br4923 DTALDDLDGTDPLAVVVGSEGKGLSRLVRHSCDEVVSIPMAGQVESLNAS
MAV_0574|M.avium_104 DTTLDDLDGSDPLVVVVGSEGKGLSRLVRQNCDEVVSIPMAGSAESLNAS
MMAR_5079|M.marinum_M DTAIDDLDGSDPIVVVVGSEGKGLSRLVRQTCDEVVSVPMAGPTESLNAS
MUL_4155|M.ulcerans_Agy99 DTAIDDLDGSDPIVVVVGSEGKGLSRLVRQTCDEVVSVPMAGPTESLNAS
TH_1749|M.thermoresistible__bu DTTLDELDGTTPLVVVVGSEGKGLSRLVRENCDLVVSIPMAGPAESLNAS
MAB_0572|M.abscessus_ATCC_1997 DTELDNLDGVGDIAVVVGSEGKGLSQLVRKTCDAVVSIPMAGPVESLNAS
.* :*::*. ***********:***. ** :**:***. .******
Mvan_5337|M.vanbaalenii_PYR-1 VAAGVVLAEIARQRRSA---------------------------------
Mflv_1447|M.gilvum_PYR-GCK VAAGVVLAEIARQRRLS---------------------------------
MSMEG_6073|M.smegmatis_MC2_155 VAAGVVLAEIARQRRS----------------------------------
Mb3610c|M.bovis_AF2122/97 VAAGVVLAAIARQRRRPREPREQDAESHDLSSNHAILRLLAPLRLDPQNL
Rv3579c|M.tuberculosis_H37Rv VAAGVVLAEIARQRRRPREPREQ-------TQNRMI--------------
MLBr_00324|M.leprae_Br4923 VAVGVVLAEIARQRRL----------------------------------
MAV_0574|M.avium_104 VAAGVVLAEISRQRRG----------------------------------
MMAR_5079|M.marinum_M VAAGVVLAEIARQRRT----------------------------------
MUL_4155|M.ulcerans_Agy99 VAAGVVLAEIARQRRT----------------------------------
TH_1749|M.thermoresistible__bu VAAGVVLADIARQRRR----------------------------------
MAB_0572|M.abscessus_ATCC_1997 VAAGVVLAEIARQRR-----------------------------------
**.***** *:****
Mvan_5337|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1447|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6073|M.smegmatis_MC2_155 --------------------------------------------------
Mb3610c|M.bovis_AF2122/97 GAGPQREHRHRQGRRHGAQSQSGVLADAGVDVVPAQHAPPQQVRQRTGIG
Rv3579c|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00324|M.leprae_Br4923 --------------------------------------------------
MAV_0574|M.avium_104 --------------------------------------------------
MMAR_5079|M.marinum_M --------------------------------------------------
MUL_4155|M.ulcerans_Agy99 --------------------------------------------------
TH_1749|M.thermoresistible__bu --------------------------------------------------
MAB_0572|M.abscessus_ATCC_1997 --------------------------------------------------
Mvan_5337|M.vanbaalenii_PYR-1 ---------
Mflv_1447|M.gilvum_PYR-GCK ---------
MSMEG_6073|M.smegmatis_MC2_155 ---------
Mb3610c|M.bovis_AF2122/97 QVGSDVDPE
Rv3579c|M.tuberculosis_H37Rv ---------
MLBr_00324|M.leprae_Br4923 ---------
MAV_0574|M.avium_104 ---------
MMAR_5079|M.marinum_M ---------
MUL_4155|M.ulcerans_Agy99 ---------
TH_1749|M.thermoresistible__bu ---------
MAB_0572|M.abscessus_ATCC_1997 ---------