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TMPAALTTAACEAVIDEIERVVVGKRAALTLILTAVLARGHVLIEDLPGLGKTLIARSFAAALGLEFKRV QFTPDLLPADLLGSTIYDMQSGRFEFRAGPIFTNLLMADEINRTPPKTQAALLEAMAEGQVSIDGQTHKL PVPFIVLATDNPIEHEGTYPLPEAQLDRFAIRLELRYLSEQDETAMLRRRLERGSAEATVNQVVDLHDLL AMRESVEQVTVHDDVLQYVVSLATATRNHPQVAVGASPRAELDLVQLSRARALLLGRDYVIPEDVKALAT ASIAHRITLRPEMWVRKIQGADVIAELLRRLPVPRTNAGSR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_2477 | moxR3 | - | 100% (322) | methanol dehydrogenase transcriptional regulatory protein MoxR3 |
| M. ulcerans Agy99 | MUL_4275 | moxR2 | 1e-78 | 49.36% (314) | methanol dehydrogenase transcriptional regulatory protein |
| M. ulcerans Agy99 | MUL_1488 | moxR1 | 4e-66 | 41.46% (316) | transcriptional regulatory protein, MoxR1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3189c | moxR3 | 1e-161 | 91.46% (316) | methanol dehydrogenase transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_0476 | - | 1e-148 | 84.24% (311) | ATPase |
| M. tuberculosis H37Rv | Rv3164c | moxR3 | 1e-162 | 91.77% (316) | methanol dehydrogenase transcriptional regulatory protein |
| M. leprae Br4923 | MLBr_01810 | moxR | 2e-66 | 41.96% (317) | MoxR homolog |
| M. abscessus ATCC 19977 | MAB_1909c | - | 1e-135 | 76.03% (317) | methanol dehydrogenase transcriptional regulatory protein MoxR3 |
| M. marinum M | MMAR_1399 | moxR3 | 1e-176 | 98.76% (322) | methanol dehydrogenase transcriptional regulatory protein |
| M. avium 104 | MAV_4052 | - | 1e-152 | 91.30% (299) | ATPase family protein associated with various cellular |
| M. smegmatis MC2 155 | MSMEG_3867 | - | 1e-106 | 85.40% (226) | ATPase family protein associated with various cellular |
| M. thermoresistible (build 8) | TH_0584 | moxR2 | 1e-139 | 77.78% (315) | PROBABLE METHANOL DEHYDROGENASE TRANSCRIPTIONAL REGULATORY |
| M. vanbaalenii PYR-1 | Mvan_0180 | - | 1e-148 | 84.57% (311) | ATPase |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_2477|M.ulcerans_Agy99 -------------------------------MTMPAALTTAACEAVIDEI
MMAR_1399|M.marinum_M -------------------------------MTMPAALTTAACEAVIDEI
Mb3189c|M.bovis_AF2122/97 -------------------------------MIMPAATTTAHCEAVLDEI
Rv3164c|M.tuberculosis_H37Rv -------------------------------MIMPAATTTAHCEAVLDEI
MAV_4052|M.avium_104 --------------------------------------------------
Mflv_0476|M.gilvum_PYR-GCK --------------------------------MSTPALTTARCEAVLDEI
Mvan_0180|M.vanbaalenii_PYR-1 --------------------------------MTTPALTTARCEAVLDEI
TH_0584|M.thermoresistible__bu --------------------------------MMPATTATAHCHAVLDEV
MAB_1909c|M.abscessus_ATCC_199 ------------------------------MTTVPISIATRHADAVLTEI
MSMEG_3867|M.smegmatis_MC2_155 ----------------------------MTSQANVDVATAAAARSVLDEI
MLBr_01810|M.leprae_Br4923 MTSAGGLPVGADGCSGPGGQSGPRAHEAPPGGADGLVAEVHTLERAIFEV
MUL_2477|M.ulcerans_Agy99 ERVVVGKRAALTLILTAVLARGHVLIEDLPGLGKTLIARSFAAALGLEFK
MMAR_1399|M.marinum_M ERVVVGKRAALTLILTAVLARGHVLIEDLPGLGKTLIARSFAAALGLEFK
Mb3189c|M.bovis_AF2122/97 GRVVVGKRSALTLILTAVLARGHVLIEDLPGLGKTLIARSFAAALGLDFT
Rv3164c|M.tuberculosis_H37Rv ERVVVGKRSALTLILTAVLARGHVLIEDLPGLGKTLIARSFAAALGLDFT
MAV_4052|M.avium_104 --MVVGKRNALRLILTAVLARGHILIEDLPGLGKTLIARSFAAALGLQFT
Mflv_0476|M.gilvum_PYR-GCK GRAVVGKRGALNLILITVLARGHVLVEDLPGLGKTLIAKSFAAALGLEFT
Mvan_0180|M.vanbaalenii_PYR-1 GRAVVGKRNALNLILITVLARGHVLVEDLPGLGKTLIAKSFAAALGLEFT
TH_0584|M.thermoresistible__bu QRAVVGNRAALELILLTVLARGHILVEDLPGLGKTLIARTFSAALGLRFT
MAB_1909c|M.abscessus_ATCC_199 ERVVVGKRDALQLILLTILARGHVLIEDLPGLGKTLIARSFASALGLDFT
MSMEG_3867|M.smegmatis_MC2_155 EKAVVGKRDALTLILTTLLARGHVLIEDLPGLGKTLIARSFAAALGLKFT
MLBr_01810|M.leprae_Br4923 KRVIVGQDQLVERMLVGLLSKGHVLLEGVPGVAKTLAVETFARVVGGTFA
:**: : :* :*::**:*:*.:**:.*** ..:*: .:* *
MUL_2477|M.ulcerans_Agy99 RVQFTPDLLPADLLGSTIYDMQSGRFEFRAGPIFTNLLMADEINRTPPKT
MMAR_1399|M.marinum_M RVQFTPDLLPADLLGSTIYDMQSGRFEFRAGPIFTNLLMADEINRTPPKT
Mb3189c|M.bovis_AF2122/97 RVQFTPDLLPADLLGSTIYDMQSGRFEFRAGPIFTNLLLADEINRTPPKT
Rv3164c|M.tuberculosis_H37Rv RVQFTPDLLPADLLGSTIYDMQSGRFEFRAGPIFTNLLLADEINRTPPKT
MAV_4052|M.avium_104 RVQFTPDLLPADLLGSTIYDMQSGRFAFRAGPIFTNLLLADEINRTPPKT
Mflv_0476|M.gilvum_PYR-GCK RVQFTPDLLPADLLGSTIYDMQSGRFEFRRGPVFTNLLLGDEINRTPPKT
Mvan_0180|M.vanbaalenii_PYR-1 RVQFTPDLLPADLLGSTIYDMQSGRFEFRRGPIFTNLLLGDEINRTPPKT
TH_0584|M.thermoresistible__bu RVQFTPDLLPADLLGTTIYDMRSGGFEFRPGPIFTNLLLADEINRTPPKT
MAB_1909c|M.abscessus_ATCC_199 RVQFTPDLLPADLLGSTIYDMSSGSFEFRTGPIFTNLLLADEINRTPPKT
MSMEG_3867|M.smegmatis_MC2_155 RVQFTPDLLPADLLGSTVYDMQSGRFEFRPGPIFTNLLLADEINRTPPKT
MLBr_01810|M.leprae_Br4923 RIQFTPDLVPTDIIGTRIYRQGKEEFDTELGPVVVNFLLADEINRAPAKV
*:******:*:*::*: :* . * . **:..*:*:.*****:*.*.
MUL_2477|M.ulcerans_Agy99 QAALLEAMAEGQVSIDGQTHKLPVPFIVLATDNPIEHEGTYPLPEAQLDR
MMAR_1399|M.marinum_M QAALLEAMAEGQVSIDGQTHKLPMPFIVLATDNPIEYEGTYPLPEAQLDR
Mb3189c|M.bovis_AF2122/97 QAALLEAMAEGQVSIDGQTHKLAMPFIVLATDNPIEYEGTYPLPEAQLDR
Rv3164c|M.tuberculosis_H37Rv QAALLEAMAEGQVSIDGQTHKLAMPFIVLATDNPIEYEGTYPLPEAQLDR
MAV_4052|M.avium_104 QAALLEAMAEGQVSIDGETHRLPKPFIVLATDNPIEYEGTYPLPEAQLDR
Mflv_0476|M.gilvum_PYR-GCK QAALLEAMAERQVSIDGATHRLPEPFLVLATDNPIEYEGTYPLPEAQLDR
Mvan_0180|M.vanbaalenii_PYR-1 QAALLEAMAEGQVSVDGVTHRLPQPFLVLATDNPIEYEGTYPLPEAQLDR
TH_0584|M.thermoresistible__bu QAALLEAMAETQVTIDGVSHRLPAPFVVLATDNPIEYEGTYPLPEAQLDR
MAB_1909c|M.abscessus_ATCC_199 QSALLEAMAEGQVSLDGQTRQLPSPFVVLATDNPIEYEGTYPLPEAQLDR
MSMEG_3867|M.smegmatis_MC2_155 QAALLEAMAEGQVSIDGQTHRLPAPFIVLATDNPIEYEGTYPLPEAQLDR
MLBr_01810|M.leprae_Br4923 QSALLEVMQERHVSIGGKTFPLPNPFLVMATQNPIEHEGVYLLPEAQRDR
*:****.* * :*::.* : *. **:*:**:****:**.* ***** **
MUL_2477|M.ulcerans_Agy99 FAIRLELRYLSEQDETAMLRRRLERGSAEATVNQVVDLHDLLAMRESVEQ
MMAR_1399|M.marinum_M FAIRLELRYLSEQDETAMLRRRLERGSAEATVNQVVDLHDLLAMRESVEQ
Mb3189c|M.bovis_AF2122/97 FAIRLELRYLSERDETSMLRRRLERGSADPTVNQVVDCHDLLAMRESVEQ
Rv3164c|M.tuberculosis_H37Rv FAIRLELRYLSERDETSMLRRRLERGSADPTVNQVVDCHDLLAMRESVEQ
MAV_4052|M.avium_104 FAIRLELRYLSERDETSMLRRRLERGSAEPAVNQVVDAHDLLAMRESVEQ
Mflv_0476|M.gilvum_PYR-GCK FAIRLELKYLSESEEATMLRRRLDRGSAPATVNQIVDAQDLLHMQESVEQ
Mvan_0180|M.vanbaalenii_PYR-1 FAIRLELKYLNESEEVTMLRRRLERGSTAPTVQQVVDSHDLLAMQESVEN
TH_0584|M.thermoresistible__bu FAVRLELGYLSAPEEVSMLRRRIERGADDVVITEVVDADALIAMREAVEA
MAB_1909c|M.abscessus_ATCC_199 FAVRLQLGYLAEDLEIEMLQRRLSRGSTLPTVSQVIAADDLIAMREAVEA
MSMEG_3867|M.smegmatis_MC2_155 FSVRLELKYLSEQDETAMLRRRLDRGSAEAGVAEVVDGPRFLAMREAVEQ
MLBr_01810|M.leprae_Br4923 FLFKINVGYPSPEEEREIIYR---MGVTPPVPKQILNAGDLLRLQEISAN
* .:::: * * :: * * ::: :: ::*
MUL_2477|M.ulcerans_Agy99 VTVHDDVLQYVVSLAT---------------------ATR----------
MMAR_1399|M.marinum_M VTVHDDVLHYVVSLAT---------------------ATR----------
Mb3189c|M.bovis_AF2122/97 VTVHEDVLHYVVSLAN---------------------ATR----------
Rv3164c|M.tuberculosis_H37Rv VTVHEDVLHYVVSLAN---------------------ATR----------
MAV_4052|M.avium_104 VTVHEDVLHYVVSLAN---------------------ATR----------
Mflv_0476|M.gilvum_PYR-GCK VSVHDDVVQYVVSLAA---------------------ASR----------
Mvan_0180|M.vanbaalenii_PYR-1 VTVHDDVLQYIVSLAT---------------------ASR----------
TH_0584|M.thermoresistible__bu VTVHDDVLDYVVALAT---------------------ATR----------
MAB_1909c|M.abscessus_ATCC_199 VSVHPDVLRYIVALAA---------------------ATR----------
MSMEG_3867|M.smegmatis_MC2_155 VSVHDDVLRYVVALRGRDAPPPAGCGRRQPPRRTRPRATREGQGLAARAG
MLBr_01810|M.leprae_Br4923 NFVHHALVDYVVRVVT---------------------ATR----------
** :: *:* : *:*
MUL_2477|M.ulcerans_Agy99 ----------------------------NHP-------------------
MMAR_1399|M.marinum_M ----------------------------NHP-------------------
Mb3189c|M.bovis_AF2122/97 ----------------------------HHP-------------------
Rv3164c|M.tuberculosis_H37Rv ----------------------------HHP-------------------
MAV_4052|M.avium_104 ----------------------------HHP-------------------
Mflv_0476|M.gilvum_PYR-GCK ----------------------------QHP-------------------
Mvan_0180|M.vanbaalenii_PYR-1 ----------------------------QHP-------------------
TH_0584|M.thermoresistible__bu ----------------------------RHP-------------------
MAB_1909c|M.abscessus_ATCC_199 ----------------------------SHS-------------------
MSMEG_3867|M.smegmatis_MC2_155 LRHPRGRQDTRGRGDGAPHQPAPGDVGAQHPRCRRHERTAAPAPRAPCGQ
MLBr_01810|M.leprae_Br4923 -----------------------------HPEQLG---------------
*.
MUL_2477|M.ulcerans_Agy99 --------------------------------------------------
MMAR_1399|M.marinum_M --------------------------------------------------
Mb3189c|M.bovis_AF2122/97 --------------------------------------------------
Rv3164c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4052|M.avium_104 --------------------------------------------------
Mflv_0476|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0180|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0584|M.thermoresistible__bu --------------------------------------------------
MAB_1909c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3867|M.smegmatis_MC2_155 PAMTVGVHVPLRWGASPLTKSVATAAAGAMLIAVLGFRWQLVIFASPLLG
MLBr_01810|M.leprae_Br4923 --------------------------------------------------
MUL_2477|M.ulcerans_Agy99 ------------QVAVGASPR-----------------------------
MMAR_1399|M.marinum_M ------------QVAVGASPR-----------------------------
Mb3189c|M.bovis_AF2122/97 ------------QVAVGASPR-----------------------------
Rv3164c|M.tuberculosis_H37Rv ------------QVAVGASPR-----------------------------
MAV_4052|M.avium_104 ------------QVAVGASPR-----------------------------
Mflv_0476|M.gilvum_PYR-GCK ------------QVAVGASPR-----------------------------
Mvan_0180|M.vanbaalenii_PYR-1 ------------QVAVGTSPR-----------------------------
TH_0584|M.thermoresistible__bu ------------QVAVGASPR-----------------------------
MAB_1909c|M.abscessus_ATCC_199 ------------HVEVGASPR-----------------------------
MSMEG_3867|M.smegmatis_MC2_155 VLCSAYWQRPRVSVEVGAEPATVRCFENESAELSVRVSSSAGADARLRVD
MLBr_01810|M.leprae_Br4923 ------MNDVKTWISFGASPR-----------------------------
: .*:.*
MUL_2477|M.ulcerans_Agy99 --------------------------------------------------
MMAR_1399|M.marinum_M --------------------------------------------------
Mb3189c|M.bovis_AF2122/97 --------------------------------------------------
Rv3164c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4052|M.avium_104 --------------------------------------------------
Mflv_0476|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0180|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0584|M.thermoresistible__bu --------------------------------------------------
MAB_1909c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3867|M.smegmatis_MC2_155 SVEGLRLEPGDRAGPEQRVRANASRWGRYPLRAHVTVTAPGGLVTGTGTV
MLBr_01810|M.leprae_Br4923 --------------------------------------------------
MUL_2477|M.ulcerans_Agy99 --AELDLVQLSR------ARALLLG-------------------RDYVIP
MMAR_1399|M.marinum_M --AELDLVQLSR------ARALLLG-------------------RDYVIP
Mb3189c|M.bovis_AF2122/97 --AELDLVQLSR------ARALLLG-------------------RDYVIP
Rv3164c|M.tuberculosis_H37Rv --AELDLVQLSR------ARALLLG-------------------RDYVIP
MAV_4052|M.avium_104 --AELDLVQLAR------ARALLLG-------------------RDYVIP
Mflv_0476|M.gilvum_PYR-GCK --AELDLVQLAR------ARALLLG-------------------RDYVIP
Mvan_0180|M.vanbaalenii_PYR-1 --AELDLVQLAR------ARALLLG-------------------RDYVIP
TH_0584|M.thermoresistible__bu --AELDLVQLAR------ARALLLN-------------------RDYVIP
MAB_1909c|M.abscessus_ATCC_199 --AELDLVQMSR------ARALLLG-------------------RDFVIP
MSMEG_3867|M.smegmatis_MC2_155 EAAELYVFPLAAPHLTPMPRAELPDRLGTHLTRHTGPGVEYADVRPYVPG
MLBr_01810|M.leprae_Br4923 --ASLGIIKASR------SLALVRG-------------------RDYVIP
*.* :. : . * : . * :*
MUL_2477|M.ulcerans_Agy99 EDVKALATASIAHRITLRPEMWVRKIQG----------------------
MMAR_1399|M.marinum_M EDVKALATASIAHRITLRPEMWVRKIQG----------------------
Mb3189c|M.bovis_AF2122/97 EDVKELATAAVAHRITLRPEMWVRKIAG----------------------
Rv3164c|M.tuberculosis_H37Rv EDVKELATAAVAHRITLRPEMWVRKIAG----------------------
MAV_4052|M.avium_104 EDVKALATAAVAHRITLRPEMWVRKIQG----------------------
Mflv_0476|M.gilvum_PYR-GCK EDVKALAVPTMAHRISLRPEMWVRRVQG----------------------
Mvan_0180|M.vanbaalenii_PYR-1 EDVKALAVPALAHRISPRPEMWVRRVQG----------------------
TH_0584|M.thermoresistible__bu EDVKTLAVPALAHRIMLRPEMWVRQIRS----------------------
MAB_1909c|M.abscessus_ATCC_199 EDVKALAVPAVAHRISLRPEMWVRRITG----------------------
MSMEG_3867|M.smegmatis_MC2_155 DHLRTVNWPVSARRGRLHVTERLTDRGGDVVVLIDTHDQAPGPATQATER
MLBr_01810|M.leprae_Br4923 QDVIEVIPDVLRHRLVLTYNALADEISP----------------------
:.: : :*
MUL_2477|M.ulcerans_Agy99 -----ADVIAELLR------------RLP---------------------
MMAR_1399|M.marinum_M -----ADVIAELLR------------RLP---------------------
Mb3189c|M.bovis_AF2122/97 -----ADVVSELLR------------RLP---------------------
Rv3164c|M.tuberculosis_H37Rv -----ADVVSELLR------------RLP---------------------
MAV_4052|M.avium_104 -----ADVIGELLH------------RLP---------------------
Mflv_0476|M.gilvum_PYR-GCK -----ADVVEELLR------------RTP---------------------
Mvan_0180|M.vanbaalenii_PYR-1 -----ADVIEELLR------------RTP---------------------
TH_0584|M.thermoresistible__bu -----GDVIGELLR------------RLP---------------------
MAB_1909c|M.abscessus_ATCC_199 -----AHVVDELLH------------RLP---------------------
MSMEG_3867|M.smegmatis_MC2_155 TARGAAQVVQSALRSGDRAGIVALGGRQPRWLGLDIGRRQFYRVLDAILG
MLBr_01810|M.leprae_Br4923 -----EIVINRVLQT----------VALPQVN------------------
*: *: *
MUL_2477|M.ulcerans_Agy99 ------------VPRTNAGSR-----------------------------
MMAR_1399|M.marinum_M ------------VPRTNTGSR-----------------------------
Mb3189c|M.bovis_AF2122/97 ------------VPRISGT-------------------------------
Rv3164c|M.tuberculosis_H37Rv ------------VPRISGT-------------------------------
MAV_4052|M.avium_104 ------------VPRTGAGPGQTG--------------------------
Mflv_0476|M.gilvum_PYR-GCK ------------VPRAR---------------------------------
Mvan_0180|M.vanbaalenii_PYR-1 ------------VPRARETQ------------------------------
TH_0584|M.thermoresistible__bu ------------VPRTGGPPP-----------------------------
MAB_1909c|M.abscessus_ATCC_199 ------------VPRASG--------------------------------
MSMEG_3867|M.smegmatis_MC2_155 AGGGFETTTGTLAPRAAVPPGAIVVAFSTMLNTEFAFALIELAKHGHAVV
MLBr_01810|M.leprae_Br4923 -----------SFPQQGHSVPSVTQAAAAASGR-----------------
*:
MUL_2477|M.ulcerans_Agy99 --------------------------------------------------
MMAR_1399|M.marinum_M --------------------------------------------------
Mb3189c|M.bovis_AF2122/97 --------------------------------------------------
Rv3164c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_4052|M.avium_104 --------------------------------------------------
Mflv_0476|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0180|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_0584|M.thermoresistible__bu --------------------------------------------------
MAB_1909c|M.abscessus_ATCC_199 --------------------------------------------------
MSMEG_3867|M.smegmatis_MC2_155 AVDILEGAPFDNPDGLDPLIPRLWALQRSAMYRDMSTIGIDVVHWRGDIP
MLBr_01810|M.leprae_Br4923 --------------------------------------------------
MUL_2477|M.ulcerans_Agy99 -----------------
MMAR_1399|M.marinum_M -----------------
Mb3189c|M.bovis_AF2122/97 -----------------
Rv3164c|M.tuberculosis_H37Rv -----------------
MAV_4052|M.avium_104 -----------------
Mflv_0476|M.gilvum_PYR-GCK -----------------
Mvan_0180|M.vanbaalenii_PYR-1 -----------------
TH_0584|M.thermoresistible__bu -----------------
MAB_1909c|M.abscessus_ATCC_199 -----------------
MSMEG_3867|M.smegmatis_MC2_155 LQDVMRLIPDRHRRRTR
MLBr_01810|M.leprae_Br4923 -----------------