For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. marinum M MMAR_1577 (-)

annotation: hydrolase
coordinates: 1895944 - 1897755
length: 603

PEGPDIVIIMTDEERAVPPYESADVLAWRQRTLTGRRWFDEHGVSFARHYTGSLACVPSRPTIFTGQYPD
LHGVTQTDGIGKRFDDSRLRWLRAGEVPTLGNWFRAAGYDTHYDGKWHISHADLEDPDTGLSLATNDDDG
EIDPAAVQRYLDADPLGPYGFSGWVGPEPHGAGNANSGFRRDPLIADRVVAWLEDRYARRRAGDEAALRP
FLLVASFINPHDVVLFPAWVRFSPLKPSHLDPPHVPAPPTADEDLRTKPAAQIAFRQAYYTGYGVAPAIK
RTYQRNAQRYRDLYYRLHAENDGPIDRVRRAVTEGGSDNAVLVRTSDHGDLLGAHGGLHQKWFNLYDEAT
RVPFVIARVGDEATTARTVSAPTSHVDLVPTLLSAAGIDTDAVAANLAESFTEVHPLPGRDLMAVVDGAP
ADEDRAIYLMTRDNVLEGDTGASLLSRQLGRTVNPPAPLRIKLPAHVAANFEGLVVRVEDSDAPGGAGHL
WKLVRTFDDPATWTEPGVRHLASNGVGGETYRTDPVDDQWELYDLTADPIETDNRWTDPELHELRQHLRM
QLKQQRASSVPERNQPWPYANRQPETGESQGPIRRLLGRIGS*
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. marinum MMMAR_1577--100% (603)hydrolase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3104-0.086.00% (600) hydrolase
M. gilvum PYR-GCKMflv_2372-0.079.13% (599) sulfatase
M. tuberculosis H37RvRv3077-0.085.83% (600) hydrolase
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_4469c-1e-2729.75% (400) sulfatase family protein
M. avium 104-----
M. smegmatis MC2 155MSMEG_1286-0.082.50% (583) sulfatase family protein
M. thermoresistible (build 8)TH_0121atsF0.081.90% (580) POSSIBLE HYDROLASE
M. ulcerans Agy99MUL_3457-0.099.17% (603) hydrolase
M. vanbaalenii PYR-1Mvan_4274-0.078.96% (599) sulfatase

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_2372|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_4274|M.vanbaalenii_PYR-1       --------------------------------------------------
MMAR_1577|M.marinum_M               --------------------------------------------------
MUL_3457|M.ulcerans_Agy99           --------------------------------------------------
Mb3104|M.bovis_AF2122/97            --------------------------------------------------
Rv3077|M.tuberculosis_H37Rv         --------------------------------------------------
MSMEG_1286|M.smegmatis_MC2_155      --------------------------------------------------
TH_0121|M.thermoresistible__bu      VAVFSRARTIPAGTERIWELLGDVGALSSWARLVDHSCVLTTGPHGDLIG
MAB_4469c|M.abscessus_ATCC_199      --------------------------------------------------
                                                                                      

Mflv_2372|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_4274|M.vanbaalenii_PYR-1       --------------------------------------------------
MMAR_1577|M.marinum_M               --------------------------------------------------
MUL_3457|M.ulcerans_Agy99           --------------------------------------------------
Mb3104|M.bovis_AF2122/97            --------------------------------------------------
Rv3077|M.tuberculosis_H37Rv         --------------------------------------------------
MSMEG_1286|M.smegmatis_MC2_155      --------------------------------------------------
TH_0121|M.thermoresistible__bu      TTRRVQIGRTTLVERITEFDPPRALSYQICGLPPQLGNVVNRWVLSPTAG
MAB_4469c|M.abscessus_ATCC_199      -------------------------MAELNRRTVLTTGAIAAGAAAVGFG
                                                                                      

Mflv_2372|M.gilvum_PYR-GCK          ---------------MTAQRPDVVIVMTDEERAIPPYESDRVRTWRDETL
Mvan_4274|M.vanbaalenii_PYR-1       ---------------MTTERPDIVVVMTDEERATPPYEPDTVRAWRSRTL
MMAR_1577|M.marinum_M               ----------------MPEGPDIVIIMTDEERAVPPYESADVLAWRQRTL
MUL_3457|M.ulcerans_Agy99           ----------------MPEGPDIVIIMTDEERAVPPYESADVLAWRQRTL
Mb3104|M.bovis_AF2122/97            ----------------MANRPDIIIVMTDEERAVPPYESAEVLAWRQRSL
Rv3077|M.tuberculosis_H37Rv         ----------------MANRPDIIIVMTDEERAVPPYESAEVLAWRQRSL
MSMEG_1286|M.smegmatis_MC2_155      ----------------MTDRPDIVIVMTDEERAIPPYESSSVLAWRERVL
TH_0121|M.thermoresistible__bu      GTVVTLTTTVXXSRPDSGGRPDIVIVMTDEERAIPPYESDDLLAWRDQTL
MAB_4469c|M.abscessus_ATCC_199      GYELLGTPRRNSSSGSDGNKPNILVIVVDQMRAPQWFPDVQKLTN---IL
                                                        *::::::.*: **   :      :     *

Mflv_2372|M.gilvum_PYR-GCK          TGRRWFEEHGVSFTRHYTGSLACVPSRPTIFTGHYPDLHGVTQTDGIGKS
Mvan_4274|M.vanbaalenii_PYR-1       GGRRWFDENGVSFLRHYTGSLACVPSRPTIFTGQYPDLHGVTQTDGIGKA
MMAR_1577|M.marinum_M               TGRRWFDEHGVSFARHYTGSLACVPSRPTIFTGQYPDLHGVTQTDGIGKR
MUL_3457|M.ulcerans_Agy99           TGRRWFDEHGVSFARHYTGSLACVPSRPTIFTGQYPDLHGVTQTDGIGKR
Mb3104|M.bovis_AF2122/97            TGRRWFDEHGISFTRHYTGSLACVPSRPTIFTGQYPDLHGVTQTDGIGKR
Rv3077|M.tuberculosis_H37Rv         TGRRWFDEHGISFTRHYTGSLACVPSRPTIFTGQYPDLHGVTQTDGIGKR
MSMEG_1286|M.smegmatis_MC2_155      TGRRWFDEHGVNFTRHYTGSLACVPSRPTMFTGHYPDLHGITQTDGLGKR
TH_0121|M.thermoresistible__bu      AGRRWFDEHGVTFTRHYTGSLACVPSRPTIFTGHYPDLHGVTQTDGLGKS
MAB_4469c|M.abscessus_ATCC_199      PNLSRLHRDSVSFASHYTASNMCTPSRGAMTTGLYSHQTGCLYTG-----
                                     .   :....:.*  ***.*  *.*** :: ** *..  *   *.     

Mflv_2372|M.gilvum_PYR-GCK          HDDSRLRWLRRGEVPTLGNWFRAAGYDTHYDGKWHISHADLTDPSTGRPL
Mvan_4274|M.vanbaalenii_PYR-1       HDDSRLRWLRRGEVPTLGNWLRAAGYDTHYDGKWHISHADLIDPGTGRSL
MMAR_1577|M.marinum_M               FDDSRLRWLRAGEVPTLGNWFRAAGYDTHYDGKWHISHADLEDPDTGLSL
MUL_3457|M.ulcerans_Agy99           FDDSRLRWLRAGEVPTLGNWFRAAGYDTHYDGKWHISHADLEDPDTGLSL
Mb3104|M.bovis_AF2122/97            FDDSRLRWLRAGEVPTLGNWFRAAGYDTHYDGKWHISHADLEDPATGAPL
Rv3077|M.tuberculosis_H37Rv         FDDSRLRWLRAGEVPTLGNWFRAAGYDTHYDGKWHISHADLEDPATGAPL
MSMEG_1286|M.smegmatis_MC2_155      YDDSRLRWLRRGEVPTLGNWFRAAGYDTHYDGKWHISHADLEDPATGEPL
TH_0121|M.thermoresistible__bu      HDDSRMRWLRRGEVPTLGHWFRAAGYDTHYDGKWHISHADLTDPRTGRPL
MAB_4469c|M.abscessus_ATCC_199      --EGPSESSLAPQFPTWGTMLRQQGYRTWWWGKWHLGDWSDTNP------
                                      :.  .     :.** *  :*  ** * : ****:.. .  :*      

Mflv_2372|M.gilvum_PYR-GCK          ATNDSDGVVDPGAVKRYLDADPLAPYGFSGWVGPEPHGAGLANAGIRRDP
Mvan_4274|M.vanbaalenii_PYR-1       DTNDDDGVVDPAAVHRYLEADPLSPYGFSGWVGPEPHGAKLSNAGIRRDP
MMAR_1577|M.marinum_M               ATNDDDGEIDPAAVQRYLDADPLGPYGFSGWVGPEPHGAGNANSGFRRDP
MUL_3457|M.ulcerans_Agy99           ATNDDDGEIDPAAVQRYLDADPLGPYGFSGWVGPEPHGAGNANSGFRRDP
Mb3104|M.bovis_AF2122/97            ATNDNEGVVDSAAVRRYLDADPLGPYGFSGWVGPEPHGAGLANSGFRRDP
Rv3077|M.tuberculosis_H37Rv         ATNDNEGVVDSAAVRRYLDADPLGPYGFSGWVGPEPHGAGLANSGFRRDP
MSMEG_1286|M.smegmatis_MC2_155      ATNDDDGVIDHAAVQAYLEADPLAPFGFSGWVGPEPHGAAMSNSGFRRDP
TH_0121|M.thermoresistible__bu      ATNDDDGVVDPAAVQRYLDADPLDPFGFSGWVGPEPHGAGLANSGLRRDP
MAB_4469c|M.abscessus_ATCC_199      --------------------EGLDAHGFSGGTFPSPN--GMPNQGLQKDP
                                                        : * ..**** . *.*:    .* *:::**

Mflv_2372|M.gilvum_PYR-GCK          LIADRVVAWLTARYAARAAGDSAALRPFLLVASFVNPHDIVLFPAWARRN
Mvan_4274|M.vanbaalenii_PYR-1       LIADRVVAWLKDRYARRRAGDPDAMRPFLLVASFVNPHDIVLFPAWARRN
MMAR_1577|M.marinum_M               LIADRVVAWLEDRYARRRAGDEAALRPFLLVASFINPHDVVLFPAWVRFS
MUL_3457|M.ulcerans_Agy99           LIADRVVAWLEDRYARRRAGDEAALRPFLLVASFINPHDVVLFPAWVRFG
Mb3104|M.bovis_AF2122/97            LVADRVVAWLTERYARRRAGDTAAMRPFLLVASFVNPHDIVLFPAWVWRS
Rv3077|M.tuberculosis_H37Rv         LVADRVVAWLTERYARRRAGDTAAMRPFLLVASFVNPHDIVLFPAWVWRS
MSMEG_1286|M.smegmatis_MC2_155      IVADRVVAWLKDRYARRRAGDPDALRPFLLVASFVNPHDIVLFPAWSRRM
TH_0121|M.thermoresistible__bu      LIADRVVAWLRDRYERRRAGDPDALRPFLLVASFVNPHDIVLFPTWARRS
MAB_4469c|M.abscessus_ATCC_199      GIVDQFAGWFDAEAGKG---------PWCTTVSLVNPHDICWWPKNP-LP
                                     :.*:...*:  .             *:  ..*::****:  :*      

Mflv_2372|M.gilvum_PYR-GCK          PLSPSPLDPPSVPPAPTADEDLSTKPAAQIAFREAYYSGYGPAGSIER-T
Mvan_4274|M.vanbaalenii_PYR-1       PLPASPLDPPPVPAAPTADEDLSTKPAAQIAFREAYYSGYGPAWSIER-T
MMAR_1577|M.marinum_M               PLKPSHLDPPHVPAPPTADEDLRTKPAAQIAFRQAYYTGYGVAPAIKR-T
MUL_3457|M.ulcerans_Agy99           PLKPSHLDPPHVPAPPTADEDLRTKPAAQIAFRQAYYTGYGVAPAIKR-T
Mb3104|M.bovis_AF2122/97            PLKPSPLDPPHVPAAPTADEDLSTKPAAQVAYREAYYSGYGLTRMVSR-N
Rv3077|M.tuberculosis_H37Rv         PLKPSPLDPPHVPAAPTADEDLSTKPAAQVAYREAYYSGYGLTRMVSR-N
MSMEG_1286|M.smegmatis_MC2_155      PFGPSELDPPHVPAAPTAEEDLRDKPAAQIAFREAYYTGYGPAMAVER-T
TH_0121|M.thermoresistible__bu      PLSPGPLDPPPVPPAPTADEDLSDKPAAHIAFREAYYSGYGPAWFVQR-T
MAB_4469c|M.abscessus_ATCC_199      EDVPHWFDGLPVNFQTPDELRQHGKPRLQIDYANFMSPIMTGAVTYSGPD
                                       .  :*   *   .. :     **  :: : :   .    :   .   

Mflv_2372|M.gilvum_PYR-GCK          YRRNAQRYRDLYYRLHAEVDEPIDRVRRAVTDG---AGAHPTVLVRTADH
Mvan_4274|M.vanbaalenii_PYR-1       YRRNAQRYRDLYYRLHAEVDTPIDRVRRAVTEGGSGDGPDDTVLVRTADH
MMAR_1577|M.marinum_M               YQRNAQRYRDLYYRLHAENDGPIDRVRRAVTEGG----SDNAVLVRTSDH
MUL_3457|M.ulcerans_Agy99           YQRNAQRYRDLYYRLHAENDGPIDRVRRAVTEGG----SDNAVLVRTSDH
Mb3104|M.bovis_AF2122/97            YARNAQRYRDLYYRLHAEVDGPIDRVRRAVTEGG----SEDAMLVRTSDH
Rv3077|M.tuberculosis_H37Rv         YARNAQRYRDLYYRLHAEVDGPIDRVGRAVTEGG----SEDAMLVRTSDH
MSMEG_1286|M.smegmatis_MC2_155      YRRKAQQYRDLYYRLHAEVDGPIDRVRRAVTEGG----SENAVLVRTSDH
TH_0121|M.thermoresistible__bu      YERNAQRYRDLYYRLHAEVDGPIDRVRRAVTAG-----SHNAVLVRTSDH
MAB_4469c|M.abscessus_ATCC_199      MARQWARCLDMYLWLQQQVDAQIGRVLDKLASRP--EIDGNTIVVFTSDH
                                      *:  :  *:*  *: : *  *.**   ::          :::* *:**

Mflv_2372|M.gilvum_PYR-GCK          GDLLGAHGGLHQKWFNLYDEATRVPFVIARTG--PDATTARTVTAPTSHV
Mvan_4274|M.vanbaalenii_PYR-1       GDLLGAHGGLHQKWFNLYDEATRVPFVIARVG--ARPTTARTVTAPTSHV
MMAR_1577|M.marinum_M               GDLLGAHGGLHQKWFNLYDEATRVPFVIARVG--DEATTARTVSAPTSHV
MUL_3457|M.ulcerans_Agy99           GDLLGAHGGLHQKWFNLYDEATRVPFVITRVG--NEATTARTVSAPTSHV
Mb3104|M.bovis_AF2122/97            GDLLGAHGGLHQKWFNLYDEATRVPFVIARIG--EKATQPRTVSAPTSHV
Rv3077|M.tuberculosis_H37Rv         GDLLGAHGGLHQKWFNLYDEATRVPFVIARIG--EKATQPRTVSAPTSHV
MSMEG_1286|M.smegmatis_MC2_155      GELLGAHGGLHQKWFNLYDEATRVPFVIARIG--TEATEARTVDAPTSHV
TH_0121|M.thermoresistible__bu      GELLGAHGGLHQKWFNLYDEATRVPFVIARIG--DRATEARTVTAPTSHV
MAB_4469c|M.abscessus_ATCC_199      GEYAGSHG-LRGKGATAYEEAIRVPLYIRDPQGVLTPKPGETRTQLTSSV
                                    *:  *:** *: *  . *:** ***: *        ..  .*    ** *

Mflv_2372|M.gilvum_PYR-GCK          DLVPTLLAAAGIDAESVAATLGESFTEVHPLPGRDLMPVVDGAPADEDRP
Mvan_4274|M.vanbaalenii_PYR-1       DLVPTLLSAAGVDVDAAATVLAESFSEVHPLPGSDLMPVVDGAPADDHRC
MMAR_1577|M.marinum_M               DLVPTLLSAAGIDTDAVAANLAESFTEVHPLPGRDLMAVVDGAPADEDRA
MUL_3457|M.ulcerans_Agy99           DLVPTLLSAAGIDTEAVAANLAESFTEVHPLPGRDLMAVVDGAPADEDRA
Mb3104|M.bovis_AF2122/97            DLVPTLLSAAGVDVDVVAAALAESFSEVHPLPGRDLMPVVDGASADEGRA
Rv3077|M.tuberculosis_H37Rv         DLVPTLLSAAGVDVDVVAAALAESFSEVHPLPGRDLMPVVDGASADEGRA
MSMEG_1286|M.smegmatis_MC2_155      DLVPTLLGAAGVDVDAAAEQLRESFSEVHPLPGRDLMPVVSGESADEHRP
TH_0121|M.thermoresistible__bu      DLVPTLLGAAGVDVDAAAARLAESFTEVHPLPGRDLMPVVDGAPADENRA
MAB_4469c|M.abscessus_ATCC_199      DLAPLLLTIG------SGGNAWRSDPRFSYLAARADIAAIAKNNAAGRKW
                                    **.* **  .       .    .* ...  *..   :..:    *   : 

Mflv_2372|M.gilvum_PYR-GCK          VYLMTRDNVLEGDTGASGLARALRLTSRVPAPLRIRVPAHTAANFEGLVL
Mvan_4274|M.vanbaalenii_PYR-1       VYLMTRDNVLEGDTGASGLARALKLTSKVPAPLRIRIPAHTAANFEGLVI
MMAR_1577|M.marinum_M               IYLMTRDNVLEGDTGASLLSRQLGRTVNPPAPLRIKLPAHVAANFEGLVV
MUL_3457|M.ulcerans_Agy99           IYLMTRDNVLEGDTGASLLSRQLGRTVNPPAPLRIKLPAHVAANFEGLVV
Mb3104|M.bovis_AF2122/97            IYLMTRDNVLEGDTGASLLSRQLGRIVNPPAPLRIKVPAHVAANFEGLVV
Rv3077|M.tuberculosis_H37Rv         IYLMTRDNVLEGDTGASLLSRQLGRIVNPPAPLRIKVPAHVAANFEGLVV
MSMEG_1286|M.smegmatis_MC2_155      IYLMTRDNVLEGDTGASGVARQLGRDVNPPAPLRIKVPAHVASNFEGLVV
TH_0121|M.thermoresistible__bu      VYLMTRDSVLDGDTGASGLARQLNLTANPPGPLRIRVPAHVASNFEGLVV
MAB_4469c|M.abscessus_ATCC_199      IAHVTDDMSVEEMA-------TLLKDPRIRAVMGENAPTEIPTSAASHIV
                                    :  :* *  ::  :        *    .  . :  . *:. .:.  . ::

Mflv_2372|M.gilvum_PYR-GCK          RVPETSAAGGGGHLWKLVRSFDDPGTWTEPGVRQLAAD-GVGGPTYRSEP
Mvan_4274|M.vanbaalenii_PYR-1       RVDEDAAPGGRGHLWKLVRSFDDPGTWTEPGVRHLAAD-GIGGPMYRTDP
MMAR_1577|M.marinum_M               RVEDSDAPGGAGHLWKLVRTFDDPATWTEPGVRHLASN-GVGGETYRTDP
MUL_3457|M.ulcerans_Agy99           RVEDSDAPGGAGHLWKLVRTFDDPATWTEPGVRHLASN-GVGGETYRTDP
Mb3104|M.bovis_AF2122/97            RVDDTDAAGGAGHLWKLVRTFDDPATWTEPGVRHLATN-GMGGDAYRTDP
Rv3077|M.tuberculosis_H37Rv         RVDDTDAAGGAGHLWKLVRTFDDPATWTEPGVRHLATN-GMGGDAYRTDP
MSMEG_1286|M.smegmatis_MC2_155      RVDDADAHGGAGHLWKLVRTFDDPSTWTEPGVRHLAAD-GLGGETYRSDP
TH_0121|M.thermoresistible__bu      CVEEATAAGGAGHLWKLVRTFDDPATWTEPGVRHLAAD-GLGGPAYRTDP
MAB_4469c|M.abscessus_ATCC_199      AVRTAEAKLANYSYWKPGGMRIDTSRPSEHEFYDYSTPSGKQESQNQAGD
                                     *    *  .    **      *..  :*  . . ::  *      ::  

Mflv_2372|M.gilvum_PYR-GCK          LDDQWELYDLTDDPIEQTNRWPDPALHALRAYLRTQLKHARAQSIPERNQ
Mvan_4274|M.vanbaalenii_PYR-1       LDDQWELYDLTDDPVEQHNRWTDPDLHELRAYLRAQLKSVRAESIPERNR
MMAR_1577|M.marinum_M               VDDQWELYDLTADPIETDNRWTDPELHELRQHLRMQLKQQRASSVPERNQ
MUL_3457|M.ulcerans_Agy99           VDDQWELYDLTADPIETDNRWTDPELHELRQHLRMQLKQQRASSVPERNQ
Mb3104|M.bovis_AF2122/97            LDDQWELYDLTADPIEAYNRWTDPQLHELRQHLRMLLKQQRAVSVPERNQ
Rv3077|M.tuberculosis_H37Rv         LDDQWELYDLTADPIEAYNRWTDPQLHELRQHLRMLLKQQRAVSVPERNQ
MSMEG_1286|M.smegmatis_MC2_155      LDDQWELYDLTADPVEAVNRWHYPDLHEVRQYLLAQLKQVRASSVPERNV
TH_0121|M.thermoresistible__bu      LDDQWELYDLTVDPIEAVNRWDDPGLDELRRHLRAQLKQARTVSVPERNE
MAB_4469c|M.abscessus_ATCC_199      STKQAQLQALIDN----------EVLPEVQAPLPAFLGQAQEQGLADMQK
                                      .* :*  *  :            *  ::  *   *   :  .:.: : 

Mflv_2372|M.gilvum_PYR-GCK          PWPYARRQPPPARRWTPGRALRRLLG-
Mvan_4274|M.vanbaalenii_PYR-1       PWPYVRRQPPQPARWSPGRALRRLRD-
MMAR_1577|M.marinum_M               PWPYANRQPETGESQGPIRRLLGRIGS
MUL_3457|M.ulcerans_Agy99           PWPYANRQPETGQSQGPIRRLLGRIGS
Mb3104|M.bovis_AF2122/97            PWPYAHRLPPSGASNGLVRRVLGRFVR
Rv3077|M.tuberculosis_H37Rv         PWPYAHRLPPSGASNGLVRRVLGRFVR
MSMEG_1286|M.smegmatis_MC2_155      PWPYARR--------GGV---------
TH_0121|M.thermoresistible__bu      PWPYVRRQAR-----------------
MAB_4469c|M.abscessus_ATCC_199      LMVLRGG--------------------