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VDPGVSPGCVRFVTLEISPSMTMQGERLDAVVAEAVAGDRNALREVLETIRPIVVRYCRARVGTVERSGL SADDVAQEVCLATITALPRYRDRGRPFLAFLYGIAAHKVADAHRAAGRDRAYPAETLPERWSADAGPEQM AIEADSVTRMNELLEILPAKQREILILRVVVGLSAEETAAAVGSTTGAVRVAQHRALQRLKDEIVAAGDY A*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3414c | sigD | - | 100% (212) | RNA polymerase sigma factor SigD |
| M. tuberculosis H37Rv | Rv2069 | sigC | 4e-09 | 29.71% (175) | RNA polymerase sigma factor SigC |
| M. tuberculosis H37Rv | Rv1221 | sigE | 1e-07 | 29.50% (139) | RNA polymerase sigma factor SigE |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3448c | sigD | 1e-116 | 100.00% (212) | RNA polymerase sigma factor SigD |
| M. gilvum PYR-GCK | Mflv_4912 | - | 2e-82 | 80.41% (194) | RNA polymerase sigma factor SigD |
| M. leprae Br4923 | MLBr_01076 | sigE | 2e-07 | 28.47% (137) | RNA polymerase sigma factor SigE |
| M. abscessus ATCC 19977 | MAB_3724c | - | 8e-74 | 74.21% (190) | RNA polymerase sigma factor SigD |
| M. marinum M | MMAR_1134 | sigD | 1e-102 | 96.45% (197) | alternative RNA polymerase sigma-D factor, SigD |
| M. avium 104 | MAV_4359 | - | 7e-92 | 90.37% (187) | RNA polymerase sigma factor SigD |
| M. smegmatis MC2 155 | MSMEG_1599 | - | 2e-80 | 79.26% (188) | RNA polymerase sigma factor SigD |
| M. thermoresistible (build 8) | TH_1681 | sigD | 3e-73 | 77.71% (175) | PROBABLE ALTERNATIVE RNA POLYMERASE SIGMA-D FACTOR SIGD |
| M. ulcerans Agy99 | MUL_0897 | sigD | 1e-102 | 96.45% (197) | RNA polymerase sigma factor SigD |
| M. vanbaalenii PYR-1 | Mvan_1508 | - | 3e-83 | 81.91% (188) | RNA polymerase sigma factor SigD |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3414c|M.tuberculosis_H37Rv -----------------------------------------MVDPGVSPG
Mb3448c|M.bovis_AF2122/97 -----------------------------------------MVDPGVSPG
MMAR_1134|M.marinum_M --------------------------------------------------
MUL_0897|M.ulcerans_Agy99 --------------------------------------------------
MAV_4359|M.avium_104 --------------------------------------------------
MSMEG_1599|M.smegmatis_MC2_155 --------------------------------------------------
TH_1681|M.thermoresistible__bu --------------------------------------------------
Mflv_4912|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_1508|M.vanbaalenii_PYR-1 --------------------------------------------------
MAB_3724c|M.abscessus_ATCC_199 --------------------------------------------------
MLBr_01076|M.leprae_Br4923 MGDGIGMEREGRWTGNTQCPLRVVPGDESPTLDGRASPEDLIITNLLSPT
Rv3414c|M.tuberculosis_H37Rv CVRFVTLEISPSMTMQGERLDAVVAEAVAGDRNALREVLETIRPIVVRYC
Mb3448c|M.bovis_AF2122/97 CVRFVTLEISPSMTMQGERLDAVVAEAVAGDRNALREVLETIRPIVVRYC
MMAR_1134|M.marinum_M ------MEISPSMTIEGERLDAVVAEAVAGDRNALREVLETIRPIVVRYC
MUL_0897|M.ulcerans_Agy99 ------MEISPSMTIEGERLDAVVAEAVAGDRNALREVLETIRPIVVRYC
MAV_4359|M.avium_104 ------MTIP-----AGERLDAVVAKAVTGDHNALREVLETIRPIVVRYC
MSMEG_1599|M.smegmatis_MC2_155 ------------MTSSGDRLDAVVAEAVAGDRDALREVLEIIRPIIVRYC
TH_1681|M.thermoresistible__bu ---------------------------VAGDRDALRHVLETIRPLVLRYC
Mflv_4912|M.gilvum_PYR-GCK ------------MTISGERLDAVVAEAVAGDRGALREVLETIRPLVVRYC
Mvan_1508|M.vanbaalenii_PYR-1 ------------MTISGERLDAVVAEAVAGDRDALREVLETIRPLVVRYC
MAB_3724c|M.abscessus_ATCC_199 ------------MTSTESGLDDVVAAAVRGDRDALSEVLSAIRPVVVRYC
MLBr_01076|M.leprae_Br4923 IMSHPPPSRDDDWVEPFDALQGTAVFDATGDKATMPSWEELVRQHAARVY
. **: :: . :* *
Rv3414c|M.tuberculosis_H37Rv RARVGTVERSGLSADDVAQEVCLATITALPRYRDRGRPFLAFLYGIAAHK
Mb3448c|M.bovis_AF2122/97 RARVGTVERSGLSADDVAQEVCLATITALPRYRDRGRPFLAFLYGIAAHK
MMAR_1134|M.marinum_M RARVGTVERSGLSADDVAQEVCLATITALPRYRDRGRPFLAFLYGIAAHK
MUL_0897|M.ulcerans_Agy99 RARVGTVERSGLSADDVAQEVCLATITALPRYRDRGRPFLAFLYGIAAHK
MAV_4359|M.avium_104 RARVGTVERGGLSADDVAQEVCLATITALPRYRDRGRPFLAFLYGIAAHK
MSMEG_1599|M.smegmatis_MC2_155 RARIGATERSGLSADDVAQEVCLAAITALPRYRDQGRPFLAFVYGIAAHK
TH_1681|M.thermoresistible__bu RARVGAGERSGLSADDVAQEVCLAAITALPRYKDQGRPFLAFVYGIAAHK
Mflv_4912|M.gilvum_PYR-GCK RARVGTAERSGLSADDVAQEVCLAAITALPRYRDQGRPFLAFVYGIAAHK
Mvan_1508|M.vanbaalenii_PYR-1 RARVGTAERSGLSADDVAQEVCLAAITALPRYKDQGRPFLAFVYGIAAHK
MAB_3724c|M.abscessus_ATCC_199 RARVGTAERSGLSADDVAQEVCLAVIAALPRYQDQGRPFLAFVYGIAAHK
MLBr_01076|M.leprae_Br4923 WLAYRLSGNQ-HDAEDLTQETFIRVFRSVQNYQPG--TFEGWLHRITTNL
. .*:*::**. : .: :: .*: .* .::: *:::
Rv3414c|M.tuberculosis_H37Rv VADAHRAAGRDRAYPAETLPERWSADA-GPEQMAIEADSVTRMNELLEIL
Mb3448c|M.bovis_AF2122/97 VADAHRAAGRDRAYPAETLPERWSADA-GPEQMAIEADSVTRMNELLEIL
MMAR_1134|M.marinum_M VADAHRAAGRDLAYPAESVPERRSADA-GPEQLAIEADSVTRMNELLEIL
MUL_0897|M.ulcerans_Agy99 VADAHRAAGRDLAYPAESVPERRSADA-GPEQLAIEADSVTRMNELLEIL
MAV_4359|M.avium_104 VADAHRAAGRDLAYPTESIPDRWSNDA-GPEQLAIEADSVSRMSELLEIL
MSMEG_1599|M.smegmatis_MC2_155 VADAHRAAARNRAEPTDVVPERFSLDA-GPEQSAIDSESSARMAKLLSVL
TH_1681|M.thermoresistible__bu VADAHRAAARNRAEPTDVLPERISTEN-GPEQMAIDAESSARMQKLLQVL
Mflv_4912|M.gilvum_PYR-GCK VADAHRAAGRNRADPMDVVPERLSGEA-GPEQMAIDSESSARMATLLKVL
Mvan_1508|M.vanbaalenii_PYR-1 VADAHRAAGRNKADPMDVVPERFSGEA-GPEQLAIDSESSARMAELLQIL
MAB_3724c|M.abscessus_ATCC_199 VADAHRAMARDKSDPAENLPEQVDRHA-GPEQEALNSESSRRMQALLEVL
MLBr_01076|M.leprae_Br4923 FLDMVRRRARIRMDALPDDYDRVPADEPNPEQIYHDSRLGPDLQAALDSL
. * * .* . :: . .*** :: : *. *
Rv3414c|M.tuberculosis_H37Rv PAKQREILILRVVVGLSAEETAAAVGSTTGAVRVAQHRALQRLKDEIVAA
Mb3448c|M.bovis_AF2122/97 PAKQREILILRVVVGLSAEETAAAVGSTTGAVRVAQHRALQRLKDEIVAA
MMAR_1134|M.marinum_M PAKQREILILRVVVGLSAEETAAAVGSTTGAVRVAQHRALQRLKDEIVAA
MUL_0897|M.ulcerans_Agy99 PAKQREILILRVVVGLSAEETAAAVGSTTGAVRVAQHRALQRLKDEIVAA
MAV_4359|M.avium_104 PAKQREILILRVVVGLSAEETAAAVGSTTGAVRVAQHRALSRLKSEMIAA
MSMEG_1599|M.smegmatis_MC2_155 PEKQREILILRVVVGMSAEETAEAVGSTAGAVRVAQHRALARLKTEIMAT
TH_1681|M.thermoresistible__bu PEKQREILILRVVVGMSAEETAEAVGSTAGAVRVAQHRALARLKAEVMAT
Mflv_4912|M.gilvum_PYR-GCK PEKQREILILRVVVGMSAEETAEAVGSTAGAVRVAQHRALSRLKAEITST
Mvan_1508|M.vanbaalenii_PYR-1 PEKQREILILRVVVGMSAEETADAVGSTAGAVRVAQHRALTRLKTEIMAA
MAB_3724c|M.abscessus_ATCC_199 PEKQREILILRVVVGLSAEETADAVGSSAGAVRVAQHRALQKLKAEMTRA
MLBr_01076|M.leprae_Br4923 PPEFRAAVVLCDIEGLSYEEIGATLGVKLGTVRSRIHRGRQALRDYLLTA
* : * ::* : *:* ** . ::* . *:** **. *: : :
Rv3414c|M.tuberculosis_H37Rv G---DYA----------
Mb3448c|M.bovis_AF2122/97 G---DYA----------
MMAR_1134|M.marinum_M G---DYA----------
MUL_0897|M.ulcerans_Agy99 G---DYA----------
MAV_4359|M.avium_104 G---DCA----------
MSMEG_1599|M.smegmatis_MC2_155 G--RDHA----------
TH_1681|M.thermoresistible__bu G--HHHG----------
Mflv_4912|M.gilvum_PYR-GCK GQGRDYA----------
Mvan_1508|M.vanbaalenii_PYR-1 G--RDHA----------
MAB_3724c|M.abscessus_ATCC_199 G---DYRG---------
MLBr_01076|M.leprae_Br4923 HP-RDGATTDATHVKSA
.