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MANRPDIIIVMTDEERAVPPYESAEVLAWRQRSLTGRRWFDEHGISFTRHYTGSLACVPSRPTIFTGQYP DLHGVTQTDGIGKRFDDSRLRWLRAGEVPTLGNWFRAAGYDTHYDGKWHISHADLEDPATGAPLATNDNE GVVDSAAVRRYLDADPLGPYGFSGWVGPEPHGAGLANSGFRRDPLVADRVVAWLTERYARRRAGDTAAMR PFLLVASFVNPHDIVLFPAWVWRSPLKPSPLDPPHVPAAPTADEDLSTKPAAQVAYREAYYSGYGLTRMV SRNYARNAQRYRDLYYRLHAEVDGPIDRVGRAVTEGGSEDAMLVRTSDHGDLLGAHGGLHQKWFNLYDEA TRVPFVIARIGEKATQPRTVSAPTSHVDLVPTLLSAAGVDVDVVAAALAESFSEVHPLPGRDLMPVVDGA SADEGRAIYLMTRDNVLEGDTGASLLSRQLGRIVNPPAPLRIKVPAHVAANFEGLVVRVDDTDAAGGAGH LWKLVRTFDDPATWTEPGVRHLATNGMGGDAYRTDPLDDQWELYDLTADPIEAYNRWTDPQLHELRQHLR MLLKQQRAVSVPERNQPWPYAHRLPPSGASNGLVRRVLGRFVR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. tuberculosis H37Rv | Rv3077 | - | - | 100% (603) | POSSIBLE HYDROLASE |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3104 | - | 0.0 | 99.83% (603) | hydrolase |
| M. gilvum PYR-GCK | Mflv_2372 | - | 0.0 | 78.07% (602) | sulfatase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4469c | - | 1e-29 | 31.25% (400) | sulfatase family protein |
| M. marinum M | MMAR_1577 | - | 0.0 | 85.83% (600) | hydrolase |
| M. avium 104 | - | - | - | - | - |
| M. smegmatis MC2 155 | MSMEG_1286 | - | 0.0 | 82.33% (583) | sulfatase family protein |
| M. thermoresistible (build 8) | TH_0121 | atsF | 0.0 | 81.72% (580) | POSSIBLE HYDROLASE |
| M. ulcerans Agy99 | MUL_3457 | - | 0.0 | 85.33% (600) | hydrolase |
| M. vanbaalenii PYR-1 | Mvan_4274 | - | 0.0 | 78.98% (590) | sulfatase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_2372|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4274|M.vanbaalenii_PYR-1 --------------------------------------------------
Rv3077|M.tuberculosis_H37Rv --------------------------------------------------
Mb3104|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1577|M.marinum_M --------------------------------------------------
MUL_3457|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_1286|M.smegmatis_MC2_155 --------------------------------------------------
TH_0121|M.thermoresistible__bu VAVFSRARTIPAGTERIWELLGDVGALSSWARLVDHSCVLTTGPHGDLIG
MAB_4469c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_2372|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4274|M.vanbaalenii_PYR-1 --------------------------------------------------
Rv3077|M.tuberculosis_H37Rv --------------------------------------------------
Mb3104|M.bovis_AF2122/97 --------------------------------------------------
MMAR_1577|M.marinum_M --------------------------------------------------
MUL_3457|M.ulcerans_Agy99 --------------------------------------------------
MSMEG_1286|M.smegmatis_MC2_155 --------------------------------------------------
TH_0121|M.thermoresistible__bu TTRRVQIGRTTLVERITEFDPPRALSYQICGLPPQLGNVVNRWVLSPTAG
MAB_4469c|M.abscessus_ATCC_199 -------------------------MAELNRRTVLTTGAIAAGAAAVGFG
Mflv_2372|M.gilvum_PYR-GCK ---------------MTAQRPDVVIVMTDEERAIPPYESDRVRTWRDETL
Mvan_4274|M.vanbaalenii_PYR-1 ---------------MTTERPDIVVVMTDEERATPPYEPDTVRAWRSRTL
Rv3077|M.tuberculosis_H37Rv ----------------MANRPDIIIVMTDEERAVPPYESAEVLAWRQRSL
Mb3104|M.bovis_AF2122/97 ----------------MANRPDIIIVMTDEERAVPPYESAEVLAWRQRSL
MMAR_1577|M.marinum_M ----------------MPEGPDIVIIMTDEERAVPPYESADVLAWRQRTL
MUL_3457|M.ulcerans_Agy99 ----------------MPEGPDIVIIMTDEERAVPPYESADVLAWRQRTL
MSMEG_1286|M.smegmatis_MC2_155 ----------------MTDRPDIVIVMTDEERAIPPYESSSVLAWRERVL
TH_0121|M.thermoresistible__bu GTVVTLTTTVXXSRPDSGGRPDIVIVMTDEERAIPPYESDDLLAWRDQTL
MAB_4469c|M.abscessus_ATCC_199 GYELLGTPRRNSSSGSDGNKPNILVIVVDQMRAPQWFPDVQKLTN---IL
*::::::.*: ** : : *
Mflv_2372|M.gilvum_PYR-GCK TGRRWFEEHGVSFTRHYTGSLACVPSRPTIFTGHYPDLHGVTQTDGIGKS
Mvan_4274|M.vanbaalenii_PYR-1 GGRRWFDENGVSFLRHYTGSLACVPSRPTIFTGQYPDLHGVTQTDGIGKA
Rv3077|M.tuberculosis_H37Rv TGRRWFDEHGISFTRHYTGSLACVPSRPTIFTGQYPDLHGVTQTDGIGKR
Mb3104|M.bovis_AF2122/97 TGRRWFDEHGISFTRHYTGSLACVPSRPTIFTGQYPDLHGVTQTDGIGKR
MMAR_1577|M.marinum_M TGRRWFDEHGVSFARHYTGSLACVPSRPTIFTGQYPDLHGVTQTDGIGKR
MUL_3457|M.ulcerans_Agy99 TGRRWFDEHGVSFARHYTGSLACVPSRPTIFTGQYPDLHGVTQTDGIGKR
MSMEG_1286|M.smegmatis_MC2_155 TGRRWFDEHGVNFTRHYTGSLACVPSRPTMFTGHYPDLHGITQTDGLGKR
TH_0121|M.thermoresistible__bu AGRRWFDEHGVTFTRHYTGSLACVPSRPTIFTGHYPDLHGVTQTDGLGKS
MAB_4469c|M.abscessus_ATCC_199 PNLSRLHRDSVSFASHYTASNMCTPSRGAMTTGLYSHQTGCLYTG-----
. :....:.* ***.* *.*** :: ** *.. * *.
Mflv_2372|M.gilvum_PYR-GCK HDDSRLRWLRRGEVPTLGNWFRAAGYDTHYDGKWHISHADLTDPSTGRPL
Mvan_4274|M.vanbaalenii_PYR-1 HDDSRLRWLRRGEVPTLGNWLRAAGYDTHYDGKWHISHADLIDPGTGRSL
Rv3077|M.tuberculosis_H37Rv FDDSRLRWLRAGEVPTLGNWFRAAGYDTHYDGKWHISHADLEDPATGAPL
Mb3104|M.bovis_AF2122/97 FDDSRLRWLRAGEVPTLGNWFRAAGYDTHYDGKWHISHADLEDPATGAPL
MMAR_1577|M.marinum_M FDDSRLRWLRAGEVPTLGNWFRAAGYDTHYDGKWHISHADLEDPDTGLSL
MUL_3457|M.ulcerans_Agy99 FDDSRLRWLRAGEVPTLGNWFRAAGYDTHYDGKWHISHADLEDPDTGLSL
MSMEG_1286|M.smegmatis_MC2_155 YDDSRLRWLRRGEVPTLGNWFRAAGYDTHYDGKWHISHADLEDPATGEPL
TH_0121|M.thermoresistible__bu HDDSRMRWLRRGEVPTLGHWFRAAGYDTHYDGKWHISHADLTDPRTGRPL
MAB_4469c|M.abscessus_ATCC_199 --EGPSESSLAPQFPTWGTMLRQQGYRTWWWGKWHLGDWSDTNP------
:. . :.** * :* ** * : ****:.. . :*
Mflv_2372|M.gilvum_PYR-GCK ATNDSDGVVDPGAVKRYLDADPLAPYGFSGWVGPEPHGAGLANAGIRRDP
Mvan_4274|M.vanbaalenii_PYR-1 DTNDDDGVVDPAAVHRYLEADPLSPYGFSGWVGPEPHGAKLSNAGIRRDP
Rv3077|M.tuberculosis_H37Rv ATNDNEGVVDSAAVRRYLDADPLGPYGFSGWVGPEPHGAGLANSGFRRDP
Mb3104|M.bovis_AF2122/97 ATNDNEGVVDSAAVRRYLDADPLGPYGFSGWVGPEPHGAGLANSGFRRDP
MMAR_1577|M.marinum_M ATNDDDGEIDPAAVQRYLDADPLGPYGFSGWVGPEPHGAGNANSGFRRDP
MUL_3457|M.ulcerans_Agy99 ATNDDDGEIDPAAVQRYLDADPLGPYGFSGWVGPEPHGAGNANSGFRRDP
MSMEG_1286|M.smegmatis_MC2_155 ATNDDDGVIDHAAVQAYLEADPLAPFGFSGWVGPEPHGAAMSNSGFRRDP
TH_0121|M.thermoresistible__bu ATNDDDGVVDPAAVQRYLDADPLDPFGFSGWVGPEPHGAGLANSGLRRDP
MAB_4469c|M.abscessus_ATCC_199 --------------------EGLDAHGFSGGTFPSPN--GMPNQGLQKDP
: * ..**** . *.*: .* *:::**
Mflv_2372|M.gilvum_PYR-GCK LIADRVVAWLTARYAARAAGDSAALRPFLLVASFVNPHDIVLFPAWARRN
Mvan_4274|M.vanbaalenii_PYR-1 LIADRVVAWLKDRYARRRAGDPDAMRPFLLVASFVNPHDIVLFPAWARRN
Rv3077|M.tuberculosis_H37Rv LVADRVVAWLTERYARRRAGDTAAMRPFLLVASFVNPHDIVLFPAWVWRS
Mb3104|M.bovis_AF2122/97 LVADRVVAWLTERYARRRAGDTAAMRPFLLVASFVNPHDIVLFPAWVWRS
MMAR_1577|M.marinum_M LIADRVVAWLEDRYARRRAGDEAALRPFLLVASFINPHDVVLFPAWVRFS
MUL_3457|M.ulcerans_Agy99 LIADRVVAWLEDRYARRRAGDEAALRPFLLVASFINPHDVVLFPAWVRFG
MSMEG_1286|M.smegmatis_MC2_155 IVADRVVAWLKDRYARRRAGDPDALRPFLLVASFVNPHDIVLFPAWSRRM
TH_0121|M.thermoresistible__bu LIADRVVAWLRDRYERRRAGDPDALRPFLLVASFVNPHDIVLFPTWARRS
MAB_4469c|M.abscessus_ATCC_199 GIVDQFAGWFDAEAGKG---------PWCTTVSLVNPHDICWWPKNP-LP
:.*:...*: . *: ..*::****: :*
Mflv_2372|M.gilvum_PYR-GCK PLSPSPLDPPSVPPAPTADEDLSTKPAAQIAFREAYYSGYGPAGSIER-T
Mvan_4274|M.vanbaalenii_PYR-1 PLPASPLDPPPVPAAPTADEDLSTKPAAQIAFREAYYSGYGPAWSIER-T
Rv3077|M.tuberculosis_H37Rv PLKPSPLDPPHVPAAPTADEDLSTKPAAQVAYREAYYSGYGLTRMVSR-N
Mb3104|M.bovis_AF2122/97 PLKPSPLDPPHVPAAPTADEDLSTKPAAQVAYREAYYSGYGLTRMVSR-N
MMAR_1577|M.marinum_M PLKPSHLDPPHVPAPPTADEDLRTKPAAQIAFRQAYYTGYGVAPAIKR-T
MUL_3457|M.ulcerans_Agy99 PLKPSHLDPPHVPAPPTADEDLRTKPAAQIAFRQAYYTGYGVAPAIKR-T
MSMEG_1286|M.smegmatis_MC2_155 PFGPSELDPPHVPAAPTAEEDLRDKPAAQIAFREAYYTGYGPAMAVER-T
TH_0121|M.thermoresistible__bu PLSPGPLDPPPVPPAPTADEDLSDKPAAHIAFREAYYSGYGPAWFVQR-T
MAB_4469c|M.abscessus_ATCC_199 EDVPHWFDGLPVNFQTPDELRQHGKPRLQIDYANFMSPIMTGAVTYSGPD
. :* * .. : ** :: : : . : .
Mflv_2372|M.gilvum_PYR-GCK YRRNAQRYRDLYYRLHAEVDEPIDRVRRAVTDG---AGAHPTVLVRTADH
Mvan_4274|M.vanbaalenii_PYR-1 YRRNAQRYRDLYYRLHAEVDTPIDRVRRAVTEGGSGDGPDDTVLVRTADH
Rv3077|M.tuberculosis_H37Rv YARNAQRYRDLYYRLHAEVDGPIDRVGRAVTEGG----SEDAMLVRTSDH
Mb3104|M.bovis_AF2122/97 YARNAQRYRDLYYRLHAEVDGPIDRVRRAVTEGG----SEDAMLVRTSDH
MMAR_1577|M.marinum_M YQRNAQRYRDLYYRLHAENDGPIDRVRRAVTEGG----SDNAVLVRTSDH
MUL_3457|M.ulcerans_Agy99 YQRNAQRYRDLYYRLHAENDGPIDRVRRAVTEGG----SDNAVLVRTSDH
MSMEG_1286|M.smegmatis_MC2_155 YRRKAQQYRDLYYRLHAEVDGPIDRVRRAVTEGG----SENAVLVRTSDH
TH_0121|M.thermoresistible__bu YERNAQRYRDLYYRLHAEVDGPIDRVRRAVTAG-----SHNAVLVRTSDH
MAB_4469c|M.abscessus_ATCC_199 MARQWARCLDMYLWLQQQVDAQIGRVLDKLASRP--EIDGNTIVVFTSDH
*: : *:* *: : * *.** :: :::* *:**
Mflv_2372|M.gilvum_PYR-GCK GDLLGAHGGLHQKWFNLYDEATRVPFVIARTG--PDATTARTVTAPTSHV
Mvan_4274|M.vanbaalenii_PYR-1 GDLLGAHGGLHQKWFNLYDEATRVPFVIARVG--ARPTTARTVTAPTSHV
Rv3077|M.tuberculosis_H37Rv GDLLGAHGGLHQKWFNLYDEATRVPFVIARIG--EKATQPRTVSAPTSHV
Mb3104|M.bovis_AF2122/97 GDLLGAHGGLHQKWFNLYDEATRVPFVIARIG--EKATQPRTVSAPTSHV
MMAR_1577|M.marinum_M GDLLGAHGGLHQKWFNLYDEATRVPFVIARVG--DEATTARTVSAPTSHV
MUL_3457|M.ulcerans_Agy99 GDLLGAHGGLHQKWFNLYDEATRVPFVITRVG--NEATTARTVSAPTSHV
MSMEG_1286|M.smegmatis_MC2_155 GELLGAHGGLHQKWFNLYDEATRVPFVIARIG--TEATEARTVDAPTSHV
TH_0121|M.thermoresistible__bu GELLGAHGGLHQKWFNLYDEATRVPFVIARIG--DRATEARTVTAPTSHV
MAB_4469c|M.abscessus_ATCC_199 GEYAGSHG-LRGKGATAYEEAIRVPLYIRDPQGVLTPKPGETRTQLTSSV
*: *:** *: * . *:** ***: * .. .* ** *
Mflv_2372|M.gilvum_PYR-GCK DLVPTLLAAAGIDAESVAATLGESFTEVHPLPGRDLMPVVDGAPADEDRP
Mvan_4274|M.vanbaalenii_PYR-1 DLVPTLLSAAGVDVDAAATVLAESFSEVHPLPGSDLMPVVDGAPADDHRC
Rv3077|M.tuberculosis_H37Rv DLVPTLLSAAGVDVDVVAAALAESFSEVHPLPGRDLMPVVDGASADEGRA
Mb3104|M.bovis_AF2122/97 DLVPTLLSAAGVDVDVVAAALAESFSEVHPLPGRDLMPVVDGASADEGRA
MMAR_1577|M.marinum_M DLVPTLLSAAGIDTDAVAANLAESFTEVHPLPGRDLMAVVDGAPADEDRA
MUL_3457|M.ulcerans_Agy99 DLVPTLLSAAGIDTEAVAANLAESFTEVHPLPGRDLMAVVDGAPADEDRA
MSMEG_1286|M.smegmatis_MC2_155 DLVPTLLGAAGVDVDAAAEQLRESFSEVHPLPGRDLMPVVSGESADEHRP
TH_0121|M.thermoresistible__bu DLVPTLLGAAGVDVDAAAARLAESFTEVHPLPGRDLMPVVDGAPADENRA
MAB_4469c|M.abscessus_ATCC_199 DLAPLLLTIG------SGGNAWRSDPRFSYLAARADIAAIAKNNAAGRKW
**.* ** . . .* ... *.. :..: * :
Mflv_2372|M.gilvum_PYR-GCK VYLMTRDNVLEGDTGASGLARALRLTSRVPAPLRIRVPAHTAANFEGLVL
Mvan_4274|M.vanbaalenii_PYR-1 VYLMTRDNVLEGDTGASGLARALKLTSKVPAPLRIRIPAHTAANFEGLVI
Rv3077|M.tuberculosis_H37Rv IYLMTRDNVLEGDTGASLLSRQLGRIVNPPAPLRIKVPAHVAANFEGLVV
Mb3104|M.bovis_AF2122/97 IYLMTRDNVLEGDTGASLLSRQLGRIVNPPAPLRIKVPAHVAANFEGLVV
MMAR_1577|M.marinum_M IYLMTRDNVLEGDTGASLLSRQLGRTVNPPAPLRIKLPAHVAANFEGLVV
MUL_3457|M.ulcerans_Agy99 IYLMTRDNVLEGDTGASLLSRQLGRTVNPPAPLRIKLPAHVAANFEGLVV
MSMEG_1286|M.smegmatis_MC2_155 IYLMTRDNVLEGDTGASGVARQLGRDVNPPAPLRIKVPAHVASNFEGLVV
TH_0121|M.thermoresistible__bu VYLMTRDSVLDGDTGASGLARQLNLTANPPGPLRIRVPAHVASNFEGLVV
MAB_4469c|M.abscessus_ATCC_199 IAHVTDDMSVEEMA-------TLLKDPRIRAVMGENAPTEIPTSAASHIV
: :* * :: : * . . : . *:. .:. . ::
Mflv_2372|M.gilvum_PYR-GCK RVPETSAAGGGGHLWKLVRSFDDPGTWTEPGVRQLAAD-GVGGPTYRSEP
Mvan_4274|M.vanbaalenii_PYR-1 RVDEDAAPGGRGHLWKLVRSFDDPGTWTEPGVRHLAAD-GIGGPMYRTDP
Rv3077|M.tuberculosis_H37Rv RVDDTDAAGGAGHLWKLVRTFDDPATWTEPGVRHLATN-GMGGDAYRTDP
Mb3104|M.bovis_AF2122/97 RVDDTDAAGGAGHLWKLVRTFDDPATWTEPGVRHLATN-GMGGDAYRTDP
MMAR_1577|M.marinum_M RVEDSDAPGGAGHLWKLVRTFDDPATWTEPGVRHLASN-GVGGETYRTDP
MUL_3457|M.ulcerans_Agy99 RVEDSDAPGGAGHLWKLVRTFDDPATWTEPGVRHLASN-GVGGETYRTDP
MSMEG_1286|M.smegmatis_MC2_155 RVDDADAHGGAGHLWKLVRTFDDPSTWTEPGVRHLAAD-GLGGETYRSDP
TH_0121|M.thermoresistible__bu CVEEATAAGGAGHLWKLVRTFDDPATWTEPGVRHLAAD-GLGGPAYRTDP
MAB_4469c|M.abscessus_ATCC_199 AVRTAEAKLANYSYWKPGGMRIDTSRPSEHEFYDYSTPSGKQESQNQAGD
* * . ** *.. :* . . :: * ::
Mflv_2372|M.gilvum_PYR-GCK LDDQWELYDLTDDPIEQTNRWPDPALHALRAYLRTQLKHARAQSIPERNQ
Mvan_4274|M.vanbaalenii_PYR-1 LDDQWELYDLTDDPVEQHNRWTDPDLHELRAYLRAQLKSVRAESIPERNR
Rv3077|M.tuberculosis_H37Rv LDDQWELYDLTADPIEAYNRWTDPQLHELRQHLRMLLKQQRAVSVPERNQ
Mb3104|M.bovis_AF2122/97 LDDQWELYDLTADPIEAYNRWTDPQLHELRQHLRMLLKQQRAVSVPERNQ
MMAR_1577|M.marinum_M VDDQWELYDLTADPIETDNRWTDPELHELRQHLRMQLKQQRASSVPERNQ
MUL_3457|M.ulcerans_Agy99 VDDQWELYDLTADPIETDNRWTDPELHELRQHLRMQLKQQRASSVPERNQ
MSMEG_1286|M.smegmatis_MC2_155 LDDQWELYDLTADPVEAVNRWHYPDLHEVRQYLLAQLKQVRASSVPERNV
TH_0121|M.thermoresistible__bu LDDQWELYDLTVDPIEAVNRWDDPGLDELRRHLRAQLKQARTVSVPERNE
MAB_4469c|M.abscessus_ATCC_199 STKQAQLQALIDN----------EVLPEVQAPLPAFLGQAQEQGLADMQK
.* :* * : * :: * * : .:.: :
Mflv_2372|M.gilvum_PYR-GCK PWPYARRQPPPARRWTPGRALRRLLG-
Mvan_4274|M.vanbaalenii_PYR-1 PWPYVRRQPPQPARWSPGRALRRLRD-
Rv3077|M.tuberculosis_H37Rv PWPYAHRLPPSGASNGLVRRVLGRFVR
Mb3104|M.bovis_AF2122/97 PWPYAHRLPPSGASNGLVRRVLGRFVR
MMAR_1577|M.marinum_M PWPYANRQPETGESQGPIRRLLGRIGS
MUL_3457|M.ulcerans_Agy99 PWPYANRQPETGQSQGPIRRLLGRIGS
MSMEG_1286|M.smegmatis_MC2_155 PWPYARR--------GGV---------
TH_0121|M.thermoresistible__bu PWPYVRRQAR-----------------
MAB_4469c|M.abscessus_ATCC_199 LMVLRGG--------------------