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IMPAATTTAHCEAVLDEIERVVVGKRSALTLILTAVLARGHVLIEDLPGLGKTLIARSFAAALGLDFTRV QFTPDLLPADLLGSTIYDMQSGRFEFRAGPIFTNLLLADEINRTPPKTQAALLEAMAEGQVSIDGQTHKL AMPFIVLATDNPIEYEGTYPLPEAQLDRFAIRLELRYLSERDETSMLRRRLERGSADPTVNQVVDCHDLL AMRESVEQVTVHEDVLHYVVSLANATRHHPQVAVGASPRAELDLVQLSRARALLLGRDYVIPEDVKELAT AAVAHRITLRPEMWVRKIAGADVVSELLRRLPVPRISGT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3164c | moxR3 | - | 100% (320) | PROBABLE METHANOL DEHYDROGENASE TRANSCRIPTIONAL REGULATORY PROTEIN MOXR3 |
| M. tuberculosis H37Rv | Rv3692 | moxR2 | 8e-78 | 49.51% (307) | methanol dehydrogenase transcriptional regulatory protein |
| M. tuberculosis H37Rv | Rv1479 | moxR1 | 2e-66 | 40.95% (315) | transcriptional regulatory protein MOXR1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3189c | moxR3 | 1e-178 | 99.69% (320) | methanol dehydrogenase transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_0476 | - | 1e-145 | 83.28% (311) | ATPase |
| M. leprae Br4923 | MLBr_01810 | moxR | 6e-67 | 41.27% (315) | MoxR homolog |
| M. abscessus ATCC 19977 | MAB_1909c | - | 1e-138 | 78.86% (317) | methanol dehydrogenase transcriptional regulatory protein MoxR3 |
| M. marinum M | MMAR_1399 | moxR3 | 1e-164 | 92.72% (316) | methanol dehydrogenase transcriptional regulatory protein |
| M. avium 104 | MAV_4052 | - | 1e-155 | 93.90% (295) | ATPase family protein associated with various cellular |
| M. smegmatis MC2 155 | MSMEG_3867 | - | 1e-104 | 84.07% (226) | ATPase family protein associated with various cellular |
| M. thermoresistible (build 8) | TH_0584 | moxR2 | 1e-141 | 78.30% (318) | PROBABLE METHANOL DEHYDROGENASE TRANSCRIPTIONAL REGULATORY |
| M. ulcerans Agy99 | MUL_2477 | moxR3 | 1e-162 | 91.77% (316) | methanol dehydrogenase transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_0180 | - | 1e-147 | 82.86% (315) | ATPase |
CLUSTAL 2.0.9 multiple sequence alignment
Rv3164c|M.tuberculosis_H37Rv -------------------------------MIMPAATTTAHCEAVLDEI
Mb3189c|M.bovis_AF2122/97 -------------------------------MIMPAATTTAHCEAVLDEI
MMAR_1399|M.marinum_M -------------------------------MTMPAALTTAACEAVIDEI
MUL_2477|M.ulcerans_Agy99 -------------------------------MTMPAALTTAACEAVIDEI
MAV_4052|M.avium_104 --------------------------------------------------
Mflv_0476|M.gilvum_PYR-GCK --------------------------------MSTPALTTARCEAVLDEI
Mvan_0180|M.vanbaalenii_PYR-1 --------------------------------MTTPALTTARCEAVLDEI
TH_0584|M.thermoresistible__bu --------------------------------MMPATTATAHCHAVLDEV
MAB_1909c|M.abscessus_ATCC_199 ------------------------------MTTVPISIATRHADAVLTEI
MSMEG_3867|M.smegmatis_MC2_155 ----------------------------MTSQANVDVATAAAARSVLDEI
MLBr_01810|M.leprae_Br4923 MTSAGGLPVGADGCSGPGGQSGPRAHEAPPGGADGLVAEVHTLERAIFEV
Rv3164c|M.tuberculosis_H37Rv ERVVVGKRSALTLILTAVLARGHVLIEDLPGLGKTLIARSFAAALGLDFT
Mb3189c|M.bovis_AF2122/97 GRVVVGKRSALTLILTAVLARGHVLIEDLPGLGKTLIARSFAAALGLDFT
MMAR_1399|M.marinum_M ERVVVGKRAALTLILTAVLARGHVLIEDLPGLGKTLIARSFAAALGLEFK
MUL_2477|M.ulcerans_Agy99 ERVVVGKRAALTLILTAVLARGHVLIEDLPGLGKTLIARSFAAALGLEFK
MAV_4052|M.avium_104 --MVVGKRNALRLILTAVLARGHILIEDLPGLGKTLIARSFAAALGLQFT
Mflv_0476|M.gilvum_PYR-GCK GRAVVGKRGALNLILITVLARGHVLVEDLPGLGKTLIAKSFAAALGLEFT
Mvan_0180|M.vanbaalenii_PYR-1 GRAVVGKRNALNLILITVLARGHVLVEDLPGLGKTLIAKSFAAALGLEFT
TH_0584|M.thermoresistible__bu QRAVVGNRAALELILLTVLARGHILVEDLPGLGKTLIARTFSAALGLRFT
MAB_1909c|M.abscessus_ATCC_199 ERVVVGKRDALQLILLTILARGHVLIEDLPGLGKTLIARSFASALGLDFT
MSMEG_3867|M.smegmatis_MC2_155 EKAVVGKRDALTLILTTLLARGHVLIEDLPGLGKTLIARSFAAALGLKFT
MLBr_01810|M.leprae_Br4923 KRVIVGQDQLVERMLVGLLSKGHVLLEGVPGVAKTLAVETFARVVGGTFA
:**: : :* :*::**:*:*.:**:.*** ..:*: .:* *
Rv3164c|M.tuberculosis_H37Rv RVQFTPDLLPADLLGSTIYDMQSGRFEFRAGPIFTNLLLADEINRTPPKT
Mb3189c|M.bovis_AF2122/97 RVQFTPDLLPADLLGSTIYDMQSGRFEFRAGPIFTNLLLADEINRTPPKT
MMAR_1399|M.marinum_M RVQFTPDLLPADLLGSTIYDMQSGRFEFRAGPIFTNLLMADEINRTPPKT
MUL_2477|M.ulcerans_Agy99 RVQFTPDLLPADLLGSTIYDMQSGRFEFRAGPIFTNLLMADEINRTPPKT
MAV_4052|M.avium_104 RVQFTPDLLPADLLGSTIYDMQSGRFAFRAGPIFTNLLLADEINRTPPKT
Mflv_0476|M.gilvum_PYR-GCK RVQFTPDLLPADLLGSTIYDMQSGRFEFRRGPVFTNLLLGDEINRTPPKT
Mvan_0180|M.vanbaalenii_PYR-1 RVQFTPDLLPADLLGSTIYDMQSGRFEFRRGPIFTNLLLGDEINRTPPKT
TH_0584|M.thermoresistible__bu RVQFTPDLLPADLLGTTIYDMRSGGFEFRPGPIFTNLLLADEINRTPPKT
MAB_1909c|M.abscessus_ATCC_199 RVQFTPDLLPADLLGSTIYDMSSGSFEFRTGPIFTNLLLADEINRTPPKT
MSMEG_3867|M.smegmatis_MC2_155 RVQFTPDLLPADLLGSTVYDMQSGRFEFRPGPIFTNLLLADEINRTPPKT
MLBr_01810|M.leprae_Br4923 RIQFTPDLVPTDIIGTRIYRQGKEEFDTELGPVVVNFLLADEINRAPAKV
*:******:*:*::*: :* . * . **:..*:*:.*****:*.*.
Rv3164c|M.tuberculosis_H37Rv QAALLEAMAEGQVSIDGQTHKLAMPFIVLATDNPIEYEGTYPLPEAQLDR
Mb3189c|M.bovis_AF2122/97 QAALLEAMAEGQVSIDGQTHKLAMPFIVLATDNPIEYEGTYPLPEAQLDR
MMAR_1399|M.marinum_M QAALLEAMAEGQVSIDGQTHKLPMPFIVLATDNPIEYEGTYPLPEAQLDR
MUL_2477|M.ulcerans_Agy99 QAALLEAMAEGQVSIDGQTHKLPVPFIVLATDNPIEHEGTYPLPEAQLDR
MAV_4052|M.avium_104 QAALLEAMAEGQVSIDGETHRLPKPFIVLATDNPIEYEGTYPLPEAQLDR
Mflv_0476|M.gilvum_PYR-GCK QAALLEAMAERQVSIDGATHRLPEPFLVLATDNPIEYEGTYPLPEAQLDR
Mvan_0180|M.vanbaalenii_PYR-1 QAALLEAMAEGQVSVDGVTHRLPQPFLVLATDNPIEYEGTYPLPEAQLDR
TH_0584|M.thermoresistible__bu QAALLEAMAETQVTIDGVSHRLPAPFVVLATDNPIEYEGTYPLPEAQLDR
MAB_1909c|M.abscessus_ATCC_199 QSALLEAMAEGQVSLDGQTRQLPSPFVVLATDNPIEYEGTYPLPEAQLDR
MSMEG_3867|M.smegmatis_MC2_155 QAALLEAMAEGQVSIDGQTHRLPAPFIVLATDNPIEYEGTYPLPEAQLDR
MLBr_01810|M.leprae_Br4923 QSALLEVMQERHVSIGGKTFPLPNPFLVMATQNPIEHEGVYLLPEAQRDR
*:****.* * :*::.* : *. **:*:**:****:**.* ***** **
Rv3164c|M.tuberculosis_H37Rv FAIRLELRYLSERDETSMLRRRLERGSADPTVNQVVDCHDLLAMRESVEQ
Mb3189c|M.bovis_AF2122/97 FAIRLELRYLSERDETSMLRRRLERGSADPTVNQVVDCHDLLAMRESVEQ
MMAR_1399|M.marinum_M FAIRLELRYLSEQDETAMLRRRLERGSAEATVNQVVDLHDLLAMRESVEQ
MUL_2477|M.ulcerans_Agy99 FAIRLELRYLSEQDETAMLRRRLERGSAEATVNQVVDLHDLLAMRESVEQ
MAV_4052|M.avium_104 FAIRLELRYLSERDETSMLRRRLERGSAEPAVNQVVDAHDLLAMRESVEQ
Mflv_0476|M.gilvum_PYR-GCK FAIRLELKYLSESEEATMLRRRLDRGSAPATVNQIVDAQDLLHMQESVEQ
Mvan_0180|M.vanbaalenii_PYR-1 FAIRLELKYLNESEEVTMLRRRLERGSTAPTVQQVVDSHDLLAMQESVEN
TH_0584|M.thermoresistible__bu FAVRLELGYLSAPEEVSMLRRRIERGADDVVITEVVDADALIAMREAVEA
MAB_1909c|M.abscessus_ATCC_199 FAVRLQLGYLAEDLEIEMLQRRLSRGSTLPTVSQVIAADDLIAMREAVEA
MSMEG_3867|M.smegmatis_MC2_155 FSVRLELKYLSEQDETAMLRRRLDRGSAEAGVAEVVDGPRFLAMREAVEQ
MLBr_01810|M.leprae_Br4923 FLFKINVGYPSPEEEREIIYR---MGVTPPVPKQILNAGDLLRLQEISAN
* .:::: * * :: * * ::: :: ::*
Rv3164c|M.tuberculosis_H37Rv VTVHEDVLHYVVSLAN---------------------ATR----------
Mb3189c|M.bovis_AF2122/97 VTVHEDVLHYVVSLAN---------------------ATR----------
MMAR_1399|M.marinum_M VTVHDDVLHYVVSLAT---------------------ATR----------
MUL_2477|M.ulcerans_Agy99 VTVHDDVLQYVVSLAT---------------------ATR----------
MAV_4052|M.avium_104 VTVHEDVLHYVVSLAN---------------------ATR----------
Mflv_0476|M.gilvum_PYR-GCK VSVHDDVVQYVVSLAA---------------------ASR----------
Mvan_0180|M.vanbaalenii_PYR-1 VTVHDDVLQYIVSLAT---------------------ASR----------
TH_0584|M.thermoresistible__bu VTVHDDVLDYVVALAT---------------------ATR----------
MAB_1909c|M.abscessus_ATCC_199 VSVHPDVLRYIVALAA---------------------ATR----------
MSMEG_3867|M.smegmatis_MC2_155 VSVHDDVLRYVVALRGRDAPPPAGCGRRQPPRRTRPRATREGQGLAARAG
MLBr_01810|M.leprae_Br4923 NFVHHALVDYVVRVVT---------------------ATR----------
** :: *:* : *:*
Rv3164c|M.tuberculosis_H37Rv ----------------------------HHP-------------------
Mb3189c|M.bovis_AF2122/97 ----------------------------HHP-------------------
MMAR_1399|M.marinum_M ----------------------------NHP-------------------
MUL_2477|M.ulcerans_Agy99 ----------------------------NHP-------------------
MAV_4052|M.avium_104 ----------------------------HHP-------------------
Mflv_0476|M.gilvum_PYR-GCK ----------------------------QHP-------------------
Mvan_0180|M.vanbaalenii_PYR-1 ----------------------------QHP-------------------
TH_0584|M.thermoresistible__bu ----------------------------RHP-------------------
MAB_1909c|M.abscessus_ATCC_199 ----------------------------SHS-------------------
MSMEG_3867|M.smegmatis_MC2_155 LRHPRGRQDTRGRGDGAPHQPAPGDVGAQHPRCRRHERTAAPAPRAPCGQ
MLBr_01810|M.leprae_Br4923 -----------------------------HPEQLG---------------
*.
Rv3164c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3189c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1399|M.marinum_M --------------------------------------------------
MUL_2477|M.ulcerans_Agy99 --------------------------------------------------
MAV_4052|M.avium_104 --------------------------------------------------
Mflv_0476|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0180|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0584|M.thermoresistible__bu --------------------------------------------------
MAB_1909c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3867|M.smegmatis_MC2_155 PAMTVGVHVPLRWGASPLTKSVATAAAGAMLIAVLGFRWQLVIFASPLLG
MLBr_01810|M.leprae_Br4923 --------------------------------------------------
Rv3164c|M.tuberculosis_H37Rv ------------QVAVGASPR-----------------------------
Mb3189c|M.bovis_AF2122/97 ------------QVAVGASPR-----------------------------
MMAR_1399|M.marinum_M ------------QVAVGASPR-----------------------------
MUL_2477|M.ulcerans_Agy99 ------------QVAVGASPR-----------------------------
MAV_4052|M.avium_104 ------------QVAVGASPR-----------------------------
Mflv_0476|M.gilvum_PYR-GCK ------------QVAVGASPR-----------------------------
Mvan_0180|M.vanbaalenii_PYR-1 ------------QVAVGTSPR-----------------------------
TH_0584|M.thermoresistible__bu ------------QVAVGASPR-----------------------------
MAB_1909c|M.abscessus_ATCC_199 ------------HVEVGASPR-----------------------------
MSMEG_3867|M.smegmatis_MC2_155 VLCSAYWQRPRVSVEVGAEPATVRCFENESAELSVRVSSSAGADARLRVD
MLBr_01810|M.leprae_Br4923 ------MNDVKTWISFGASPR-----------------------------
: .*:.*
Rv3164c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3189c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1399|M.marinum_M --------------------------------------------------
MUL_2477|M.ulcerans_Agy99 --------------------------------------------------
MAV_4052|M.avium_104 --------------------------------------------------
Mflv_0476|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0180|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0584|M.thermoresistible__bu --------------------------------------------------
MAB_1909c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3867|M.smegmatis_MC2_155 SVEGLRLEPGDRAGPEQRVRANASRWGRYPLRAHVTVTAPGGLVTGTGTV
MLBr_01810|M.leprae_Br4923 --------------------------------------------------
Rv3164c|M.tuberculosis_H37Rv --AELDLVQLSR------ARALLLG-------------------RDYVIP
Mb3189c|M.bovis_AF2122/97 --AELDLVQLSR------ARALLLG-------------------RDYVIP
MMAR_1399|M.marinum_M --AELDLVQLSR------ARALLLG-------------------RDYVIP
MUL_2477|M.ulcerans_Agy99 --AELDLVQLSR------ARALLLG-------------------RDYVIP
MAV_4052|M.avium_104 --AELDLVQLAR------ARALLLG-------------------RDYVIP
Mflv_0476|M.gilvum_PYR-GCK --AELDLVQLAR------ARALLLG-------------------RDYVIP
Mvan_0180|M.vanbaalenii_PYR-1 --AELDLVQLAR------ARALLLG-------------------RDYVIP
TH_0584|M.thermoresistible__bu --AELDLVQLAR------ARALLLN-------------------RDYVIP
MAB_1909c|M.abscessus_ATCC_199 --AELDLVQMSR------ARALLLG-------------------RDFVIP
MSMEG_3867|M.smegmatis_MC2_155 EAAELYVFPLAAPHLTPMPRAELPDRLGTHLTRHTGPGVEYADVRPYVPG
MLBr_01810|M.leprae_Br4923 --ASLGIIKASR------SLALVRG-------------------RDYVIP
*.* :. : . * : . * :*
Rv3164c|M.tuberculosis_H37Rv EDVKELATAAVAHRITLRPEMWVRKIAG----------------------
Mb3189c|M.bovis_AF2122/97 EDVKELATAAVAHRITLRPEMWVRKIAG----------------------
MMAR_1399|M.marinum_M EDVKALATASIAHRITLRPEMWVRKIQG----------------------
MUL_2477|M.ulcerans_Agy99 EDVKALATASIAHRITLRPEMWVRKIQG----------------------
MAV_4052|M.avium_104 EDVKALATAAVAHRITLRPEMWVRKIQG----------------------
Mflv_0476|M.gilvum_PYR-GCK EDVKALAVPTMAHRISLRPEMWVRRVQG----------------------
Mvan_0180|M.vanbaalenii_PYR-1 EDVKALAVPALAHRISPRPEMWVRRVQG----------------------
TH_0584|M.thermoresistible__bu EDVKTLAVPALAHRIMLRPEMWVRQIRS----------------------
MAB_1909c|M.abscessus_ATCC_199 EDVKALAVPAVAHRISLRPEMWVRRITG----------------------
MSMEG_3867|M.smegmatis_MC2_155 DHLRTVNWPVSARRGRLHVTERLTDRGGDVVVLIDTHDQAPGPATQATER
MLBr_01810|M.leprae_Br4923 QDVIEVIPDVLRHRLVLTYNALADEISP----------------------
:.: : :*
Rv3164c|M.tuberculosis_H37Rv -----ADVVSELLR------------RLP---------------------
Mb3189c|M.bovis_AF2122/97 -----ADVVSELLR------------RLP---------------------
MMAR_1399|M.marinum_M -----ADVIAELLR------------RLP---------------------
MUL_2477|M.ulcerans_Agy99 -----ADVIAELLR------------RLP---------------------
MAV_4052|M.avium_104 -----ADVIGELLH------------RLP---------------------
Mflv_0476|M.gilvum_PYR-GCK -----ADVVEELLR------------RTP---------------------
Mvan_0180|M.vanbaalenii_PYR-1 -----ADVIEELLR------------RTP---------------------
TH_0584|M.thermoresistible__bu -----GDVIGELLR------------RLP---------------------
MAB_1909c|M.abscessus_ATCC_199 -----AHVVDELLH------------RLP---------------------
MSMEG_3867|M.smegmatis_MC2_155 TARGAAQVVQSALRSGDRAGIVALGGRQPRWLGLDIGRRQFYRVLDAILG
MLBr_01810|M.leprae_Br4923 -----EIVINRVLQT----------VALPQVN------------------
*: *: *
Rv3164c|M.tuberculosis_H37Rv ------------VPRISGT-------------------------------
Mb3189c|M.bovis_AF2122/97 ------------VPRISGT-------------------------------
MMAR_1399|M.marinum_M ------------VPRTNTGSR-----------------------------
MUL_2477|M.ulcerans_Agy99 ------------VPRTNAGSR-----------------------------
MAV_4052|M.avium_104 ------------VPRTGAGPGQTG--------------------------
Mflv_0476|M.gilvum_PYR-GCK ------------VPRAR---------------------------------
Mvan_0180|M.vanbaalenii_PYR-1 ------------VPRARETQ------------------------------
TH_0584|M.thermoresistible__bu ------------VPRTGGPPP-----------------------------
MAB_1909c|M.abscessus_ATCC_199 ------------VPRASG--------------------------------
MSMEG_3867|M.smegmatis_MC2_155 AGGGFETTTGTLAPRAAVPPGAIVVAFSTMLNTEFAFALIELAKHGHAVV
MLBr_01810|M.leprae_Br4923 -----------SFPQQGHSVPSVTQAAAAASGR-----------------
*:
Rv3164c|M.tuberculosis_H37Rv --------------------------------------------------
Mb3189c|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1399|M.marinum_M --------------------------------------------------
MUL_2477|M.ulcerans_Agy99 --------------------------------------------------
MAV_4052|M.avium_104 --------------------------------------------------
Mflv_0476|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0180|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0584|M.thermoresistible__bu --------------------------------------------------
MAB_1909c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3867|M.smegmatis_MC2_155 AVDILEGAPFDNPDGLDPLIPRLWALQRSAMYRDMSTIGIDVVHWRGDIP
MLBr_01810|M.leprae_Br4923 --------------------------------------------------
Rv3164c|M.tuberculosis_H37Rv -----------------
Mb3189c|M.bovis_AF2122/97 -----------------
MMAR_1399|M.marinum_M -----------------
MUL_2477|M.ulcerans_Agy99 -----------------
MAV_4052|M.avium_104 -----------------
Mflv_0476|M.gilvum_PYR-GCK -----------------
Mvan_0180|M.vanbaalenii_PYR-1 -----------------
TH_0584|M.thermoresistible__bu -----------------
MAB_1909c|M.abscessus_ATCC_199 -----------------
MSMEG_3867|M.smegmatis_MC2_155 LQDVMRLIPDRHRRRTR
MLBr_01810|M.leprae_Br4923 -----------------