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MELLGGPRVGNTESQLCVADGDDLPTYCSANSEDLNITTITTLSPTSMSHPQQVRDDQWVEPSDQLQGTA VFDATGDKATMPSWDELVRQHADRVYRLAYRLSGNQHDAEDLTQETFIRVFRSVQNYQPGTFEGWLHRIT TNLFLDMVRRRARIRMEALPEDYDRVPADEPNPEQIYHDARLGPDLQAALASLPPEFRAAVVLCDIEGLS YEEIGATLGVKLGTVRSRIHRGRQALRDYLAAHPEHGECAVHVNPVR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv1221 | sigE | - | 100% (257) | RNA polymerase sigma factor SigE |
| M. tuberculosis H37Rv | Rv3223c | sigH | 9e-21 | 34.59% (159) | RNA polymerase sigma factor RpoE |
| M. tuberculosis H37Rv | Rv0735 | sigL | 9e-13 | 34.42% (154) | RNA polymerase sigma factor SigL |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1253 | sigE | 1e-151 | 100.00% (257) | RNA polymerase sigma factor SigE |
| M. gilvum PYR-GCK | Mflv_2200 | - | 1e-104 | 88.24% (204) | RNA polymerase sigma factor SigE |
| M. leprae Br4923 | MLBr_01076 | sigE | 1e-112 | 82.14% (252) | RNA polymerase sigma factor SigE |
| M. abscessus ATCC 19977 | MAB_1362 | - | 5e-93 | 73.75% (240) | alternative RNA polymerase sigma factor |
| M. marinum M | MMAR_4216 | sigE | 1e-118 | 86.48% (244) | alternative RNA polymerase sigma factor SigE |
| M. avium 104 | MAV_1365 | - | 1e-115 | 84.30% (242) | RNA polymerase sigma-70 factor |
| M. smegmatis MC2 155 | MSMEG_5072 | - | 1e-103 | 87.80% (205) | RNA polymerase sigma factor SigE |
| M. thermoresistible (build 8) | TH_0545 | sigE | 1e-100 | 85.64% (202) | ALTERNATIVE RNA POLYMERASE SIGMA FACTOR SIGE |
| M. ulcerans Agy99 | MUL_4519 | sigE | 1e-117 | 86.07% (244) | RNA polymerase sigma factor SigE |
| M. vanbaalenii PYR-1 | Mvan_4496 | - | 1e-105 | 86.67% (210) | RNA polymerase sigma factor SigE |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2200|M.gilvum_PYR-GCK MTEGARTDTVRTARIDSARSRNENASARVAEHD-GSPQGGPHHHLEDPTT
Mvan_4496|M.vanbaalenii_PYR-1 MTDGAFS-----ARPDHARLGNNIPTGRVVAFERSSPSDRTHLETEDPTT
MSMEG_5072|M.smegmatis_MC2_155 MEHDDRR-------ASQVRAGNNRVVIRVEQIE-----NNAVHEQEGSTT
Rv1221|M.tuberculosis_H37Rv -----------MELLGGPRVGNTESQLCVADGD-DLPTYCS-ANSEDLNI
Mb1253|M.bovis_AF2122/97 -----------MELLGGPRVGNTESQLCVADGD-DLPTYCS-ANSEDLNI
MMAR_4216|M.marinum_M -----------MER-GGRGLGNTEWQLRVAAGD-ELPMSDGREKPEEHTI
MUL_4519|M.ulcerans_Agy99 -----------MER-GGRGLGNTAWQLRVAAGD-ELPMSDGREKPEEHTI
MLBr_01076|M.leprae_Br4923 -----MGDGIGMER-EGRWTGNTQCPLRVVPGD-ESPTLDGRASPEDLII
MAV_1365|M.avium_104 -----------MDR-GARETGNTEWQLPVAAND-EMP-LIGMPNSEELII
TH_0545|M.thermoresistible__bu --------------------------------------------------
MAB_1362|M.abscessus_ATCC_1997 ----MSRSILNQSPSDPRLSGNNTDGIWVEQAD-GLPTGGEAAVTEQ---
Mflv_2200|M.gilvum_PYR-GCK TTQAPTSSVSAAAPVAAPVAAPVSMAHREQFTEAEWVEPT--DELTGTAV
Mvan_4496|M.vanbaalenii_PYR-1 TTQAPT---------AAPVAAPVTMAHLEQFTDAAWVEPA--DELTGTAV
MSMEG_5072|M.smegmatis_MC2_155 IASQPV---------TATHAAPVSMAHLEQFTDSDWVEPS--DEPTGTAV
Rv1221|M.tuberculosis_H37Rv TT--------------ITTLSPTSMSHPQQVRDDQWVEPS--DQLQGTAV
Mb1253|M.bovis_AF2122/97 TT--------------ITTLSPTSMSHPQQVRDDQWVEPS--DQLQGTAV
MMAR_4216|M.marinum_M T-----------------TLSTTTMSHPQLVRDDEWAETS--DGLLGTAV
MUL_4519|M.ulcerans_Agy99 T-----------------TLSTTTMSHPQLVRDDEWAETS--DGLLGTAV
MLBr_01076|M.leprae_Br4923 TN----------------LLSPTIMSHPPPSRDDDWVEPF--DALQGTAV
MAV_1365|M.avium_104 TT----------------LLSPSSMSHAHDPSADGWAEPS--DGLQGTAV
TH_0545|M.thermoresistible__bu ------------------MSVPASMTHFAPPQATEWAEPV--EEPTGTAV
MAB_1362|M.abscessus_ATCC_1997 ------------------EEHAISLTRISEPDYTEFVDAANADELSGTAV
. ::: :.:. : ****
Mflv_2200|M.gilvum_PYR-GCK FDATGDKAAMPSWDELVRQHADRVYRLAYRLSGNQHDAEDLTQETFIRVF
Mvan_4496|M.vanbaalenii_PYR-1 FDATGDKAAMPSWDELVRQHADRVYRLAYRLSGNQHDAEDLTQETFIRVF
MSMEG_5072|M.smegmatis_MC2_155 FDATGDQAAMPSWDELVRQHADRVYRLAYRLSGNQHDAEDLTQETFIRVF
Rv1221|M.tuberculosis_H37Rv FDATGDKATMPSWDELVRQHADRVYRLAYRLSGNQHDAEDLTQETFIRVF
Mb1253|M.bovis_AF2122/97 FDATGDKATMPSWDELVRQHADRVYRLAYRLSGNQHDAEDLTQETFIRVF
MMAR_4216|M.marinum_M FDATGDKAAMPSWDELVRQHADRVYRLAYRLSGNQQDAEDLTQETFIRVF
MUL_4519|M.ulcerans_Agy99 FDATGDKAAMPSWDELVRQHADRVYRLAYRLSGNQQDAEDLTQETFIRVF
MLBr_01076|M.leprae_Br4923 FDATGDKATMPSWEELVRQHAARVYWLAYRLSGNQHDAEDLTQETFIRVF
MAV_1365|M.avium_104 FDATGDKTAMPSWDELVRQHADRVYRLAYRLSGNQHDAEDLTQETFIRVF
TH_0545|M.thermoresistible__bu FDATGDKSTMPSWDELVRQHADRVYRLAYRLSGNQHDAEDLTQETFIRVF
MAB_1362|M.abscessus_ATCC_1997 FDATGDQAAMPSWDELVREHADRVYRLAYRLSGSQQDAEDLTQETFIRVF
******:::****:****:** *** *******.*:**************
Mflv_2200|M.gilvum_PYR-GCK RSVQNYQPGTFEGWLHRITTNLFLDMVRRRGRIRMEALPEDYDRVPADEP
Mvan_4496|M.vanbaalenii_PYR-1 RSVQNYQPGTFEGWLHRITTNLFLDMVRRRGRIRMEALPEDYDRVPADEP
MSMEG_5072|M.smegmatis_MC2_155 RSVQNYQPGTFEGWLHRITTNLFLDMVRRRGRIRMEALPEDYDRVPAEDP
Rv1221|M.tuberculosis_H37Rv RSVQNYQPGTFEGWLHRITTNLFLDMVRRRARIRMEALPEDYDRVPADEP
Mb1253|M.bovis_AF2122/97 RSVQNYQPGTFEGWLHRITTNLFLDMVRRRARIRMEALPEDYDRVPADEP
MMAR_4216|M.marinum_M RSVQNYQPGTFEGWLHRITTNLFLDMVRRRSRIRMEALPEDYDRVPADDP
MUL_4519|M.ulcerans_Agy99 RSVQNYQPGTFEGWLHRITTNLFLDMVRRRSRIRMEALPEDYDRVPADDP
MLBr_01076|M.leprae_Br4923 RSVQNYQPGTFEGWLHRITTNLFLDMVRRRARIRMDALPDDYDRVPADEP
MAV_1365|M.avium_104 RSVQNYQPGTFEGWLHRITTNLFLDMVRRRSRIRMEALPEDYERVPADEP
TH_0545|M.thermoresistible__bu RSLQNYQPGTFEGWLHRITTNLFLDMVRRRGRIRMESLPEDYDRVPGNSP
MAB_1362|M.abscessus_ATCC_1997 RSLQNYQPGTFEGWLHRITTNLFLDMVRRRGRIRMEALPEDYDRVPATDP
**:***************************.****::**:**:***. .*
Mflv_2200|M.gilvum_PYR-GCK NPEQIYHDSRLGADLQAALDSLAPEFRAAVVLCDIEGLSYEEIGATLGVK
Mvan_4496|M.vanbaalenii_PYR-1 NPEQIYHDSRLGPDLQAALDSLAPEFRAAVVLCDIEGLSYEEIGATLGVK
MSMEG_5072|M.smegmatis_MC2_155 NPEQIYHDSRLGADLQAALDSLPPEFRAAVVLCDIEGLSYEEIGATLGVK
Rv1221|M.tuberculosis_H37Rv NPEQIYHDARLGPDLQAALASLPPEFRAAVVLCDIEGLSYEEIGATLGVK
Mb1253|M.bovis_AF2122/97 NPEQIYHDARLGPDLQAALASLPPEFRAAVVLCDIEGLSYEEIGATLGVK
MMAR_4216|M.marinum_M NPEQIYHDSRLGPDLQAALDSLPPEFRAAVVLCDIEGLSYEEIGATLGVK
MUL_4519|M.ulcerans_Agy99 NPEQIYHDSRLGPDLQAALDSLPPEFRAAVVLCDIEGLSYEEIGATLGVK
MLBr_01076|M.leprae_Br4923 NPEQIYHDSRLGPDLQAALDSLPPEFRAAVVLCDIEGLSYEEIGATLGVK
MAV_1365|M.avium_104 NPEEIYHDSRLGPDLQAALDSLPPEFRAAVVLCDIEGLSYEEIGATLGVK
TH_0545|M.thermoresistible__bu NPEQIYHDARLGPDLQAALDSLPPDFRAAVVLCDIEGLSYEEIGATLGVK
MAB_1362|M.abscessus_ATCC_1997 DPEQIYHDAQLGADLQAALDSLAPEFRAAVVLCDIEGLSYEEIGATLDVK
:**:****::**.****** **.*:**********************.**
Mflv_2200|M.gilvum_PYR-GCK LGTVRSRIHRGRQALRDH-LARHSDVGAGRDTAKSA--------------
Mvan_4496|M.vanbaalenii_PYR-1 LGTVRSRIHRGRQALREY-LARHSDAGAGRDTARSA--------------
MSMEG_5072|M.smegmatis_MC2_155 LGTVRSRIHRGRQQLRDY-LAKHS-----SETAQSA--------------
Rv1221|M.tuberculosis_H37Rv LGTVRSRIHRGRQALRDY-LAAHP-EHGEC-AVHVNPVR-----------
Mb1253|M.bovis_AF2122/97 LGTVRSRIHRGRQALRDY-LAAHP-EHGEC-AVHVNPVR-----------
MMAR_4216|M.marinum_M LGTVRSRIHRGRQALRDY-LAAHP-EHSELSPRLVGTAR-----------
MUL_4519|M.ulcerans_Agy99 LGTVRSRIHRGRQALRDY-LAAHP-EHSELSPRLVGTAR-----------
MLBr_01076|M.leprae_Br4923 LGTVRSRIHRGRQALRDYLLTAHPRDGATTDATHVKSA------------
MAV_1365|M.avium_104 LGTVRSRIHRGRQALRDY-LAAHPDHDALRASLGVVSARPANVRAAIQRL
TH_0545|M.thermoresistible__bu LGTVRSRIHRGRQALRDY-LARHSQNSGQSATTS----------------
MAB_1362|M.abscessus_ATCC_1997 LGTVRSRIHRGRQAIREY-LAAHSSASALAAAE-----------------
************* :*:: *: *. .
Mflv_2200|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4496|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5072|M.smegmatis_MC2_155 --------------------------------------------------
Rv1221|M.tuberculosis_H37Rv --------------------------------------------------
Mb1253|M.bovis_AF2122/97 --------------------------------------------------
MMAR_4216|M.marinum_M --------------------------------------------------
MUL_4519|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01076|M.leprae_Br4923 --------------------------------------------------
MAV_1365|M.avium_104 CGLGLGIGRPVALHSKKANKAAIRMNGKELAMPDRGHVFRRAFSWLPAQF
TH_0545|M.thermoresistible__bu --------------------------------------------------
MAB_1362|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2200|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4496|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5072|M.smegmatis_MC2_155 --------------------------------------------------
Rv1221|M.tuberculosis_H37Rv --------------------------------------------------
Mb1253|M.bovis_AF2122/97 --------------------------------------------------
MMAR_4216|M.marinum_M --------------------------------------------------
MUL_4519|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01076|M.leprae_Br4923 --------------------------------------------------
MAV_1365|M.avium_104 ASQSDAPVGAPRQFGSTEHLSVEAIAAFVDGELRMNAHLRAAHHLSQCAQ
TH_0545|M.thermoresistible__bu --------------------------------------------------
MAB_1362|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2200|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4496|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_5072|M.smegmatis_MC2_155 --------------------------------------------------
Rv1221|M.tuberculosis_H37Rv --------------------------------------------------
Mb1253|M.bovis_AF2122/97 --------------------------------------------------
MMAR_4216|M.marinum_M --------------------------------------------------
MUL_4519|M.ulcerans_Agy99 --------------------------------------------------
MLBr_01076|M.leprae_Br4923 --------------------------------------------------
MAV_1365|M.avium_104 CAAEVDDQSRARAALRDSRPIRIPANLLGMLAEIPYESPDAPDRLADRDA
TH_0545|M.thermoresistible__bu --------------------------------------------------
MAB_1362|M.abscessus_ATCC_1997 --------------------------------------------------
Mflv_2200|M.gilvum_PYR-GCK -------
Mvan_4496|M.vanbaalenii_PYR-1 -------
MSMEG_5072|M.smegmatis_MC2_155 -------
Rv1221|M.tuberculosis_H37Rv -------
Mb1253|M.bovis_AF2122/97 -------
MMAR_4216|M.marinum_M -------
MUL_4519|M.ulcerans_Agy99 -------
MLBr_01076|M.leprae_Br4923 -------
MAV_1365|M.avium_104 RDRRRRP
TH_0545|M.thermoresistible__bu -------
MAB_1362|M.abscessus_ATCC_1997 -------