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PFHPQPGKVLQRRPPGPSYVDFVPDTLRRVAVHALGPREAAAADLVLPAEQPLAELVPSIVDTVFGGPVG PRQWQLATPAGVPLDSSMSLRDNVVEDGDVIVLTTARVPPPRLLPTDPCAVVADAAEKGTPGRGVNRAAG AAGIVACAVALVWSGTAAPTHWHLWCAAALSGSAAVGAVAAARAEPELTALLSTAAVVFATAAGLLAVRS APWPATVLLASSAGFCMSVLLLRLVADRALLTAFTAAGGAATAAAGLANLAASPVTAGAALAALSTAALS VAPKLAVVTAGPEPAAAHSTLTGLVAGWSATAAAGGVTVAAVAGPAESSTILAALFAADLGGLLVLRTRS HVVVHRRIALGAAGSVSLLAAFTVTVVAAPVHAPWLCACAAVLCVLAVRGAGSPASPNPLAHRMIQVTEY AALVALVPLAFWVSGIYGLVRQLSLA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_1446 | - | - | 100% (447) | hypothetical protein Mvan_1446 |
| M. vanbaalenii PYR-1 | Mvan_0420 | - | 1e-13 | 24.47% (470) | hypothetical protein Mvan_0420 |
| M. vanbaalenii PYR-1 | Mvan_0081 | - | 2e-11 | 23.92% (510) | hypothetical protein Mvan_0081 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3478 | - | 5e-40 | 31.97% (466) | integral membrane protein |
| M. gilvum PYR-GCK | Mflv_4960 | - | 1e-102 | 48.39% (434) | hypothetical protein Mflv_4960 |
| M. tuberculosis H37Rv | Rv3448 | - | 9e-41 | 32.19% (466) | integral membrane protein |
| M. leprae Br4923 | MLBr_01539 | - | 4e-11 | 24.45% (499) | hypothetical protein MLBr_01539 |
| M. abscessus ATCC 19977 | MAB_3757 | - | 3e-30 | 28.11% (498) | hypothetical protein MAB_3757 |
| M. marinum M | MMAR_1101 | - | 2e-31 | 28.85% (461) | hypothetical protein MMAR_1101 |
| M. avium 104 | MAV_4391 | - | 4e-43 | 33.33% (453) | hypothetical protein MAV_4391 |
| M. smegmatis MC2 155 | MSMEG_1535 | - | 4e-53 | 35.31% (439) | hypothetical protein MSMEG_1535 |
| M. thermoresistible (build 8) | TH_3996 | - | 4e-41 | 32.37% (482) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_0859 | - | 5e-31 | 28.85% (461) | hypothetical protein MUL_0859 |
CLUSTAL 2.0.9 multiple sequence alignment
Mvan_1446|M.vanbaalenii_PYR-1 MPFHPQPGKVLQRRPPGPSYVDFVPDTLRRVAVHALG--------PREAA
Mflv_4960|M.gilvum_PYR-GCK -----------------------MPDTLCRLTVHVVG--------ADESA
MSMEG_1535|M.smegmatis_MC2_155 ----------------------MMPESLYRVSIHCA-------AADHAG-
TH_3996|M.thermoresistible__bu -----------------------VSDSVRRVSVQIDTLVDMLIGTDRGGT
Mb3478|M.bovis_AF2122/97 --------------------MPTSDPGLRRVTVHAGA------------Q
Rv3448|M.tuberculosis_H37Rv --------------------MPTSDPGLRRVTVHAGA------------Q
MMAR_1101|M.marinum_M -------------------MLSGSEPGLCRVAVHSGT------------A
MUL_0859|M.ulcerans_Agy99 -------------------MLSGSEPGLCRVAVHSGT------------A
MAV_4391|M.avium_104 ------------------MALAVSTTGLCRVSVHWET------------Q
MAB_3757|M.abscessus_ATCC_1997 -----------MTHAQSGAEQRSAVLELCRVSIQAER------------T
MLBr_01539|M.leprae_Br4923 --------MTAVADAPRTDIEGTSSPRVVVVGIVAGEG-----------A
: : :
Mvan_1446|M.vanbaalenii_PYR-1 AADLVLPAEQPLAELVPSIVDTVFGGP----------VGPRQWQLATPAG
Mflv_4960|M.gilvum_PYR-GCK AVDLVLPAACPLGELMPSLVDTIFGDT----------AGQEHWQLTRVTG
MSMEG_1535|M.smegmatis_MC2_155 AADLVLPAAMTVSQLLPSIVAAVGAPG----------DLPRRWYLAPPGG
TH_3996|M.thermoresistible__bu VIDVTLPSGVEVAELIPAIVDLAVGADG------VDAESPTAWKLARVGG
Mb3478|M.bovis_AF2122/97 AVDLTLPAAVPVATLIPSIVDILGD-------RGASPATAARYQLSALGA
Rv3448|M.tuberculosis_H37Rv AVDLTLPAAVPVATLIPSIVDILGD-------RGASPATAARYQLSALGA
MMAR_1101|M.marinum_M VVDLSLPAALPVAELIPAIVESLGG-------RDIG-AAPTRYQLCPLGA
MUL_0859|M.ulcerans_Agy99 VVDLSLPAALPFAELIPAIVESLGG-------RDIG-AAPTRYQLCPLGA
MAV_4391|M.avium_104 AVDVSLPAEIAVAELIPSLVDMLGA-------GDGG---AGRYRLSAPGA
MAB_3757|M.abscessus_ATCC_1997 QVDLALPTSVPLALLVGSIVDIINQHVGVPELTSPEDAVETHWRLSRPGQ
MLBr_01539|M.leprae_Br4923 QISVLLDANAPVSVMTDPLLKVINSRLCELGEGTLEPTGRGRWALCLIDG
.: * : .. : .:: : *
Mvan_1446|M.vanbaalenii_PYR-1 VPLDSSMSLRDNVVEDGDVIVLTTARVPPPRLLPTDPCAVVADAAEKGTP
Mflv_4960|M.gilvum_PYR-GCK PPLNPALSLRDNDIGDGDMVMLTASRVPSPRISPTEACTVVALAGGNRES
MSMEG_1535|M.smegmatis_MC2_155 APLDESMTLAQNEVHDGAVLVLTARLPVAPRSYGLIHALTAAAPTPTPPP
TH_3996|M.thermoresistible__bu TVLDASRTLTENGIREGELLMLTG---AASAPVTRAEAPPGLEPAAGRWH
Mb3478|M.bovis_AF2122/97 PALPNATTLAQCGIRDGAVLVLHKSSAQPPTPRCDDVAEAVAAALDTTAR
Rv3448|M.tuberculosis_H37Rv PALPNATTLAQCGIRDGAVLVLHKSSAQPPTPRCDDVAEAVAAALDTTAR
MMAR_1101|M.marinum_M GALPPSQSLAQSGIRDGTVLSLSRCSAEPAPGPHDDDAEAVLATLRGSTR
MUL_0859|M.ulcerans_Agy99 GALPPSKSLAQRGIRDGTVLSLSRCSAEPAPGPHDDDAEAVLATLRGSTR
MAV_4391|M.avium_104 AALDPSTTLAHNHIGDGAILVLSRIDVPLPAPRYRDIADTVSAALDATAR
MAB_3757|M.abscessus_ATCC_1997 PPLQMSSTLGELEVRDGDLLILTRSDVAAPDPLFDDVFLAVSTFRTVSAH
MLBr_01539|M.leprae_Br4923 TPLWPTQSLTEQDVYDGDRLWIRFIADTERRSQVIEHISTAVSANLSKRF
* : :* . : :* : :
Mvan_1446|M.vanbaalenii_PYR-1 GRGVNRAAGAAGIVACAVALVW------------SGTAAPTHWHLWCAAA
Mflv_4960|M.gilvum_PYR-GCK GHGAT-PWCIAGIIVAAVTLVR------------SGMVTPGGWHLWCAAA
MSMEG_1535|M.smegmatis_MC2_155 ASRMFAGLWTCAVGMAAVLCAG------------IGTGGPTRVIVAAVVA
TH_3996|M.thermoresistible__bu GARTALALWCPIAGTAAVVWTG------------LMRDDIGRTVPAAMLT
Mb3478|M.bovis_AF2122/97 PQCQRTTRLSGALAASCITAGGGLMLVRNALGTNVTRYSDATAGVVAAAG
Rv3448|M.tuberculosis_H37Rv PQCQRTTRLSGALAASCITAGGGLMLVRNALGTNVTRYSDATAGVVAAAG
MMAR_1101|M.marinum_M PPSRRAKELTGALTAGGVGGVGAVLLVRDALG-NTDRHGAATAVVAITSG
MUL_0859|M.ulcerans_Agy99 PPSRRAKELTGALTAGGVGGVGAVLLVRDALG-NTDRHGAATAVVAITSR
MAV_4391|M.avium_104 P-DVAVRRVAGAAAAASFVAAGGLQLVRNTFSASVVPDSGGTVAVLVSTT
MAB_3757|M.abscessus_ATCC_1997 PWSRNAARILGASVCGLSALLGATALLR----AGATNPGLLLPIIAVAIA
MLBr_01539|M.leprae_Br4923 AAIDSIVAVQVGALMVATGVLASSVLLVWWRWHHGFWLSVIYATVIALLI
Mvan_1446|M.vanbaalenii_PYR-1 LSGSAAVGAVAAARAEPELTALLSTAAVVFATAAGLLAVRSAPWPATVLL
Mflv_4960|M.gilvum_PYR-GCK LSGIAGTMSVALGRADRRVSTVLNTAAVVFAAATGVLAVPAAAWPAATLL
MSMEG_1535|M.smegmatis_MC2_155 VAVTAVAFASRRLALTAAAATSVQSLAVASVAILGFVAVPSDSGPGNVFL
TH_3996|M.thermoresistible__bu VGAVAAVLPYR-HRRDPLTATASALIVVMLAAVLGLLVVPDGPGPPNLML
Mb3478|M.bovis_AF2122/97 LAALLFAVIACRTYRDPIAGLTLSVIATIFGAVAGLLAVPGVPGVHSVLV
Rv3448|M.tuberculosis_H37Rv LAALLFAVIACRTYRDPIAGLTLSVIATIFGAVAGLLAVPGVPGVHSVLV
MMAR_1101|M.marinum_M VLALLVAGMARRTGREPTAVFTLNVIATTFVAVGALLAVPGRLGVPNLML
MUL_0859|M.ulcerans_Agy99 VLALLVAGMTRRTGREPTAVFTLNVIATTFVAVGALLAVPGRLGVPNLML
MAV_4391|M.avium_104 LLTLGAAAVAHRGYRDPGAALALGAIATVFAGLAGFVAVPGAPSLSHVLL
MAB_3757|M.abscessus_ATCC_1997 LVAMTAAVFANRVYDDSLASVMLSHCAVGFSAVAGALFVPGKYGAPHAML
MLBr_01539|M.leprae_Br4923 LVMSTLVLMRATTREDRRAGDIMLLSGIAPVTAAAAAAPPGPLGSPHAVM
: . . .:
Mvan_1446|M.vanbaalenii_PYR-1 ASSAGFCMSVLLLRLVAD-RALLTAFTAAGGAATAAAGLANLAAS-PVTA
Mflv_4960|M.gilvum_PYR-GCK AAASALAMSTLLARMCPG-AADLPAFCAVAGAVTAAAALSHLAAPRLTTA
MSMEG_1535|M.smegmatis_MC2_155 AATAAASLGVVLLRLTDGSVETMHAVVAFAVIAGIGAAVATLFPLDIQAF
TH_3996|M.thermoresistible__bu AAAAAAAAAMVMARLTGVDIVGLTAVATGAAAVAISLIPAVLWPVPTVVI
Mb3478|M.bovis_AF2122/97 AAMAAAATSVLAMRITGCGGITLTAVACCAVVVAAATLVGAITAAPVPAI
Rv3448|M.tuberculosis_H37Rv AAMAAAATSVLAMRITGCGGITLTAVACCAVVVAAATLVGAITAAPVPAI
MMAR_1101|M.marinum_M AAMGASVAAALAIRLTGCGGVTFTAVMCCAIVIAAAALCGVITGAALYVV
MUL_0859|M.ulcerans_Agy99 AAMGASVAAALAIRLTGCGGVTFTAVMCCAIVIAAAALCGVITGAALYVV
MAV_4391|M.avium_104 AAAAAGLAAVSAIGLSGCG-AGLLALACWCLILATAALAGVLSGAPLPAV
MAB_3757|M.abscessus_ATCC_1997 ALMVAMVVSILAMRATGTGTTSLVAVASASFLGFAAALGYVLFEPPIYSL
MLBr_01539|M.leprae_Br4923 GFGVFAIAAMLALRFTGRQLSIYTAMITISVVVAIASLARMVAMTSAVTL
. . *. . :
Mvan_1446|M.vanbaalenii_PYR-1 GAALAALSTAALSVAPKLAVVTAGPEP-----------------------
Mflv_4960|M.gilvum_PYR-GCK GAVLVVLSLAGLAISPRITIALARLSPSRPAVDDE---------------
MSMEG_1535|M.smegmatis_MC2_155 GACLGALGIAALSLSPRMSIILAGLTPG-EASPAG---------------
TH_3996|M.thermoresistible__bu GVLTASLSMAVLAVAPRLSIALAGLTPAPDGGPDAP--------------
Mb3478|M.bovis_AF2122/97 GSLDTLASFGLLEVSARMAVLLAGLSPRLPPALNP---------------
Rv3448|M.tuberculosis_H37Rv GSLATLASFGLLEVSARMAVLLAGLSPRLPPALNP---------------
MMAR_1101|M.marinum_M GSLTTLAALVALEVSARVSMVVAGLSPKLPAAPGS---------------
MUL_0859|M.ulcerans_Agy99 GSLTTLAALVALEVSARVSMVVAGLSPKLPAAPGS---------------
MAV_4391|M.avium_104 ASAAGLVSLCLLGMAARASLALAGLSPRPATAPAG---------------
MAB_3757|M.abscessus_ATCC_1997 GAVLGSVGICAVALSPRVAMVLARLPLPPVPTQGAPSRPEHSTAPIEAIE
MLBr_01539|M.leprae_Br4923 LSCVMLACVLLYHCAPALSRRLAGIRLPVFPSATSRWVFEARPDLPN---
:. : *
Mvan_1446|M.vanbaalenii_PYR-1 ----------------------------AAAHSTLTGLVAGWSATAAAGG
Mflv_4960|M.gilvum_PYR-GCK --------------------------EAAAAHTLLTALVAGWSSSAALGA
MSMEG_1535|M.smegmatis_MC2_155 ----------------------DVDVVAARGHRILCGLVAGASAAAALGA
TH_3996|M.thermoresistible__bu ---------------GSLFDDAPAAPRLVRGNAILTGILTGAAVTAVIGT
Mb3478|M.bovis_AF2122/97 ------------DDADALPTTDRLTTRANRADAWLTSLLAAFAASATIGA
Rv3448|M.tuberculosis_H37Rv ------------DDADALPTTDRLTTRANRADAWLTSLLAAFAASATIGA
MMAR_1101|M.marinum_M ------------EEAPELAAPDLLATRAVRADRWLNGLHGGFSSAAALGA
MUL_0859|M.ulcerans_Agy99 ------------EEAPELAAPDLLATRAIRADRWLNGLHGGFSSAAALGA
MAV_4391|M.avium_104 ------------GPE---PGEAWVSARARRADRWLTGLLAGLSSSATVGA
MAB_3757|M.abscessus_ATCC_1997 GLDGLDTEGDDVEDATALPPLPDLREKALRAHAVLTGLVCGTSAVTAVGA
MLBr_01539|M.leprae_Br4923 ---TVVRSDGGPPVLEGPASVRDVLLQSERARSYLSGLLLGLGVLLVVSL
. * .: . . . .
Mvan_1446|M.vanbaalenii_PYR-1 VTVAAVAG-----------PAESSTILAALFAADLGGLLVLRTRSHVVVH
Mflv_4960|M.gilvum_PYR-GCK VVVAAATI-----------VSGASAGLCAGLCVAAGVVLILRRNSHADGV
MSMEG_1535|M.smegmatis_MC2_155 VLVAAD-------------GCGSVTFAAIAFDAAIGLALLSRGRSHASGR
TH_3996|M.thermoresistible__bu TLIALGGVLVGQAAREPGSGPGGPWWTGPLFTALLAAALVLRARSHADAL
Mb3478|M.bovis_AF2122/97 IGTAVATHGIHRSS-----------MGGIALAAVTGALLLLRARS-ADTR
Rv3448|M.tuberculosis_H37Rv IGTAVATHGIHRSS-----------MGGIALAAVTGALLLLRARS-ADTR
MMAR_1101|M.marinum_M V---VAVLGSQR---------------AIGLTAVTGAVLLLRARAQVDGR
MUL_0859|M.ulcerans_Agy99 V---VAVFGSQR---------------AIGLTAVTGAVLLLRARAQVDGR
MAV_4391|M.avium_104 A--VTVLAGAPR-------------LCCLAFGTGTGALLLLRSRG-GDGT
MAB_3757|M.abscessus_ATCC_1997 MLAALTFSGAGGHHP-----TGAHRLSGVVLAGLIALAMMLRARSHADLA
MLBr_01539|M.leprae_Br4923 TALSNPHVG--------------QRWLPLLLAGFTSGFLLLRGRSYVDRW
: . :: * ..
Mvan_1446|M.vanbaalenii_PYR-1 RRIALGAAGSVSLLAAFT--VTVVAAPVHAPWLCACAAVLC--VLAVRGA
Mflv_4960|M.gilvum_PYR-GCK RRLWLGTSGFIACAAAVP--AVADAAPAQAFWLSVAVAGGC--VAGALRA
MSMEG_1535|M.smegmatis_MC2_155 CRTVLGVTGFCALTAMFV--LVVAWSPPYGNWVGAAAVAVG--LAAMCSL
TH_3996|M.thermoresistible__bu RRGVLVGCGVGCATMAFT--AVVIEHPGQASAWGALAVAIG--LVAAGGR
Mb3478|M.bovis_AF2122/97 RSLVFAICGITTVATAFT--VAADRALEHGPWIAALTAMLAAVAMFLGFV
Rv3448|M.tuberculosis_H37Rv RSLVFAICGITTVATAFT--VAADRALEHGPWIAALTAMLAAVAMFLGFV
MMAR_1101|M.marinum_M SRLMFLIAGYVAGTAAFA--VAAPGLAQHGPWIAILTAALTALALHLGFI
MUL_0859|M.ulcerans_Agy99 SRLMFLIAGYVAGTAAFA--VAAPGLAQHGPWIAILTAALTALALHLGFI
MAV_4391|M.avium_104 RALVFAAGGIVTTATTFG--VAAWSAPLPGPWVAATTATLVAAALYLGCA
MAB_3757|M.abscessus_ATCC_1997 QTVAINLGGIAIPAAAFA--FVAVAYPTAAVFTTVLAAIAAGSAIALGFL
MLBr_01539|M.leprae_Br4923 QAITLAATAVLIVAAVVVRYALVLSSPLAVSIGAAILVLLPAAGLIAAAV
: . . . .
Mvan_1446|M.vanbaalenii_PYR-1 GSPASPNPLAHRMIQVTEYAALVALVPLAFWVSGIYGLVRQLSLA--
Mflv_4960|M.gilvum_PYR-GCK GRPEPSNPALRHGIQVLEYVALAAVIPLAFWVSGVYGLVRDASLL--
MSMEG_1535|M.smegmatis_MC2_155 GPASLTNAGILRIADAAEYVALAAVAPLACWLAGIFDAVRGFGM---
TH_3996|M.thermoresistible__bu -PSAPVSPLIRRAADVAECVVLAALAPLACWVAGVYGLVRGLALW--
Mb3478|M.bovis_AF2122/97 APALSLSPVTYRTIELLECLALIAMVPLTAWLCGAYSAVRHLDLTWT
Rv3448|M.tuberculosis_H37Rv APALSLSPVTYRTIELLECLALIAMVPLTAWLCGAYSAVRHLDLTWT
MMAR_1101|M.marinum_M APTRPPSPIACRLIDALEFSASASLLPLACWTCGVFSAVGGLGLTWT
MUL_0859|M.ulcerans_Agy99 APTRPPSPIACRLIDALEFSASASLLPLACWTCGVFSAVGGLGLTWT
MAV_4391|M.avium_104 P--RTCSPVLSRAADLLEWLALAALVPLTCWIAGLYGTVRGLTLG--
MAB_3757|M.abscessus_ATCC_1997 VSARKYSPVARRTVEIIEYIALSLIVPIAVWVCGVYSAVRGLNLP--
MLBr_01539|M.leprae_Br4923 VPNTIYSPLFRKLVEWIEYLCLVPIFPLALWLMDVYTAIRYR-----
.. : : * : *:: * . : :